Call
+918447748545

Published on: Jan 20, 2021
1 minute read
By: Dr Rajan Choudhary

MRNA Vaccines – Uses Beyond COVID

mRNA vaccines – uses beyond COVID

Last year we estimated it would take over a year for a vaccine against COVID to be approved, with vaccinations expected by spring 2021. Incredibly we have managed to meet this prediction, and by the start of January over 42 million doses have been administered in 51 countries. What is even more astounding is that two of the approved vaccines use a completely new vaccination method never used before. mRNA vaccines can be used to easily deliver a variety of different vaccines by changing the mRNA inside the vaccine capsule, and its benefits may not be limited to just infections.

A recent publication in NATURE has demonstrated the use of mRNA vaccines against auto-immune diseases such as multiple sclerosis. MS is an autoimmune condition in which the protective lining of nerves is destroyed by the body’s immune system, significantly slowing down or altering nerve impulse propagation. This leads to symptoms such as fatigue, vision problems, numbness, tingling, aberrant pain, muscle spasms and weakness.

The study looked at introducing antigen-specific tolerance in mice models of MS. This was achieved by activating anti-inflammatory white blood cells. Normally vaccines activate inflammatory white cells to produce a response but altered mRNA with one specific change to its base structure induces and activates anti-inflammatory cells instead.

Furthermore, this anti-inflammatory response is specific to cells that are activated by and attack the body’s nerve cells, thereby delivering a targeted response and not affecting the immune response against infections or cancer. Global immunosuppression is a common side effect of steroids and chemotherapy agents that are normally used to treat auto-immune conditions, and mRNA vaccines may avoid this side effect altogether.

A further advantage is its versatility. This has been demonstrated against multiple sclerosis, but changing the mRNA delivered by the vaccine, it may prove beneficial in far more auto-immune conditions. Of course, we have to emphasize this was an animal study and human trials are unlikely to happen in the next few years, but this study nicely demonstrates how the impact of the COVID pandemic may already be providing beneficial gains for the future.

Read Blog

Health Risks of Sedentary Lifestyle: Why Sitting Too Much Can Harm Your Health

Modern lifestyles have become increasingly sedentary. With the rise of desk jobs, digital devices and long working hours, many individuals spend a significant portion of their day sitting. While technology and convenience have improved productivity, they have also contributed to reduced physical activity.

Understanding the health risks of a sedentary lifestyle is essential for preventing chronic diseases and maintaining overall wellbeing.

What Is a Sedentary Lifestyle?

A sedentary lifestyle refers to a pattern of behavior characterized by prolonged sitting or inactivity with minimal physical movement.

Common examples include:

Sitting at a desk for long hours
Watching television for extended periods
Spending significant time on computers or smartphones
Limited engagement in physical exercise

When the body remains inactive for long durations, various physiological functions may become impaired.

1. Increased Risk of Obesity

Physical inactivity reduces calorie expenditure.

When calorie intake exceeds the energy burned through activity, excess calories are stored as body fat.

This can lead to weight gain and increase the risk of obesity.

Obesity is a major risk factor for several chronic health conditions.

2. Higher Risk of Cardiovascular Disease

Prolonged sitting has been associated with increased risk of heart disease.

Sedentary behavior may contribute to:

Elevated blood pressure
Increased cholesterol levels
Reduced blood circulation

These factors increase the likelihood of cardiovascular complications over time.

3. Increased Risk of Type 2 Diabetes

Physical activity helps regulate blood sugar levels.

A sedentary lifestyle may impair the body’s ability to use insulin effectively, leading to insulin resistance.

Over time, this can increase the risk of developing type 2 diabetes.

4. Poor Metabolic Health

Metabolism refers to the body’s ability to convert food into energy.

Long periods of inactivity may slow metabolic processes and reduce the body’s efficiency in managing glucose and fat levels.

This can contribute to metabolic syndrome.

5. Musculoskeletal Problems

Sitting for extended periods can strain muscles and joints.

Common issues include:

Lower back pain
Neck stiffness
Shoulder discomfort
Poor posture

These problems are particularly common among office workers.

6. Reduced Mental Wellbeing

Physical activity plays a significant role in supporting mental health.

Sedentary behavior may contribute to:

Increased stress levels
Reduced mood
Lower energy levels

Regular movement helps improve mental wellbeing.

7. Increased Risk of Premature Mortality

Studies have shown that prolonged inactivity may increase the risk of early death due to chronic diseases.

Maintaining an active lifestyle significantly improves long-term health outcomes.

Sedentary Lifestyle in the Indian Context

Urbanization and technological advancements have led to more sedentary work environments in India.

Long commuting hours, desk-based professions and digital entertainment have reduced physical activity levels for many individuals.

As a result, lifestyle-related diseases such as diabetes and heart disease have increased significantly in recent years.

Public health initiatives now emphasize the importance of regular physical activity to counter these trends.

How to Reduce Sedentary Behavior

Take Frequent Movement Breaks

Stand up and stretch every 30–60 minutes during work.

Incorporate Walking into Daily Routine

Short walks during breaks can improve circulation and energy levels.

Use Active Workstations

Standing desks or adjustable workstations encourage movement.

Exercise Regularly

Engage in moderate physical activity such as walking, cycling or yoga.

Health guidelines recommend at least 150 minutes of exercise per week.

Limit Screen Time

Reducing recreational screen time encourages more active habits.

Benefits of an Active Lifestyle

Increasing daily physical activity provides several health benefits:

Improved cardiovascular health
Better weight management
Enhanced mental wellbeing
Stronger muscles and bones
Improved metabolic function

Even small lifestyle changes can make a significant difference over time.

When to Seek Medical Advice

Consult a healthcare professional if you experience:

Persistent back pain
Unexplained weight gain
Chronic fatigue
Signs of metabolic disorders

Early intervention can help manage health risks effectively.

Conclusion

A sedentary lifestyle may significantly impact physical and mental health. Prolonged sitting and lack of movement increase the risk of obesity, cardiovascular disease, diabetes and musculoskeletal problems.

Adopting an active lifestyle that includes regular movement, exercise and healthy habits is essential for maintaining overall wellbeing.

Simple changes such as standing frequently, walking regularly and engaging in physical activity can greatly reduce the health risks associated with sedentary behavior.

Maintaining an active lifestyle is one of the most effective ways to support long-term health and prevent chronic disease.

References

World Health Organization – Physical Activity Guidelines
Indian Council of Medical Research – Lifestyle Disease Reports
National Family Health Survey – Health and Lifestyle Data
Lancet Global Health – Sedentary Behavior Research
Journal of Preventive Medicine – Physical Activity Studies

Request A Callback

+91

By using this website/app, I confirm that I am at least 18 years old and consent to the processing of my personal data in accordance with the Terms of Service, Privacy Policy, and Declaration.