• Published on: Jan 20, 2021
  • 1 minute read
  • By: Dr Rajan Choudhary

MRNA Vaccines – Uses Beyond COVID

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mRNA vaccines – uses beyond COVID

Last year we estimated it would take over a year for a vaccine against COVID to be approved, with vaccinations expected by spring 2021. Incredibly we have managed to meet this prediction, and by the start of January over 42 million doses have been administered in 51 countries. What is even more astounding is that two of the approved vaccines use a completely new vaccination method never used before. mRNA vaccines can be used to easily deliver a variety of different vaccines by changing the mRNA inside the vaccine capsule, and its benefits may not be limited to just infections.

A recent publication in NATURE has demonstrated the use of mRNA vaccines against auto-immune diseases such as multiple sclerosis. MS is an autoimmune condition in which the protective lining of nerves is destroyed by the body’s immune system, significantly slowing down or altering nerve impulse propagation. This leads to symptoms such as fatigue, vision problems, numbness, tingling, aberrant pain, muscle spasms and weakness.

The study looked at introducing antigen-specific tolerance in mice models of MS. This was achieved by activating anti-inflammatory white blood cells. Normally vaccines activate inflammatory white cells to produce a response but altered mRNA with one specific change to its base structure induces and activates anti-inflammatory cells instead.

Furthermore, this anti-inflammatory response is specific to cells that are activated by and attack the body’s nerve cells, thereby delivering a targeted response and not affecting the immune response against infections or cancer. Global immunosuppression is a common side effect of steroids and chemotherapy agents that are normally used to treat auto-immune conditions, and mRNA vaccines may avoid this side effect altogether.

A further advantage is its versatility. This has been demonstrated against multiple sclerosis, but changing the mRNA delivered by the vaccine, it may prove beneficial in far more auto-immune conditions. Of course, we have to emphasize this was an animal study and human trials are unlikely to happen in the next few years, but this study nicely demonstrates how the impact of the COVID pandemic may already be providing beneficial gains for the future.

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Insufficient water intake

How Poor Hydration Affects Joint Health: Why Water Matters for Mobility

Water is essential for nearly every function in the human body, yet many people underestimate its importance for joint health. While hydration is commonly associated with digestion and skin health, it also plays a crucial role in maintaining smooth and pain-free joint movement.

Understanding how poor hydration affects joint health can help prevent stiffness, discomfort and long-term mobility issues.

 

The Role of Water in Joint Function

Joints are where two bones meet, allowing movement and flexibility. Healthy joints rely on:

  • Cartilage
     

  • Synovial fluid
     

  • Ligaments
     

  • Tendons
     

Cartilage, which cushions bones, contains a high percentage of water. Synovial fluid acts as a lubricant, reducing friction during movement.

Proper hydration ensures these components function effectively.

 

What Happens When You Are Dehydrated?

When the body lacks sufficient water:

  • Synovial fluid production may decrease
     

  • Cartilage may lose elasticity
     

  • Joint cushioning becomes less effective
     

This can result in stiffness and discomfort.

 

1. Reduced Joint Lubrication

Synovial fluid requires adequate hydration to maintain volume and viscosity.

Without enough water:

  • Friction between bones increases
     

  • Movement becomes less smooth
     

  • Risk of wear and tear rises
     

 

2. Increased Joint Stiffness

Dehydration may cause joints to feel tight, especially:

  • In the morning
     

  • After prolonged sitting
     

  • During physical activity
     

Stiffness may limit flexibility.

 

3. Higher Risk of Injury

Poorly lubricated joints may be more prone to:

  • Sprains
     

  • Strains
     

  • Cartilage damage
     

Hydration supports tissue resilience.

 

4. Worsening of Existing Joint Conditions

Individuals with conditions such as osteoarthritis may experience increased discomfort if hydration is inadequate.

While water does not cure arthritis, it supports overall joint function.

 

5. Reduced Nutrient Delivery

Water helps transport nutrients to joint tissues.

Dehydration may impair circulation and nutrient exchange, slowing tissue repair.

 

Signs of Dehydration That May Affect Joints

  • Dry mouth
     

  • Dark urine
     

  • Fatigue
     

  • Headaches
     

  • Muscle cramps
     

  • Joint stiffness
     

Recognizing early dehydration signs prevents complications.

 

How Much Water Do You Need?

Hydration needs vary depending on:

  • Body weight
     

  • Climate
     

  • Physical activity level
     

  • Health conditions
     

On average, adults may require 2–3 liters of water daily.

In hot climates such as India, higher intake may be necessary due to increased sweating.

 

Tips to Maintain Proper Hydration

1. Drink Water Regularly

Do not wait until you feel thirsty.

 

2. Eat Water-Rich Foods

Include:

  • Cucumbers
     

  • Watermelon
     

  • Oranges
     

  • Tomatoes
     

 

3. Limit Excessive Caffeine and Alcohol

These may contribute to fluid loss.

 

4. Carry a Water Bottle

Keeping water accessible encourages consistent intake.

5. Hydrate Before and After Exercise

Physical activity increases fluid loss through sweat.

 

Hydration and Joint Health in India

In India’s hot and humid climate, dehydration is common, especially during summer months.

Outdoor workers, athletes and elderly individuals are particularly vulnerable.

Maintaining adequate hydration supports not only joint health but overall wellbeing.

 

When to Consult a Doctor

Seek medical advice if you experience:

  • Persistent joint pain
     

  • Swelling
     

  • Limited range of motion
     

  • Redness or warmth around joints
     

These may indicate underlying joint disorders requiring evaluation.

 

Conclusion

Poor hydration can negatively affect joint health by reducing lubrication, increasing stiffness and raising injury risk. Since cartilage and synovial fluid depend heavily on water, maintaining adequate hydration is essential for smooth movement and long-term mobility.

Drinking sufficient water daily is a simple yet powerful step toward protecting joint health. Combined with regular exercise and balanced nutrition, proper hydration supports active and pain-free living.

Small daily hydration habits can make a significant difference in how your joints feel and function.

 

References

  • Indian Council of Medical Research – Hydration Guidelines

  • World Health Organization – Water and Health Resources

  • Indian Journal of Orthopaedics – Joint Health Studies

  • National Institute of Nutrition India – Fluid Intake Recommendations

  • Journal of Sports Medicine – Hydration and Musculoskeletal Health Research

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