• Published on: Jan 20, 2021
  • 1 minute read
  • By: Dr Rajan Choudhary

MRNA Vaccines – Uses Beyond COVID

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mRNA vaccines – uses beyond COVID

Last year we estimated it would take over a year for a vaccine against COVID to be approved, with vaccinations expected by spring 2021. Incredibly we have managed to meet this prediction, and by the start of January over 42 million doses have been administered in 51 countries. What is even more astounding is that two of the approved vaccines use a completely new vaccination method never used before. mRNA vaccines can be used to easily deliver a variety of different vaccines by changing the mRNA inside the vaccine capsule, and its benefits may not be limited to just infections.

A recent publication in NATURE has demonstrated the use of mRNA vaccines against auto-immune diseases such as multiple sclerosis. MS is an autoimmune condition in which the protective lining of nerves is destroyed by the body’s immune system, significantly slowing down or altering nerve impulse propagation. This leads to symptoms such as fatigue, vision problems, numbness, tingling, aberrant pain, muscle spasms and weakness.

The study looked at introducing antigen-specific tolerance in mice models of MS. This was achieved by activating anti-inflammatory white blood cells. Normally vaccines activate inflammatory white cells to produce a response but altered mRNA with one specific change to its base structure induces and activates anti-inflammatory cells instead.

Furthermore, this anti-inflammatory response is specific to cells that are activated by and attack the body’s nerve cells, thereby delivering a targeted response and not affecting the immune response against infections or cancer. Global immunosuppression is a common side effect of steroids and chemotherapy agents that are normally used to treat auto-immune conditions, and mRNA vaccines may avoid this side effect altogether.

A further advantage is its versatility. This has been demonstrated against multiple sclerosis, but changing the mRNA delivered by the vaccine, it may prove beneficial in far more auto-immune conditions. Of course, we have to emphasize this was an animal study and human trials are unlikely to happen in the next few years, but this study nicely demonstrates how the impact of the COVID pandemic may already be providing beneficial gains for the future.

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caffeine

Health Problems Linked to Excessive Caffeine Intake: When Too Much Becomes Harmful

Caffeine is one of the most widely consumed stimulants in the world. Found in coffee, tea, energy drinks and many soft drinks, it is often used to improve alertness and combat fatigue. While moderate caffeine consumption can be safe for most people, understanding the health problems linked to excessive caffeine intake is important, especially as daily consumption levels continue to rise in India.

Urban lifestyles, long working hours and increased reliance on energy drinks have made caffeine overconsumption a growing public health concern.

 

How Caffeine Works in the Body

Caffeine stimulates the central nervous system by blocking adenosine, a chemical responsible for promoting sleep and relaxation.

This results in:

  • increased alertness

  • faster heart rate

  • heightened mental activity

However, overstimulation places stress on multiple body systems.

 

What Is Considered Excessive Caffeine Intake?

According to WHO and global health guidelines:

  • up to 400 mg per day is considered safe for most healthy adults

Excessive intake occurs when:

  • multiple caffeinated beverages are consumed daily

  • energy drinks are used frequently

  • caffeine is consumed late in the day

Many people unknowingly exceed safe limits.

 

Nervous System Overstimulation

Excess caffeine overstimulates the brain.

Common symptoms include:

  • restlessness

  • nervousness

  • tremors

  • irritability

Chronic overstimulation can worsen stress and reduce emotional stability.

 

Anxiety and Panic Symptoms

Caffeine increases adrenaline release.

This can:

  • trigger anxiety attacks

  • worsen panic disorder

  • increase feelings of unease

ICMR mental health studies note caffeine as a common trigger for anxiety symptoms in sensitive individuals.

 

Sleep Disruption and Insomnia

Sleep is one of the first systems affected.

Excessive caffeine:

  • delays sleep onset

  • reduces deep sleep

  • shortens total sleep duration

Even caffeine consumed 6–8 hours before bedtime can impair sleep quality.

 

Impact on Heart Health

High caffeine intake affects the cardiovascular system.

