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Published on: Jan 20, 2021
1 minute read
By: Dr Rajan Choudhary

MRNA Vaccines – Uses Beyond COVID

mRNA vaccines – uses beyond COVID

Last year we estimated it would take over a year for a vaccine against COVID to be approved, with vaccinations expected by spring 2021. Incredibly we have managed to meet this prediction, and by the start of January over 42 million doses have been administered in 51 countries. What is even more astounding is that two of the approved vaccines use a completely new vaccination method never used before. mRNA vaccines can be used to easily deliver a variety of different vaccines by changing the mRNA inside the vaccine capsule, and its benefits may not be limited to just infections.

A recent publication in NATURE has demonstrated the use of mRNA vaccines against auto-immune diseases such as multiple sclerosis. MS is an autoimmune condition in which the protective lining of nerves is destroyed by the body’s immune system, significantly slowing down or altering nerve impulse propagation. This leads to symptoms such as fatigue, vision problems, numbness, tingling, aberrant pain, muscle spasms and weakness.

The study looked at introducing antigen-specific tolerance in mice models of MS. This was achieved by activating anti-inflammatory white blood cells. Normally vaccines activate inflammatory white cells to produce a response but altered mRNA with one specific change to its base structure induces and activates anti-inflammatory cells instead.

Furthermore, this anti-inflammatory response is specific to cells that are activated by and attack the body’s nerve cells, thereby delivering a targeted response and not affecting the immune response against infections or cancer. Global immunosuppression is a common side effect of steroids and chemotherapy agents that are normally used to treat auto-immune conditions, and mRNA vaccines may avoid this side effect altogether.

A further advantage is its versatility. This has been demonstrated against multiple sclerosis, but changing the mRNA delivered by the vaccine, it may prove beneficial in far more auto-immune conditions. Of course, we have to emphasize this was an animal study and human trials are unlikely to happen in the next few years, but this study nicely demonstrates how the impact of the COVID pandemic may already be providing beneficial gains for the future.

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Heat Exhaustion Warning Signs: Symptoms You Should Never Ignore

Heat-related illnesses are common during hot weather, particularly in tropical countries like India where summer temperatures can become extreme. Heat exhaustion is a serious condition that occurs when the body overheats due to prolonged exposure to high temperatures and inadequate hydration.

Recognizing heat exhaustion warning signs early can prevent life-threatening complications such as heatstroke.

What Is Heat Exhaustion?

Heat exhaustion is a heat-related illness caused by:

Excessive heat exposure
Dehydration
Loss of electrolytes through sweating

It often occurs during outdoor work, exercise or travel in hot environments.

If untreated, it may progress to heatstroke — a medical emergency.

Common Heat Exhaustion Warning Signs

1. Heavy Sweating

Excessive sweating is one of the earliest signs.

The body attempts to cool itself through perspiration, leading to fluid loss.

2. Dizziness or Lightheadedness

Low blood pressure due to dehydration may cause:

Feeling faint
Blurred vision
Weakness

3. Fatigue and Weakness

Muscle weakness and exhaustion occur as the body struggles to regulate temperature.

4. Nausea and Vomiting

Digestive discomfort is common in heat-related illnesses.

5. Headache

Dehydration and heat stress can trigger throbbing headaches.

6. Muscle Cramps

Electrolyte imbalance may cause painful muscle cramps, especially in legs.

7. Rapid Heartbeat

Increased heart rate helps circulate blood for cooling but may indicate strain.

8. Cool, Clammy Skin

Despite hot weather, skin may feel cool and moist due to heavy sweating.

Who Is at Higher Risk?

Certain groups are more vulnerable:

Outdoor laborers
Athletes
Elderly individuals
Children
People with chronic illnesses
Individuals on certain medications

Urban heat exposure increases risk during peak summer months in India.

Heat Exhaustion vs Heatstroke

Heat exhaustion is serious but manageable if treated promptly.

Heatstroke symptoms include:

High body temperature (above 40°C)
Confusion or disorientation
Dry, hot skin
Seizures
Loss of consciousness

Heatstroke requires immediate emergency medical attention.

Immediate Steps to Take

If heat exhaustion is suspected:

Move to a cool, shaded area
Loosen tight clothing
Drink water or oral rehydration solution
Apply cool cloths to body
Rest until symptoms improve

Seek medical care if symptoms persist beyond one hour.

Prevention Tips

Stay Hydrated

Drink water regularly, even if not thirsty.

Avoid Peak Sun Hours

Limit outdoor activity between 12 PM and 4 PM.

Wear Light Clothing

Choose loose, breathable fabrics.

Use Sun Protection

Wear hats and sunglasses when outdoors.

Take Frequent Breaks

Rest in shaded or air-conditioned areas.

Maintain Electrolyte Balance

Use oral rehydration solutions if sweating heavily.

Heat Illness in the Indian Context

India frequently experiences heatwaves, especially in northern and central regions. Public awareness about hydration and heat safety is essential to reduce hospitalizations and fatalities.

Community-level education can significantly improve prevention.

When to Seek Medical Help

Immediate medical attention is required if:

Symptoms worsen
Body temperature rises significantly
Confusion develops
Fainting occurs
Vomiting persists

Early treatment prevents severe complications.

Conclusion

Heat exhaustion is a preventable but potentially dangerous condition. Recognizing warning signs such as heavy sweating, dizziness, nausea and muscle cramps allows timely intervention.

With rising summer temperatures, especially in India, proactive hydration and heat safety measures are essential. Preventive care and awareness can protect vulnerable individuals and reduce health risks.

Staying cool and hydrated is the simplest way to safeguard your health during hot weather.

References

Indian Meteorological Department – Heatwave Reports
World Health Organization – Heat-Related Illness Guidelines
Indian Council of Medical Research – Public Health Advisory
National Disaster Management Authority (India) – Heatwave Action Plan
Lancet Planetary Health – Climate and Health Research

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