• Published on: Jan 20, 2021
  • 1 minute read
  • By: Dr Rajan Choudhary

MRNA Vaccines – Uses Beyond COVID

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mRNA vaccines – uses beyond COVID

Last year we estimated it would take over a year for a vaccine against COVID to be approved, with vaccinations expected by spring 2021. Incredibly we have managed to meet this prediction, and by the start of January over 42 million doses have been administered in 51 countries. What is even more astounding is that two of the approved vaccines use a completely new vaccination method never used before. mRNA vaccines can be used to easily deliver a variety of different vaccines by changing the mRNA inside the vaccine capsule, and its benefits may not be limited to just infections.

A recent publication in NATURE has demonstrated the use of mRNA vaccines against auto-immune diseases such as multiple sclerosis. MS is an autoimmune condition in which the protective lining of nerves is destroyed by the body’s immune system, significantly slowing down or altering nerve impulse propagation. This leads to symptoms such as fatigue, vision problems, numbness, tingling, aberrant pain, muscle spasms and weakness.

The study looked at introducing antigen-specific tolerance in mice models of MS. This was achieved by activating anti-inflammatory white blood cells. Normally vaccines activate inflammatory white cells to produce a response but altered mRNA with one specific change to its base structure induces and activates anti-inflammatory cells instead.

Furthermore, this anti-inflammatory response is specific to cells that are activated by and attack the body’s nerve cells, thereby delivering a targeted response and not affecting the immune response against infections or cancer. Global immunosuppression is a common side effect of steroids and chemotherapy agents that are normally used to treat auto-immune conditions, and mRNA vaccines may avoid this side effect altogether.

A further advantage is its versatility. This has been demonstrated against multiple sclerosis, but changing the mRNA delivered by the vaccine, it may prove beneficial in far more auto-immune conditions. Of course, we have to emphasize this was an animal study and human trials are unlikely to happen in the next few years, but this study nicely demonstrates how the impact of the COVID pandemic may already be providing beneficial gains for the future.

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Digestive

Digestive System Disorders: Common Causes, Symptoms, and Prevention Tips

The digestive system plays a vital role in overall health by breaking down food, absorbing nutrients and eliminating waste. When this system does not function properly, it can lead to discomfort, poor nutrition and chronic illness. Digestive system disorders are increasingly common due to modern lifestyles, dietary habits and stress. Understanding their causes, symptoms and prevention strategies is essential for maintaining long-term gut health.

Public health research shows that a large proportion of adults experience digestive symptoms at some point in their lives, yet many delay seeking care until problems become severe.

 

What Are Digestive System Disorders?

Digestive system disorders are conditions that affect:

  • the oesophagus
     

  • stomach
     

  • intestines
     

  • liver
     

  • pancreas
     

  • gallbladder
     

They may be temporary or chronic and range from mild functional issues to serious inflammatory or structural diseases.

 

Common Digestive System Disorders

Acid Reflux and GERD

Gastroesophageal reflux disease (GERD) occurs when stomach acid flows back into the oesophagus.

Symptoms include:

  • heartburn
     

  • chest discomfort
     

  • sour taste in mouth
     

  • difficulty swallowing
     

Long-term reflux can damage the oesophagus if untreated.

 

Irritable Bowel Syndrome (IBS)

IBS is a functional bowel disorder.

Symptoms include:

  • abdominal pain
     

  • bloating
     

  • diarrhoea or constipation
     

  • alternating bowel habits
     

Stress and diet often trigger symptoms.

 

Constipation

Constipation involves infrequent or difficult bowel movements.

Causes include:

  • low fibre intake
     

  • dehydration
     

  • sedentary lifestyle
     

Chronic constipation affects comfort and gut function.

 

Diarrhoea

Diarrhoea results from rapid bowel movements.

Common causes include:

  • infections
     

  • food intolerance
     

  • medication side effects
     

Persistent diarrhoea may lead to dehydration and nutrient loss.

 

Peptic Ulcer Disease

Ulcers are sores in the stomach or intestinal lining.

Symptoms include:

  • burning stomach pain
     

  • nausea
     

  • bloating
     

They are often linked to infections or long-term medication use.

