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Published on: Nov 28, 2021
2 minute read
By: Second Medic Expert

A Variant Of Concern: Omicron

A variant of Concern: Omicron

The World Health Organization has designated the strain, now named Omicron, as a variant of concern and said multiple studies are underway to monitor its development.

The Unknowns - Scientists are warning that the variant could be more contagious, but they don't really know for sure. They also worry about its effects on vaccine efficacy and severity of disease - we'll just have to wait until there's more research!
Where it has been identified - The variant has so far been identified in South Africa, Botswana, Hong Kong, and Belgium. A specimen from the first known case of the variant in South Africa was collected November 9, the WHO said Friday.
The number of variant cases - Now, the number of variant cases seems to be increasing in nearly every province of the country, the WHO said. South Africa has currently fully vaccinated less than 36% of its adult population and its rate of new vaccinations had fallen in recent days, according to the country's health department.
Cases Identified - South African officials also initially said there was one confirmed case in a traveler from South Africa to Hong Kong. Friday, Hong Kong health authorities identified a second case of the variant among returning travelers on the same floor of a designated quarantine hotel. Health authorities ordered at least 12 people in nearby rooms to undergo mandatory Covid-19 testing and two weeks of quarantine in a government center. Also on Friday, the Belgian government said an individual who had recently traveled from Egypt and was unvaccinated, tested positive for the variant, marking the first case in Europe.
High number of Mutations: South African genomic scientists said earlier this week the variant has an unusually high number of mutations, with more than 30 in the key spike protein -- the structure the virus uses to get into the cells they attack.
The concern: Scientists are concerned those mutations could make the variant more transmissible and could result in immune evasion. Scientists are working to find out whether the variant could evade immunity, saying its mutations can help hint or predict whether it will be the case.
Vaccine Efficacy: The million-dollar question is, is there a tiny hit to vaccine efficacy, or is there a large hit? we'll get some preliminary data probably in the next few days.
How it compares with other variants - While mutations -- and new variants -- of the virus are expected as it continues to spread, experts say there's more reason for concern with Omicron. As per the scientists they have seen a lot of variants pop up over the last five, six months, and most of them have not amounted to much but this looks different. It's acting differently, it looks like it's much more contagious than even the Delta variant." WHO officials also said in their statement Friday preliminary evidence suggests Omicron also poses a higher risk of reinfection, compared to other variants of concern.

What vaccine makers are saying

In a Friday news release, Moderna said it was rapidly working to test the ability of its vaccine to neutralize the variant, and data is expected in the coming weeks.

The strain includes mutations "seen in the Delta variant that are believed to increase transmissibility and mutations seen in the Beta and Delta variants that are believed to promote immune escape," Moderna said. "The combination of mutations represents a significant potential risk to accelerate the waning of natural and vaccine-induced immunity."

The Solution: If its current vaccine and booster are insufficient against the variant, one possible solution is boosting people with a larger dose, which Moderna said it is testing. The company is also evaluating two multivalent booster candidates to see if they provide better protection against Omicron -- both of which include some of the viral mutations present in the variant. Moderna said it is also testing an Omicron-specific booster. AstraZeneca also said it was looking to understand the impact Omicron has on its vaccine, which is not currently authorized for use in the US. A Johnson & Johnson spokesperson told CNN in a statement the company was also testing the effectiveness of its vaccine against Omicron.

Why Travel Restrictions?

Travel restrictions will buy governments some time to investigate the variant, but it's inevitable the strain will eventually appear and spread.

Source : who,cnn

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Tuberculosis Symptoms and Treatment: Early Signs, Diagnosis, and Recovery

Tuberculosis (TB) is one of the oldest known infectious diseases and continues to be a major public health concern, especially in developing countries. India accounts for a significant proportion of global TB cases, despite advances in diagnosis and treatment. The good news is that tuberculosis is preventable, treatable and curable when detected early and managed properly.

Understanding tuberculosis symptoms and treatment is critical for reducing disease spread, preventing complications and achieving complete recovery.

What Is Tuberculosis?

Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis. It primarily affects the lungs (pulmonary TB) but can also involve other parts of the body such as:

lymph nodes
bones and joints
kidneys
brain

TB spreads through the air when an infected person coughs, sneezes or speaks.

