• Published on: Jan 20, 2021
  • 1 minute read
  • By: Dr Rajan Choudhary

MRNA Vaccines – Uses Beyond COVID

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mRNA vaccines – uses beyond COVID

Last year we estimated it would take over a year for a vaccine against COVID to be approved, with vaccinations expected by spring 2021. Incredibly we have managed to meet this prediction, and by the start of January over 42 million doses have been administered in 51 countries. What is even more astounding is that two of the approved vaccines use a completely new vaccination method never used before. mRNA vaccines can be used to easily deliver a variety of different vaccines by changing the mRNA inside the vaccine capsule, and its benefits may not be limited to just infections.

A recent publication in NATURE has demonstrated the use of mRNA vaccines against auto-immune diseases such as multiple sclerosis. MS is an autoimmune condition in which the protective lining of nerves is destroyed by the body’s immune system, significantly slowing down or altering nerve impulse propagation. This leads to symptoms such as fatigue, vision problems, numbness, tingling, aberrant pain, muscle spasms and weakness.

The study looked at introducing antigen-specific tolerance in mice models of MS. This was achieved by activating anti-inflammatory white blood cells. Normally vaccines activate inflammatory white cells to produce a response but altered mRNA with one specific change to its base structure induces and activates anti-inflammatory cells instead.

Furthermore, this anti-inflammatory response is specific to cells that are activated by and attack the body’s nerve cells, thereby delivering a targeted response and not affecting the immune response against infections or cancer. Global immunosuppression is a common side effect of steroids and chemotherapy agents that are normally used to treat auto-immune conditions, and mRNA vaccines may avoid this side effect altogether.

A further advantage is its versatility. This has been demonstrated against multiple sclerosis, but changing the mRNA delivered by the vaccine, it may prove beneficial in far more auto-immune conditions. Of course, we have to emphasize this was an animal study and human trials are unlikely to happen in the next few years, but this study nicely demonstrates how the impact of the COVID pandemic may already be providing beneficial gains for the future.

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Pale skin

Pale Skin Symptoms: Causes, Health Conditions, and When to Seek Medical Care

Skin colour provides important clues about internal health. When the skin becomes noticeably lighter than usual, it may indicate an underlying medical condition. Pale skin symptoms, also referred to as pallor, are commonly associated with reduced blood flow, low hemoglobin levels or impaired oxygen delivery to tissues.

In India, pale skin is frequently linked to anemia, nutritional deficiencies and chronic illnesses, making early recognition essential.

 

What Is Pale Skin?

Pale skin refers to:

  • lighter-than-normal skin tone

  • reduced redness

  • pale appearance of lips, gums or nail beds

It can affect the entire body or specific areas such as the face or hands.

Common Pale Skin Symptoms

Typical signs include:

  • pale face or complexion

  • pale lips or tongue

  • light-colored gums

  • pale nail beds

  • cold hands and feet

  • fatigue and weakness

These symptoms often occur together.

 

Most Common Causes of Pale Skin

Anemia

Anemia occurs when hemoglobin levels are low.

This reduces oxygen delivery to tissues, causing:

  • pale skin

  • fatigue

  • breathlessness

  • dizziness

NFHS-5 reports anemia affects a large proportion of Indian adults, especially women.

 

Iron Deficiency

Iron deficiency is the leading cause of anemia.

Contributing factors include:

  • poor dietary intake

  • blood loss

  • absorption problems

ICMR identifies iron deficiency as a major public health issue.

 

Poor Blood Circulation

Reduced circulation causes:

  • less blood reaching the skin

  • visible pallor

Conditions such as heart disease or shock impair circulation.

 

Acute Blood Loss

Sudden blood loss from:

  • injury

  • gastrointestinal bleeding

  • heavy menstrual bleeding

can cause rapid pallor and weakness.

 

Chronic Diseases

Chronic illnesses such as:

  • kidney disease

  • liver disease

  • cancer

often cause anemia and pallor over time.

 

Infections and Inflammation

Severe infections cause:

  • blood vessel constriction

  • redistribution of blood flow

This leads to pale or clammy skin.

 

Nutritional Deficiencies

Deficiencies of:

  • vitamin B12

  • folate

affect red blood cell production and cause pallor.

 

Hormonal Imbalance

Conditions like hypothyroidism reduce metabolic activity, causing:

  • pale, dry skin

  • fatigue

Thyroid disorders are common but underdiagnosed.

 

Genetic Conditions

Inherited disorders such as thalassemia affect hemoglobin production, leading to chronic pallor.

 

Pale Skin in Children and Older Adults

Children:

  • may develop pallor due to iron deficiency or infections

Older adults:

  • often develop pallor due to chronic disease or nutritional deficiency

Both groups need careful evaluation.

 

Warning Signs That Need Immediate Medical Attention

Seek urgent care if pale skin is associated with:

  • sudden weakness

  • chest pain

  • breathlessness

  • fainting

  • rapid heartbeat

These may indicate serious medical emergencies.

 

How Pale Skin Affects Daily Life

Persistent pallor often causes:

  • low energy

  • reduced physical endurance

  • difficulty concentrating

Quality of life may decline without treatment.

 

Diagnostic Evaluation

Doctors may recommend:

  • complete blood count

  • iron studies

  • vitamin B12 and folate levels

  • kidney and liver function tests

Identifying the cause is critical for treatment.

 

Role of Preventive Health Checkups

Preventive screening helps detect:

  • early anemia

  • nutritional deficiencies

  • chronic disease

Early treatment prevents complications.

 

Management and Treatment Options

Treatment depends on cause and may include:

  • iron or vitamin supplementation

  • treatment of underlying disease

  • dietary correction

  • medical therapy for chronic conditions

Self-treatment without diagnosis should be avoided.

 

Lifestyle Measures to Prevent Pallor

Helpful strategies include:

  • balanced diet rich in iron and vitamins

  • adequate hydration

  • regular health monitoring

  • treating infections early

Lifestyle changes support long-term health.

 

Importance of Early Detection

Ignoring pale skin delays diagnosis of:

  • anemia

  • internal bleeding

  • chronic illness

Early recognition improves outcomes.

 

Conclusion

Pale skin symptoms are more than a cosmetic concern. They often signal anemia, poor circulation, nutritional deficiencies or underlying medical conditions. While temporary pallor may occur due to minor causes, persistent or sudden pale skin requires medical evaluation. Early diagnosis, preventive health screening and appropriate treatment can restore normal skin tone, improve energy levels and protect long-term health.

 

References

  • Indian Council of Medical Research (ICMR) – Anemia and Nutritional Deficiency Reports

  • National Family Health Survey (NFHS-5) – Anemia and Adult Health Data

  • World Health Organization (WHO) – Anemia and Circulatory Health

  • Lancet – Pallor, Anemia and Chronic Disease Research

  • NITI Aayog – Preventive Healthcare and Early Symptom Detection

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