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Published on: Jul 17, 2020
2 minute read
By: Dr Rajan Choudhary

MRNA Vaccine Against SARS CoV2

An mRNA Vaccine against SARS CoV2

We have previously discussed vaccines against SARS-CoV-2, the virus responsible for COVID-19. On the 14th of July, a preliminary study was published in the New England Journal of Medicine, an internationally reputable medical journal. This study looks at mRNA vaccines in Phase 1 human clinical trials, a first for the virus. Here we will discuss what this means and the results of the study.

mRNA vaccine

Vaccines target the immune system’s memory by presenting them with pieces of these infective diseases. The small amounts do not cause any infective symptoms, but if the person is infected later in life their body will mount a quicker response and prevent them from falling ill. These vaccines can contain broken up parts of the organisms, “dead” organisms or “live” versions that have been severely weakened so they cannot cause any harm.

In 2018 a new type of vaccine was described. Instead of using pre-made protein markers that identify infectious organisms, mRNA vaccines contain genetic material with instructions to produce these markers. Once injected, the person’s cells use these instructions to produce copies of these protein markers. These markers are displayed on the surface of the cell, which in turn is recognized by the immune system, initiating an immune response and producing protective antibodies.

BENEFITS

A major advantage of RNA vaccines is the ease by which they can be made in a laboratory from a DNA template. During a pandemic, this would result in a rapid response and vaccine against a new disease. Conventional vaccines require the use of chicken eggs or cells to produce the vaccines, which can be expensive and time-consuming. These vaccines can be delivered via injections into the skin, blood, muscle, or organs, needle-free into the skin, or via nasal spray. Because these vaccines are so new, we still do not know the best way to deliver it.

Because these vaccines are not made with parts of infective organisms or from live organisms, they are not infectious and will not cause harm through a strong immune response to the vaccine itself, or by causing the disease they aim to vaccinate against. They also appear to be very efficient at generating a reliable immune response to produce antibodies and are well tolerated with few side effects.

NEEDS IMPROVEMENT

Because these types of vaccines are so new there is still a lot we do not understand about them. They may cause unintended effects that we have not yet encountered in human clinical studies. These vaccines also need to be frozen or refrigerated, and so would not be suitable for countries with limited or no refrigeration facilities.

COVID

The SARS-CoV-2 mRNA vaccine codes for one of the virus’ surface spike proteins, responsible for recognizing target cells and fusing the virus into the cell for entry and infection. It was previously recognized as a target for the SARS and MERS viruses.

45 participants received 2 intramuscular injections 28 days apart. None of the participants had any serious side effects after the first injection, or any side effects significant enough to stop the trial. Many had minor to moderate side effects after their second injection (such as fatigue, chills, headache, myalgia, and pain at the injection site), and half the participants taking high dose vaccines had febrile side effects. Overall the side effects were rated as acceptable.

Prior to the vaccine trials, none of the participants had any antibodies against COVID, or any capacity to stop a COIVD infection. After the injections, all participants had noticeable increases in antibodies produced, measurable in their blood. After 43 days, the participant's blood had enough antibodies to reduce infection by SARS-CoV-2 by over 80%.

What is the takeaway? The vaccine is capable of producing an adequate response to protect the vaccine recipient without eliciting any major side effects. These results will be used in phase 2 clinical trials (enrolment began in May) and a phase 3 trial in July 2020. Essentially this means further human trials to further look for side effects in a larger number of volunteers with a more diverse health profile.

This represents an interesting development in producing a rapid vaccine against a new virus responsible for a world-changing pandemic. This new type of vaccine may be the future of vaccines for a broader range of viruses, bacteria, and even cancers.

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Why Your Anxiety Could Be Linked to Your Gut Health

Have you ever had “butterflies in your stomach” before a big event? Or felt your stomach twist when you’re nervous? These feelings are more than just expressions. They reveal a real connection between your brain and your gut. Today, science is uncovering fascinating links between gut health and mental health—especially anxiety. Let’s explore how your gut might be silently affecting your mood and why it’s so important to keep it healthy.

The Gut-Brain Connection: More Than You Think

The gut and brain are connected through a network known as the gut-brain axis. This communication highway uses nerves, hormones, and chemicals to send messages between the two. The vagus nerve, the longest cranial nerve, plays a key role in this connection. It runs from your brain to your abdomen and helps regulate digestion, mood, and even immune response.

This means your brain can affect your gut—and your gut can affect your brain.

