• Published on: Jan 20, 2021
  • 1 minute read
  • By: Dr Rajan Choudhary

MRNA Vaccines – Uses Beyond COVID

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mRNA vaccines – uses beyond COVID

Last year we estimated it would take over a year for a vaccine against COVID to be approved, with vaccinations expected by spring 2021. Incredibly we have managed to meet this prediction, and by the start of January over 42 million doses have been administered in 51 countries. What is even more astounding is that two of the approved vaccines use a completely new vaccination method never used before. mRNA vaccines can be used to easily deliver a variety of different vaccines by changing the mRNA inside the vaccine capsule, and its benefits may not be limited to just infections.

A recent publication in NATURE has demonstrated the use of mRNA vaccines against auto-immune diseases such as multiple sclerosis. MS is an autoimmune condition in which the protective lining of nerves is destroyed by the body’s immune system, significantly slowing down or altering nerve impulse propagation. This leads to symptoms such as fatigue, vision problems, numbness, tingling, aberrant pain, muscle spasms and weakness.

The study looked at introducing antigen-specific tolerance in mice models of MS. This was achieved by activating anti-inflammatory white blood cells. Normally vaccines activate inflammatory white cells to produce a response but altered mRNA with one specific change to its base structure induces and activates anti-inflammatory cells instead.

Furthermore, this anti-inflammatory response is specific to cells that are activated by and attack the body’s nerve cells, thereby delivering a targeted response and not affecting the immune response against infections or cancer. Global immunosuppression is a common side effect of steroids and chemotherapy agents that are normally used to treat auto-immune conditions, and mRNA vaccines may avoid this side effect altogether.

A further advantage is its versatility. This has been demonstrated against multiple sclerosis, but changing the mRNA delivered by the vaccine, it may prove beneficial in far more auto-immune conditions. Of course, we have to emphasize this was an animal study and human trials are unlikely to happen in the next few years, but this study nicely demonstrates how the impact of the COVID pandemic may already be providing beneficial gains for the future.

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Fatigue

why fatigue should not be ignored

Feeling tired occasionally is a normal response to physical exertion, lack of sleep or emotional stress. However, when fatigue becomes persistent, overwhelming or unexplained, it should not be dismissed. Fatigue is one of the most common symptoms reported in healthcare, yet it is also one of the most frequently ignored.

Understanding why fatigue should not be ignored is essential because it often acts as an early warning sign of deeper physical or mental health issues.

 

What Is Fatigue?

Fatigue is a state of ongoing physical, mental or emotional exhaustion that:

  • lasts longer than expected
     

  • interferes with daily activities
     

  • does not improve with rest or sleep
     

Unlike ordinary tiredness, fatigue affects motivation, concentration and overall functioning.

 

Why Fatigue Is Commonly Ignored

Fatigue is often dismissed because:

  • busy lifestyles normalise exhaustion
     

  • symptoms develop gradually
     

  • people attribute fatigue to stress or ageing
     

  • rest temporarily masks the issue
     

Ignoring fatigue allows underlying conditions to progress unnoticed.

 

Common Medical Causes of Persistent Fatigue

Nutritional Deficiencies

Deficiencies in:

  • iron
     

  • vitamin B12
     

  • vitamin D
     

  • magnesium
     

can significantly reduce energy levels and cause weakness.

 

Anaemia

Anaemia reduces oxygen delivery to tissues, leading to:

  • constant tiredness
     

  • breathlessness
     

  • dizziness
     

It is one of the most common yet underdiagnosed causes of fatigue.

 

Thyroid Disorders

Both underactive and overactive thyroid conditions affect metabolism.

Symptoms include:

  • fatigue
     

  • weight changes
     

  • cold or heat intolerance
     

Thyroid-related fatigue often persists despite rest.

 

Chronic Infections

Low-grade or unresolved infections keep the immune system activated, causing prolonged fatigue.

 

Hormonal Imbalance

Hormones regulate energy, sleep and metabolism.

Imbalance may lead to:

  • exhaustion
     

  • poor sleep
     

  • low motivation
     

 

Poor Sleep Quality

Even with sufficient sleep duration, poor sleep quality can cause fatigue due to:

  • sleep apnea
     

  • frequent awakenings
     

  • stress-related insomnia
     

 

Mental Health Conditions

Anxiety, depression and chronic stress commonly present with fatigue as a primary symptom.

Mental fatigue is as real and impactful as physical fatigue.

 

Lifestyle Factors That Worsen Fatigue

Certain habits intensify tiredness:

  • irregular meals
     

  • excessive caffeine
     

  • dehydration
     

  • lack of physical activity
     

  • prolonged screen use
     

Lifestyle-related fatigue often coexists with medical causes.

 

How Fatigue Affects Daily Life

Persistent fatigue impacts:

  • work performance
     

  • concentration and memory
     

  • emotional regulation
     

  • physical activity
     

  • social relationships
     

Over time, quality of life declines significantly.

 

Warning Signs That Fatigue Needs Medical Attention

Seek evaluation if fatigue:

  • lasts more than two weeks
     

  • worsens progressively
     

  • occurs with weight loss or fever
     

  • is associated with breathlessness
     

  • interferes with daily tasks
     

These signs suggest an underlying issue.

 

Why Early Evaluation Matters

Early identification of fatigue causes:

  • prevents disease progression
     

  • simplifies treatment
     

  • improves recovery time
     

  • restores normal energy levels
     

Delayed care often leads to chronic complications.

 

Diagnostic Evaluation for Fatigue

Assessment may include:

  • detailed history
     

  • blood tests
     

  • nutritional screening
     

  • hormonal evaluation
     

  • sleep assessment
     

Testing helps identify root causes rather than treating symptoms alone.

 

Can Fatigue Be Prevented?

Some preventive measures include:

  • balanced nutrition
     

  • adequate hydration
     

  • regular physical activity
     

  • consistent sleep routine
     

  • stress management
     

However, prevention does not replace evaluation when fatigue persists.

 

Fatigue and Chronic Disease Risk

Long-term fatigue may be linked to:

  • cardiovascular disease
     

  • metabolic disorders
     

  • immune dysfunction
     

This makes fatigue an important early health signal.

 

When Rest Is Not Enough

If energy does not return after:

  • adequate sleep
     

  • reduced workload
     

  • lifestyle changes
     

medical evaluation is essential.

 

The Cost of Ignoring Fatigue

Ignoring fatigue can lead to:

  • delayed diagnosis
     

  • worsening health conditions
     

  • reduced productivity
     

  • emotional burnout
     

Listening to the body early prevents long-term consequences.

 

Conclusion

Fatigue is not merely a sign of a busy life—it is often the body’s way of signalling imbalance or illness. Persistent tiredness that does not improve with rest should never be ignored. Whether caused by nutritional deficiencies, hormonal changes, chronic stress or underlying disease, fatigue deserves attention. Early evaluation and timely care can restore energy, prevent complications and significantly improve quality of life. Listening to fatigue is an act of self-care and preventive health.

 

References

  • Indian Council of Medical Research (ICMR) – Fatigue and Lifestyle Health Report

  •  World Health Organization (WHO) – Chronic Fatigue and Health Guidelines

  •  National Institute of Nutrition (NIN) – Nutrient Deficiency and Energy Research

  • Lancet – Fatigue as a Marker of Chronic Disease Studie

  •  Indian Journal of Medicine – Persistent Fatigue and Diagnosis

  • Statista – Fatigue, Stress and Health Trend Analysis

See all

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