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Published on: Jul 17, 2020
2 minute read
By: Dr Rajan Choudhary

MRNA Vaccine Against SARS CoV2

An mRNA Vaccine against SARS CoV2

We have previously discussed vaccines against SARS-CoV-2, the virus responsible for COVID-19. On the 14th of July, a preliminary study was published in the New England Journal of Medicine, an internationally reputable medical journal. This study looks at mRNA vaccines in Phase 1 human clinical trials, a first for the virus. Here we will discuss what this means and the results of the study.

mRNA vaccine

Vaccines target the immune system’s memory by presenting them with pieces of these infective diseases. The small amounts do not cause any infective symptoms, but if the person is infected later in life their body will mount a quicker response and prevent them from falling ill. These vaccines can contain broken up parts of the organisms, “dead” organisms or “live” versions that have been severely weakened so they cannot cause any harm.

In 2018 a new type of vaccine was described. Instead of using pre-made protein markers that identify infectious organisms, mRNA vaccines contain genetic material with instructions to produce these markers. Once injected, the person’s cells use these instructions to produce copies of these protein markers. These markers are displayed on the surface of the cell, which in turn is recognized by the immune system, initiating an immune response and producing protective antibodies.

BENEFITS

A major advantage of RNA vaccines is the ease by which they can be made in a laboratory from a DNA template. During a pandemic, this would result in a rapid response and vaccine against a new disease. Conventional vaccines require the use of chicken eggs or cells to produce the vaccines, which can be expensive and time-consuming. These vaccines can be delivered via injections into the skin, blood, muscle, or organs, needle-free into the skin, or via nasal spray. Because these vaccines are so new, we still do not know the best way to deliver it.

Because these vaccines are not made with parts of infective organisms or from live organisms, they are not infectious and will not cause harm through a strong immune response to the vaccine itself, or by causing the disease they aim to vaccinate against. They also appear to be very efficient at generating a reliable immune response to produce antibodies and are well tolerated with few side effects.

NEEDS IMPROVEMENT

Because these types of vaccines are so new there is still a lot we do not understand about them. They may cause unintended effects that we have not yet encountered in human clinical studies. These vaccines also need to be frozen or refrigerated, and so would not be suitable for countries with limited or no refrigeration facilities.

COVID

The SARS-CoV-2 mRNA vaccine codes for one of the virus’ surface spike proteins, responsible for recognizing target cells and fusing the virus into the cell for entry and infection. It was previously recognized as a target for the SARS and MERS viruses.

45 participants received 2 intramuscular injections 28 days apart. None of the participants had any serious side effects after the first injection, or any side effects significant enough to stop the trial. Many had minor to moderate side effects after their second injection (such as fatigue, chills, headache, myalgia, and pain at the injection site), and half the participants taking high dose vaccines had febrile side effects. Overall the side effects were rated as acceptable.

Prior to the vaccine trials, none of the participants had any antibodies against COVID, or any capacity to stop a COIVD infection. After the injections, all participants had noticeable increases in antibodies produced, measurable in their blood. After 43 days, the participant's blood had enough antibodies to reduce infection by SARS-CoV-2 by over 80%.

What is the takeaway? The vaccine is capable of producing an adequate response to protect the vaccine recipient without eliciting any major side effects. These results will be used in phase 2 clinical trials (enrolment began in May) and a phase 3 trial in July 2020. Essentially this means further human trials to further look for side effects in a larger number of volunteers with a more diverse health profile.

This represents an interesting development in producing a rapid vaccine against a new virus responsible for a world-changing pandemic. This new type of vaccine may be the future of vaccines for a broader range of viruses, bacteria, and even cancers.

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Best Home Remedies for Glowing Skin

Glowing skin is not simply a cosmetic goal. It is a visible reflection of skin health, hydration, and cellular repair. While the market is flooded with serums and treatments, dermatologists consistently observe that the most sustainable skin glow comes from consistent, simple, and evidence-supported practices. The good news is that many of the most effective ingredients are already available in an Indian kitchen.

Why Skin Loses Its Natural Glow

Before applying any remedy, understanding the root cause of dull skin is essential. Dermatologists identify the following as the most common triggers in the Indian context:

Cause	Effect on Skin
Pollution and sun exposure	Oxidative stress, pigmentation, uneven tone
Dehydration	Reduced elasticity, dryness, dullness
Poor diet and nutrient deficiency	Slowed cell renewal, loss of radiance
Disrupted sleep	Impaired skin repair, dark circles, puffiness
Hormonal imbalance	Acne, oiliness, pigmentation
Harsh skincare products	Damaged skin barrier, redness, sensitivity

Identifying and addressing the underlying cause is as important as applying any topical remedy. Skin that appears dull despite consistent care often signals an internal factor requiring dietary or medical attention.

Which Home Remedy is Best for Glowing Skin?

Among all widely used natural ingredients, raw honey combined with aloe vera gel is considered the most universally effective home remedy for glowing skin. Honey acts as a humectant, drawing moisture into the skin, while its antibacterial and antioxidant compounds protect against environmental damage. Aloe vera complements this by delivering vitamins A, C, and E directly into the skin, supporting collagen synthesis and reducing inflammation.

This combination works across all skin types, requires no preparation time, and demonstrates consistent results in clinical observations relating to skin hydration and barrier repair. Applied three times a week for 15 to 20 minutes, this remedy produces visible improvement in skin texture and brightness within two to three weeks of regular use. For individuals with oily or acne-prone skin, aloe vera used alone without honey is the preferred option as it is non-comedogenic and lightweight.

