• Published on: Jan 20, 2021
  • 1 minute read
  • By: Dr Rajan Choudhary

MRNA Vaccines – Uses Beyond COVID

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mRNA vaccines – uses beyond COVID

Last year we estimated it would take over a year for a vaccine against COVID to be approved, with vaccinations expected by spring 2021. Incredibly we have managed to meet this prediction, and by the start of January over 42 million doses have been administered in 51 countries. What is even more astounding is that two of the approved vaccines use a completely new vaccination method never used before. mRNA vaccines can be used to easily deliver a variety of different vaccines by changing the mRNA inside the vaccine capsule, and its benefits may not be limited to just infections.

A recent publication in NATURE has demonstrated the use of mRNA vaccines against auto-immune diseases such as multiple sclerosis. MS is an autoimmune condition in which the protective lining of nerves is destroyed by the body’s immune system, significantly slowing down or altering nerve impulse propagation. This leads to symptoms such as fatigue, vision problems, numbness, tingling, aberrant pain, muscle spasms and weakness.

The study looked at introducing antigen-specific tolerance in mice models of MS. This was achieved by activating anti-inflammatory white blood cells. Normally vaccines activate inflammatory white cells to produce a response but altered mRNA with one specific change to its base structure induces and activates anti-inflammatory cells instead.

Furthermore, this anti-inflammatory response is specific to cells that are activated by and attack the body’s nerve cells, thereby delivering a targeted response and not affecting the immune response against infections or cancer. Global immunosuppression is a common side effect of steroids and chemotherapy agents that are normally used to treat auto-immune conditions, and mRNA vaccines may avoid this side effect altogether.

A further advantage is its versatility. This has been demonstrated against multiple sclerosis, but changing the mRNA delivered by the vaccine, it may prove beneficial in far more auto-immune conditions. Of course, we have to emphasize this was an animal study and human trials are unlikely to happen in the next few years, but this study nicely demonstrates how the impact of the COVID pandemic may already be providing beneficial gains for the future.

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Frequent

Early Signs of a Weakened Immune System: Symptoms You Should Not Ignore

The immune system is the body’s natural defense mechanism against infections, bacteria and viruses. It works continuously to identify and eliminate harmful pathogens that may threaten health. However, when the immune system becomes weakened, the body becomes more vulnerable to illness and infections.

Recognizing the early signs of a weakened immune system is essential for maintaining overall health and preventing serious complications. Early awareness allows individuals to make lifestyle changes and seek medical advice if necessary.

 

Understanding the Immune System

The immune system is composed of:

  • White blood cells
     

  • Antibodies
     

  • Lymph nodes
     

  • Bone marrow
     

  • The spleen and thymus
     

These components work together to detect and destroy harmful organisms. When immunity is compromised, this protective mechanism becomes less effective.

 

1. Frequent Infections

One of the most common signs of weakened immunity is experiencing frequent infections.

These may include:

  • Recurrent colds
     

  • Sinus infections
     

  • Ear infections
     

  • Respiratory illnesses
     

If infections occur repeatedly or take longer than usual to recover, it may indicate reduced immune strength.

 

2. Persistent Fatigue

Constant tiredness despite adequate sleep may signal an underlying immune imbalance.

When the immune system is weakened, the body uses more energy to fight potential threats, leading to prolonged fatigue.

3. Slow Wound Healing

A healthy immune system supports tissue repair and healing.

Cuts, bruises or minor injuries that take longer than usual to heal may indicate weakened immune function.

Delayed healing may also increase infection risk.

 

4. Digestive Problems

A significant portion of the immune system is located in the gastrointestinal tract.

Digestive symptoms such as:

  • Frequent diarrhea
     

  • Bloating
     

  • Constipation
     

may reflect imbalance in gut health and immunity.

 

5. Frequent Allergies or Sensitivities

A weakened immune system may overreact to harmless substances, causing allergic reactions.

Symptoms may include:

  • Sneezing
     

  • Skin irritation
     

  • Food sensitivities
     

Maintaining immune balance helps regulate these responses.

 

6. Recurring Fever

Frequent low-grade fever may occur when the body is constantly attempting to fight infections.

This may indicate ongoing immune stress.

 

7. Increased Susceptibility to Stress

Chronic stress significantly affects immune function.

Stress hormones such as cortisol may suppress immune responses, making the body more vulnerable to illness.

 

Common Causes of Weak Immunity

Several lifestyle and health factors can weaken the immune system:

  • Poor nutrition
     

  • Lack of sleep
     

  • Chronic stress
     

  • Sedentary lifestyle
     

  • Smoking or excessive alcohol consumption
     

  • Chronic illnesses
     

Identifying these factors is important for improving immune health.

 

Strengthening the Immune System Naturally

Maintain a Balanced Diet

Consume foods rich in:

  • Vitamin C
     

  • Vitamin D
     

  • Zinc
     

  • Antioxidants
     

Fruits, vegetables, nuts and whole grains support immune function.

 

Prioritize Sleep

Adequate sleep allows the immune system to repair and regenerate.

Adults should aim for 7–8 hours of sleep daily.

 

Stay Physically Active

Moderate physical activity improves circulation and supports immune response.

Regular exercise also reduces stress levels.

 

Manage Stress

Practices such as meditation, breathing exercises and relaxation techniques help regulate stress hormones.

 

Maintain Hygiene

Simple habits like handwashing reduce exposure to harmful pathogens.

 

Weak Immunity in the Indian Context

In India, factors such as nutritional deficiencies, pollution exposure and high stress levels contribute to weakened immunity among many individuals.

Public health initiatives increasingly emphasize balanced nutrition, vaccination and healthy lifestyle habits to improve immune resilience.

 

When to Consult a Doctor

Seek medical advice if you experience:

  • Frequent infections
     

  • Persistent fatigue
     

  • Unexplained weight loss
     

  • Recurrent fever
     

  • Slow healing wounds
     

Medical evaluation may identify underlying health conditions affecting immunity.

 

Conclusion

Recognizing the early signs of a weakened immune system is essential for protecting long-term health. Symptoms such as frequent infections, fatigue and slow wound healing may indicate that the body’s defense mechanisms need support.

By adopting healthy lifestyle habits, maintaining balanced nutrition and managing stress effectively, individuals can strengthen immune function and reduce the risk of illness.

Listening to the body’s warning signals and seeking timely medical guidance ensures better health outcomes and improved wellbeing.

A strong immune system is the foundation of a healthy life.

 

References

  • Indian Council of Medical Research – Immunity and Nutrition Reports

  • World Health Organization – Immune Health Guidelines

  • National Institute of Nutrition India – Dietary Recommendations

  • Journal of Clinical Immunology – Immune System Research

  • Lancet Global Health – Public Health and Immunity Studies

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