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Published on: Jul 17, 2020
2 minute read
By: Dr Rajan Choudhary

MRNA Vaccine Against SARS CoV2

An mRNA Vaccine against SARS CoV2

We have previously discussed vaccines against SARS-CoV-2, the virus responsible for COVID-19. On the 14th of July, a preliminary study was published in the New England Journal of Medicine, an internationally reputable medical journal. This study looks at mRNA vaccines in Phase 1 human clinical trials, a first for the virus. Here we will discuss what this means and the results of the study.

mRNA vaccine

Vaccines target the immune system’s memory by presenting them with pieces of these infective diseases. The small amounts do not cause any infective symptoms, but if the person is infected later in life their body will mount a quicker response and prevent them from falling ill. These vaccines can contain broken up parts of the organisms, “dead” organisms or “live” versions that have been severely weakened so they cannot cause any harm.

In 2018 a new type of vaccine was described. Instead of using pre-made protein markers that identify infectious organisms, mRNA vaccines contain genetic material with instructions to produce these markers. Once injected, the person’s cells use these instructions to produce copies of these protein markers. These markers are displayed on the surface of the cell, which in turn is recognized by the immune system, initiating an immune response and producing protective antibodies.

BENEFITS

A major advantage of RNA vaccines is the ease by which they can be made in a laboratory from a DNA template. During a pandemic, this would result in a rapid response and vaccine against a new disease. Conventional vaccines require the use of chicken eggs or cells to produce the vaccines, which can be expensive and time-consuming. These vaccines can be delivered via injections into the skin, blood, muscle, or organs, needle-free into the skin, or via nasal spray. Because these vaccines are so new, we still do not know the best way to deliver it.

Because these vaccines are not made with parts of infective organisms or from live organisms, they are not infectious and will not cause harm through a strong immune response to the vaccine itself, or by causing the disease they aim to vaccinate against. They also appear to be very efficient at generating a reliable immune response to produce antibodies and are well tolerated with few side effects.

NEEDS IMPROVEMENT

Because these types of vaccines are so new there is still a lot we do not understand about them. They may cause unintended effects that we have not yet encountered in human clinical studies. These vaccines also need to be frozen or refrigerated, and so would not be suitable for countries with limited or no refrigeration facilities.

COVID

The SARS-CoV-2 mRNA vaccine codes for one of the virus’ surface spike proteins, responsible for recognizing target cells and fusing the virus into the cell for entry and infection. It was previously recognized as a target for the SARS and MERS viruses.

45 participants received 2 intramuscular injections 28 days apart. None of the participants had any serious side effects after the first injection, or any side effects significant enough to stop the trial. Many had minor to moderate side effects after their second injection (such as fatigue, chills, headache, myalgia, and pain at the injection site), and half the participants taking high dose vaccines had febrile side effects. Overall the side effects were rated as acceptable.

Prior to the vaccine trials, none of the participants had any antibodies against COVID, or any capacity to stop a COIVD infection. After the injections, all participants had noticeable increases in antibodies produced, measurable in their blood. After 43 days, the participant's blood had enough antibodies to reduce infection by SARS-CoV-2 by over 80%.

What is the takeaway? The vaccine is capable of producing an adequate response to protect the vaccine recipient without eliciting any major side effects. These results will be used in phase 2 clinical trials (enrolment began in May) and a phase 3 trial in July 2020. Essentially this means further human trials to further look for side effects in a larger number of volunteers with a more diverse health profile.

This represents an interesting development in producing a rapid vaccine against a new virus responsible for a world-changing pandemic. This new type of vaccine may be the future of vaccines for a broader range of viruses, bacteria, and even cancers.

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Monthly Healthy Potluck at Health Hubs: Building Community-Centered Preventive Wellness in India

India is facing a growing burden of lifestyle-related health conditions, including diabetes, obesity, hypertension and heart disease. According to ICMR and NFHS-5 data, dietary habits play a central role in the development and prevention of these conditions. While awareness around nutrition is increasing, sustaining healthy eating habits remains a challenge for many individuals.

The Monthly Healthy Potluck at Health Hubs is a community-driven initiative designed to address this gap. By bringing people together around nutritious food, shared learning and expert guidance, these potlucks transform healthy eating from an individual responsibility into a collective experience.

SecondMedic supports these events as part of its broader preventive healthcare mission, combining community engagement with medical expertise and digital health tools.

Why Community-Based Nutrition Initiatives Matter in India

1. Rising lifestyle disease burden

ICMR reports show that diet-related conditions account for a significant proportion of non-communicable diseases in India. Excess sugar, refined carbohydrates and processed foods are common contributors.

2. Nutrition knowledge gaps

NFHS-5 highlights widespread deficiencies in:

protein intake
micronutrients
dietary diversity

Community events help translate knowledge into practice.

3. Behaviour change is easier together

Research published in The Lancet suggests that group-based interventions are more effective in sustaining lifestyle changes than isolated efforts.

