• Published on: Oct 01, 2021
  • 3 minute read
  • By: Second Medic Expert

Why Is Cholesterol Management Important?

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Why is cholesterol management important?

Cholesterol is a major component of cell membranes and provides rigidity, controls permeability, and regulates fat transport. It also helps regulate inflammation, homeostasis (balance), immune response, nerve signaling function, thyroid hormone activity, sex hormone activation/control/synthesis from complex proteins from ovarian follicles. Cholesterol is an essential structural component of all human cell membranes and also supports all other cell functions—and without sufficient dietary intake or production by the liver that amount in the bloodstream declines.

Cholesterol can cause arterial plaque buildup which is one of the main underlying causes of heart disease. It also encourages the formation of an atherosclerotic deposit. Since cholesterol-rich atheromatous plaques are less stable than normal vessels, they are prone to rupture, and then they subsequently cross into their stable neighbors causing turbulence in blood flow.

If LDL cholesterol levels remain high, it contributes to the progression of atherogenic changes in the vessel wall that block the endothelial function (the cells lining your arteries) which undermines cardiovascular protection for both coronary artery disease and peripheral vascular disease patients. Eating a diet high in saturated fat is linked with an increased level of cholesterol in the blood.

Cholesterol is a type of fat that circulates through your bloodstream and gives all of your cells the energy they need, as well as helping to keep skin healthy. A diet rich in cholesterol may protect from strokes and heart attacks, but eating too much-saturated fat can still have harmful effects on your health over time.

It seems like what you should be asking is "why isn't this information more common?" After all, it's not just about high cholesterol causing heart disease - it's also about eating less than 10?lories from saturates (the fatty acids found in butter, cheese, beef) which might protect against inflammation over

Cholesterol-rich plaque developed in the blood vessels, causing them to narrow and stiffen, reducing blood flow. It can lead to angina (chest pain) or heart disease. If one's cholesterol levels are high throughout life - due either to heredity or diet, chances are that risk of developing coronary artery disease is higher than for people with lower levels. The more often LDL particle size is small, called "Pattern A," the less likely it is that someone will progress into coronary artery disease over time. Conversely, the more often LDL particles are large, called "Pattern B," then they're at greater risk than those who have fewer Pattern-B LDLs. So minimizing carbohydrates and other sugars helps prevent high cholesterol.

The higher your cholesterol, the more likely it is for plaque to build up in the blood vessels, which can potentially restrict or reduce blood flow. There are two major health issues that come with the lack of cholesterol management: heart disease and strokes. About 27% of American adults have prediabetes, which is a pre-existing condition that suggests they'll develop type 2 diabetes in the future. When an individual has type 2 diabetes, their erythrocytes become deformed and do not function as well as normal erythrocytes might. This leaves them at risk for high blood pressure and myocardial infarctions (otherwise known as heart attacks). Additionally, individuals with type II diabetes often eventually end up on cholesterol medications like statins to control their levels of LDL cholesterol (the bad kind). 

Improving cholesterol levels is an easy way for many people to maintain a healthier body, with a really potent payoff in the form of longevity and better physical condition. If your cholesterol levels are already optimal then you don't have anything to lose by eating one or two pieces of dark chocolate every day. Eating dark chocolate has been shown to lower LDL cholesterol and raise HDL-cholesterol, the good type that's been linked with a lower risk of heart disease. Dark chocolate contains cocoa butter which contains stearic acid, the part of the fat that doesn't affect either blood clotting or inflammation in healthy individuals.

It's important because cholesterol is also the precursor to many hormones and hormone-like substances called steroids, so it's evolutionarily adaptive for humans to maintain low cholesterol levels as a result. Maintaining low cholesterol levels can reduce your risk of heart disease and other conditions such as heart attacks, stroke, atherosclerosis (hardening of the arteries), Alzheimer’s disease or dementia.

Cholesterol is a waxy substance that's found in all animal cells and causes calcification of tissues and leads to cell death. It also forms the framework for certain pathogens, such as the herpes virus. Some people may need cholesterol medications because their own ability to make it depletes (decreases) over time, such as in cases of hypothyroidism or Addison's disease. Low-density lipoprotein, or LDL, is one indication that cholesterol has built up and can build up within veins and arteries leading to serious health problems like heart attack and stroke. Patients should be aware of these risks and consult with physicians regularly about their lipid levels while on therapy. They need cholesterol to build cell walls, and it's an essential part of our metabolism.

It delivers oxygen from the lungs or gills to all parts of your body, including the heart, brain, and other organs. It helps make hormones like estrogen and testosterone. Plus, cholesterol is how cells move nutrients in and out... We get more than half of our cholesterol from the food we eat... But your liver also makes more when you have too many calories -- especially from fat-containing foods that have saturated fats or high amounts of unhealthy trans fats.

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Genetic Predisposition Testing India: Understanding Your DNA to Prevent Future Disease

Genetic Predisposition Testing India: Understanding Your DNA to Prevent Future Disease

Genetics plays a significant role in determining an individual’s risk for various diseases. In India, where chronic illnesses like diabetes, heart disease, cancer, and neurological disorders are increasing rapidly, genetic predisposition testing has emerged as a powerful preventive tool. It helps individuals understand inherited risk factors long before symptoms appear, allowing timely intervention.

