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Published on: Aug 30, 2021
2 minute read
By: Dr Rakesh Rai

What Are The Causes Of Liver Cirrhosis?

"What are the causes of liver cirrhosis?"

Several diseases can lead to cirrhosis of the liver, which is characterized by hardening and scarring to the organ's tissue. These include alcoholism, hepatitis C, chronic hepatitis B, and fatty liver disease.

Smoking, drinking too much alcohol, and hepatitis infection. Smoking and excessive drinking can lead to liver cirrhosis because they reduce the amount of oxygen and nutrients delivered to the liver. Smokers also have an increased risk of developing alcoholic hepatitis if they drink as well. Diseases such as chronic pancreatitis, a condition often caused by alcoholism, may also cause cirrhosis. Hepatitis infections are one prime example; people who will contract this type of virus have a greater likelihood of developing the liver disease later in life than those who haven't been exposed to it.

Cirrhosis is a condition that results when healthy cells inside the liver are replaced by scar tissue because of an injury, infection, or chronic disease. This eventually reduces the functionality of the organ and may eventually lead to liver failure, which in many cases can necessitate a transplant. Prevention and early detection for common conditions associated with liver cirrhosis should be pursued such as hepatitis B or C or Wilson’s Disease (a rare genetic disorder). Treatment options vary depending on the severity of cirrhosis but may include alcohol abstinence, medication to promote regeneration of diseased hepatocytes (specialized cells in the lining), surgery to remove any pools of blood/scar tissue from within the abdominal cavity that would otherwise compress other organs.

There are many possible causes, including genetics, diseases of the biliary tract system, drugs, and alcohol abuse. The cirrhotic liver has less elasticity than a typically healthy liver. This can lead to ruptured blood vessels within the organ that will cause bleeding into the cavity of the organ. The result of this bleeding is swelling and destruction of cells in that area; it's also called 'cirrhosis.' As cirrhosis progresses, there are limits to how much your damaged liver can work towards cleansing and detoxifying your body by removing poisons or toxins from the food you eat - because a damaged liver cannot produce enough bile that helps aid digestion.

There are many causes for liver cirrhosis, so it's not as though we can generalize. Some symptoms of liver damage include jaundice (yellowing skin) and frequent urination. Most signs of liver failure occur only in the advanced stages when the organ becomes too large to be compensated for by other organs or systems of the body. One should also note that alcohol is a primary cause of cirrhosis and often comes with other complications such as malnutrition, high blood pressure, and diabetes.

A) Symptoms of liver cirrhosis include jaundice, bruising easily, abnormal swelling in the legs and abdomen.

B) Hepatitis is a potential cause of liver cirrhosis.

C) Liver cancer can also produce symptoms related to liver cirrhosis such as enlarged lymph nodes or fluid buildup in the abdomen.

D) People who have eaten too much alcohol for many years are more likely to develop chronic alcohol abuse which destroys the cells on your liver causing it to stop functioning for good resulting in death. (this answer would be an ideal opportunity for advertising a medical consultation site but just mentioning their name could result in being reported)

E) Long-term exposure to viral hepatitis B or C

There are many causes of liver cirrhosis. Open sores on the skin, inflammation of the liver (cirrhosis), gall bladder problems, heavy drinking/overuse of alcohol, viral hepatitis, or other infections that cause scarring in the liver.

Liver cirrhosis is most often caused by chronic or acute alcoholism, drug abuse, hepatitis C, and other conditions that impair liver function. Liver cirrhosis causes your liver to be enlarged as its cells increase in number and fill up with fat. Liver cells normally work to get rid of any extra substances found in the blood and body fluids because these substances can cause damage to various organs including the liver. As diseased cells accumulate rapidly in the liver, they cannot do their job efficiently leading to additional organ damage such as end-stage renal disease. This whole process exposes you more easily to viruses such as hepatitis B and C which ultimately leads to advanced disease of the lungs called "cryptogenic pulmonary alveolar proteinosis".

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Genetic Predisposition Testing India: Understanding Your DNA to Prevent Future Disease

Genetics plays a significant role in determining an individual’s risk for various diseases. In India, where chronic illnesses like diabetes, heart disease, cancer, and neurological disorders are increasing rapidly, genetic predisposition testing has emerged as a powerful preventive tool. It helps individuals understand inherited risk factors long before symptoms appear, allowing timely intervention.

SecondMedic offers guided genetic screening to help patients uncover DNA-based risks and take proactive control of their long-term health.

What Is Genetic Predisposition Testing?

