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Published on: Jul 17, 2020
2 minute read
By: Dr Rajan Choudhary

MRNA Vaccine Against SARS CoV2

An mRNA Vaccine against SARS CoV2

We have previously discussed vaccines against SARS-CoV-2, the virus responsible for COVID-19. On the 14th of July, a preliminary study was published in the New England Journal of Medicine, an internationally reputable medical journal. This study looks at mRNA vaccines in Phase 1 human clinical trials, a first for the virus. Here we will discuss what this means and the results of the study.

mRNA vaccine

Vaccines target the immune system’s memory by presenting them with pieces of these infective diseases. The small amounts do not cause any infective symptoms, but if the person is infected later in life their body will mount a quicker response and prevent them from falling ill. These vaccines can contain broken up parts of the organisms, “dead” organisms or “live” versions that have been severely weakened so they cannot cause any harm.

In 2018 a new type of vaccine was described. Instead of using pre-made protein markers that identify infectious organisms, mRNA vaccines contain genetic material with instructions to produce these markers. Once injected, the person’s cells use these instructions to produce copies of these protein markers. These markers are displayed on the surface of the cell, which in turn is recognized by the immune system, initiating an immune response and producing protective antibodies.

BENEFITS

A major advantage of RNA vaccines is the ease by which they can be made in a laboratory from a DNA template. During a pandemic, this would result in a rapid response and vaccine against a new disease. Conventional vaccines require the use of chicken eggs or cells to produce the vaccines, which can be expensive and time-consuming. These vaccines can be delivered via injections into the skin, blood, muscle, or organs, needle-free into the skin, or via nasal spray. Because these vaccines are so new, we still do not know the best way to deliver it.

Because these vaccines are not made with parts of infective organisms or from live organisms, they are not infectious and will not cause harm through a strong immune response to the vaccine itself, or by causing the disease they aim to vaccinate against. They also appear to be very efficient at generating a reliable immune response to produce antibodies and are well tolerated with few side effects.

NEEDS IMPROVEMENT

Because these types of vaccines are so new there is still a lot we do not understand about them. They may cause unintended effects that we have not yet encountered in human clinical studies. These vaccines also need to be frozen or refrigerated, and so would not be suitable for countries with limited or no refrigeration facilities.

COVID

The SARS-CoV-2 mRNA vaccine codes for one of the virus’ surface spike proteins, responsible for recognizing target cells and fusing the virus into the cell for entry and infection. It was previously recognized as a target for the SARS and MERS viruses.

45 participants received 2 intramuscular injections 28 days apart. None of the participants had any serious side effects after the first injection, or any side effects significant enough to stop the trial. Many had minor to moderate side effects after their second injection (such as fatigue, chills, headache, myalgia, and pain at the injection site), and half the participants taking high dose vaccines had febrile side effects. Overall the side effects were rated as acceptable.

Prior to the vaccine trials, none of the participants had any antibodies against COVID, or any capacity to stop a COIVD infection. After the injections, all participants had noticeable increases in antibodies produced, measurable in their blood. After 43 days, the participant's blood had enough antibodies to reduce infection by SARS-CoV-2 by over 80%.

What is the takeaway? The vaccine is capable of producing an adequate response to protect the vaccine recipient without eliciting any major side effects. These results will be used in phase 2 clinical trials (enrolment began in May) and a phase 3 trial in July 2020. Essentially this means further human trials to further look for side effects in a larger number of volunteers with a more diverse health profile.

This represents an interesting development in producing a rapid vaccine against a new virus responsible for a world-changing pandemic. This new type of vaccine may be the future of vaccines for a broader range of viruses, bacteria, and even cancers.

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Busting Nutrition Myths in India: An Evidence-Based Guide Powered by SecondMedic’s AI Health Guide

Nutrition misinformation has become increasingly common in India. From viral social media diets to generational food beliefs, many individuals struggle to separate fact from fiction. These myths can influence daily habits, delay proper treatment and contribute to the growing burden of lifestyle diseases.

SecondMedic’s AI Health Guide was designed to offer clarity. By analysing scientific literature, Indian dietary patterns and personal health inputs, it explains complex nutrition topics in a human-friendly, practical manner. This blog explores the most widespread nutrition myths in India and how an AI-enabled approach helps users make informed dietary decisions.

Why Nutrition Myths Persist in India

1. Cultural dietary traditions

Food practices often evolve through experience but not always through evidence. Certain long-held assumptions continue despite scientific updates.

