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Published on: Jul 17, 2020
2 minute read
By: Dr Rajan Choudhary

MRNA Vaccine Against SARS CoV2

An mRNA Vaccine against SARS CoV2

We have previously discussed vaccines against SARS-CoV-2, the virus responsible for COVID-19. On the 14th of July, a preliminary study was published in the New England Journal of Medicine, an internationally reputable medical journal. This study looks at mRNA vaccines in Phase 1 human clinical trials, a first for the virus. Here we will discuss what this means and the results of the study.

mRNA vaccine

Vaccines target the immune system’s memory by presenting them with pieces of these infective diseases. The small amounts do not cause any infective symptoms, but if the person is infected later in life their body will mount a quicker response and prevent them from falling ill. These vaccines can contain broken up parts of the organisms, “dead” organisms or “live” versions that have been severely weakened so they cannot cause any harm.

In 2018 a new type of vaccine was described. Instead of using pre-made protein markers that identify infectious organisms, mRNA vaccines contain genetic material with instructions to produce these markers. Once injected, the person’s cells use these instructions to produce copies of these protein markers. These markers are displayed on the surface of the cell, which in turn is recognized by the immune system, initiating an immune response and producing protective antibodies.

BENEFITS

A major advantage of RNA vaccines is the ease by which they can be made in a laboratory from a DNA template. During a pandemic, this would result in a rapid response and vaccine against a new disease. Conventional vaccines require the use of chicken eggs or cells to produce the vaccines, which can be expensive and time-consuming. These vaccines can be delivered via injections into the skin, blood, muscle, or organs, needle-free into the skin, or via nasal spray. Because these vaccines are so new, we still do not know the best way to deliver it.

Because these vaccines are not made with parts of infective organisms or from live organisms, they are not infectious and will not cause harm through a strong immune response to the vaccine itself, or by causing the disease they aim to vaccinate against. They also appear to be very efficient at generating a reliable immune response to produce antibodies and are well tolerated with few side effects.

NEEDS IMPROVEMENT

Because these types of vaccines are so new there is still a lot we do not understand about them. They may cause unintended effects that we have not yet encountered in human clinical studies. These vaccines also need to be frozen or refrigerated, and so would not be suitable for countries with limited or no refrigeration facilities.

COVID

The SARS-CoV-2 mRNA vaccine codes for one of the virus’ surface spike proteins, responsible for recognizing target cells and fusing the virus into the cell for entry and infection. It was previously recognized as a target for the SARS and MERS viruses.

45 participants received 2 intramuscular injections 28 days apart. None of the participants had any serious side effects after the first injection, or any side effects significant enough to stop the trial. Many had minor to moderate side effects after their second injection (such as fatigue, chills, headache, myalgia, and pain at the injection site), and half the participants taking high dose vaccines had febrile side effects. Overall the side effects were rated as acceptable.

Prior to the vaccine trials, none of the participants had any antibodies against COVID, or any capacity to stop a COIVD infection. After the injections, all participants had noticeable increases in antibodies produced, measurable in their blood. After 43 days, the participant's blood had enough antibodies to reduce infection by SARS-CoV-2 by over 80%.

What is the takeaway? The vaccine is capable of producing an adequate response to protect the vaccine recipient without eliciting any major side effects. These results will be used in phase 2 clinical trials (enrolment began in May) and a phase 3 trial in July 2020. Essentially this means further human trials to further look for side effects in a larger number of volunteers with a more diverse health profile.

This represents an interesting development in producing a rapid vaccine against a new virus responsible for a world-changing pandemic. This new type of vaccine may be the future of vaccines for a broader range of viruses, bacteria, and even cancers.

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Replace Junk with Subscription Snack Packs: A Practical Approach to Preventive Nutrition in India

India is witnessing a growing shift toward healthier eating habits, yet junk food consumption continues to rise across all age groups. According to ICMR and NFHS-5 data, high-calorie packaged snacks, sugary beverages and deep-fried foods contribute significantly to obesity, diabetes and cardiovascular risk. Replacing these items with nutritious snack alternatives is one of the simplest yet most effective steps toward preventive wellness.

Subscription snack packs offer a structured, convenient and affordable way to transition from unhealthy snacking to balanced nutrition. SecondMedic promotes this approach as part of a broader preventive health ecosystem that focuses on long-term behavioural change rather than temporary diets.