Top Home Remedies for Glowing Skin by Skin Type

One of the most significant gaps in standard advice is that remedies are rarely matched to skin type. Applying the wrong ingredient can worsen the skin condition rather than improve it. Dermatologists recommend the following skin-type specific approach:

Skin Type	Best Remedy	Key Benefit	Frequency
Dry Skin	Raw honey and milk paste	Deep hydration, lactic acid exfoliation	3 times per week
Oily Skin	Multani mitti with rose water	Sebum control, pore tightening	2 times per week
Combination Skin	Aloe vera gel	Balances moisture without clogging pores	Daily
Sensitive Skin	Oat flour and plain yogurt pack	Soothes inflammation, gentle exfoliation	2 times per week
Normal Skin	Turmeric and honey mask	Antioxidant boost, brightening	2 to 3 times per week
Dull or Pigmented Skin	Potato juice or tomato pulp	Natural kojic acid, reduces pigmentation	3 times per week

Matching the remedy to skin type is the single most important factor in achieving consistent results from any natural skincare routine.

Which Kitchen Ingredients Work Best for Skin Glow?

Several common Indian kitchen ingredients carry clinically recognised skin benefits. The mechanism behind each ingredient matters as much as the application method:

Turmeric (Haldi): Contains curcumin, a potent antioxidant and anti-inflammatory compound. Curcumin inhibits melanin synthesis, which helps reduce pigmentation and uneven skin tone over time. Used as a paste with milk or honey, turmeric is one of the most researched natural brightening agents.

Raw Milk: Contains lactic acid, a naturally occurring alpha hydroxy acid (AHA) that gently exfoliates dead skin cells, stimulates collagen production, and improves skin luminosity. Applying raw cold milk with a cotton pad and leaving it for 15 minutes is a simple and effective brightening practice.

Besan (Gram Flour): Functions as a mild physical exfoliant and oil absorber. Mixed with turmeric and rose water, besan-based face packs have been used across Indian households for generations and remain dermatologically appropriate for most skin types.

Aloe Vera: Rich in polysaccharides that support skin hydration and mucilaginous compounds that form a protective barrier. Clinical data supports its use in reducing UV-induced skin damage and accelerating epidermal repair.

Potato Juice: Contains catecholase, an enzyme with mild skin-lightening properties. Particularly useful for reducing dark circles, tan lines, and post-inflammatory hyperpigmentation.

How to Get Glowing Skin Naturally in One Week

Most competitors list remedies without telling readers how to actually use them together. The following 7-day routine is structured to progressively address cleansing, exfoliation, hydration, and brightening within a single week:

Day	Morning	Evening
Day 1	Raw milk cotton pad cleanse	Aloe vera gel application
Day 2	Rose water toner	Honey and aloe vera mask (15 min)
Day 3	Raw milk cleanse	Turmeric and honey mask (10 min)
Day 4	Rose water toner	Aloe vera gel application
Day 5	Raw milk cleanse	Besan, turmeric and rose water pack (15 min)
Day 6	Rose water toner	Potato juice on dark spots (20 min)
Day 7	Raw milk cleanse	Honey and aloe vera mask (15 min)

This routine uses no more than three to four ingredients across the entire week, minimising the risk of ingredient overload or skin irritation. Always perform a patch test on the inner forearm before applying any new ingredient to the face.

Lifestyle Habits That Support Glowing Skin From Within

Topical remedies address the surface. Skin glow that is deep and lasting is primarily determined by internal health factors that all four competitor articles fail to address:

Hydration: Dermatologists observe that inadequate water intake is the single most common and most overlooked cause of dull skin among Indian adults. A minimum of 2.5 to 3 litres of water daily supports cellular metabolism and maintains skin turgor.

Diet: Skin cells require vitamins C, E, and A along with zinc and omega-3 fatty acids for repair and renewal. Indian dietary staples such as amla (Indian gooseberry), carrots, spinach, walnuts, and flaxseeds provide these nutrients in bioavailable forms. Reducing refined sugar intake is equally important, as excess glucose triggers glycation, a process that breaks down collagen and accelerates skin ageing.

Sleep: The skin's repair cycle peaks during deep sleep between 11 PM and 3 AM. Chronic sleep deprivation elevates cortisol, which degrades collagen and increases inflammatory skin conditions. Clinical specialists recommend seven to eight hours of uninterrupted sleep as a non-negotiable component of any skin improvement plan.

Gut Health: Emerging dermatological research on the gut-skin axis confirms that dysbiosis (imbalance of gut bacteria) is linked to acne, rosacea, and dull skin. Incorporating fermented foods such as curd and buttermilk into the daily diet supports gut microbiome balance, which in turn improves skin clarity.

Home Remedies to Avoid: What Dermatologists Warn Against

This section exists in none of the competing articles and represents the most clinically important addition to this topic. Several widely promoted "natural" skin remedies are actively harmful:

Lemon juice directly on skin: Lemon juice has a pH of approximately 2, far too acidic for direct skin application. It disrupts the skin's natural acid mantle (pH 4.5 to 5.5), causes photosensitivity, and can result in chemical burns or permanent pigmentation when skin is exposed to sunlight post-application.

Baking soda: Despite its popularity on social media, baking soda has an alkaline pH of 9, which severely disrupts the skin barrier, strips natural oils, and causes microbial imbalance on the skin surface.

Toothpaste on pimples: Toothpaste contains fluoride, menthol, and hydrogen peroxide, none of which are formulated for skin. It causes contact dermatitis, dryness, and post-inflammatory hyperpigmentation, particularly on Indian skin tones.

Undiluted essential oils: Applying undiluted tea tree oil, lavender oil, or any essential oil directly on the face without a carrier oil causes irritant contact dermatitis and skin sensitisation.

Dermatologists advise that if a remedy causes stinging, redness, or visible irritation, it should be discontinued immediately regardless of how widely it is recommended online.

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