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Published on: Jan 20, 2021
1 minute read
By: Dr Rajan Choudhary

MRNA Vaccines – Uses Beyond COVID

mRNA vaccines – uses beyond COVID

Last year we estimated it would take over a year for a vaccine against COVID to be approved, with vaccinations expected by spring 2021. Incredibly we have managed to meet this prediction, and by the start of January over 42 million doses have been administered in 51 countries. What is even more astounding is that two of the approved vaccines use a completely new vaccination method never used before. mRNA vaccines can be used to easily deliver a variety of different vaccines by changing the mRNA inside the vaccine capsule, and its benefits may not be limited to just infections.

A recent publication in NATURE has demonstrated the use of mRNA vaccines against auto-immune diseases such as multiple sclerosis. MS is an autoimmune condition in which the protective lining of nerves is destroyed by the body’s immune system, significantly slowing down or altering nerve impulse propagation. This leads to symptoms such as fatigue, vision problems, numbness, tingling, aberrant pain, muscle spasms and weakness.

The study looked at introducing antigen-specific tolerance in mice models of MS. This was achieved by activating anti-inflammatory white blood cells. Normally vaccines activate inflammatory white cells to produce a response but altered mRNA with one specific change to its base structure induces and activates anti-inflammatory cells instead.

Furthermore, this anti-inflammatory response is specific to cells that are activated by and attack the body’s nerve cells, thereby delivering a targeted response and not affecting the immune response against infections or cancer. Global immunosuppression is a common side effect of steroids and chemotherapy agents that are normally used to treat auto-immune conditions, and mRNA vaccines may avoid this side effect altogether.

A further advantage is its versatility. This has been demonstrated against multiple sclerosis, but changing the mRNA delivered by the vaccine, it may prove beneficial in far more auto-immune conditions. Of course, we have to emphasize this was an animal study and human trials are unlikely to happen in the next few years, but this study nicely demonstrates how the impact of the COVID pandemic may already be providing beneficial gains for the future.

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Importance of Regular Health Checkups: Early Detection Saves Lives

In today’s fast-paced lifestyle, many individuals prioritise work and family responsibilities while neglecting their own health. However, understanding the importance of regular health checkups is critical for preventing serious medical conditions. Many diseases develop silently without noticeable symptoms, making routine screening essential for early diagnosis and effective treatment.

According to the Indian Council of Medical Research (ICMR), non-communicable diseases such as diabetes, hypertension and cardiovascular conditions are rising across India. Early detection through preventive checkups significantly reduces complications and mortality.

What Are Regular Health Checkups?

Regular health checkups involve:

routine blood tests
blood pressure monitoring
cholesterol screening
organ function tests
lifestyle risk assessments

These assessments help identify abnormalities before they progress into severe conditions.

Why Preventive Healthcare Matters

Preventive healthcare focuses on:

identifying risk factors
detecting disease early
preventing complications

The World Health Organization states that preventive care reduces long-term healthcare burden and improves life expectancy.

Early Detection of Chronic Diseases

Diabetes

India has over 100 million people living with diabetes, according to ICMR data. Many individuals are unaware until complications arise.

Early screening detects:

elevated blood sugar
insulin resistance

Hypertension

NFHS-5 reports that nearly one in four adults in India has hypertension.

Regular monitoring prevents:

stroke
heart attack
kidney damage

Heart Disease

Cholesterol screening identifies risk before symptoms appear.

Timely lifestyle modifications reduce cardiovascular events.

Cancer Screening and Survival Rates

Screenings such as:

mammograms
Pap smears
colon cancer screening

significantly improve survival when disease is detected early.

Monitoring Organ Function

Regular checkups assess:

liver health
kidney function
thyroid levels

Silent organ dysfunction can be detected early.

Benefits of Regular Health Checkups

Reduced Healthcare Costs

Treating advanced disease is more expensive than preventive care.

Improved Quality of Life

Early treatment reduces long-term complications.

Peace of Mind

Knowing health parameters are normal reduces anxiety.

Better Lifestyle Decisions

Screening results motivate healthier habits.

Who Should Get Regular Health Checkups?

adults above 30 years
individuals with family history of chronic disease
smokers
overweight individuals
sedentary professionals

High-risk groups may require more frequent testing.

Frequency of Health Screenings

General recommendation:

Annual checkup for adults
Biannual or quarterly monitoring for high-risk individuals

Doctors personalise schedules based on medical history.

Corporate Health Checkups

Many organisations conduct:

workplace screening camps
employee wellness programs

These initiatives improve workforce productivity and reduce absenteeism.

Preventive Health in India

NITI Aayog highlights preventive healthcare as essential for reducing national disease burden.

Increasing awareness about routine checkups is critical.

Common Tests in Annual Health Packages

Complete blood count
Lipid profile
Fasting blood sugar
HbA1c
Liver function test
Kidney function test
Thyroid profile
Vitamin levels

These tests provide comprehensive health insight.

Addressing Common Misconceptions

Many people avoid checkups because:

they feel healthy
they fear results
they lack time

However, absence of symptoms does not mean absence of disease.

Lifestyle Diseases and Urbanisation

Urban lifestyles contribute to:

sedentary behaviour
poor diet
stress

Regular monitoring counters these risks.

Digital Health and Screening Accessibility

Online booking platforms and home sample collection make preventive care more accessible and convenient.

Technology supports proactive health management.

Building a Culture of Preventive Health

Encouraging:

annual screenings
family health awareness
workplace initiatives

creates healthier communities.

Conclusion

Understanding the importance of regular health checkups is essential for preventing chronic disease and improving life expectancy. Early detection of diabetes, hypertension, heart disease and other conditions allows timely treatment and reduces complications. Preventive healthcare is not an expense but an investment in long-term wellbeing. Scheduling routine screenings today can protect health and save lives tomorrow.

References

Indian Council of Medical Research (ICMR) – Non-Communicable Disease Reports
National Family Health Survey (NFHS-5) – Adult Health Data
World Health Organization (WHO) – Preventive Healthcare Guidelines
NITI Aayog – National Health and Preventive Strategy Reports
Lancet – Early Detection and Disease Prevention Studies

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