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Published on: Nov 28, 2021
2 minute read
By: Second Medic Expert

A Variant Of Concern: Omicron

A variant of Concern: Omicron

The World Health Organization has designated the strain, now named Omicron, as a variant of concern and said multiple studies are underway to monitor its development.

The Unknowns - Scientists are warning that the variant could be more contagious, but they don't really know for sure. They also worry about its effects on vaccine efficacy and severity of disease - we'll just have to wait until there's more research!
Where it has been identified - The variant has so far been identified in South Africa, Botswana, Hong Kong, and Belgium. A specimen from the first known case of the variant in South Africa was collected November 9, the WHO said Friday.
The number of variant cases - Now, the number of variant cases seems to be increasing in nearly every province of the country, the WHO said. South Africa has currently fully vaccinated less than 36% of its adult population and its rate of new vaccinations had fallen in recent days, according to the country's health department.
Cases Identified - South African officials also initially said there was one confirmed case in a traveler from South Africa to Hong Kong. Friday, Hong Kong health authorities identified a second case of the variant among returning travelers on the same floor of a designated quarantine hotel. Health authorities ordered at least 12 people in nearby rooms to undergo mandatory Covid-19 testing and two weeks of quarantine in a government center. Also on Friday, the Belgian government said an individual who had recently traveled from Egypt and was unvaccinated, tested positive for the variant, marking the first case in Europe.
High number of Mutations: South African genomic scientists said earlier this week the variant has an unusually high number of mutations, with more than 30 in the key spike protein -- the structure the virus uses to get into the cells they attack.
The concern: Scientists are concerned those mutations could make the variant more transmissible and could result in immune evasion. Scientists are working to find out whether the variant could evade immunity, saying its mutations can help hint or predict whether it will be the case.
Vaccine Efficacy: The million-dollar question is, is there a tiny hit to vaccine efficacy, or is there a large hit? we'll get some preliminary data probably in the next few days.
How it compares with other variants - While mutations -- and new variants -- of the virus are expected as it continues to spread, experts say there's more reason for concern with Omicron. As per the scientists they have seen a lot of variants pop up over the last five, six months, and most of them have not amounted to much but this looks different. It's acting differently, it looks like it's much more contagious than even the Delta variant." WHO officials also said in their statement Friday preliminary evidence suggests Omicron also poses a higher risk of reinfection, compared to other variants of concern.

What vaccine makers are saying

In a Friday news release, Moderna said it was rapidly working to test the ability of its vaccine to neutralize the variant, and data is expected in the coming weeks.

The strain includes mutations "seen in the Delta variant that are believed to increase transmissibility and mutations seen in the Beta and Delta variants that are believed to promote immune escape," Moderna said. "The combination of mutations represents a significant potential risk to accelerate the waning of natural and vaccine-induced immunity."

The Solution: If its current vaccine and booster are insufficient against the variant, one possible solution is boosting people with a larger dose, which Moderna said it is testing. The company is also evaluating two multivalent booster candidates to see if they provide better protection against Omicron -- both of which include some of the viral mutations present in the variant. Moderna said it is also testing an Omicron-specific booster. AstraZeneca also said it was looking to understand the impact Omicron has on its vaccine, which is not currently authorized for use in the US. A Johnson & Johnson spokesperson told CNN in a statement the company was also testing the effectiveness of its vaccine against Omicron.

Why Travel Restrictions?

Travel restrictions will buy governments some time to investigate the variant, but it's inevitable the strain will eventually appear and spread.

Source : who,cnn

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Monkeypox Virus Symptoms: Early Signs, Disease Progression, and When to Seek Care

Monkeypox, now commonly referred to as mpox, is a viral infection that has gained global attention due to outbreaks beyond traditionally affected regions. Understanding monkeypox virus symptoms is essential for early detection, timely isolation and prevention of further spread.

According to the World Health Organization and Indian public health authorities, awareness of symptom patterns plays a critical role in controlling outbreaks and protecting vulnerable populations.