Why Indians are Choosing Healthy Snack Subscriptions

1. Convenience in fast-paced lifestyles

Urban and semi-urban households often depend on quick, accessible snacks to keep up with busy schedules. Healthy subscription packs bring pre-portioned nutrition directly to the doorstep.

2. Rising health concerns

India now ranks among the world’s highest in:

Diabetes prevalence
Childhood obesity
Hypertension
High cholesterol

Replacing junk food is essential for reducing these long-term risks.

3. Growing awareness of clean eating

People are moving toward:

Low-sugar
Low-sodium
High-fibre
High-protein
Non-fried
snack alternatives.

4. Cost-effectiveness

Contrary to belief, balanced snack packs cost less than repeated purchases of unhealthy packaged foods.

What Makes Subscription Snack Packs Healthier?

Healthy snack packs are curated for balanced nutrition:

• Nuts and seeds

Rich in healthy fats, fibre and minerals.

• Millet-based snacks

Low GI, nutrient-dense and suitable for diabetics.

• Dried fruits

Provide natural sweetness without refined sugar.

• Roasted chana and legumes

Excellent plant-based protein sources.

• Low-sugar bars

Made from oats, dates, nuts and seeds.

• Whole-grain crackers

Better than refined flour biscuits.

• Herbal teas

Support digestion and relaxation.

These snacks reduce cravings while supporting metabolic health.

Why Junk Food Needs Replacement

• High in trans fats

Linked to heart disease and inflammation.

• Excess sugar

Promotes insulin resistance, weight gain and metabolic syndrome.

• Refined flour

Lacks fibre and elevates glucose rapidly.

• Additives & preservatives

May contribute to long-term digestive and metabolic issues.

• Instant cravings

Junk foods trigger overeating by stimulating dopamine pathways.

Replacing them with healthier options breaks this cycle.

How Subscription Snack Packs Support Preventive Healthcare

1. Portion control

Pre-measured servings reduce the risk of overeating.

2. Balanced nutrition

Snack packs provide fibre, healthy fats and micronutrients missing from typical Indian diets.

3. Reduced decision fatigue

Users do not have to search for healthy options daily.

4. Behavioural consistency

Weekly or monthly packs promote long-term habit formation.

5. Support for chronic disease management

Especially helpful for:

Diabetes
PCOS
Thyroid issues
Heart disease

SecondMedic integrates snack guidance into dietitian consultations and AI-driven nutrition analysis.

The Role of AI Health Guide in Smarter Snacking

SecondMedic’s AI Health Guide provides:

• Calorie and nutrient insights

Evaluates daily intake based on user habits.

• Snack recommendations

Based on medical conditions, preferences and goals.

• Craving pattern analysis

Identifies triggers for unhealthy eating.

• Personalised preventive plans

Aligns snacking habits with heart, gut and metabolic health.

This makes snack substitution easier and more sustainable.

How to Transition from Junk Food to Healthy Snack Packs

Step 1: Identify your biggest cravings

Sugary, salty, crunchy or fried?

Step 2: Find healthier alternatives

For example:

Replace chips ? roasted makhana
Replace sweets ? dates + nuts
Replace biscuits ? whole-grain crackers

Step 3: Use subscription packs for structure

Pre-curated boxes guide behaviour change.

Step 4: Track progress

Energy levels improve within 2-4 weeks.

Step 5: Build long-term habits

Consistency leads to metabolic improvement.

Conclusion

Replacing junk food with subscription snack packs is an effective and convenient step toward preventive wellness in India. By combining healthier ingredients, balanced nutrition and consistent delivery, subscription packs help individuals make better choices daily. With expert guidance and AI-driven insights from SecondMedic, these changes become sustainable, personalised and impactful for long-term health.

References

• ICMR - Dietary Patterns & Junk Food Consumption Study
• NFHS-5 - Nutrition Deficiencies & Lifestyle Data India
• NITI Aayog - Preventive Health & Nutrition Strategy
• WHO - Healthy Diet & Non-Communicable Disease Guidelines
• Lancet - Consumption Patterns & Cardiometabolic Risk
• Statista India - Healthy Snacking Trends
• EY-FICCI - Consumer Behaviour Toward Preventive Health

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