Genetic predisposition testing analyzes a person’s DNA to identify mutations, variations, or inherited markers associated with increased disease risk. It does not diagnose a disease but reveals how likely an individual is to develop certain conditions.

What the test identifies:

Gene mutations
Family-linked disease patterns
Hereditary cancer markers
Metabolic and cardiovascular risks
Neurological conditions
Autoimmune predispositions

These insights help individuals and doctors make informed preventive health decisions.

Why Genetic Testing Is Growing in India

1. High prevalence of lifestyle and hereditary diseases

India is the diabetes capital of the world, and many metabolic disorders have genetic roots.

2. Increasing cancer burden

BRCA and other hereditary cancer syndromes are being detected more often.

3. Awareness about preventive healthcare

People want to act early rather than wait for disease onset.

4. Growth of digital healthcare

Easy access through telemedicine platforms like SecondMedic.

5. Rising chronic cases at younger ages

Genetic predispositions often accelerate early onset of disease.

What Diseases Can Genetic Testing Predict?

1. Cancer Risk

Includes hereditary cancers such as:

Breast
Ovarian
Colorectal
Prostate
Pancreatic

BRCA1, BRCA2, and Lynch syndrome genes are key markers.

2. Heart Disease & Hypertension

Genes that influence:

Cholesterol levels
Plaque formation
Blood pressure regulation

3. Diabetes

Genes that affect insulin sensitivity and metabolic function.

4. Obesity

Markers linked to appetite regulation and fat storage.

5. Neurological Disorders

Including Alzheimer’s, Parkinson’s, and epilepsy predispositions.

6. Autoimmune Diseases

Genes related to lupus, rheumatoid arthritis, and thyroid disorders.

7. Drug Response (Pharmacogenomics)

DNA determines how the body reacts to certain medications.

How Genetic Predisposition Testing Works

Step 1: Sample Collection

Usually saliva, blood, or buccal swab.

Step 2: DNA Sequencing

Advanced technology identifies variations in your genome.

Step 3: Risk Analysis

Gene mutations are mapped to known disease risks.

Step 4: Expert Interpretation

SecondMedic’s genetic counsellors and doctors review results.

Step 5: Preventive Plan

Includes recommended lifestyle changes, screenings, and monitoring.

Benefits of Genetic Predisposition Testing

1. Detect Risk Before Symptoms

Allows decades of preventive action.

2. Personalized Health Planning

Diet, exercise, and medical screening tailored to DNA.

3. Early Cancer Detection

Essential for women with hereditary breast/ovarian cancer risk.

4. Family Health Insights

Identifies conditions that may affect children and siblings.

5. Improved Treatment Outcomes

Knowing your risk helps doctors monitor you more closely.

6. Better Drug Selection

Pharmacogenomics ensures medications match your genetic profile.

Who Should Consider Genetic Testing?

People with family history of cancer
Individuals whose relatives had early heart attacks
Families with diabetes across generations
Women with breast or ovarian cancer history
Couples planning pregnancy
People with unexplained chronic conditions
Individuals wanting personalized preventive healthcare

Limitations of Genetic Testing

1. Not a diagnosis

It shows probability, not certainty.

2. Environmental and lifestyle factors still matter

Genes interact with habits and environment.

3. Requires professional interpretation

Raw results without counselling can be confusing.

SecondMedic ensures accurate guidance through experienced specialists.

How SecondMedic Supports Genetic Testing

1. End-to-End Genetic Screening

From sample collection to detailed analysis.

2. Expert Review

Genetic counselors and doctors explain every risk factor.

3. Personalized Preventive Plan

Nutrition, exercise, and screening based on DNA.

4. Confidential Reporting

All data is securely stored.

5. Integrated Preventive Tracking

Follow-up tests and monitoring for high-risk individuals.

Future of Genetic Testing in India

AI-based genome interpretation
Affordable whole-genome sequencing
Predictive analytics for early cancer
Family-wide health risk mapping
Integration with digital health IDs under ABDM

SecondMedic aims to make genetic screening widely accessible and scientifically guided.

Conclusion

Genetic predisposition testing India empowers individuals by revealing inherited disease risks long before symptoms develop. It supports preventive healthcare, early cancer detection, and personalized wellness planning. With platforms like SecondMedic offering expert-guided genetic testing, Indians can now take proactive control of their long-term health.

To book your genetic test, visit www.secondmedic.com

References

ICMR – Genetic research insights
NIH – Genetic testing guidelines
WHO – Genomic medicine developments
Statista – DNA testing market India
SecondMedic genetic health studies

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