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Published on: Jul 17, 2020
2 minute read
By: Dr Rajan Choudhary

MRNA Vaccine Against SARS CoV2

An mRNA Vaccine against SARS CoV2

We have previously discussed vaccines against SARS-CoV-2, the virus responsible for COVID-19. On the 14th of July, a preliminary study was published in the New England Journal of Medicine, an internationally reputable medical journal. This study looks at mRNA vaccines in Phase 1 human clinical trials, a first for the virus. Here we will discuss what this means and the results of the study.

mRNA vaccine

Vaccines target the immune system’s memory by presenting them with pieces of these infective diseases. The small amounts do not cause any infective symptoms, but if the person is infected later in life their body will mount a quicker response and prevent them from falling ill. These vaccines can contain broken up parts of the organisms, “dead” organisms or “live” versions that have been severely weakened so they cannot cause any harm.

In 2018 a new type of vaccine was described. Instead of using pre-made protein markers that identify infectious organisms, mRNA vaccines contain genetic material with instructions to produce these markers. Once injected, the person’s cells use these instructions to produce copies of these protein markers. These markers are displayed on the surface of the cell, which in turn is recognized by the immune system, initiating an immune response and producing protective antibodies.

BENEFITS

A major advantage of RNA vaccines is the ease by which they can be made in a laboratory from a DNA template. During a pandemic, this would result in a rapid response and vaccine against a new disease. Conventional vaccines require the use of chicken eggs or cells to produce the vaccines, which can be expensive and time-consuming. These vaccines can be delivered via injections into the skin, blood, muscle, or organs, needle-free into the skin, or via nasal spray. Because these vaccines are so new, we still do not know the best way to deliver it.

Because these vaccines are not made with parts of infective organisms or from live organisms, they are not infectious and will not cause harm through a strong immune response to the vaccine itself, or by causing the disease they aim to vaccinate against. They also appear to be very efficient at generating a reliable immune response to produce antibodies and are well tolerated with few side effects.

NEEDS IMPROVEMENT

Because these types of vaccines are so new there is still a lot we do not understand about them. They may cause unintended effects that we have not yet encountered in human clinical studies. These vaccines also need to be frozen or refrigerated, and so would not be suitable for countries with limited or no refrigeration facilities.

COVID

The SARS-CoV-2 mRNA vaccine codes for one of the virus’ surface spike proteins, responsible for recognizing target cells and fusing the virus into the cell for entry and infection. It was previously recognized as a target for the SARS and MERS viruses.

45 participants received 2 intramuscular injections 28 days apart. None of the participants had any serious side effects after the first injection, or any side effects significant enough to stop the trial. Many had minor to moderate side effects after their second injection (such as fatigue, chills, headache, myalgia, and pain at the injection site), and half the participants taking high dose vaccines had febrile side effects. Overall the side effects were rated as acceptable.

Prior to the vaccine trials, none of the participants had any antibodies against COVID, or any capacity to stop a COIVD infection. After the injections, all participants had noticeable increases in antibodies produced, measurable in their blood. After 43 days, the participant's blood had enough antibodies to reduce infection by SARS-CoV-2 by over 80%.

What is the takeaway? The vaccine is capable of producing an adequate response to protect the vaccine recipient without eliciting any major side effects. These results will be used in phase 2 clinical trials (enrolment began in May) and a phase 3 trial in July 2020. Essentially this means further human trials to further look for side effects in a larger number of volunteers with a more diverse health profile.

This represents an interesting development in producing a rapid vaccine against a new virus responsible for a world-changing pandemic. This new type of vaccine may be the future of vaccines for a broader range of viruses, bacteria, and even cancers.

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Clothing Drives for Secondhand Donation: Serving Society Sustainably

Clothing is a basic human need, yet millions of people across India lack access to adequate apparel, especially during extreme weather conditions. At the same time, urban households discard large volumes of wearable clothing each year. Clothing drives for secondhand donation bridge this gap by connecting surplus with need in a dignified, sustainable manner.

These initiatives are not merely charitable activities. They represent a structured approach to social responsibility, environmental stewardship and community wellbeing.

The Growing Need for Clothing Donation in India

India faces significant socio-economic disparity.