Meet Your Second Brain: The Gut Microbiome

Your gut is home to trillions of bacteria, fungi, and other microorganisms. This complex ecosystem is called the gut microbiome. It helps you digest food, absorb nutrients, fight harmful germs, and even create important chemicals.

Surprisingly, many of these chemicals influence your mood. One key player is serotonin, a “feel-good” hormone. Did you know that about 90% of serotonin is made in the gut? So, if your gut is unhealthy, your mood could suffer too.

How Gut Health Affects Anxiety

When your gut microbiome is balanced, you feel good—physically and mentally. But when it’s out of balance (a condition called dysbiosis), problems can begin.

1. Inflammation

An unhealthy gut can cause inflammation throughout the body, including the brain. This inflammation can interfere with normal brain function and contribute to anxiety and other mood disorders.

2. Leaky Gut Syndrome

If the gut lining becomes too weak, harmful bacteria and toxins can leak into the bloodstream. This is known as leaky gut. These toxins may trigger inflammation and affect your nervous system, increasing feelings of stress and anxiety.

3. Poor Nutrient Absorption

The gut absorbs nutrients like magnesium, B vitamins, and omega-3s—all of which are essential for brain health. If your gut isn’t working well, your brain might not get what it needs to stay calm and balanced.

4. Chemical Imbalance

The gut produces neurotransmitters like dopamine and serotonin. An imbalance in gut bacteria can disrupt their production, potentially leading to anxiety, depression, or mood swings.

Signs Your Gut Might Be Affecting Your Mental Health

If you’re struggling with anxiety, it’s worth asking whether your gut could be involved. Here are some signs your gut health might be impacting your mood:

Frequent bloating or gas
Constipation or diarrhea
Sugar cravings
Food intolerances
Brain fog or difficulty concentrating
Feeling tired all the time
Poor sleep quality

If you have both anxiety and digestive issues, the two could be connected.

How to Improve Gut Health and Reduce Anxiety

Thankfully, you can take simple steps to support your gut health—and improve your mental well-being along the way.

1. Eat More Fiber

Fiber feeds the good bacteria in your gut. Add more fruits, vegetables, whole grains, and legumes to your diet. Foods like apples, bananas, carrots, oats, and lentils are excellent choices.

2. Include Probiotics and Prebiotics

Probiotics are live bacteria that help balance your gut microbiome. You can find them in yogurt, kefir, kimchi, sauerkraut, and miso. Prebiotics, on the other hand, are foods that feed your good bacteria—like garlic, onions, and bananas.

3. Limit Processed and Sugary Foods

Sugar and highly processed foods can promote bad bacteria and inflammation. Try to reduce your intake of soft drinks, white bread, fast food, and sweets.

4. Manage Stress

Chronic stress can disrupt gut health. Practice stress-reducing techniques like deep breathing, meditation, yoga, or even spending time in nature.

5. Exercise Regularly

Physical activity helps regulate the gut microbiome and boosts mood-enhancing chemicals in the brain. Aim for at least 30 minutes of moderate exercise most days.

6. Get Enough Sleep

Poor sleep affects both gut health and mental health. Aim for 7–9 hours of quality sleep every night. A relaxing bedtime routine can help.

7. Stay Hydrated

Water helps keep your digestion smooth and your gut bacteria balanced. Drink at least 8 glasses of water a day.

8. Consider Supplements (If Needed)

If dietary changes aren’t enough, consider talking to a healthcare provider about probiotic or vitamin supplements. Don’t self-medicate—always consult a professional first.

When to See a Doctor

If you’re experiencing severe anxiety, depression, or digestive problems, don’t ignore it. A doctor or mental health professional can help you find the right treatment. In some cases, therapy, medication, or medical tests may be necessary.

Also, a nutritionist or gastroenterologist can help you identify and manage any gut-related issues contributing to your mental health symptoms.

Final Thoughts

Your gut is not just about digestion—it plays a powerful role in how you feel emotionally. Modern research shows that keeping your gut healthy can positively impact anxiety and overall mental well-being.

By taking simple steps to support your digestive system—like eating well, managing stress, and getting enough sleep—you can help improve both your gut and your mind.

Conclusion

In today’s fast-paced world, taking care of your mental health is more important than ever. And one of the most overlooked ways to do that is by taking care of your gut. From serotonin production to inflammation control, your gut plays a major role in how you feel every day. So next time you're feeling anxious, take a moment to think about your digestive health too. After all, it’s not just in your head—it could be in your stomach too.

If you're wondering why your anxiety could be linked to your gut health, it's time to start listening to your gut and making changes that support your entire well-being.

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