• Published on: Jan 20, 2021
  • 1 minute read
  • By: Dr Rajan Choudhary

MRNA Vaccines – Uses Beyond COVID

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mRNA vaccines – uses beyond COVID

Last year we estimated it would take over a year for a vaccine against COVID to be approved, with vaccinations expected by spring 2021. Incredibly we have managed to meet this prediction, and by the start of January over 42 million doses have been administered in 51 countries. What is even more astounding is that two of the approved vaccines use a completely new vaccination method never used before. mRNA vaccines can be used to easily deliver a variety of different vaccines by changing the mRNA inside the vaccine capsule, and its benefits may not be limited to just infections.

A recent publication in NATURE has demonstrated the use of mRNA vaccines against auto-immune diseases such as multiple sclerosis. MS is an autoimmune condition in which the protective lining of nerves is destroyed by the body’s immune system, significantly slowing down or altering nerve impulse propagation. This leads to symptoms such as fatigue, vision problems, numbness, tingling, aberrant pain, muscle spasms and weakness.

The study looked at introducing antigen-specific tolerance in mice models of MS. This was achieved by activating anti-inflammatory white blood cells. Normally vaccines activate inflammatory white cells to produce a response but altered mRNA with one specific change to its base structure induces and activates anti-inflammatory cells instead.

Furthermore, this anti-inflammatory response is specific to cells that are activated by and attack the body’s nerve cells, thereby delivering a targeted response and not affecting the immune response against infections or cancer. Global immunosuppression is a common side effect of steroids and chemotherapy agents that are normally used to treat auto-immune conditions, and mRNA vaccines may avoid this side effect altogether.

A further advantage is its versatility. This has been demonstrated against multiple sclerosis, but changing the mRNA delivered by the vaccine, it may prove beneficial in far more auto-immune conditions. Of course, we have to emphasize this was an animal study and human trials are unlikely to happen in the next few years, but this study nicely demonstrates how the impact of the COVID pandemic may already be providing beneficial gains for the future.

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Diabetes symptoms

Diabetes Symptoms in Men: Early Warning Signs You Should Not Ignore

Diabetes is one of the fastest-growing health challenges worldwide, and men are particularly vulnerable to its long-term complications. In India, the burden of diabetes has increased sharply over the past two decades, driven by lifestyle changes, sedentary habits and dietary patterns. Despite this, many men remain unaware of early diabetes symptoms or delay medical consultation until complications develop.

Understanding diabetes symptoms in men is essential for early diagnosis, effective management and prevention of serious health consequences.

 

What Is Diabetes?

Diabetes is a chronic metabolic disorder characterised by high blood sugar levels due to:

  • insufficient insulin production
     

  • ineffective insulin action
     

  • or both
     

The most common form affecting men is type 2 diabetes, which is strongly linked to lifestyle factors.

 

Why Men Are at Higher Risk

Several factors increase diabetes risk in men:

  • higher abdominal fat accumulation
     

  • smoking and alcohol consumption
     

  • irregular eating patterns
     

  • work-related stress
     

  • lower healthcare-seeking behaviour
     

According to Indian Council of Medical Research data, a significant proportion of men remain undiagnosed until advanced stages.

 

Early Diabetes Symptoms in Men

Frequent Urination

Excess sugar in the blood causes kidneys to work harder, leading to increased urination, especially at night.

 

Excessive Thirst

Frequent urination leads to dehydration, causing constant thirst.

 

Fatigue and Weakness

Cells cannot utilise glucose efficiently, resulting in low energy levels and persistent tiredness.

 

Unexplained Weight Changes

Men may experience unexplained weight loss despite normal or increased appetite.

 

Increased Hunger

Insulin resistance prevents glucose from entering cells, triggering frequent hunger.

 

Diabetes Symptoms Unique or Commonly Seen in Men

Erectile Dysfunction

Diabetes damages blood vessels and nerves, leading to erectile dysfunction.

Studies show a strong association between diabetes and male sexual health problems.

 

Reduced Testosterone Levels

Men with diabetes often have lower testosterone, affecting libido, muscle mass and mood.

 

Decreased Muscle Strength

Poor glucose utilisation affects muscle health and physical stamina.

 

Skin and Infection-Related Symptoms

Slow-Healing Wounds

High blood sugar impairs wound healing, increasing infection risk.

 

Frequent Infections

Men with diabetes are more prone to:

  • skin infections
     

  • urinary tract infections
     

  • fungal infections
     

 

Vision and Nerve Symptoms

Blurred Vision

Fluctuating blood sugar affects eye lenses, causing blurred vision.

 

Tingling or Numbness

Nerve damage, known as diabetic neuropathy, causes tingling or numbness in hands and feet.

 

Why Diabetes Symptoms Are Often Ignored by Men

Many men dismiss symptoms as:

  • work-related fatigue
     

  • ageing
     

  • stress
     

This delay increases the risk of complications.

 

Long-Term Complications of Untreated Diabetes

If untreated, diabetes can lead to:

  • heart disease
     

  • kidney failure
     

  • nerve damage
     

  • vision loss
     

  • sexual dysfunction
     

According to WHO and Lancet studies, early detection significantly reduces complication risk.

 

Importance of Early Diagnosis

Early diagnosis allows:

  • better blood sugar control
     

  • lifestyle modification
     

  • prevention of organ damage
     

Routine screening is crucial, even in the absence of symptoms.

 

When Should Men Get Tested?

Men should consider testing if they:

  • are over 30 years old
     

  • have a family history of diabetes
     

  • are overweight
     

  • have a sedentary lifestyle
     

  • experience any warning signs
     

Annual screening is recommended for at-risk individuals.

 

Managing Diabetes After Diagnosis

Effective management includes:

  • healthy diet
     

  • regular physical activity
     

  • weight control
     

  • stress management
     

  • medical treatment as advised
     

Early management improves quality of life.

 

Role of Preventive Healthcare

Preventive healthcare focuses on:

  • early screening
     

  • lifestyle intervention
     

  • regular follow-up
     

According to NITI Aayog, preventive strategies are essential to control India’s diabetes burden.

 

Mental Health and Diabetes in Men

Diabetes can affect mental wellbeing, leading to:

  • stress
     

  • anxiety
     

  • depression
     

Addressing emotional health improves diabetes outcomes.

 

Breaking the Stigma Around Men’s Health

Men often avoid seeking help due to stigma.

Promoting awareness helps:

  • normalise health conversations
     

  • encourage timely medical care
     

  • reduce preventable complications
     

 

Conclusion

Diabetes symptoms in men often develop gradually and may go unnoticed for years. Frequent urination, fatigue, unexplained weight changes and sexual health issues should never be ignored. Early diagnosis and timely management significantly reduce the risk of serious complications and improve long-term health outcomes. Awareness, routine screening and proactive healthcare are essential steps for men to protect their health and wellbeing in an era of rising lifestyle diseases.

 

References

  • Indian Council of Medical Research (ICMR) – Diabetes Epidemiology and Risk Studies
  • World Health Organization (WHO) – Diabetes Prevention and Management Guidelines
  • National Family Health Survey (NFHS-5) – Diabetes Prevalence in Men
  • Lancet Diabetes & Endocrinology – Male-Specific Diabetes Outcomes
  • NITI Aayog – Non-Communicable Disease Prevention Reports
  • Statista – Global Diabetes Trends and Gender Differences

 

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