2. Rise of viral misinformation

Millions of Indians search diet advice online daily, and misleading content spreads rapidly without expert review.

3. High prevalence of lifestyle diseases

ICMR and NFHS-5 highlight escalating rates of:

Diabetes
Obesity
Hypertension
PCOS
Thyroid disorders

The public seeks quick solutions, making myths appealing.

4. Limited access to qualified dietitians

Many people rely on hearsay or generic tips rather than personalised nutrition guidance.

SecondMedic’s AI Health Guide bridges this gap by offering accessible, evidence-backed explanations.

Myth 1: “Carbohydrates always lead to weight gain.”

Carbohydrates are not inherently harmful.
The problem lies in refined carbohydrates like white bread, sugary drinks and packaged snacks.

What the science says

Whole grains, millets, oats and fibre-rich carbs improve:

Gut health
Blood sugar regulation
Energy levels

Research in Lancet Public Health confirms that complex carbs support metabolic wellbeing.

AI Health Guide perspective

The system evaluates:

Activity level
Blood sugar trends
Dietary preferences

Then recommends the type and quantity of carbs suitable for the individual.

Myth 2: “Protein damages the kidneys.”

This is one of India’s most common misconceptions.

Clinical reality

Protein affects kidneys only in individuals with existing kidney disease.

NFHS-5 shows that most Indians do not meet their daily protein requirement.

Balanced approach

Safe protein sources:

Lentils
Paneer
Eggs
Tofu
Chicken
Fish

An AI-guided nutrition plan ensures intake matches needs and health conditions.

Myth 3: “All fats are unhealthy.”

Fats play essential roles in:

Hormone production
Brain function
Vitamin absorption

Good fats

Nuts and seeds
Olive oil
Flaxseed
Fatty fish

Harmful fats

Trans fats
Hydrogenated oils
Deep-fried packaged snacks

SecondMedic’s AI Health Guide analyses dietary logs to suggest healthier fat alternatives.

Myth 4: “Detox diets cleanse the body.”

Detox teas, juices and cleanses are popular but not scientifically validated.

Actual detoxification

The liver, kidneys and digestive system naturally remove toxins.

Risks of extreme detox diets

Fatigue
Digestive distress
Slow metabolism
Nutrient deficiencies

A sustainable alternative includes balanced meals, hydration and fibre-rich foods.

Myth 5: “Eating after 8 PM causes weight gain.”

Timing is not the primary factor.
Weight gain depends on:

Total calorie intake
Food quality
Portion control
Sleep-wake cycles

For shift workers or late diners, an AI-based guide personalises eating windows that match biological rhythms.

How AI Personalises Nutrition Guidance for India

The AI Health Guide adapts advice based on:

• Clinical inputs

Blood reports, symptoms, chronic conditions.

• Lifestyle signals

Sleep, activity, stress, work schedules.

• Cultural eating patterns

North Indian, South Indian, vegetarian, non-vegetarian diets.

• Personal health goals

Weight control, energy improvement, disease management.

This ensures that the guidance is not generic-it is tailored for real-life Indian scenarios.

How an AI Health Guide Supports Preventive Healthcare

1. Early risk identification

AI recognises patterns that may indicate:

Rising blood sugar
Nutrient deficiencies
Poor digestion
Inflammatory markers

2. Behavioural nudges

Small, realistic changes are suggested instead of extreme diet plans.

3. Improved health literacy

Users understand why certain foods are better choices.

4. Better medical support

Clear explanations enhance doctor and dietitian consultations.

Conclusion

Nutrition myths can lead individuals toward restrictive diets, nutrient deficiencies and misguided health decisions. With rising lifestyle diseases in India, accurate nutrition knowledge is essential. A scientific, personalised approach-supported by an AI Health Guide-helps individuals navigate misinformation confidently.

By combining evidence-based insights with individual dietary needs, SecondMedic’s AI-driven guidance empowers people to adopt sustainable, preventive and truly health-enhancing food habits.

References

• ICMR Indian Nutrition Profile & Dietary Science Study
• National Family Health Survey (NFHS-5) - Protein Intake & Micronutrient Data
• NITI Aayog - Preventive Health & Digital Nutrition Insights
• WHO Global Dietary Guidelines & Balanced Nutrition Framework
• Lancet Public Health - Carbohydrate Quality & Metabolic Health Studies
• Statista - India Digital Nutrition & Health Behaviour Analysis
• EY-FICCI - AI and Preventive Healthcare Consumer Report

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