• Published on: Jan 20, 2021
  • 1 minute read
  • By: Dr Rajan Choudhary

MRNA Vaccines – Uses Beyond COVID

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mRNA vaccines – uses beyond COVID

Last year we estimated it would take over a year for a vaccine against COVID to be approved, with vaccinations expected by spring 2021. Incredibly we have managed to meet this prediction, and by the start of January over 42 million doses have been administered in 51 countries. What is even more astounding is that two of the approved vaccines use a completely new vaccination method never used before. mRNA vaccines can be used to easily deliver a variety of different vaccines by changing the mRNA inside the vaccine capsule, and its benefits may not be limited to just infections.

A recent publication in NATURE has demonstrated the use of mRNA vaccines against auto-immune diseases such as multiple sclerosis. MS is an autoimmune condition in which the protective lining of nerves is destroyed by the body’s immune system, significantly slowing down or altering nerve impulse propagation. This leads to symptoms such as fatigue, vision problems, numbness, tingling, aberrant pain, muscle spasms and weakness.

The study looked at introducing antigen-specific tolerance in mice models of MS. This was achieved by activating anti-inflammatory white blood cells. Normally vaccines activate inflammatory white cells to produce a response but altered mRNA with one specific change to its base structure induces and activates anti-inflammatory cells instead.

Furthermore, this anti-inflammatory response is specific to cells that are activated by and attack the body’s nerve cells, thereby delivering a targeted response and not affecting the immune response against infections or cancer. Global immunosuppression is a common side effect of steroids and chemotherapy agents that are normally used to treat auto-immune conditions, and mRNA vaccines may avoid this side effect altogether.

A further advantage is its versatility. This has been demonstrated against multiple sclerosis, but changing the mRNA delivered by the vaccine, it may prove beneficial in far more auto-immune conditions. Of course, we have to emphasize this was an animal study and human trials are unlikely to happen in the next few years, but this study nicely demonstrates how the impact of the COVID pandemic may already be providing beneficial gains for the future.

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breath

Shortness of Breath Causes: From Common Triggers to Serious Health Conditions

Shortness of breath, medically known as dyspnea, is a symptom that ranges from mild discomfort during exertion to a distressing sensation of not getting enough air. In India, increasing air pollution, lifestyle diseases and respiratory infections have made breathlessness a frequent complaint across age groups. Understanding shortness of breath causes is essential to identify when it is harmless and when it signals a medical emergency.

 

What Is Shortness of Breath?

Shortness of breath refers to difficulty breathing or a feeling of air hunger.

It may present as:

  • rapid breathing

  • shallow breathing

  • tightness in the chest

  • inability to take a deep breath

The sensation can develop suddenly or gradually.

 

Common and Benign Causes of Shortness of Breath

Physical Exertion

During exercise, the body demands more oxygen.

Temporary breathlessness during:

  • climbing stairs

  • running

  • heavy physical work

is normal and resolves with rest.

 

Anxiety and Panic Attacks

Stress and anxiety alter breathing patterns.

Symptoms include:

  • rapid breathing

  • chest tightness

  • dizziness

These episodes often resolve with calming techniques.

 

Respiratory Causes of Shortness of Breath

Asthma

Asthma causes airway narrowing and inflammation.

Symptoms include:

  • wheezing

  • chest tightness

  • breathlessness during exertion or at night

Asthma is a leading cause of chronic breathlessness.

Chronic Obstructive Pulmonary Disease

COPD includes chronic bronchitis and emphysema.

Risk factors include:

  • smoking

  • indoor air pollution

  • occupational exposure

WHO identifies COPD as a major cause of breathlessness in adults.

 

Respiratory Infections

Infections such as pneumonia and bronchitis reduce lung capacity.

Breathlessness may be accompanied by:

  • cough

  • fever

  • chest pain

Severe infections require urgent treatment.

 

Heart-Related Causes of Shortness of Breath

Heart Failure

The heart fails to pump blood efficiently.

This leads to:

  • fluid accumulation in lungs

  • breathlessness on exertion

  • breathlessness while lying flat

ICMR data shows heart disease as a major contributor to unexplained breathlessness.

 

Coronary Artery Disease

Reduced blood supply to the heart can cause:

  • breathlessness

  • chest discomfort

  • fatigue

This may occur even without chest pain in some individuals.

 

Blood and Metabolic Causes

Anemia

Low hemoglobin reduces oxygen delivery.

Common symptoms include:

  • fatigue

  • breathlessness on mild activity

  • pale skin

NFHS-5 highlights anemia as highly prevalent in India.

 

Thyroid Disorders

Hyperthyroidism increases metabolic demand, causing breathlessness.

Hypothyroidism may contribute indirectly through weight gain and reduced stamina.

 

Lung Circulation Disorders

Pulmonary Embolism

A blood clot in the lungs causes sudden, severe breathlessness.

This is a medical emergency and may be accompanied by:

  • chest pain

  • coughing blood

  • fainting

Immediate treatment is critical.

 

Lifestyle-Related Causes

Obesity

Excess body weight restricts lung expansion.

Breathlessness occurs due to:

  • increased oxygen demand

  • reduced lung volumes

Weight management improves breathing efficiency.

 

Sedentary Lifestyle

Poor physical conditioning reduces respiratory muscle strength.

Even mild exertion may cause breathlessness.

 

Environmental and Occupational Factors

Air Pollution

Pollutants irritate airways and reduce lung function.

Urban populations experience higher rates of breathlessness.

Workplace Exposure

Dust, chemicals and fumes increase respiratory risk.

Protective measures are essential in high-risk occupations.

When Shortness of Breath Is a Warning Sign

Seek urgent care if breathlessness:

  • starts suddenly

  • worsens rapidly

  • occurs at rest

  • is associated with chest pain, bluish lips or confusion

These may indicate life-threatening conditions.

 

How Shortness of Breath Is Diagnosed

Evaluation may include:

  • physical examination

  • chest imaging

  • blood tests

  • lung function tests

  • heart evaluation

Diagnosis focuses on identifying the root cause.

 

Preventive Measures and Lifestyle Care

Prevention includes:

  • regular physical activity

  • pollution protection

  • smoking cessation

  • weight control

  • managing chronic conditions

Preventive healthcare reduces long-term risk.

 

Importance of Early Medical Evaluation

Delayed diagnosis can worsen outcomes, especially in:

  • heart disease

  • lung infections

  • anemia

Early care improves treatment success.

 

Conclusion

Shortness of breath causes range from temporary exertion and anxiety to serious heart, lung and blood disorders. While occasional breathlessness may be harmless, persistent or sudden symptoms should never be ignored. Understanding the underlying causes and seeking timely medical evaluation can prevent complications and save lives. Paying attention to changes in breathing is an essential step toward protecting overall health and wellbeing.

 

References

  • Indian Council of Medical Research (ICMR) – Respiratory and Cardiac Health Reports

  • World Health Organization (WHO) – Breathlessness and Chronic Disease Guidelines

  • National Family Health Survey (NFHS-5) – Anemia and Respiratory Health Data

  • Lancet – Dyspnea Evaluation and Outcomes Research

  • NITI Aayog – Non-Communicable Disease Prevention Reports

  • Statista – Respiratory Disease and Air Pollution Trends

See all

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