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Published on: Jul 17, 2020
2 minute read
By: Dr Rajan Choudhary

MRNA Vaccine Against SARS CoV2

An mRNA Vaccine against SARS CoV2

We have previously discussed vaccines against SARS-CoV-2, the virus responsible for COVID-19. On the 14th of July, a preliminary study was published in the New England Journal of Medicine, an internationally reputable medical journal. This study looks at mRNA vaccines in Phase 1 human clinical trials, a first for the virus. Here we will discuss what this means and the results of the study.

mRNA vaccine

Vaccines target the immune system’s memory by presenting them with pieces of these infective diseases. The small amounts do not cause any infective symptoms, but if the person is infected later in life their body will mount a quicker response and prevent them from falling ill. These vaccines can contain broken up parts of the organisms, “dead” organisms or “live” versions that have been severely weakened so they cannot cause any harm.

In 2018 a new type of vaccine was described. Instead of using pre-made protein markers that identify infectious organisms, mRNA vaccines contain genetic material with instructions to produce these markers. Once injected, the person’s cells use these instructions to produce copies of these protein markers. These markers are displayed on the surface of the cell, which in turn is recognized by the immune system, initiating an immune response and producing protective antibodies.

BENEFITS

A major advantage of RNA vaccines is the ease by which they can be made in a laboratory from a DNA template. During a pandemic, this would result in a rapid response and vaccine against a new disease. Conventional vaccines require the use of chicken eggs or cells to produce the vaccines, which can be expensive and time-consuming. These vaccines can be delivered via injections into the skin, blood, muscle, or organs, needle-free into the skin, or via nasal spray. Because these vaccines are so new, we still do not know the best way to deliver it.

Because these vaccines are not made with parts of infective organisms or from live organisms, they are not infectious and will not cause harm through a strong immune response to the vaccine itself, or by causing the disease they aim to vaccinate against. They also appear to be very efficient at generating a reliable immune response to produce antibodies and are well tolerated with few side effects.

NEEDS IMPROVEMENT

Because these types of vaccines are so new there is still a lot we do not understand about them. They may cause unintended effects that we have not yet encountered in human clinical studies. These vaccines also need to be frozen or refrigerated, and so would not be suitable for countries with limited or no refrigeration facilities.

COVID

The SARS-CoV-2 mRNA vaccine codes for one of the virus’ surface spike proteins, responsible for recognizing target cells and fusing the virus into the cell for entry and infection. It was previously recognized as a target for the SARS and MERS viruses.

45 participants received 2 intramuscular injections 28 days apart. None of the participants had any serious side effects after the first injection, or any side effects significant enough to stop the trial. Many had minor to moderate side effects after their second injection (such as fatigue, chills, headache, myalgia, and pain at the injection site), and half the participants taking high dose vaccines had febrile side effects. Overall the side effects were rated as acceptable.

Prior to the vaccine trials, none of the participants had any antibodies against COVID, or any capacity to stop a COIVD infection. After the injections, all participants had noticeable increases in antibodies produced, measurable in their blood. After 43 days, the participant's blood had enough antibodies to reduce infection by SARS-CoV-2 by over 80%.

What is the takeaway? The vaccine is capable of producing an adequate response to protect the vaccine recipient without eliciting any major side effects. These results will be used in phase 2 clinical trials (enrolment began in May) and a phase 3 trial in July 2020. Essentially this means further human trials to further look for side effects in a larger number of volunteers with a more diverse health profile.

This represents an interesting development in producing a rapid vaccine against a new virus responsible for a world-changing pandemic. This new type of vaccine may be the future of vaccines for a broader range of viruses, bacteria, and even cancers.

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World AIDS Day 2024: The Role of Diagnostic Centers in Combating HIV/AIDS

World AIDS Day, observed annually on December 1st, serves as a critical reminder of the global fight against HIV/AIDS. This year, the theme focuses on collaboration and innovation in the healthcare sector to combat the epidemic effectively. Diagnostic centres play an indispensable role in this fight, driving early detection, routine screening, and stigma-free testing. Let’s explore how diagnostic centers are pivotal in HIV prevention and treatment, emphasizing the importance of HIV testing on World AIDS Day.