 

Inflammatory Bowel Disease (IBD)

IBD includes conditions like Crohn’s disease and ulcerative colitis.

Symptoms include:

  • chronic diarrhoea
     

  • abdominal pain
     

  • weight loss
     

  • fatigue
     

IBD requires long-term medical management.

Common Symptoms of Digestive Disorders

Digestive system disorders often present with:

  • abdominal pain or cramps
     

  • bloating and gas
     

  • nausea or vomiting
     

  • constipation or diarrhoea
     

  • heartburn
     

  • unexplained weight changes
     

Symptoms may fluctuate and worsen with stress or poor diet.

 

Causes of Digestive System Disorders

Poor Dietary Habits

Diets high in:

  • processed foods
     

  • refined sugars
     

  • unhealthy fats
     

strain the digestive system and alter gut microbiota.

 

Stress and Mental Health

Chronic stress affects gut-brain communication, worsening digestive symptoms.

 

Infections

Bacterial, viral or parasitic infections disrupt gut function.

 

Food Intolerances

Lactose, gluten or other intolerances cause digestive distress.

 

Sedentary Lifestyle

Lack of physical activity slows digestion and bowel movement.

 

Medication Use

Certain medications irritate the stomach lining or alter gut flora.

 

Who Is at Higher Risk?

People at increased risk include:

  • individuals with poor diet
     

  • those under chronic stress
     

  • older adults
     

  • people with family history of gut disease
     

  • individuals with sedentary lifestyles
     

Early lifestyle correction reduces risk significantly.

 

Diagnosis of Digestive Disorders

Evaluation may include:

  • medical history
     

  • physical examination
     

  • blood tests
     

  • stool tests
     

  • imaging or endoscopy
     

Diagnosis depends on symptom severity and duration.

 

Treatment Approaches

Medical Management

Treatment varies by condition and may include:

  • acid suppressants
     

  • anti-inflammatory medications
     

  • probiotics
     

  • antibiotics when needed
     

 

Dietary Modifications

  • increase fibre intake
     

  • limit trigger foods
     

  • eat regular meals
     

  • avoid excessive alcohol
     

Diet plays a central role in gut health.

 

Lifestyle Changes

  • manage stress
     

  • exercise regularly
     

  • stay hydrated
     

  • maintain sleep routine
     

Healthy habits support digestive function.

 

Prevention Tips for Digestive Health

Eat a Balanced Diet

Include fruits, vegetables, whole grains and lean proteins.

 

Stay Hydrated

Water supports digestion and prevents constipation.

 

Manage Stress

Mindfulness and relaxation techniques improve gut-brain balance.

 

Be Physically Active

Movement stimulates bowel activity and gut motility.

 

Avoid Smoking and Excess Alcohol

These irritate the digestive tract and worsen symptoms.

 

Seek Early Medical Advice

Early care prevents complications and chronic disease.

 

Long-Term Impact of Ignoring Digestive Problems

Untreated digestive disorders may lead to:

  • nutrient deficiencies
     

  • chronic inflammation
     

  • poor quality of life
     

  • increased disease complications
     

Early intervention is more effective and less invasive.

 

When to Consult a Doctor

Medical advice is recommended if:

  • symptoms persist beyond weeks
     

  • pain is severe
     

  • blood appears in stool
     

  • unexplained weight loss occurs
     

Prompt evaluation ensures safe management.

 

Conclusion

Digestive system disorders are common but often underestimated health issues. Symptoms such as bloating, pain, constipation and heartburn may seem minor initially but can signal deeper problems if ignored. Understanding causes, recognising early symptoms and adopting preventive habits help protect digestive health. With timely care, balanced nutrition and healthy lifestyle choices, most digestive disorders can be effectively managed, allowing the digestive system to function smoothly and support overall wellbeing.

 

References

  • Indian Council of Medical Research (ICMR) – Digestive Health and Nutrition Reports

  • World Health Organization (WHO) – Digestive Disorders and Gut Health Guideline

  •  National Institute of Nutrition (NIN) – Dietary Fibre and Gut Health Researc

  •  Lancet – Gastrointestinal Disease and Prevention Studies

  •  Indian Journal of Gastroenterology – Digestive Disorder Research

  •  Statista – Digestive Health Trends and Lifestyle Factors

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