Why Tuberculosis Remains a Major Health Issue

According to the World Health Organization and ICMR data:

millions of new TB cases are reported annually
delayed diagnosis increases transmission
incomplete treatment leads to drug resistance

Early detection and treatment are key to TB control.

Common Tuberculosis Symptoms

TB symptoms often develop gradually and may be mild in the early stages, leading to delayed diagnosis.

Persistent Cough

A cough lasting more than two to three weeks is a hallmark symptom of pulmonary TB.

The cough may:

be dry or productive
worsen over time
sometimes produce blood

Fever and Night Sweats

Low-grade fever, especially in the evenings, is common.

Night sweats that soak clothing or bedding are a classic TB sign.

Unexplained Weight Loss

TB increases metabolic demand and reduces appetite, leading to significant weight loss.

Fatigue and Weakness

Persistent tiredness and reduced stamina occur due to chronic infection.

Chest Pain

Chest discomfort or pain may occur during coughing or breathing.

Symptoms of Extra-Pulmonary TB

When TB affects organs outside the lungs, symptoms depend on the site involved and may include:

swollen lymph nodes
bone or joint pain
headaches or neurological symptoms
urinary issues

Why TB Symptoms Are Often Ignored

Many TB symptoms resemble common infections or general weakness.

This leads to:

delayed medical consultation
prolonged transmission
disease progression

Awareness improves early detection.

How Tuberculosis Is Diagnosed

Diagnosis involves a combination of:

sputum tests
chest X-ray
molecular tests such as CBNAAT
blood tests and imaging for extra-pulmonary TB

Early and accurate diagnosis is essential for effective treatment.

Tuberculosis Treatment Explained

TB treatment involves a combination of antibiotics taken over a fixed duration.

Standard TB Treatment

For drug-sensitive TB, treatment typically lasts:

6 months

The regimen includes multiple antibiotics taken in phases to ensure complete bacterial clearance.

Importance of Treatment Adherence

TB bacteria are slow-growing and resilient.

Stopping treatment early can result in:

incomplete cure
relapse
drug-resistant TB

Completing the full course is essential.

Drug-Resistant TB

If TB bacteria become resistant to standard drugs, treatment becomes longer and more complex.

Drug-resistant TB requires:

specialised medications
longer treatment duration
close medical supervision

Prevention of resistance depends on correct treatment from the start.

Side Effects of TB Treatment

Some individuals may experience side effects such as:

nausea
loss of appetite
mild liver enzyme changes

Most side effects are manageable with medical guidance and do not require stopping treatment.

TB and Public Health

TB is not just an individual health issue but a community concern.

Effective TB control requires:

early diagnosis
treatment adherence
contact tracing
public awareness

India’s national TB elimination programmes focus on these strategies.

Preventing Tuberculosis

Preventive measures include:

early detection and treatment of active TB
improving nutrition and immunity
adequate ventilation in living spaces
screening close contacts

BCG vaccination offers partial protection, especially in children.

Living With and Recovering From TB

With proper treatment:

symptoms gradually improve
infection becomes non-contagious
normal life can be resumed

Regular follow-up ensures complete recovery.

When to Seek Medical Help

Consult a healthcare provider if experiencing:

cough lasting more than two weeks
unexplained weight loss
persistent fever or night sweats
blood in sputum

Early action saves lives and prevents spread.

Long-Term Outlook After TB Treatment

Most individuals who complete treatment:

recover fully
regain normal lung function
return to daily activities

Long-term complications are rare with timely care.

Conclusion

Tuberculosis symptoms and treatment must be understood clearly to combat this preventable and curable disease. Persistent cough, fever, night sweats and weight loss should never be ignored. Early diagnosis, complete treatment adherence and regular follow-up are essential for curing TB and preventing transmission. With proper medical care and public awareness, tuberculosis can be effectively controlled and eliminated as a public health threat.

References

Indian Council of Medical Research (ICMR) – Tuberculosis Epidemiology and Treatment Guidelines
World Health Organization (WHO) – Global Tuberculosis Report
National Tuberculosis Elimination Programme (NTEP) – Government of India
Lancet Infectious Diseases – TB Diagnosis and Treatment Outcomes
National Family Health Survey (NFHS-5) – Infectious Disease Indicators
Statista – Global Tuberculosis Burden and Trends

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