Possible effects include:

  • increased heart rate

  • palpitations

  • irregular heart rhythm

People with underlying heart conditions are particularly vulnerable.

 

Blood Pressure Elevation

Caffeine temporarily raises blood pressure.

Chronic excessive intake may:

  • worsen hypertension

  • increase cardiovascular risk

NFHS-5 data highlights rising hypertension prevalence in India, making caffeine moderation important.

 

Digestive System Problems

Caffeine stimulates stomach acid production.

This can cause:

  • acidity

  • heartburn

  • gastritis

  • bloating

People with sensitive digestion may experience symptoms even at lower doses.

 

Dependency and Withdrawal Symptoms

Regular high intake leads to caffeine dependence.

Withdrawal symptoms include:

  • headaches

  • fatigue

  • irritability

  • difficulty concentrating

Dependence reinforces overconsumption cycles.

 

Effect on Bone Health

Excessive caffeine:

  • increases calcium loss through urine

  • may affect bone density over time

This is particularly concerning for older adults and women.

 

Dehydration and Electrolyte Imbalance

Caffeine has a mild diuretic effect.

High intake without adequate hydration may lead to:

  • dehydration

  • muscle cramps

  • fatigue

Hot climates increase this risk.

 

Impact on Blood Sugar and Metabolism

Caffeine affects glucose metabolism.

Excessive intake:

  • worsens insulin sensitivity

  • increases stress hormone release

This may increase diabetes risk when combined with poor lifestyle habits.

 

Energy Drinks and Hidden Risks

Energy drinks often contain:

  • very high caffeine levels

  • added sugar

  • stimulants

Lancet reports associate energy drink overuse with heart rhythm disturbances and metabolic stress.

 

High-Risk Groups

Certain individuals should be especially cautious:

  • people with anxiety disorders

  • those with heart disease

  • pregnant women

  • individuals with sleep disorders

Safe limits may be lower for these groups.

 

Signs You May Be Consuming Too Much Caffeine

Warning signs include:

  • frequent palpitations

  • chronic insomnia

  • persistent anxiety

  • digestive discomfort

  • reliance on caffeine to function

These signals indicate the need for reduction.

 

How to Reduce Caffeine Intake Safely

Effective strategies include:

  • gradual reduction rather than abrupt stopping

  • switching to decaffeinated options

  • avoiding caffeine after mid-afternoon

  • improving sleep and nutrition

Small steps prevent withdrawal symptoms.

 

Healthier Alternatives for Energy

Better ways to improve energy include:

  • adequate sleep

  • balanced meals

  • hydration

  • regular physical activity

These support sustained energy without overstimulation.

 

Role of Preventive Health Awareness

Preventive healthcare focuses on:

  • identifying lifestyle triggers

  • reducing dependency habits

NITI Aayog highlights lifestyle modification as key to non-communicable disease prevention.

 

Long-Term Health Consequences of Ignoring Excess Intake

Chronic caffeine overuse increases risk of:

  • sleep disorders

  • anxiety and mood issues

  • heart rhythm problems

  • digestive disorders

These conditions often develop gradually.

Conclusion

The health problems linked to excessive caffeine intake extend beyond temporary jitters or sleep loss. Chronic overconsumption strains the nervous system, disrupts sleep, affects heart rhythm, worsens anxiety and impacts digestion and metabolism. While caffeine can be enjoyed safely in moderation, recognising personal limits and maintaining balance is essential for long-term health. Listening to early warning signs and adopting healthier energy habits can prevent serious health consequences.

 

References

  • World Health Organization (WHO) – Caffeine Intake and Health Guidelines

  • Indian Council of Medical Research (ICMR) – Nutrition and Mental Health Studies

  • National Family Health Survey (NFHS-5) – Hypertension and Lifestyle Risk Data

  • Lancet – Energy Drinks, Caffeine and Cardiovascular Effects

  • NITI Aayog – Preventive Health and Lifestyle Modification Reports

  • Statista – Caffeine Consumption Trends in India

See all

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