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Published on: Nov 13, 2020
2 minute read
By: Dr Rajan ( Medical Second Opinion Cell)

What Are Some Common Side Effects Of The COVID-19 Vaccine?

COVID Vaccine, the Pfizer update

On Monday Pfizer announced to the world the vaccine, once it has been developing with Germany's BioNTech, was found to be more than 90?fective. If this is substantiated, it may be possible for countries to receive the vaccine before the end of the year.

The Vaccine is an mRNA Vaccine, a novel method that introduces viral RNA into the body via a viral coat. The vaccine is incorporated into the person's cell, where the viral RNA is read and viral proteins are produced, including the coronavirus coat proteins. As the body reads and recognizes these proteins, it produces antibodies against these viral proteins and activates immune T cells against the virus.

The Pfizer results are based of a phase 3 clinical trial with 43, 538 participants with a diverse background. In this trial, the participants were split between those receiving a vaccine, and those who received a placebo with no effect. The vaccine is administered in two parts, with a 90?ficacy obtained 7 days after the second dose. This would mean a person is vaccinated just 28 days after the initial vaccination.

The FDA usually looks for a minimum 50?ficacy in vaccination when approving new vaccines. It may surprise you that the annual flu jab is also estimated to be 50?fective. The data from Pfizer was verified by an external, independent Data Monitoring Committee. It used data from 94 patients enrolled in the trial and subsequently developed COVID. It is from this groupset that 90% of efficacy is obtained. This is not the final data analysis, and further publications are expected in late November, with a potential FDA Emergency Use Authorisation approval if the data continues to show promise.

If approved, Pfizer has the ability to make 50 million shots before the end of the year, and 1.3 billion by the end of 2021. Many countries are clamoring for their fair share of these limited resources; the US has already negotiated 200m shots, UK 50m, and Germany (one of the major financers for the Pfizer vaccine) over 300m for European Countries.

We should emphasize that rapid vaccine development on this scale at this speed was unheard of prior to COVID. Usually, the animal studies for vaccines can take 1-2 years. In that time Pfizer and others have managed phase 1-3 clinical trials in humans, something that usually takes upwards of 10 years.

There are many unanswered questions that remain from this information.

How safe is the vaccine? Whilst safety information was not published, overall the vaccine appears to have minimal side effects. This is particularly difficult to state however since mRNA vaccines have never been used in people before.
Does the vaccine prevent transmission? In theory, yes. If you are immunized the replication of the virus should be limited significantly, so the number of viruses in each cough will be much lower. However, we do not have data to prove that there is no transmission, but that is also because we have very little data overall.
How long does the protection last? This is a very critical question. The 90?fectiveness rate was calculated just 7 days after the second shot, but it is likely this will change as data is collected over the long term. Some studies have suggested the antibody response fades within months following COVID infection. T Cell immunity on the other hand can stay for years, and it may be the effectiveness of creating a T cell immunity that dictates just how good this vaccine will be .

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Virtual Second Opinion Services India: Making Medical Decisions Safer, Smarter, and More Accurate

Healthcare decisions can be overwhelming, especially when dealing with serious diagnoses, complex treatment options, or long-term health conditions. In India, where diagnostic variability and specialist availability differ across regions, seeking a second medical opinion has become essential for clarity and confidence. Virtual second opinion services India allow patients to consult top specialists online, review diagnoses, validate reports, and confirm treatment plans without traveling long distances.

SecondMedic has emerged as a trusted platform for virtual second opinions, connecting users with experienced specialists across cardiology, oncology, neurology, orthopedics, nephrology, endocrinology, and other medical fields. These services empower patients with accurate information and reduce the risk of misdiagnosis or unnecessary treatments.

Why Second Opinions Are Becoming Important in India

According to WHO, nearly 20-30% of medical errors globally stem from misdiagnoses. In India, disparities in medical access and diagnostic quality can make it harder for patients to rely on a single opinion-especially for complex or high-risk conditions.

