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Published on: Jul 17, 2020
2 minute read
By: Dr Rajan Choudhary

MRNA Vaccine Against SARS CoV2

An mRNA Vaccine against SARS CoV2

We have previously discussed vaccines against SARS-CoV-2, the virus responsible for COVID-19. On the 14th of July, a preliminary study was published in the New England Journal of Medicine, an internationally reputable medical journal. This study looks at mRNA vaccines in Phase 1 human clinical trials, a first for the virus. Here we will discuss what this means and the results of the study.

mRNA vaccine

Vaccines target the immune system’s memory by presenting them with pieces of these infective diseases. The small amounts do not cause any infective symptoms, but if the person is infected later in life their body will mount a quicker response and prevent them from falling ill. These vaccines can contain broken up parts of the organisms, “dead” organisms or “live” versions that have been severely weakened so they cannot cause any harm.

In 2018 a new type of vaccine was described. Instead of using pre-made protein markers that identify infectious organisms, mRNA vaccines contain genetic material with instructions to produce these markers. Once injected, the person’s cells use these instructions to produce copies of these protein markers. These markers are displayed on the surface of the cell, which in turn is recognized by the immune system, initiating an immune response and producing protective antibodies.

BENEFITS

A major advantage of RNA vaccines is the ease by which they can be made in a laboratory from a DNA template. During a pandemic, this would result in a rapid response and vaccine against a new disease. Conventional vaccines require the use of chicken eggs or cells to produce the vaccines, which can be expensive and time-consuming. These vaccines can be delivered via injections into the skin, blood, muscle, or organs, needle-free into the skin, or via nasal spray. Because these vaccines are so new, we still do not know the best way to deliver it.

Because these vaccines are not made with parts of infective organisms or from live organisms, they are not infectious and will not cause harm through a strong immune response to the vaccine itself, or by causing the disease they aim to vaccinate against. They also appear to be very efficient at generating a reliable immune response to produce antibodies and are well tolerated with few side effects.

NEEDS IMPROVEMENT

Because these types of vaccines are so new there is still a lot we do not understand about them. They may cause unintended effects that we have not yet encountered in human clinical studies. These vaccines also need to be frozen or refrigerated, and so would not be suitable for countries with limited or no refrigeration facilities.

COVID

The SARS-CoV-2 mRNA vaccine codes for one of the virus’ surface spike proteins, responsible for recognizing target cells and fusing the virus into the cell for entry and infection. It was previously recognized as a target for the SARS and MERS viruses.

45 participants received 2 intramuscular injections 28 days apart. None of the participants had any serious side effects after the first injection, or any side effects significant enough to stop the trial. Many had minor to moderate side effects after their second injection (such as fatigue, chills, headache, myalgia, and pain at the injection site), and half the participants taking high dose vaccines had febrile side effects. Overall the side effects were rated as acceptable.

Prior to the vaccine trials, none of the participants had any antibodies against COVID, or any capacity to stop a COIVD infection. After the injections, all participants had noticeable increases in antibodies produced, measurable in their blood. After 43 days, the participant's blood had enough antibodies to reduce infection by SARS-CoV-2 by over 80%.

What is the takeaway? The vaccine is capable of producing an adequate response to protect the vaccine recipient without eliciting any major side effects. These results will be used in phase 2 clinical trials (enrolment began in May) and a phase 3 trial in July 2020. Essentially this means further human trials to further look for side effects in a larger number of volunteers with a more diverse health profile.

This represents an interesting development in producing a rapid vaccine against a new virus responsible for a world-changing pandemic. This new type of vaccine may be the future of vaccines for a broader range of viruses, bacteria, and even cancers.

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Monthly Field Day with Patients & Staff: Building Trust, Engagement, and Wellbeing

Healthcare is built on relationships. While diagnosis, treatment and technology are critical, the human connection between patients and healthcare staff remains central to healing and recovery. A Monthly Field Day with Patients & Staff is a thoughtful initiative designed to strengthen these relationships by creating opportunities for interaction outside routine clinical environments.

In today’s healthcare systems, patient engagement and staff wellbeing are recognised as essential components of quality care. Monthly field days provide a structured yet informal platform to support both.

