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Published on: Jul 17, 2020
2 minute read
By: Dr Rajan Choudhary

MRNA Vaccine Against SARS CoV2

An mRNA Vaccine against SARS CoV2

We have previously discussed vaccines against SARS-CoV-2, the virus responsible for COVID-19. On the 14th of July, a preliminary study was published in the New England Journal of Medicine, an internationally reputable medical journal. This study looks at mRNA vaccines in Phase 1 human clinical trials, a first for the virus. Here we will discuss what this means and the results of the study.

mRNA vaccine

Vaccines target the immune system’s memory by presenting them with pieces of these infective diseases. The small amounts do not cause any infective symptoms, but if the person is infected later in life their body will mount a quicker response and prevent them from falling ill. These vaccines can contain broken up parts of the organisms, “dead” organisms or “live” versions that have been severely weakened so they cannot cause any harm.

In 2018 a new type of vaccine was described. Instead of using pre-made protein markers that identify infectious organisms, mRNA vaccines contain genetic material with instructions to produce these markers. Once injected, the person’s cells use these instructions to produce copies of these protein markers. These markers are displayed on the surface of the cell, which in turn is recognized by the immune system, initiating an immune response and producing protective antibodies.

BENEFITS

A major advantage of RNA vaccines is the ease by which they can be made in a laboratory from a DNA template. During a pandemic, this would result in a rapid response and vaccine against a new disease. Conventional vaccines require the use of chicken eggs or cells to produce the vaccines, which can be expensive and time-consuming. These vaccines can be delivered via injections into the skin, blood, muscle, or organs, needle-free into the skin, or via nasal spray. Because these vaccines are so new, we still do not know the best way to deliver it.

Because these vaccines are not made with parts of infective organisms or from live organisms, they are not infectious and will not cause harm through a strong immune response to the vaccine itself, or by causing the disease they aim to vaccinate against. They also appear to be very efficient at generating a reliable immune response to produce antibodies and are well tolerated with few side effects.

NEEDS IMPROVEMENT

Because these types of vaccines are so new there is still a lot we do not understand about them. They may cause unintended effects that we have not yet encountered in human clinical studies. These vaccines also need to be frozen or refrigerated, and so would not be suitable for countries with limited or no refrigeration facilities.

COVID

The SARS-CoV-2 mRNA vaccine codes for one of the virus’ surface spike proteins, responsible for recognizing target cells and fusing the virus into the cell for entry and infection. It was previously recognized as a target for the SARS and MERS viruses.

45 participants received 2 intramuscular injections 28 days apart. None of the participants had any serious side effects after the first injection, or any side effects significant enough to stop the trial. Many had minor to moderate side effects after their second injection (such as fatigue, chills, headache, myalgia, and pain at the injection site), and half the participants taking high dose vaccines had febrile side effects. Overall the side effects were rated as acceptable.

Prior to the vaccine trials, none of the participants had any antibodies against COVID, or any capacity to stop a COIVD infection. After the injections, all participants had noticeable increases in antibodies produced, measurable in their blood. After 43 days, the participant's blood had enough antibodies to reduce infection by SARS-CoV-2 by over 80%.

What is the takeaway? The vaccine is capable of producing an adequate response to protect the vaccine recipient without eliciting any major side effects. These results will be used in phase 2 clinical trials (enrolment began in May) and a phase 3 trial in July 2020. Essentially this means further human trials to further look for side effects in a larger number of volunteers with a more diverse health profile.

This represents an interesting development in producing a rapid vaccine against a new virus responsible for a world-changing pandemic. This new type of vaccine may be the future of vaccines for a broader range of viruses, bacteria, and even cancers.

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Lipid Profile Test – Normal Range and Risks

Keeping your heart healthy isn’t just about staying active or eating green veggies. It also means knowing what’s going on inside your body—especially your cholesterol levels. One of the best ways to track this is through a lipid profile test.

If you’re wondering what this test means, what the numbers should be, and what risks you face if they're abnormal—this blog is for you.

