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Published on: Sep 01, 2021
3 minute read
By: Second Medic Expert

Why Do We Need Two Doses Of Vaccine?

Why do we need two doses of vaccine?

Vaccination is a two-fold protective measure for preventing illness. The first dose alerts the immune system to the presence of a certain virus or bacterium, and it creates a cellular immunity of sorts. The second dose is required to alert the body's antibodies, which are typically slower acting but more powerful bodies of defenses. These antibodies present themselves naturally in our bodies after vaccination, forming what we know as "natural specific immunity." To get that natural specific immunity from your second vaccination shot, you will need both injections at least six weeks apart. Essentially then, getting vaccinated twice in quick succession has no effect on your ability to build up natural specific immunity because you'll already be protected by cellular-specific immunity when you receive your second one.

The second dose helps to reduce the incidence of infectious disease. A major reason for a second dose is "herd immunity," in which a high proportion of people within a population have been vaccinated to provide what is known as "community protection" against an infection's spread. This limits the number of individuals who might otherwise be vulnerable or susceptible to contracting and transmitting infection. For this reason, everyone needs to do their part in making sure their own vaccinations are up-to-date and take care does not infect others when they're around them with compromised immune systems--primarily infants too young to have ever been vaccinated or anyone who cannot get vaccines for medical reasons such as being immunosuppressed.

The second dose of the vaccine introduces a different version of the virus into your system to allow your body to develop an immunity because not all viruses are 100% susceptible to the first vaccine.

The effectiveness of vaccination does decline over time, so another injection can help prolong immunity for 5-6 years before it's necessary to vaccinate again. It may be because there are different versions or "strains" or versions of viruses that vaccines don't always work well on. Or there are definitions for "immunity" that are different from ours - whether you have antibodies in your blood doesn't always show true protection against an infection! Of course, we recommend asking a medical professional if you're really interested in this question.

Reason #1: Whether an individual had natural immunity previously. The first shot could wear off for some people, so the second dose ensures that there is protection long after the first dose has worn off.

Reason #2: Some children do not develop strong enough immunity when given just one vaccine dose or they received their vaccines too early in life and later required a booster shot so the best way to protect them is with two doses.

Third Medic Medical consultation online To improve chances of inducing protective immunity in unvaccinated groups during outbreaks, it may be advisable to administer two doses of vaccines to maximize coverage among these populations The cold virus mutates extremely rapidly, and your chances of contracting a mutated strain of cold virus from the vaccine are higher if you skipped the first round. The goal here is to vaccinate as many people as possible with a vaccine that is most likely going to protect them from infection. That’s because even if 50% of those vaccinated this year will not be protected from contracting the disease, that 50% who do end up not being able to contract it are still more protected than they would have been had there been no vaccination. If you argue that vaccines don't work, then you are arguing that children should go untreated for deadly diseases because populations can never get rid of all illnesses at once!

This is a two-fold concern. First, we're aiming to create immunity against the disease more rapidly and it appears that this isn't accurate if we only vaccinate once; we need to boost with two doses at least one month apart. Second, because there are limitations in the science behind vaccination, it's difficult to tell who will have the highest reaction or reaction frequency. So for absolute safety, most doctors recommend three doses at any point in life for those who've never been vaccinated before

Second dose of the vaccine is to confer "immunity." If you happen to be exposed to a virus or bacteria and recover, your body will remember and create antibodies for that specific infection. A second dose of the vaccine provides enough time for those immunities to build up.

If you take the first dose, and go out right afterward to play with friends--this could lead the immune system into mistakenly attacking your own tissues as if they were infected as well because it doesn't yet know not them as healthy tissue.

The first dose is more or less a "primer" and the second dose corresponds with the timing of the typical infectious disease infection. Estimating how long it takes for immunity to develop also depends on which vaccine is being administered. Different viruses elicit variable immune responses, which means that they need different types of vaccines to work best. It's been found, for instance, that most people who receive an influenza vaccination require two doses about four weeks apart to fight off the flu properly. In addition, live attenuated influenza vaccine spurs fewer immunological side effects because it contains weakened versions of elements from virus strains already circulating among humans – since those factors are weaker than their intact counterparts found in a regular flu shot or nasal spray.

The two-dose vaccine regimen is a tried and tested method showing excellent effectiveness.

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Genetic Predisposition Testing India: Understanding Your DNA to Prevent Future Disease

Genetics plays a significant role in determining an individual’s risk for various diseases. In India, where chronic illnesses like diabetes, heart disease, cancer, and neurological disorders are increasing rapidly, genetic predisposition testing has emerged as a powerful preventive tool. It helps individuals understand inherited risk factors long before symptoms appear, allowing timely intervention.