4. Cultural relevance of shared meals

Food is deeply social in Indian culture. Potlucks leverage this tradition to promote healthier choices without imposing rigid rules.

What Is the Monthly Healthy Potluck at Health Hubs?

The Monthly Healthy Potluck is a recurring wellness event hosted at designated Health Hubs. Participants bring healthy, home-prepared dishes and engage in guided discussions about nutrition, ingredients and portion balance.

The goal is not calorie counting, but mindful, informed eating that aligns with preventive health principles.

Key Components of the Healthy Potluck Program

1. Nutritious Home-Cooked Food

Participants are encouraged to prepare dishes using:

whole grains
seasonal vegetables
lean proteins
healthy fats
minimal added sugar and salt

This showcases practical, everyday meals rather than restrictive diets.

2. Nutrition Education in Simple Language

Dietitians and healthcare professionals explain:

why certain ingredients are beneficial
how portion sizes affect metabolism
ways to modify traditional recipes for better health

This bridges the gap between theory and daily cooking.

3. Peer Learning and Motivation

Participants learn from each other’s recipes, challenges and successes. This shared experience builds motivation and accountability.

4. Preventive Health Focus

Discussions link food choices to prevention of:

diabetes
heart disease
obesity
gut disorders
nutrient deficiencies

The emphasis is on long-term wellbeing, not short-term fixes.

Who Can Benefit from Monthly Healthy Potlucks?

Working professionals

Learn quick, balanced meal ideas suited for busy schedules.

Families

Encourage healthier eating habits for children and elders alike.

Seniors

Focus on nutrient-dense foods that support ageing and immunity.

Individuals with lifestyle conditions

Gain practical guidance for diabetes-friendly, heart-healthy or weight-conscious meals.

Health-conscious individuals

Build consistency and community support around wellness goals.

The Role of Health Hubs in Preventive Care

Health Hubs act as physical spaces where preventive healthcare becomes accessible and engaging. By hosting regular potlucks, these hubs move beyond diagnostics and consultations to address everyday behaviours that shape health outcomes.

SecondMedic integrates these community activities with:

preventive screening programs
nutrition consultations
AI Health Guide insights
digital health records

This ensures that learning from the potluck translates into measurable health improvements.

How AI Health Guide Enhances Community Nutrition Programs

SecondMedic’s AI Health Guide complements potluck initiatives by:

• Identifying common dietary gaps

Based on participant data and screening results.

• Personalising recommendations

Aligns food choices with individual health profiles.

• Tracking progress over time

Monitors changes in weight, glucose, cholesterol and energy levels.

• Supporting expert guidance

Provides data-backed insights for dietitians during discussions.

This blend of community engagement and technology strengthens preventive outcomes.

Benefits of Monthly Healthy Potlucks

1. Improved nutrition awareness

Participants gain clarity on healthy ingredients and cooking methods.

2. Sustainable behaviour change

Monthly repetition reinforces habits without overwhelm.

3. Reduced reliance on processed food

Exposure to simple, healthy recipes encourages home cooking.

4. Stronger community bonds

Shared goals foster trust, motivation and support.

5. Alignment with preventive healthcare

Nutrition becomes a proactive tool for disease prevention.

Long-Term Impact on Public Health

Community-driven initiatives like healthy potlucks can have a significant impact on public health outcomes. According to WHO and NITI Aayog, population-level dietary improvements are among the most cost-effective strategies for reducing non-communicable diseases.

By normalising healthy eating through social interaction, Monthly Healthy Potlucks contribute to:

reduced lifestyle disease risk
improved dietary diversity
greater health literacy

How SecondMedic Supports and Scales These Initiatives

SecondMedic plays a key role in ensuring that these events are structured, evidence-based and scalable by providing:

• Expert involvement

Dietitians and doctors guide discussions.

• Digital follow-up

Participants receive personalised insights post-event.

• Preventive health integration

Links potluck learnings with screenings and consultations.

• Community engagement tools

Newsletters, reminders and educational resources maintain momentum.

Conclusion

The Monthly Healthy Potluck at Health Hubs represents a powerful shift in how preventive healthcare is delivered in India. By combining community participation, nutrition education and expert guidance, these events make healthy eating practical, enjoyable and sustainable. Supported by SecondMedic’s preventive healthcare ecosystem, healthy potlucks transform everyday food choices into long-term wellness strategies.

7?? References

ICMR – Dietary Patterns and Lifestyle Disease Prevention
National Family Health Survey (NFHS-5) – Nutrition and Health Indicators
NITI Aayog – Preventive Health and Community Wellness Reports
WHO – Community-Based Nutrition Interventions Guidelines
Lancet – Effectiveness of Group-Based Lifestyle Interventions
Statista – Nutrition Awareness and Preventive Health Trends India
EY-FICCI – Preventive Healthcare and Community Engagement Studies

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