• Published on: Jan 20, 2021
  • 1 minute read
  • By: Dr Rajan Choudhary

MRNA Vaccines – Uses Beyond COVID

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mRNA vaccines – uses beyond COVID

Last year we estimated it would take over a year for a vaccine against COVID to be approved, with vaccinations expected by spring 2021. Incredibly we have managed to meet this prediction, and by the start of January over 42 million doses have been administered in 51 countries. What is even more astounding is that two of the approved vaccines use a completely new vaccination method never used before. mRNA vaccines can be used to easily deliver a variety of different vaccines by changing the mRNA inside the vaccine capsule, and its benefits may not be limited to just infections.

A recent publication in NATURE has demonstrated the use of mRNA vaccines against auto-immune diseases such as multiple sclerosis. MS is an autoimmune condition in which the protective lining of nerves is destroyed by the body’s immune system, significantly slowing down or altering nerve impulse propagation. This leads to symptoms such as fatigue, vision problems, numbness, tingling, aberrant pain, muscle spasms and weakness.

The study looked at introducing antigen-specific tolerance in mice models of MS. This was achieved by activating anti-inflammatory white blood cells. Normally vaccines activate inflammatory white cells to produce a response but altered mRNA with one specific change to its base structure induces and activates anti-inflammatory cells instead.

Furthermore, this anti-inflammatory response is specific to cells that are activated by and attack the body’s nerve cells, thereby delivering a targeted response and not affecting the immune response against infections or cancer. Global immunosuppression is a common side effect of steroids and chemotherapy agents that are normally used to treat auto-immune conditions, and mRNA vaccines may avoid this side effect altogether.

A further advantage is its versatility. This has been demonstrated against multiple sclerosis, but changing the mRNA delivered by the vaccine, it may prove beneficial in far more auto-immune conditions. Of course, we have to emphasize this was an animal study and human trials are unlikely to happen in the next few years, but this study nicely demonstrates how the impact of the COVID pandemic may already be providing beneficial gains for the future.

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Anemia Diet Plan: What to Eat to Improve Hemoglobin Levels Naturally

Anemia is one of the most widespread nutritional disorders in India, affecting people across age groups. According to NFHS-5 and ICMR data, more than half of Indian women and a significant proportion of men suffer from anemia. While supplements are sometimes required, a structured anemia diet plan plays a central role in preventing and managing the condition.

Anemia occurs when the body lacks sufficient healthy red blood cells or hemoglobin to carry oxygen efficiently. Nutrition is the foundation of hemoglobin production, making dietary correction essential.

 

Understanding the Nutritional Causes of Anemia

Anemia commonly results from deficiencies of:

  • iron

  • vitamin B12

  • folate

Each nutrient plays a specific role in red blood cell formation.

 

Iron: The Core Nutrient in Anemia

Iron is a key component of hemoglobin.

Iron deficiency leads to:

  • fatigue

  • weakness

  • pale skin

  • shortness of breath

ICMR identifies iron deficiency as the leading cause of anemia in India.

 

Types of Dietary Iron

Heme Iron

Found in animal foods and absorbed efficiently.

Sources include:

  • eggs

  • fish

  • chicken

  • liver

 

Non-Heme Iron

Found in plant-based foods and absorbed less efficiently.

Sources include:

  • spinach

  • lentils

  • chickpeas

  • jaggery

  • dates

Vitamin C improves non-heme iron absorption.

 

Role of Vitamin B12 in Anemia

Vitamin B12 is essential for red blood cell maturation.

Deficiency causes:

  • megaloblastic anemia

  • nerve symptoms

  • memory issues

Vegetarians are at higher risk due to limited dietary sources.

 

Role of Folate

Folate supports:

  • DNA synthesis

  • red blood cell formation

Low folate intake worsens anemia, especially during pregnancy.

 

Foods to Include in an Anemia Diet Plan

Iron-Rich Foods

  • green leafy vegetables (spinach, amaranth)

  • legumes and pulses

  • dates, raisins and figs

  • jaggery

  • red meat and eggs

 

Vitamin C-Rich Foods

  • citrus fruits

  • guava

  • tomatoes

  • bell peppers

These enhance iron absorption.

 

Vitamin B12 Sources

  • milk and dairy products

  • eggs

  • fish

  • fortified cereals

 

Folate-Rich Foods

  • green leafy vegetables

  • beans and peas

  • peanuts

  • whole grains

 

Sample Daily Anemia Diet Plan

Breakfast

  • vegetable omelette or sprouted moong

  • citrus fruit or guava

 

Mid-Morning

  • soaked raisins or dates

  • lemon water

 

Lunch

  • brown rice or roti

  • dal or chickpeas

  • green leafy vegetable sabzi

  • salad with lemon dressing

 

Evening Snack

  • roasted peanuts or chana

  • fruit rich in vitamin C

 

Dinner

  • vegetable curry with paneer or fish

  • whole wheat roti

  • lightly cooked greens

 

Bedtime

  • warm milk if tolerated

 

Foods That Reduce Iron Absorption

Certain foods interfere with iron absorption:

  • tea and coffee

  • excess calcium

  • highly processed foods

These should be avoided close to iron-rich meals.

 

Special Considerations for Women

Women require more iron due to:

  • menstruation

  • pregnancy

  • lactation

NFHS-5 highlights anemia as a major women’s health concern in India.

 

Anemia in Men and Older Adults

In men and elderly individuals, anemia may signal:

  • nutritional deficiency

  • chronic disease

  • gastrointestinal issues

Dietary correction should be combined with medical evaluation.

 

When Diet Alone Is Not Enough

Diet may not be sufficient if:

  • anemia is severe

  • absorption is impaired

  • chronic illness is present

In such cases, supplements or treatment of underlying causes is required.

 

Importance of Regular Blood Tests

Monitoring hemoglobin helps:

  • assess improvement

  • guide dietary adjustments

  • prevent recurrence

Preventive checkups are essential for high-risk groups.

 

Lifestyle Factors That Support Recovery

Along with diet:

  • adequate sleep

  • stress management

  • regular physical activity

support blood health and recovery.

 

Preventing Anemia Long-Term

Long-term prevention includes:

  • balanced meals

  • iron-rich cooking methods

  • avoiding excessive junk food

  • periodic screening

WHO and NITI Aayog emphasize nutrition education as a preventive strategy.

 

Conclusion

A well-structured anemia diet plan is the cornerstone of improving hemoglobin levels and restoring energy. By including iron-rich foods, supporting nutrients like vitamin B12 and folate, and improving absorption through smart food combinations, anemia can be effectively managed and prevented. Early dietary intervention, supported by regular health monitoring, helps avoid long-term complications and improves overall quality of life.

 

References

  • Indian Council of Medical Research (ICMR) – Anemia and Micronutrient Deficiency Reports

  • National Family Health Survey (NFHS-5) – Anemia Prevalence Data

  • World Health Organization (WHO) – Nutrition and Anemia Guidelines

  • Lancet – Micronutrient Deficiency and Public Health Research

  • NITI Aayog – Poshan Abhiyaan and Nutrition Policy Reports

  • Statista – Nutrition and Health Trends in India

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