What Is a Monthly Field Day with Patients & Staff?

A Monthly Field Day is a planned engagement event where patients and healthcare staff come together to participate in non-clinical activities. These events focus on:

interaction
wellbeing
communication
community-building

They are not medical appointments but shared experiences that promote trust and understanding.

Why Field Days Matter in Healthcare

Healthcare Is Emotionally Demanding

Patients often experience anxiety, fear and uncertainty. Staff face long hours, emotional stress and high responsibility. Field days offer a space for:

relaxed interaction
emotional connection
mutual understanding

This humanises care delivery.

Strengthening Patient–Staff Trust

Trust grows through:

open communication
shared experiences
consistent engagement

Field days reduce perceived barriers between patients and healthcare teams.

Benefits for Patients

Improved Comfort and Confidence

Patients feel more at ease when they know the people involved in their care beyond clinical roles.

Better Engagement in Care

Engaged patients are more likely to:

ask questions
follow care plans
attend follow-ups

This leads to improved health outcomes.

Emotional and Social Wellbeing

Social interaction, light activity and positive experiences support mental and emotional health, especially for patients with chronic conditions.

Benefits for Healthcare Staff

Reduced Burnout

Regular non-clinical engagement helps:

reduce emotional fatigue
restore motivation
improve job satisfaction

Stronger Team Relationships

Shared activities strengthen teamwork and communication among staff members.

Renewed Sense of Purpose

Seeing patients outside stressful clinical settings reinforces the meaningful impact of healthcare work.

Organisational Benefits

Enhanced Patient-Centered Culture

Field days reinforce values of empathy, accessibility and respect.

Improved Patient Satisfaction

Trust and familiarity contribute to better patient experiences and feedback.

Better Communication and Feedback

Informal settings encourage honest dialogue, helping organisations understand patient needs and expectations.

Activities Commonly Included in Field Days

Wellness Activities

gentle exercises
stretching or yoga
breathing sessions

Educational Interactions

health awareness talks
preventive care discussions
lifestyle guidance

Recreational and Social Activities

group games
creative sessions
interactive challenges

These activities promote joy, connection and inclusion.

Inclusivity and Accessibility

Effective field days are:

inclusive of different age groups
adaptable for physical limitations
culturally sensitive
welcoming and non-competitive

Inclusivity ensures meaningful participation for all.

Why Monthly Frequency Works Best

Monthly scheduling:

maintains continuity
builds long-term trust
prevents disengagement
supports gradual relationship building

Consistency transforms engagement into culture.

Evidence Supporting Engagement Initiatives

Research shows that:

patient engagement improves health outcomes
staff wellbeing reduces errors and burnout
relationship-based care enhances satisfaction

Global health frameworks emphasise people-centred care models.

Measuring the Impact of Field Days

Impact can be evaluated through:

patient feedback
staff engagement surveys
participation rates
qualitative testimonials

Regular assessment helps refine the program.

Implementing a Successful Monthly Field Day

Key elements include:

leadership support
clear objectives
simple, inclusive activities
consistent scheduling
feedback-driven improvement

Success depends on commitment rather than scale.

Long-Term Impact on Healthcare Culture

Over time, Monthly Field Days contribute to:

stronger trust
improved communication
better morale
enhanced care experience

They reinforce the idea that healthcare is a partnership between people.

Conclusion

A Monthly Field Day with Patients & Staff is more than an engagement activity—it is a meaningful investment in trust, wellbeing and human connection. By creating shared experiences beyond clinical settings, healthcare organisations strengthen relationships that directly influence care quality and satisfaction. In an environment often driven by efficiency and outcomes, monthly field days remind us that compassion, communication and community remain at the heart of effective healthcare.

References

World Health Organization (WHO) – People-Centred Care and Patient Engagement
Indian Council of Medical Research (ICMR) – Patient Experience and Care Quality Studie
Lancet – Patient–Provider Relationships and Health Outcomes
National Health Systems Resource Centre – Community Engagement in Healthcare
Indian Journal of Healthcare Management – Staff Wellbeing and Patient Satisfaction
Statista – Healthcare Engagement and Experience Trends

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