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Published on: Jul 17, 2020
2 minute read
By: Dr Rajan Choudhary

MRNA Vaccine Against SARS CoV2

An mRNA Vaccine against SARS CoV2

We have previously discussed vaccines against SARS-CoV-2, the virus responsible for COVID-19. On the 14th of July, a preliminary study was published in the New England Journal of Medicine, an internationally reputable medical journal. This study looks at mRNA vaccines in Phase 1 human clinical trials, a first for the virus. Here we will discuss what this means and the results of the study.

mRNA vaccine

Vaccines target the immune system’s memory by presenting them with pieces of these infective diseases. The small amounts do not cause any infective symptoms, but if the person is infected later in life their body will mount a quicker response and prevent them from falling ill. These vaccines can contain broken up parts of the organisms, “dead” organisms or “live” versions that have been severely weakened so they cannot cause any harm.

In 2018 a new type of vaccine was described. Instead of using pre-made protein markers that identify infectious organisms, mRNA vaccines contain genetic material with instructions to produce these markers. Once injected, the person’s cells use these instructions to produce copies of these protein markers. These markers are displayed on the surface of the cell, which in turn is recognized by the immune system, initiating an immune response and producing protective antibodies.

BENEFITS

A major advantage of RNA vaccines is the ease by which they can be made in a laboratory from a DNA template. During a pandemic, this would result in a rapid response and vaccine against a new disease. Conventional vaccines require the use of chicken eggs or cells to produce the vaccines, which can be expensive and time-consuming. These vaccines can be delivered via injections into the skin, blood, muscle, or organs, needle-free into the skin, or via nasal spray. Because these vaccines are so new, we still do not know the best way to deliver it.

Because these vaccines are not made with parts of infective organisms or from live organisms, they are not infectious and will not cause harm through a strong immune response to the vaccine itself, or by causing the disease they aim to vaccinate against. They also appear to be very efficient at generating a reliable immune response to produce antibodies and are well tolerated with few side effects.

NEEDS IMPROVEMENT

Because these types of vaccines are so new there is still a lot we do not understand about them. They may cause unintended effects that we have not yet encountered in human clinical studies. These vaccines also need to be frozen or refrigerated, and so would not be suitable for countries with limited or no refrigeration facilities.

COVID

The SARS-CoV-2 mRNA vaccine codes for one of the virus’ surface spike proteins, responsible for recognizing target cells and fusing the virus into the cell for entry and infection. It was previously recognized as a target for the SARS and MERS viruses.

45 participants received 2 intramuscular injections 28 days apart. None of the participants had any serious side effects after the first injection, or any side effects significant enough to stop the trial. Many had minor to moderate side effects after their second injection (such as fatigue, chills, headache, myalgia, and pain at the injection site), and half the participants taking high dose vaccines had febrile side effects. Overall the side effects were rated as acceptable.

Prior to the vaccine trials, none of the participants had any antibodies against COVID, or any capacity to stop a COIVD infection. After the injections, all participants had noticeable increases in antibodies produced, measurable in their blood. After 43 days, the participant's blood had enough antibodies to reduce infection by SARS-CoV-2 by over 80%.

What is the takeaway? The vaccine is capable of producing an adequate response to protect the vaccine recipient without eliciting any major side effects. These results will be used in phase 2 clinical trials (enrolment began in May) and a phase 3 trial in July 2020. Essentially this means further human trials to further look for side effects in a larger number of volunteers with a more diverse health profile.

This represents an interesting development in producing a rapid vaccine against a new virus responsible for a world-changing pandemic. This new type of vaccine may be the future of vaccines for a broader range of viruses, bacteria, and even cancers.

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Weekly Health Roundup Newsletter: India’s Trusted Source for Preventive Wellness Insights

Health information today is abundant, but not always reliable. With countless articles, social media trends, home remedies and conflicting opinions, individuals often struggle to separate credible medical advice from misinformation. This challenge becomes especially significant in India, where rising lifestyle diseases, nutritional gaps and limited public health awareness create a pressing need for accurate guidance.