Why World AIDS Day Matters

World AIDS Day 2024 marks an opportunity to reflect on progress, advocate for better healthcare policies, and raise awareness about HIV/AIDS. Despite significant advancements, the epidemic persists, with millions unaware of their HIV status. Early detection through diagnostic centres is a cornerstone in tackling this issue, aligning with global efforts to eliminate HIV by 2030.

The Role of Diagnostic Centers in HIV Prevention

Diagnostic centres are at the heart of HIV prevention, offering services that range from early detection to community education. Here's how they contribute:

1. Early HIV Detection and Its Importance

The role of diagnostic centres in HIV early detection cannot be overstated. Identifying HIV in its initial stages:

Prevents disease progression: Early treatment helps maintain immune function.
Reduces transmission: Individuals aware of their status can take precautions to prevent spreading the virus.
Improves health outcomes: Patients diagnosed early are more likely to lead healthy, productive lives.

2. Routine Screening Saves Lives

Routine HIV screening, as offered by diagnostic centres, is vital for at-risk populations. Benefits include:

Early intervention through antiretroviral therapy (ART).
Reduced stigma by normalizing testing.
Empowerment of individuals through knowledge of their health status.

3. Advanced HIV Diagnostic Technologies

Modern diagnostic centres utilize cutting-edge technologies for HIV testing. These advancements include:

Rapid testing kits: Deliver results in minutes.
PCR (Polymerase Chain Reaction): Detects HIV in the early stages.
CD4 count and viral load tests: Monitor disease progression and treatment effectiveness.

These innovations ensure accurate, timely diagnoses, significantly improving patient care.

How Diagnostic Centers Fight HIV/AIDS

Diagnostic centres go beyond testing; they are integral to comprehensive HIV care.

Community Awareness Programs

Promoting awareness about the importance of HIV testing on World AIDS Day is a key initiative. Centers often collaborate with NGOs and public health campaigns to:

Educate communities on the benefits of routine HIV screening.
Break myths and misconceptions about HIV/AIDS.
Promote stigma-free HIV diagnosis on World AIDS Day.

Linking Testing to Treatment

A diagnosis is only the beginning. Diagnostic centres serve as a bridge to medical treatment by:

Providing access to ART programs.
Offering counselling services for newly diagnosed individuals.
Partnering with healthcare providers for continuous care.

Stigma-Free Testing

A major barrier to HIV testing is the fear of judgment. Diagnostic centres actively work to create safe, confidential environments, ensuring:

Patients feel comfortable seeking services.
Testing has become a routine aspect of healthcare.

Community Role in HIV/AIDS Awareness

The fight against HIV/AIDS requires collective effort. Communities play a critical role by:

Supporting Testing Drives: Participating in initiatives organized by diagnostic centres.
Promoting Education: Encouraging discussions about HIV to reduce stigma.
Advocating for Change: Demanding accessible healthcare services for all.

By collaborating with diagnostic centres, communities can amplify the message of World AIDS Day 2024.

Benefits of Routine HIV Screening

Diagnostic centres emphasize routine HIV screening for everyone, especially high-risk groups. Here’s why:

Improved Public Health: Early detection limits the virus's spread.
Cost-Effective Care: Preventive measures and early treatment reduce long-term healthcare costs.
Psychological Well-Being: Knowing one’s status brings clarity and peace of mind.

Promoting Second Medic’s Stigma-Free HIV Diagnosis

At Second Medic Health Hub Diagnostic Center, we are committed to providing high-quality, confidential HIV testing and screening services. This World AIDS Day, we invite you to:

Take advantage of our advanced diagnostic technologies.
Join our community outreach programs to spread awareness.
Commit to routine screenings as part of your healthcare plan.

Our mission is to ensure that everyone has access to accurate, stigma-free healthcare. Together, we can make a difference.

Conclusion

World AIDS Day 2024 reminds us of the power of collective action. Diagnostic centres, such as Second Medic, are essential in the battle against HIV/AIDS, offering testing, education, and support to affected communities. By embracing routine screenings and promoting early detection, we can envision a future free of HIV. This World AIDS Day, let’s renew our commitment to fighting stigma and providing care to those who need it most.

Take the step today—book your HIV screening with Second Medic and be part of the change.