SecondMedic offers guided genetic screening to help patients uncover DNA-based risks and take proactive control of their long-term health.

What Is Genetic Predisposition Testing?

Genetic predisposition testing analyzes a person’s DNA to identify mutations, variations, or inherited markers associated with increased disease risk. It does not diagnose a disease but reveals how likely an individual is to develop certain conditions.

What the test identifies:

  • Gene mutations
     

  • Family-linked disease patterns
     

  • Hereditary cancer markers
     

  • Metabolic and cardiovascular risks
     

  • Neurological conditions
     

  • Autoimmune predispositions
     

These insights help individuals and doctors make informed preventive health decisions.

Why Genetic Testing Is Growing in India

1. High prevalence of lifestyle and hereditary diseases

India is the diabetes capital of the world, and many metabolic disorders have genetic roots.

2. Increasing cancer burden

BRCA and other hereditary cancer syndromes are being detected more often.

3. Awareness about preventive healthcare

People want to act early rather than wait for disease onset.

4. Growth of digital healthcare

Easy access through telemedicine platforms like SecondMedic.

5. Rising chronic cases at younger ages

Genetic predispositions often accelerate early onset of disease.

What Diseases Can Genetic Testing Predict?

1. Cancer Risk

Includes hereditary cancers such as:

  • Breast
     

  • Ovarian
     

  • Colorectal
     

  • Prostate
     

  • Pancreatic
     

BRCA1, BRCA2, and Lynch syndrome genes are key markers.

2. Heart Disease & Hypertension

Genes that influence:

  • Cholesterol levels
     

  • Plaque formation
     

  • Blood pressure regulation
     

3. Diabetes

Genes that affect insulin sensitivity and metabolic function.

4. Obesity

Markers linked to appetite regulation and fat storage.

5. Neurological Disorders

Including Alzheimer’s, Parkinson’s, and epilepsy predispositions.

6. Autoimmune Diseases

Genes related to lupus, rheumatoid arthritis, and thyroid disorders.

7. Drug Response (Pharmacogenomics)

DNA determines how the body reacts to certain medications.

How Genetic Predisposition Testing Works

Step 1: Sample Collection

Usually saliva, blood, or buccal swab.

Step 2: DNA Sequencing

Advanced technology identifies variations in your genome.

Step 3: Risk Analysis

Gene mutations are mapped to known disease risks.

Step 4: Expert Interpretation

SecondMedic’s genetic counsellors and doctors review results.

Step 5: Preventive Plan

Includes recommended lifestyle changes, screenings, and monitoring.

Benefits of Genetic Predisposition Testing

1. Detect Risk Before Symptoms

Allows decades of preventive action.

2. Personalized Health Planning

Diet, exercise, and medical screening tailored to DNA.

3. Early Cancer Detection

Essential for women with hereditary breast/ovarian cancer risk.

4. Family Health Insights

Identifies conditions that may affect children and siblings.

5. Improved Treatment Outcomes

Knowing your risk helps doctors monitor you more closely.

6. Better Drug Selection

Pharmacogenomics ensures medications match your genetic profile.

Who Should Consider Genetic Testing?

  • People with family history of cancer
     

  • Individuals whose relatives had early heart attacks
     

  • Families with diabetes across generations
     

  • Women with breast or ovarian cancer history
     

  • Couples planning pregnancy
     

  • People with unexplained chronic conditions
     

  • Individuals wanting personalized preventive healthcare
     

Limitations of Genetic Testing

1. Not a diagnosis

It shows probability, not certainty.

2. Environmental and lifestyle factors still matter

Genes interact with habits and environment.

3. Requires professional interpretation

Raw results without counselling can be confusing.

SecondMedic ensures accurate guidance through experienced specialists.

How SecondMedic Supports Genetic Testing

1. End-to-End Genetic Screening

From sample collection to detailed analysis.

2. Expert Review

Genetic counselors and doctors explain every risk factor.

3. Personalized Preventive Plan

Nutrition, exercise, and screening based on DNA.

4. Confidential Reporting

All data is securely stored.

5. Integrated Preventive Tracking

Follow-up tests and monitoring for high-risk individuals.

Future of Genetic Testing in India

  • AI-based genome interpretation
     

  • Affordable whole-genome sequencing
     

  • Predictive analytics for early cancer
     

  • Family-wide health risk mapping
     

  • Integration with digital health IDs under ABDM
     

SecondMedic aims to make genetic screening widely accessible and scientifically guided.

Conclusion

Genetic predisposition testing India empowers individuals by revealing inherited disease risks long before symptoms develop. It supports preventive healthcare, early cancer detection, and personalized wellness planning. With platforms like SecondMedic offering expert-guided genetic testing, Indians can now take proactive control of their long-term health.

To book your genetic test, visit www.secondmedic.com

References

  • ICMR – Genetic research insights
     

  • NIH – Genetic testing guidelines
     

  • WHO – Genomic medicine developments
     

  • Statista – DNA testing market India
     

  • SecondMedic genetic health studies

See all

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