• Published on: Jan 20, 2021
  • 1 minute read
  • By: Dr Rajan Choudhary

MRNA Vaccines – Uses Beyond COVID

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mRNA vaccines – uses beyond COVID

Last year we estimated it would take over a year for a vaccine against COVID to be approved, with vaccinations expected by spring 2021. Incredibly we have managed to meet this prediction, and by the start of January over 42 million doses have been administered in 51 countries. What is even more astounding is that two of the approved vaccines use a completely new vaccination method never used before. mRNA vaccines can be used to easily deliver a variety of different vaccines by changing the mRNA inside the vaccine capsule, and its benefits may not be limited to just infections.

A recent publication in NATURE has demonstrated the use of mRNA vaccines against auto-immune diseases such as multiple sclerosis. MS is an autoimmune condition in which the protective lining of nerves is destroyed by the body’s immune system, significantly slowing down or altering nerve impulse propagation. This leads to symptoms such as fatigue, vision problems, numbness, tingling, aberrant pain, muscle spasms and weakness.

The study looked at introducing antigen-specific tolerance in mice models of MS. This was achieved by activating anti-inflammatory white blood cells. Normally vaccines activate inflammatory white cells to produce a response but altered mRNA with one specific change to its base structure induces and activates anti-inflammatory cells instead.

Furthermore, this anti-inflammatory response is specific to cells that are activated by and attack the body’s nerve cells, thereby delivering a targeted response and not affecting the immune response against infections or cancer. Global immunosuppression is a common side effect of steroids and chemotherapy agents that are normally used to treat auto-immune conditions, and mRNA vaccines may avoid this side effect altogether.

A further advantage is its versatility. This has been demonstrated against multiple sclerosis, but changing the mRNA delivered by the vaccine, it may prove beneficial in far more auto-immune conditions. Of course, we have to emphasize this was an animal study and human trials are unlikely to happen in the next few years, but this study nicely demonstrates how the impact of the COVID pandemic may already be providing beneficial gains for the future.

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Why Recurring Sore Throat Can Be a Serious Issue

Why Recurring Sore Throat Can Be a Serious Issue

A sore throat is a common complaint. Most of us experience it during seasonal changes, after a cold, or when we catch the flu. But what if your sore throat keeps coming back again and again? While many people dismiss it as a minor irritation, a recurring sore throat can actually signal more serious health issues that require proper attention.

What is a recurring sore throat?

A recurring sore throat refers to repeated or persistent throat discomfort that comes back multiple times in a year or lasts longer than usual. Normally, a viral sore throat improves within a week. If the problem lingers beyond 10 days or returns frequently, it falls into the category of chronic or recurring sore throat.

Why is it serious?

  1. Undiagnosed infections
    A single sore throat from a virus is not concerning. But if bacterial infections like strep throat keep coming back, they may damage the throat and spread to other parts of the body if untreated.
     

  2. Inflammation and tissue damage
    Constant irritation from allergies or acid reflux can harm the delicate tissues of the throat. Over time, this may affect your voice and overall throat function.
     

  3. Underlying medical conditions
    Recurring sore throat can be linked to issues like gastroesophageal reflux disease (GERD), allergies, tonsil problems, or immune system weakness. In some cases, it may also be an early warning sign of more serious diseases such as tumors.
     

  4. Complications
    Recurrent infections can lead to abscesses around the tonsils, ear infections, or sinus problems. Inadequate or repeated antibiotic use can also cause resistance.
     

  5. Impact on daily life
    A constant sore throat affects your eating, speaking, sleeping, and quality of life. It leads to repeated doctor visits, discomfort, and stress.
     

Common causes of recurring sore throat

  • Bacterial infections like strep throat or chronic tonsillitis
     

  • Viral infections that linger or reactivate
     

  • Allergies that trigger postnasal drip and throat irritation
     

  • Acid reflux or GERD causing stomach acid to irritate the throat
     

  • Environmental irritants such as smoke, dust, and pollution
     

  • Mouth breathing during sleep due to nasal blockage
     

  • Immune weakness making you prone to repeated infections
     

Warning signs to watch for

You should never ignore these symptoms if they accompany a recurring sore throat:

  • Sore throat lasting longer than 2–3 weeks
     

  • Difficulty swallowing or breathing
     

  • Lump or swelling in the throat or neck
     

  • Persistent hoarseness or voice changes
     

  • Unexplained weight loss
     

  • Blood in saliva or phlegm
     

  • Fever with night sweats
     

These are red flags that need immediate medical evaluation.

How lab tests help

Lab tests play a critical role in finding out why you have a recurring sore throat. Some useful investigations include:

  • Throat swab or culture to identify bacterial infections
     

  • Rapid antigen test for strep for quick diagnosis
     

  • Complete Blood Count (CBC) to detect infection or immune problems
     

  • CRP and ESR to check inflammation
     

  • Allergy tests to identify triggers like dust or pollen
     

  • Thyroid function tests to rule out thyroid-related throat problems
     

  • Reflux evaluation if GERD is suspected
     

  • Immune status tests if infections are unusually frequent
     

Through SecondMedic/Thyrocare, these tests can be arranged easily, giving you faster results and treatment planning.

Treatment and prevention

The treatment of recurring sore throat depends on its cause:

  • Bacterial infections are treated with antibiotics prescribed by a doctor. Completing the full course is essential.
     

  • Viral infections usually require rest, hydration, and symptom management.
     

  • Acid reflux can be controlled with lifestyle changes like avoiding late meals, reducing spicy foods, and medications if required.
     

  • Allergies can be managed by identifying and avoiding triggers, along with prescribed medicines.
     

  • Tonsil problems may require surgical removal if infections are frequent and severe.
     

Preventive steps include:

  • Staying hydrated
     

  • Avoiding smoking and exposure to polluted air
     

  • Maintaining good throat hygiene
     

  • Managing acid reflux through diet and posture
     

  • Strengthening immunity with balanced nutrition and rest
     

When to see a doctor

If you suffer from frequent sore throats or if your symptoms come with any red flags, consult a healthcare professional without delay. Early evaluation prevents complications and ensures better outcomes.

Conclusion

Recurring sore throat is more than just an inconvenience. It is often a signal from your body that something is not right. Identifying the cause early and undergoing the right tests can help you recover faster and avoid long-term damage.

At SecondMedic, you can access lab tests, doctor consultations, and treatment guidance all in one place. Don’t ignore a sore throat that keeps returning — take charge of your health today and book your tests with SecondMedic/Thyrocare for accurate results and expert support.

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