Let’s dive into lipid profile test – normal range and risks in easy and clear language.

What Is a Lipid Profile Test?

A lipid profile test is a blood test that measures the amount of fat (lipids) in your blood. These lipids include different types of cholesterol and triglycerides.

The test helps evaluate your risk of heart disease, stroke, and clogged arteries.

What Does the Lipid Profile Test Measure?

A complete lipid profile usually measures:

Total Cholesterol – the overall amount of cholesterol in your blood
LDL (Low-Density Lipoprotein) – the “bad” cholesterol that can block arteries
HDL (High-Density Lipoprotein) – the “good” cholesterol that protects your heart
Triglycerides – a type of fat that provides energy but can cause heart issues in high amounts

Sometimes, the test also calculates VLDL and a cholesterol/HDL ratio to better assess your health risks.

Lipid Profile – Normal Range

Understanding what your numbers mean is key. Here are the recommended normal ranges:

Test Component	Normal Range
Total Cholesterol	Less than 200 mg/dL
LDL (Bad Cholesterol)	Less than 100 mg/dL
HDL (Good Cholesterol)	40 mg/dL or more (men), 50+ (women)
Triglycerides	Less than 150 mg/dL

Note: Values may vary slightly depending on labs and age. Always consult your doctor for interpretation.

Why Is This Test Important?

High cholesterol usually shows no symptoms. That’s why it's called a silent threat.

Your arteries may slowly get clogged without you knowing it, increasing the risk of:

Heart attacks
Strokes
Peripheral artery disease
High blood pressure

A lipid profile gives an early warning so you can make timely changes to protect your heart.

Risks of Abnormal Lipid Profile

Here’s what happens when the results are not in the normal range:

High LDL Cholesterol

Builds plaque in your arteries
Increases risk of heart attack or stroke

Low HDL Cholesterol

Reduces protection for your heart
Makes it easier for bad cholesterol to stick to artery walls

High Triglycerides

Can lead to pancreatitis and diabetes
Often linked with obesity and poor lifestyle

High Total Cholesterol

General risk marker for cardiovascular diseases

Causes of High Cholesterol or Triglycerides

Unhealthy diet (high in fried, fatty, and sugary foods)
Lack of physical activity
Smoking and alcohol consumption
Obesity
Diabetes or thyroid problems
Genetic/family history of high cholesterol

How to Improve Your Lipid Profile Naturally

If your test results are abnormal, you don’t always need medicine right away. Often, small changes in your lifestyle can bring big improvements.

Eat a Heart-Healthy Diet

Choose whole grains, fruits, vegetables, and lean proteins
Avoid processed food, red meat, and fried items
Include omega-3 rich foods like fish, flaxseeds, and walnuts

Exercise Regularly

30 minutes of walking, yoga, cycling, or swimming at least 5 days a week

Quit Smoking & Limit Alcohol

These habits lower HDL and increase LDL

Maintain a Healthy Weight

Losing even 5–10% of body weight can improve lipid levels

How and When to Take the Lipid Profile Test

When to Take:

Once every 12 months for adults above 30
More often if you have heart disease, diabetes, obesity, or a family history

Fasting Required?

Yes, you should fast for 8–12 hours before giving the blood sample for the most accurate results.

Can I Get This Test at Home?

Yes! Platforms like SecondMedic.com offer home sample collection for the Lipid Profile Test, powered by trusted labs like Thyrocare.

You just book the test online, and a technician collects the sample from your doorstep. Results are available digitally within 24–48 hours.

Total cholesterol over 240 mg/dL, LDL over 160 mg/dL, and triglycerides over 200 mg/dL are considered high-risk levels.

Conclusion

A lipid profile test is a simple yet powerful tool that gives deep insights into your heart health. Knowing the normal range and understanding the risks of abnormal levels can help you take control early and live a longer, healthier life.

Stay proactive about your health. Book a lipid profile test – normal range and risks checkup today and make heart-smart choices.

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