• Published on: Sep 06, 2020
  • 1 minute read
  • By: Medical Second Opinion

Honeybee Venom Reduced Metastases Of Breast Cancer To The Lung

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How bees can cure cancer

We have previously discussed the difficulties faced trying to treat cancer. Cancer is caused by faulty cells replicating and spreading out of control. To destroy cancer our current medication targets and destroys rapidly replicating cells through chemo and radiotherapy, or specifically target cells displaying cancer markers with newer chemo and immunotherapy agents. Unfortunately, these methods have side effects damaging healthy replicating tissue, causing hair loss, gut problems, infertility and more. We are always on the hunt for newer, more targeted therapy that only hits cancer cells and leaves our healthy tissue alive. Sometimes the ideas for these chemicals come from the most unlikely sources.

This month, they came from bees.

Bees have been the source of many medicinal products, including honey, propolis, and even the venom has previously been found to have anti-tumour effects. It has shown to have some effect in melanoma, lung cancer, glioblastoma, leukaemia, ovarian, cervical and pancreatic cancers. It is able to be selective against these cancerous cells, leaving the healthy cells relatively untouched.

Until recently it has been a mystery how the honeybee venom works. In their September 2020 paper, the researchers were able to produce a synthetic version of the honeybee venom (melittin) and observe its action on cancer cells. They found it punctured the cancer cell surface and form holes on the surface. 20 minutes later they also interfered with the cancer signalling pathways inside that are vital to let cancer cells grow and replicate unimpeded.

When combined with known chemotherapy agents, the melittin pores allowed the chemo agents to enter cancer cells more effectively and work more effectively. This was able to reduce tumour growth in mice more efficiently.

The paper also demonstrated its effectiveness in triple-negative breast cancer. This form of breast cancer does not express oestrogen and progesterone receptors, nor do they have HER2 proteins. As a result, they are very difficult to target with chemotherapy or hormonal therapy. The fact melittin was able to potentiate the effects of current chemotherapy against triple-negative breast cancer shows its potential as an agent in fighting breast cancer.

Of course, it is early days yet, and these experiments have only been conducted in mice. It will be a few years until the therapy can be trialled with any confidence in human subjects. Nevertheless, it is interesting to see how innovative medical researchers are in procuring new therapies in the fight against cancer.

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women

early signs of hormonal imbalance

Hormones act as chemical messengers that regulate nearly every function in the body, from metabolism and mood to sleep, growth and reproduction. When hormone levels fall out of balance, the effects can be widespread and often confusing. Understanding the early signs of hormonal imbalance is essential because these changes are frequently subtle and mistaken for stress, ageing or lifestyle fatigue.

According to endocrine and public health studies, many adults live with undiagnosed hormonal imbalances for years, allowing symptoms to worsen and increase the risk of chronic health conditions.

 

What Is Hormonal Imbalance?

Hormonal imbalance occurs when:

  • hormone production is too high or too low
     

  • hormone release timing is disrupted
     

  • feedback mechanisms fail
     

Even small imbalances can cause noticeable symptoms because hormones influence multiple organ systems simultaneously.

 

Why Hormonal Imbalances Are Increasing

Modern lifestyles contribute significantly to hormonal disruption.

Key factors include:

  • chronic stress
     

  • poor sleep
     

  • sedentary behaviour
     

  • processed diets
     

  • environmental toxins
     

  • ageing and metabolic changes
     

These factors strain the endocrine system over time.

Common Early Signs of Hormonal Imbalance

Persistent Fatigue

Unexplained, ongoing tiredness is one of the earliest signs.

Hormonal causes include:

  • thyroid dysfunction
     

  • cortisol imbalance
     

  • insulin resistance
     

Fatigue that does not improve with rest requires evaluation.

 

Unexplained Weight Changes

Sudden weight gain or loss without dietary changes may signal:

  • thyroid hormone imbalance
     

  • insulin resistance
     

  • cortisol dysregulation
     

Hormonal weight changes often occur around the abdomen.

 

Mood Swings and Emotional Changes

Hormones directly influence brain chemistry.

Early emotional signs include:

  • irritability
     

  • anxiety
     

  • low mood
     

  • poor stress tolerance
     

These symptoms are often misattributed to mental health alone.

