• Published on: Jan 20, 2021
  • 1 minute read
  • By: Dr Rajan Choudhary

MRNA Vaccines – Uses Beyond COVID

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mRNA vaccines – uses beyond COVID

Last year we estimated it would take over a year for a vaccine against COVID to be approved, with vaccinations expected by spring 2021. Incredibly we have managed to meet this prediction, and by the start of January over 42 million doses have been administered in 51 countries. What is even more astounding is that two of the approved vaccines use a completely new vaccination method never used before. mRNA vaccines can be used to easily deliver a variety of different vaccines by changing the mRNA inside the vaccine capsule, and its benefits may not be limited to just infections.

A recent publication in NATURE has demonstrated the use of mRNA vaccines against auto-immune diseases such as multiple sclerosis. MS is an autoimmune condition in which the protective lining of nerves is destroyed by the body’s immune system, significantly slowing down or altering nerve impulse propagation. This leads to symptoms such as fatigue, vision problems, numbness, tingling, aberrant pain, muscle spasms and weakness.

The study looked at introducing antigen-specific tolerance in mice models of MS. This was achieved by activating anti-inflammatory white blood cells. Normally vaccines activate inflammatory white cells to produce a response but altered mRNA with one specific change to its base structure induces and activates anti-inflammatory cells instead.

Furthermore, this anti-inflammatory response is specific to cells that are activated by and attack the body’s nerve cells, thereby delivering a targeted response and not affecting the immune response against infections or cancer. Global immunosuppression is a common side effect of steroids and chemotherapy agents that are normally used to treat auto-immune conditions, and mRNA vaccines may avoid this side effect altogether.

A further advantage is its versatility. This has been demonstrated against multiple sclerosis, but changing the mRNA delivered by the vaccine, it may prove beneficial in far more auto-immune conditions. Of course, we have to emphasize this was an animal study and human trials are unlikely to happen in the next few years, but this study nicely demonstrates how the impact of the COVID pandemic may already be providing beneficial gains for the future.

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Asthma

Asthma Symptoms in Adults: Early Signs, Triggers, and When to Seek Care

Asthma is often perceived as a childhood condition, but a significant number of cases develop or persist into adulthood. In India, adult asthma is increasingly recognised due to rising air pollution, occupational exposure and lifestyle-related risk factors. Unfortunately, asthma symptoms in adults are frequently misdiagnosed as recurrent infections, allergies or age-related breathlessness, leading to delayed treatment.

Understanding adult asthma symptoms is critical for early diagnosis, effective control and prevention of severe attacks.

 

What Is Asthma?

Asthma is a chronic inflammatory disease of the airways. In asthma, the airways become:

  • inflamed
     

  • narrow
     

  • overly sensitive to triggers
     

This leads to difficulty in breathing, especially during exposure to specific stimuli.

 

Why Adult Asthma Is Often Missed

Adult asthma symptoms may:

  • appear gradually
     

  • vary in severity
     

  • mimic common respiratory conditions
     

According to Indian Council of Medical Research and WHO data, many adults remain undiagnosed for years, increasing the risk of complications.

 

Common Asthma Symptoms in Adults

Wheezing

A high-pitched whistling sound while breathing, especially during exhalation, is a classic asthma sign.

 

Shortness of Breath

Adults with asthma often feel:

  • breathless during routine activities
     

  • difficulty taking deep breaths
     

This may worsen at night or early morning.

 

Chest Tightness

Many describe a sensation of pressure or tightness in the chest, which can be mistaken for heart-related issues.

 

Chronic Cough

A persistent cough, especially:

  • at night
     

  • early morning
     

  • after exercise
     

is a common but overlooked asthma symptom.

 

Symptoms That Worsen With Triggers

Asthma symptoms often intensify after exposure to specific triggers.

Air Pollution and Smoke

Urban pollution, vehicle emissions and indoor smoke significantly worsen asthma symptoms in adults.

 

Allergens

Dust mites, pollen, mould and pet dander are common triggers.

 

Respiratory Infections

Viral infections can trigger asthma flare-ups or reveal undiagnosed asthma.