Patients seek second opinions for:

Cancer diagnosis
Cardiac issues (blockages, angioplasty recommendations)
Orthopedic surgeries
Neurological disorders
Kidney and liver conditions
Autoimmune diseases
Rare or chronic illnesses

A second opinion ensures that treatment decisions are well-informed and evidence-based.

How Virtual Second Opinion Services Work

Virtual second opinion platforms like SecondMedic make the process simple and accessible.

Steps include:

Uploading medical reports, scans, prescriptions, and lab results.
Selecting the specialty or condition.
AI tools help summarize and organize the case.
A specialist reviews the case in detail.
The patient receives a written report or video consultation explaining the recommendations.
Follow-up guidance is provided when needed.

This digital-first approach saves time and helps patients receive expert evaluations from anywhere in India.

Key Benefits of Virtual Second Opinions

1. Access to Top Specialists

Patients can connect with some of India's best doctors without needing to visit major metro hospitals.

2. Prevention of Misdiagnosis

A fresh review reduces the risk of incorrect or incomplete diagnoses.

3. Verification of Treatment Plans

Before committing to surgery or long-term therapy, patients receive reassurance and clarity.

4. Time and Cost Savings

Virtual reviews eliminate travel, long waiting lines, and high hospital consultation fees.

5. Emotional Confidence

Patients and families gain peace of mind through expert validation of medical decisions.

SecondMedic ensures case reviews are thorough, unbiased, and personalized.

Use Cases Where Second Opinions Make a Big Difference

Oncology

Cancer diagnoses often require multi-specialty inputs. Virtual tumor board reviews help patients choose the right treatment path.

Cardiology

Heart conditions like blockages, angioplasty recommendations, or arrhythmia management require accurate evaluations.

Orthopedics

Joint replacement or spine surgery recommendations often need second validation to avoid unnecessary procedures.

Neurology

Conditions like epilepsy, stroke, or movement disorders benefit from deeper case review.

Chronic Illnesses

Diabetes, hypertension, kidney disease, and thyroid disorders require long-term management strategies.

Why Virtual Second Opinion Is Better Than In-Person for Many Patients

More specialist availability
Faster review times
Ability to compare multiple expert opinions
Digital access to consolidated medical records
Better accommodation of busy schedules
Suitable for rural patients with limited access to tertiary care hospitals

Digital second opinions remove geographic barriers completely.

The Role of Technology in Second Opinions

AI enhances the clarity and accuracy of second opinions by:

Pre-sorting medical documents
Highlighting abnormalities in lab results
Summarizing doctor notes
Identifying missing tests
Flagging potential medical risks

SecondMedic combines AI insights with top specialist expertise, resulting in stronger, data-backed recommendations.

Challenges in India’s Traditional Second Opinion System

Long wait times at major hospitals
Difficulty obtaining complete medical records
Travel to metro cities
Lack of specialized doctors in Tier 2/3 cities
Inconsistent diagnostic quality

Virtual second opinion services solve all of these pain points.

Future Outlook

Virtual medical reviews will continue growing with:

AI-powered case analysis
Integration with electronic health records (EHRs)
Multi-specialty collaborative boards
Predictive diagnostics
Global doctor networks

SecondMedic aims to lead this space by offering deeper, faster, and more accurate medical reassessments.

Conclusion

Virtual second opinion services India empower patients to make informed, safe, and confident healthcare decisions. By connecting users with top specialists and leveraging AI-driven insights, SecondMedic ensures that every major medical choice is backed by expertise and clarity. This is especially valuable for complex diagnoses, chronic conditions, and surgical recommendations.

To request a virtual second opinion, visit www.secondmedic.com

References

WHO - Misdiagnosis data and clinical errors
NITI Aayog - Digital health transformation reports
ABDM - Digital health records and interoperability
Statista - Telehealth adoption in India
Lancet & NEJM - Studies on second opinions
SecondMedic clinical team insights

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