The Weekly Health Roundup Newsletter by SecondMedic addresses this gap by offering a clear, expert-driven and accessible summary of everything people need to know about their health each week. Designed for families, patients, caregivers and wellness-focused readers, it transforms medical updates into practical, everyday insights.

Why India Needs a Weekly Health Roundup

1. Growing Lifestyle Disease Burden

ICMR and NFHS-5 highlight significant increases in:

Diabetes
Heart disease
Thyroid disorders
Obesity
PCOS

A weekly educational resource empowers individuals to make preventive choices before complications arise.

2. Overload of Health Information

Millions of Indians rely on social media for health advice, leading to confusion and misinformation.
A curated newsletter ensures accuracy.

3. Rising Interest in Preventive Healthcare

People want to understand their bodies better, track health metrics and adopt healthier lifestyles.
The newsletter provides guidance supported by medical evidence.

4. Technological Growth in Healthcare

AI-based tools, wearables and digital monitoring are reshaping healthcare.
Readers learn how to use them effectively.

What the Weekly Health Roundup Covers

• Medical Research Summaries

Digestible versions of new findings from:

ICMR
WHO
Lancet
NITI Aayog
Global medical journals

• Nutrition and Lifestyle Guidance

Includes:

Balanced diets
Myth-busting
Portion control
Affordable nutrition ideas for Indian households

• Chronic Disease Management Tips

Expert insights on:

Diabetes control
Heart health
Blood pressure
Hormonal disorders

• Mental Wellbeing

Stress reduction, emotional resilience and sleep optimisation tips.

• Fitness Recommendations

Simple routines, mobility tips, strength guidance and step-based activity recommendations.

• Seasonal Health Alerts

Information on:

Pollution
Heatwaves
Monsoon infections
Viral outbreaks

• Digital Health Education

Guidance on:

AI health tools
Wearable devices
Teleconsultation benefits
Remote monitoring

How SecondMedic Ensures Accuracy and Quality

Expert Verification

Doctors, nutritionists, physiotherapists and mental health specialists review every issue.

Evidence-Based Approach

Content uses:

Peer-reviewed studies
Real-world health data
National and global guidelines

Personalised Relevance

Topics are selected based on what Indian families most commonly search, ask or struggle with.

Preventive Care Focus

Instead of addressing illness alone, the newsletter promotes long-term lifestyle improvement.

How Readers Benefit

1. Improved Health Literacy

People understand conditions earlier and seek help at the right time.

2. Practical, Actionable Advice

The newsletter offers:

Simple diet swaps
Daily routine tips
Easy-to-follow health habits

3. Early Detection Support

By recognizing symptoms and risk patterns, individuals can prevent complications.

4. Better Use of Digital Tools

Readers learn how AI health guides and wearables support monitoring and early intervention.

5. Family-Centered Wellness

Content is relevant to:

Children
Working adults
Elderly individuals
Chronic disease patients

Example Weekly Topics

A sample edition may include:

"New Findings on Vitamin D Deficiency in Indian Adults"
"How to Interpret Your Blood Sugar Patterns"
"5 AI Tools That Improve Home Health Monitoring"
"Early Signs of Heart Disease You Shouldn’t Ignore"
"Preventive Care Checklist for Busy Professionals"

Conclusion

The Weekly Health Roundup Newsletter is more than just a health update-it is a practical wellness companion. With expert insights, scientific clarity and personalised relevance, it empowers people across India to make smarter health decisions every week.

By turning complex medical knowledge into everyday guidance, SecondMedic strengthens India’s preventive healthcare movement one newsletter at a time.

References

• ICMR - Lifestyle Disease Burden & Research Updates
• NFHS-5 - National Health Indicators & Wellness Trends
• NITI Aayog - Digital Health & Preventive Care Framework
• WHO - Global Wellness & Preventive Healthcare Guidelines
• Lancet - Public Health Research & Behaviour Studies
• Statista India - Digital Health Usage & Reader Behaviour
• EY-FICCI - Health Awareness & Preventive Care Landscape

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