SecondMedic offers guided genetic screening to help patients uncover DNA-based risks and take proactive control of their long-term health.

What Is Genetic Predisposition Testing?

Genetic predisposition testing analyzes a person’s DNA to identify mutations, variations, or inherited markers associated with increased disease risk. It does not diagnose a disease but reveals how likely an individual is to develop certain conditions.

What the test identifies:

Gene mutations
Family-linked disease patterns
Hereditary cancer markers
Metabolic and cardiovascular risks
Neurological conditions
Autoimmune predispositions

These insights help individuals and doctors make informed preventive health decisions.

Why Genetic Testing Is Growing in India

1. High prevalence of lifestyle and hereditary diseases

India is the diabetes capital of the world, and many metabolic disorders have genetic roots.

2. Increasing cancer burden

BRCA and other hereditary cancer syndromes are being detected more often.

3. Awareness about preventive healthcare

People want to act early rather than wait for disease onset.

4. Growth of digital healthcare

Easy access through telemedicine platforms like SecondMedic.

5. Rising chronic cases at younger ages

Genetic predispositions often accelerate early onset of disease.

What Diseases Can Genetic Testing Predict?

1. Cancer Risk

Includes hereditary cancers such as:

Breast
Ovarian
Colorectal
Prostate
Pancreatic

BRCA1, BRCA2, and Lynch syndrome genes are key markers.

2. Heart Disease & Hypertension

Genes that influence:

Cholesterol levels
Plaque formation
Blood pressure regulation

3. Diabetes

Genes that affect insulin sensitivity and metabolic function.

4. Obesity

Markers linked to appetite regulation and fat storage.

5. Neurological Disorders

Including Alzheimer’s, Parkinson’s, and epilepsy predispositions.

6. Autoimmune Diseases

Genes related to lupus, rheumatoid arthritis, and thyroid disorders.

7. Drug Response (Pharmacogenomics)

DNA determines how the body reacts to certain medications.

How Genetic Predisposition Testing Works

Step 1: Sample Collection

Usually saliva, blood, or buccal swab.

Step 2: DNA Sequencing

Advanced technology identifies variations in your genome.

Step 3: Risk Analysis

Gene mutations are mapped to known disease risks.

Step 4: Expert Interpretation

SecondMedic’s genetic counsellors and doctors review results.

Step 5: Preventive Plan

Includes recommended lifestyle changes, screenings, and monitoring.

Benefits of Genetic Predisposition Testing

1. Detect Risk Before Symptoms

Allows decades of preventive action.

2. Personalized Health Planning

Diet, exercise, and medical screening tailored to DNA.

3. Early Cancer Detection

Essential for women with hereditary breast/ovarian cancer risk.

4. Family Health Insights

Identifies conditions that may affect children and siblings.

5. Improved Treatment Outcomes

Knowing your risk helps doctors monitor you more closely.

6. Better Drug Selection

Pharmacogenomics ensures medications match your genetic profile.

Who Should Consider Genetic Testing?

People with family history of cancer
Individuals whose relatives had early heart attacks
Families with diabetes across generations
Women with breast or ovarian cancer history
Couples planning pregnancy
People with unexplained chronic conditions
Individuals wanting personalized preventive healthcare

Limitations of Genetic Testing

1. Not a diagnosis

It shows probability, not certainty.

2. Environmental and lifestyle factors still matter

Genes interact with habits and environment.

3. Requires professional interpretation

Raw results without counselling can be confusing.

SecondMedic ensures accurate guidance through experienced specialists.

How SecondMedic Supports Genetic Testing

1. End-to-End Genetic Screening

From sample collection to detailed analysis.

2. Expert Review

Genetic counselors and doctors explain every risk factor.

3. Personalized Preventive Plan

Nutrition, exercise, and screening based on DNA.

4. Confidential Reporting

All data is securely stored.

5. Integrated Preventive Tracking

Follow-up tests and monitoring for high-risk individuals.

Future of Genetic Testing in India

AI-based genome interpretation
Affordable whole-genome sequencing
Predictive analytics for early cancer
Family-wide health risk mapping
Integration with digital health IDs under ABDM

SecondMedic aims to make genetic screening widely accessible and scientifically guided.

Conclusion

Genetic predisposition testing India empowers individuals by revealing inherited disease risks long before symptoms develop. It supports preventive healthcare, early cancer detection, and personalized wellness planning. With platforms like SecondMedic offering expert-guided genetic testing, Indians can now take proactive control of their long-term health.

To book your genetic test, visit www.secondmedic.com

References

ICMR – Genetic research insights
NIH – Genetic testing guidelines
WHO – Genomic medicine developments
Statista – DNA testing market India
SecondMedic genetic health studies

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