 

Sleep Disturbances

Hormones regulate circadian rhythm.

Imbalances may cause:

  • difficulty falling asleep
     

  • frequent waking
     

  • non-restorative sleep
     

Poor sleep further worsens hormonal disruption.

 

Changes in Appetite and Cravings

Hormonal shifts affect hunger signals.

People may experience:

  • intense sugar cravings
     

  • irregular appetite
     

  • overeating despite fullness
     

These changes are linked to insulin and cortisol imbalance.

 

Skin, Hair and Nail Changes

Early physical signs include:

  • acne in adulthood
     

  • hair thinning or hair fall
     

  • dry skin
     

  • brittle nails
     

These often reflect thyroid, androgen or estrogen imbalance.

 

Menstrual or Reproductive Changes

In women, early signs include:

  • irregular periods
     

  • heavy or painful menstruation
     

  • missed cycles
     

In men, symptoms may include:

  • reduced libido
     

  • fatigue
     

  • mood changes
     

Reproductive symptoms are key indicators of hormonal health.

 

Hormonal Imbalance and Metabolic Health

Hormonal disruption affects:

  • blood sugar regulation
     

  • fat metabolism
     

  • cholesterol balance
     

Left untreated, this increases the risk of diabetes, obesity and heart disease.

 

Why Early Symptoms Are Often Ignored

Hormonal imbalance is frequently overlooked because:

  • symptoms develop gradually
     

  • signs are non-specific
     

  • people self-manage with lifestyle changes alone
     

Unfortunately, delay allows progression.

 

Conditions Commonly Linked to Hormonal Imbalance

Hormonal imbalances may underlie:

  • thyroid disorders
     

  • polycystic ovary syndrome (PCOS)
     

  • insulin resistance
     

  • adrenal fatigue patterns
     

  • menopause-related changes
     

Early detection simplifies management.

 

Importance of Early Diagnosis

Identifying hormonal imbalance early:

  • prevents complications
     

  • reduces medication dependence
     

  • improves quality of life
     

  • supports metabolic and mental health
     

Early intervention is more effective and less invasive.

 

How Hormonal Imbalance Is Evaluated

Evaluation may include:

  • symptom assessment
     

  • blood hormone testing
     

  • metabolic screening
     

  • lifestyle analysis
     

Testing is guided by symptoms and clinical findings.

 

Lifestyle Measures That Support Hormonal Balance

Stress Management

Reducing stress normalises cortisol and improves overall hormone regulation.

 

Sleep Hygiene

Consistent sleep schedules support endocrine rhythm.

 

Balanced Nutrition

Adequate protein, fibre and micronutrients support hormone production.

 

Physical Activity

Regular movement improves insulin sensitivity and hormonal balance.

 

When to Seek Medical Advice

Consult a healthcare professional if:

  • symptoms persist beyond weeks
     

  • multiple symptoms occur together
     

  • quality of life declines
     

  • weight, mood or sleep changes worsen
     

Early evaluation prevents long-term damage.

 

Long-Term Risks of Untreated Hormonal Imbalance

Ignoring symptoms may lead to:

  • infertility
     

  • metabolic syndrome
     

  • osteoporosis
     

  • chronic fatigue
     

  • mental health disorders
     

Early care significantly reduces these risks.

 

Conclusion

Early signs of hormonal imbalance often appear subtle but reflect deeper endocrine disruption. Persistent fatigue, weight changes, mood swings, sleep problems and skin changes are not just lifestyle issues—they are signals the body should not ignore. Recognising these early signs and seeking timely medical evaluation allows for effective management, prevents chronic disease and restores long-term health balance. Hormonal health is foundational to wellbeing, and early action makes all the difference.

 

References

  • Indian Council of Medical Research (ICMR) – Endocrine and Metabolic Health Report

  •  National Institute of Nutrition (NIN) – Hormones and Metabolism Research

  • World Health Organization (WHO) – Endocrine System and Hormonal Health Guideline

  •  Lancet – Hormonal Imbalance and Chronic Disease Studies

  • Indian Journal of Endocrinology and Metabolism – Hormone Disorder Research

  • Statista – Hormonal Health and Lifestyle Trends India

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