• Published on: Jan 20, 2021
  • 1 minute read
  • By: Dr Rajan Choudhary

MRNA Vaccines – Uses Beyond COVID

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mRNA vaccines – uses beyond COVID

Last year we estimated it would take over a year for a vaccine against COVID to be approved, with vaccinations expected by spring 2021. Incredibly we have managed to meet this prediction, and by the start of January over 42 million doses have been administered in 51 countries. What is even more astounding is that two of the approved vaccines use a completely new vaccination method never used before. mRNA vaccines can be used to easily deliver a variety of different vaccines by changing the mRNA inside the vaccine capsule, and its benefits may not be limited to just infections.

A recent publication in NATURE has demonstrated the use of mRNA vaccines against auto-immune diseases such as multiple sclerosis. MS is an autoimmune condition in which the protective lining of nerves is destroyed by the body’s immune system, significantly slowing down or altering nerve impulse propagation. This leads to symptoms such as fatigue, vision problems, numbness, tingling, aberrant pain, muscle spasms and weakness.

The study looked at introducing antigen-specific tolerance in mice models of MS. This was achieved by activating anti-inflammatory white blood cells. Normally vaccines activate inflammatory white cells to produce a response but altered mRNA with one specific change to its base structure induces and activates anti-inflammatory cells instead.

Furthermore, this anti-inflammatory response is specific to cells that are activated by and attack the body’s nerve cells, thereby delivering a targeted response and not affecting the immune response against infections or cancer. Global immunosuppression is a common side effect of steroids and chemotherapy agents that are normally used to treat auto-immune conditions, and mRNA vaccines may avoid this side effect altogether.

A further advantage is its versatility. This has been demonstrated against multiple sclerosis, but changing the mRNA delivered by the vaccine, it may prove beneficial in far more auto-immune conditions. Of course, we have to emphasize this was an animal study and human trials are unlikely to happen in the next few years, but this study nicely demonstrates how the impact of the COVID pandemic may already be providing beneficial gains for the future.

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Symptoms of Chronic Inflammation in the Body: Early Warning Signs Explained

Inflammation is a natural defense mechanism that helps the body fight infections and heal injuries. However, when inflammation persists for months or even years without a clear cause, it becomes chronic. Chronic inflammation can silently damage tissues and increase the risk of serious diseases.

In India, rising cases of lifestyle diseases such as diabetes, heart disease and autoimmune disorders are often linked to long-term inflammatory processes. Recognizing the symptoms of chronic inflammation in the body is essential for early prevention and treatment.

 

What Is Chronic Inflammation?

Acute inflammation is short-term and occurs in response to injury or infection. Chronic inflammation, on the other hand, is:

  • Persistent
     

  • Low-grade
     

  • Often symptomatically subtle
     

  • Linked to long-term health conditions
     

It may occur due to unhealthy lifestyle habits, stress, obesity or underlying disease.

 

Common Symptoms of Chronic Inflammation

1. Persistent Fatigue

Ongoing tiredness that does not improve with rest may indicate systemic inflammation.

Inflammatory chemicals in the body can interfere with energy production.

 

2. Joint and Muscle Pain

Unexplained pain, stiffness or swelling in joints may suggest inflammatory conditions such as arthritis.

Pain may:

  • Last for weeks
     

  • Worsen in the morning
     

  • Occur without injury
     

 

3. Digestive Issues

Chronic inflammation may affect the gut, leading to:

  • Bloating
     

  • Diarrhea or constipation
     

  • Abdominal discomfort
     

  • Food sensitivities
     

Gut health and immune function are closely connected.

 

4. Frequent Infections

A weakened immune response due to chronic inflammation may result in:

  • Recurrent colds
     

  • Slow wound healing
     

  • Persistent sore throat
     

 

5. Skin Problems

Inflammatory skin conditions include:

  • Acne
     

  • Eczema
     

  • Psoriasis
     

  • Rashes
     

Persistent skin issues may reflect internal inflammation.

 

6. Brain Fog and Mood Changes

Inflammation can affect brain function, causing:

  • Difficulty concentrating
     

  • Memory issues
     

  • Irritability
     

  • Low mood
     

Mental and physical health are interconnected.

 

7. Unexplained Weight Changes

Inflammation may disrupt metabolism, leading to:

  • Abdominal weight gain
     

  • Difficulty losing weight
     

Obesity itself can further promote inflammation.

 

Causes of Chronic Inflammation

Common contributing factors include:

  • Poor diet high in processed foods
     

  • Excess sugar intake
     

  • Smoking
     

  • Alcohol abuse
     

  • Chronic stress
     

  • Lack of exercise
     

  • Sleep deprivation
     

  • Environmental pollution
     

Addressing these factors is essential for prevention.

 

Diseases Linked to Chronic Inflammation

Long-term inflammation is associated with:

  • Type 2 diabetes
     

  • Cardiovascular disease
     

  • Cancer
     

  • Autoimmune disorders
     

  • Fatty liver disease
     

  • Alzheimer’s disease
     

Early intervention reduces risk significantly.

 

How to Reduce Chronic Inflammation Naturally

1. Adopt an Anti-Inflammatory Diet

Include:

  • Fresh fruits and vegetables
     

  • Whole grains
     

  • Nuts and seeds
     

  • Fatty fish
     

  • Olive oil
     

Avoid processed foods and excessive sugar.

 

2. Exercise Regularly

Moderate physical activity lowers inflammatory markers.

Aim for at least 30 minutes daily.

 

3. Manage Stress

Chronic stress increases inflammatory hormones.

Practice:

  • Meditation
     

  • Yoga
     

  • Deep breathing exercises
     

 

4. Improve Sleep

7–8 hours of quality sleep supports immune regulation.

 

5. Maintain Healthy Weight

Reducing excess body fat lowers inflammation levels.

6. Avoid Smoking and Limit Alcohol

Both habits promote inflammatory responses in the body.

 

When to Seek Medical Advice

Consult a healthcare professional if you experience:

  • Persistent fatigue
     

  • Joint swelling
     

  • Recurrent infections
     

  • Unexplained pain
     

  • Long-lasting digestive problems
     

Blood tests such as C-reactive protein (CRP) may help assess inflammation levels.

 

Chronic Inflammation in the Indian Context

Rapid urbanization, sedentary lifestyle and dietary shifts in India have contributed to increasing inflammatory-related diseases. Public awareness about preventive measures can significantly reduce healthcare burden.

Early lifestyle changes play a crucial role in improving long-term outcomes.

 

Conclusion

Chronic inflammation may present subtle symptoms such as fatigue, joint pain, digestive issues and brain fog. Although often overlooked, long-term inflammation can increase the risk of serious diseases.

Adopting healthy eating habits, regular exercise, stress management and adequate sleep can help reduce inflammation naturally. Recognizing early warning signs and seeking medical advice when needed ensures better long-term health.

Taking proactive steps today can prevent major complications tomorrow.

 

References

  • Indian Council of Medical Research – Chronic Disease Reports

  • World Health Organization – Non-Communicable Disease Guidelines

  • National Institute of Nutrition India – Dietary Recommendations

  • Lancet Global Health – Inflammation Research

  • Journal of Clinical Medicine – Chronic Inflammation Studies

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