 

Physical Activity

Exercise-induced asthma causes breathlessness and wheezing during or after physical exertion.

 

Weather Changes

Cold air, humidity and sudden temperature changes can aggravate symptoms.

 

Adult-Onset Asthma

Adult-onset asthma differs from childhood asthma.

Characteristics include:

  • onset after age 20–30
     

  • less association with childhood allergies
     

  • more persistent symptoms
     

  • higher likelihood of severe disease
     

Occupational exposure and hormonal changes contribute to adult-onset asthma.

 

Risk Factors for Asthma in Adults

Several factors increase asthma risk:

  • long-term exposure to pollution
     

  • smoking or passive smoking
     

  • occupational chemicals or dust
     

  • obesity
     

  • family history of asthma
     

  • chronic sinusitis or allergies
     

Women may experience asthma onset or worsening during hormonal changes.

 

When Asthma Symptoms Become Serious

Seek immediate medical attention if experiencing:

  • severe breathlessness
     

  • difficulty speaking in full sentences
     

  • bluish lips or fingertips
     

  • rapid worsening of symptoms
     

  • poor response to usual inhalers
     

These signs indicate a potentially life-threatening asthma attack.

 

How Adult Asthma Is Diagnosed

Diagnosis includes:

  • detailed symptom history
     

  • physical examination
     

  • lung function tests (spirometry)
     

  • response to bronchodilators
     

Early diagnosis improves long-term outcomes.

 

Impact of Untreated Asthma

Untreated asthma can lead to:

  • frequent attacks
     

  • reduced lung function
     

  • sleep disturbances
     

  • missed workdays
     

  • reduced quality of life
     

According to Lancet respiratory studies, uncontrolled asthma increases hospitalisation risk.

 

Managing Asthma Symptoms in Adults

Effective asthma management focuses on:

  • identifying and avoiding triggers
     

  • using prescribed inhalers correctly
     

  • monitoring symptoms regularly
     

  • maintaining follow-up care
     

Asthma action plans help patients recognise worsening symptoms early.

 

Role of Preventive Healthcare

Preventive healthcare helps:

  • detect asthma early
     

  • assess lung function
     

  • guide lifestyle modifications
     

Regular health checkups are especially important for individuals with respiratory symptoms or occupational exposure.

 

Lifestyle Measures That Support Asthma Control

Helpful practices include:

  • avoiding smoking
     

  • improving indoor air quality
     

  • wearing masks in polluted environments
     

  • maintaining healthy weight
     

  • regular, moderate exercise
     

Lifestyle support complements medical treatment.

 

Mental Health and Asthma

Stress and anxiety can worsen asthma symptoms.

Stress management:

  • reduces symptom frequency
     

  • improves medication response
     

Holistic care improves asthma outcomes.

 

Importance of Medication Adherence

Asthma medications work best when:

  • taken regularly as prescribed
     

  • inhaler technique is correct
     

Skipping treatment increases flare-up risk.

 

Long-Term Outlook for Adults With Asthma

With proper management:

  • symptoms are well controlled
     

  • severe attacks are preventable
     

  • normal activity levels are achievable
     

Most adults with asthma lead active, productive lives.

 

Conclusion

Asthma symptoms in adults are often subtle, variable and easily mistaken for common respiratory problems. Wheezing, breathlessness, chest tightness and chronic cough should not be ignored, especially when triggered by pollution, exercise or weather changes. Early diagnosis, trigger control and consistent treatment are essential to prevent severe attacks and preserve lung health. Recognising adult asthma early empowers individuals to manage symptoms effectively and maintain a good quality of life.

 

References

  • Indian Council of Medical Research (ICMR) – Respiratory Disease and Asthma Studies
  • World Health Organization (WHO) – Asthma Management and Prevention Guidelines
  • National Family Health Survey (NFHS-5) – Respiratory Health Indicators
  • Lancet Respiratory Medicine – Adult Asthma Outcomes and Management
  • NITI Aayog – Air Pollution and Respiratory Health Reports
  • Statista – Global Asthma Prevalence and Trends

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