What Is the Monkeypox Virus?

Monkeypox is caused by the monkeypox virus, a member of the Orthopoxvirus family, which also includes smallpox. While generally less severe than smallpox, monkeypox can still cause significant illness and discomfort.

The virus spreads primarily through close physical contact.

Incubation Period of Monkeypox

After exposure, symptoms typically appear within:

5 to 21 days
most commonly 6 to 13 days

Individuals may feel well during this period but can become infectious once symptoms begin.

Early Monkeypox Virus Symptoms

Fever

Fever is usually the first symptom and may be:

sudden in onset
moderate to high grade
accompanied by chills

Fever signals the start of systemic infection.

Headache and Body Aches

Patients often experience:

severe headache
muscle aches
back pain

These symptoms resemble many viral illnesses.

Fatigue and Weakness

Marked tiredness and low energy levels are common and may limit daily activities.

Swollen Lymph Nodes

Swollen lymph nodes are a distinguishing feature of monkeypox.

Common sites include:

neck
armpits
groin

This helps differentiate monkeypox from chickenpox or smallpox.

Development of Monkeypox Rash

The skin rash usually appears:

1 to 3 days after fever onset

It may begin on the face or genital area and spread to other parts of the body.

Stages of Monkeypox Rash

The rash progresses through well-defined stages:

Macules

Flat red spots on the skin.

Papules

Raised, firm bumps.

Vesicles

Fluid-filled blisters.

Pustules

Pus-filled lesions that are painful.

Scabs

Lesions crust over and eventually fall off.

Complete healing occurs once scabs detach.

Distribution of Rash

Rash commonly affects:

face
hands and feet
mouth
genital and anal areas

The number of lesions can vary widely.

Pain and Discomfort

Rash lesions may be:

painful
itchy during healing

Pain severity differs between individuals.

Other Possible Symptoms

Additional symptoms may include:

sore throat
cough
nasal congestion

These reflect upper respiratory involvement.

Duration of Illness

Monkeypox symptoms typically last:

2 to 4 weeks

Recovery occurs gradually as lesions heal.

Who Is at Higher Risk of Severe Illness?

Higher risk groups include:

children
pregnant women
individuals with weakened immunity
people with chronic illness

Early care is crucial in these groups.

Complications of Monkeypox

Though uncommon, complications may include:

secondary bacterial skin infections
dehydration
pneumonia
eye involvement

Prompt medical guidance reduces risk.

How Monkeypox Is Transmitted

Transmission occurs through:

direct skin-to-skin contact
contact with lesions or bodily fluids
respiratory droplets during close contact
contaminated clothing or bedding

Understanding transmission helps prevent spread.

When to Seek Medical Care

Seek medical evaluation if:

fever is followed by rash
lymph nodes become swollen
rash appears in genital or facial areas

Early diagnosis supports isolation and care.

Diagnosis and Testing

Diagnosis may involve:

clinical examination
laboratory testing of lesion samples

Public health authorities guide testing protocols.

Prevention and Control Measures

Preventive steps include:

avoiding close contact with infected individuals
maintaining good hand hygiene
isolating during illness
following public health guidance

Vaccination may be recommended for high-risk groups.

Role of Public Awareness

Awareness of symptoms:

enables early detection
reduces stigma
supports timely care

WHO emphasises community education in outbreak control.

Conclusion

Monkeypox virus symptoms typically begin with fever, body aches and swollen lymph nodes, followed by a characteristic rash that progresses through defined stages. While most cases are self-limiting, early recognition, medical evaluation and isolation are essential to prevent complications and reduce transmission. Staying informed and acting promptly protects both individual and public health.

References

World Health Organization (WHO) – Mpox (Monkeypox) Clinical and Public Health Guidance
Indian Council of Medical Research (ICMR) – Emerging Viral Infections Reports
National Centre for Disease Control (NCDC), India – Monkeypox Advisories
Lancet – Clinical Features and Outcomes of Mpox
NITI Aayog – Public Health Preparedness and Infectious Disease Control

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