According to government and NGO data:

millions live below the poverty line
seasonal weather exposes vulnerable populations to health risks
access to basic clothing remains inconsistent

Clothing insecurity directly affects dignity, health and social participation.

Environmental Impact of Textile Waste

The fashion and textile industry is among the largest contributors to environmental pollution.

Textile waste leads to:

landfill accumulation
water pollution from dyes
increased carbon footprint

Reusing clothing through donation significantly reduces environmental strain.

Why Secondhand Clothing Matters

Secondhand clothing extends the lifecycle of garments.

Benefits include:

reduced demand for new production
conservation of water and energy
lower environmental emissions

According to sustainability studies, reuse has a far lower environmental cost than recycling or disposal.

Social Impact of Clothing Drives

Clothing donation drives provide:

protection from heat, cold and rain
improved hygiene and comfort
enhanced dignity and self-esteem

For recipients, clean, appropriate clothing supports physical health and social inclusion.

Role of Clothing Drives in Community Wellbeing

Community-based donation drives:

encourage collective responsibility
foster empathy and awareness
strengthen social bonds

When organised locally, they ensure relevance and timely distribution.

Corporate and Institutional Participation

Many organisations integrate clothing drives into CSR initiatives.

Benefits for organisations include:

measurable social impact
employee engagement
alignment with sustainability goals

EY-FICCI CSR reports highlight employee-driven social initiatives as highly effective engagement tools.

How to Organise an Effective Clothing Drive

Successful drives follow structured processes.

Key steps include:

clear communication on donation guidelines
segregation by size, gender and season
quality checks for usability
hygienic packing and storage

Organisation ensures dignity for recipients.

Importance of Quality and Dignity

Donations should always respect the recipient.

Essential guidelines:

clothes must be clean and wearable
damaged or unusable items should be excluded
culturally appropriate clothing should be prioritised

Dignified donation builds trust and respect.

Seasonal Relevance of Clothing Drives

Seasonal drives maximise impact.

Examples include:

winter clothing drives
monsoon protection apparel
school clothing collections

Timing ensures practical usefulness.

Health and Wellbeing Benefits

Adequate clothing reduces:

exposure-related illnesses
skin infections
respiratory conditions during cold weather

WHO recognises appropriate clothing as a basic determinant of health.

Sustainability and Circular Economy

Clothing drives support a circular economy by:

keeping materials in use longer
reducing waste generation
encouraging responsible consumption

They align with global sustainability goals.

Community Partnerships and NGOs

Collaborating with NGOs ensures:

efficient distribution
identification of genuine needs
transparency and accountability

Partnerships amplify reach and impact.

Measuring the Impact of Clothing Drives

Impact can be assessed through:

number of beneficiaries
quantity of clothing reused
environmental waste reduction
community feedback

Data-driven evaluation improves future initiatives.

Challenges and How to Address Them

Common challenges include:

poor-quality donations
storage and logistics issues
uneven distribution

Clear guidelines and partnerships help overcome these barriers.

Long-Term Value of Sustainable Donation Drives

Regular clothing drives:

normalise responsible disposal habits
build sustainable communities
encourage conscious consumption

They move society from waste to welfare.

Integrating Clothing Drives with Broader Wellness Initiatives

Clothing drives complement:

health camps
nutrition programs
community wellness initiatives

Holistic approaches improve overall social wellbeing.

Conclusion

Clothing drives for secondhand donation represent a powerful intersection of compassion and sustainability. By redirecting wearable clothing to those who need it most, these initiatives protect dignity, improve health outcomes and reduce environmental impact. In a society striving for sustainable development, organised clothing donation drives serve as practical, high-impact actions that benefit communities and the planet alike. When individuals and organisations come together to serve responsibly, small acts of reuse create lasting social change.

References

World Health Organization (WHO) – Social Determinants of Health Reports
Indian Council of Medical Research (ICMR) – Environmental and Community Health Studies
NITI Aayog – Sustainability and Social Impact Frameworks
EY-FICCI – Corporate Social Responsibility and Sustainability Reports
Statista – Textile Waste and Sustainability Data
UN Environment Programme – Sustainable Consumption and Circular Economy

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