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Published on: Aug 18, 2022
2 minute read
By: Second Medic Expert

Understanding Liver Function Test

A liver function test is a blood test that measures the levels of various enzymes and proteins in your blood. These substances are produced by the liver, and they can be a sign of liver damage or disease.

There are a number of different liver function tests (LFTs) that can be used to assess the health of your liver. The most common ones are Bilirubin, Alkaline Phosphatase (ALP), Aspartate Aminotransferase (AST), and Alanine Transaminase (ALT).

Bilirubin is a pigment that is produced when the liver breaks down red blood cells. Elevated levels of bilirubin in the blood can be a sign of liver damage or disease.

ALP is an enzyme that is produced in the liver. High levels of ALP in the blood can indicate liver damage or disease.

There are a few different types of liver function tests, but they all basically measure the same thing: how well your liver is functioning. The most common liver function test is called the serum blood panel. This measures the levels of enzymes in your blood that are produced by the liver. These enzymes include:

- ALP (alkaline phosphatase): This enzyme helps with the digestion of fats and is increased when there is damage to the bile ducts.

- ALT (alanine transaminase): This enzyme helps with the breakdown of amino acids and is usually elevated when there is damage to hepatic cells.

- AST (aspartate aminotransferase):

The liver function test is a common medical test that is used to evaluate the health of your liver. The test measures levels of enzymes in your blood that are found mainly in the liver. Enzymes are proteins that help with chemical reactions in your body. When something is wrong with the liver, these enzymes can be released into the blood, where they can be detected by the Liver Function Test. Some of the things that can be checked with this test include hepatitis, cirrhosis, jaundice, and fatty liver disease. It can also give clues about other problems such as an toxins or alcoholism. The test is usually done as part of a routine checkup or when someone has symptoms that might be related to liver.

There are a few different liver function tests that your doctor may order, depending on your individual situation. These tests can help to assess how well your liver is functioning and whether or not there is any damage present.

There are a few different liver function tests (LFTs) that your doctor may order, depending on what they suspect might be going on with your liver. The most common LFT is the alanine transaminase (ALT) test. This measures the level of an enzyme called ALT in your blood. ALT is normally found in liver cells, so high levels of it in your blood can indicate liver damage. Other LFTs that may be ordered include the aspartate transaminase (AST) test, the alkaline phosphatase (ALP) test, and the gamma-glutamyl transferase (GGT) test. A liver function test is a blood test that measures the levels of enzymes in your blood. These enzymes are produced by your liver and help to break down fats, proteins, and carbohydrates. There are several different types of liver function tests, but the most common one is the alanine transaminase (ALT) test.

ALT is an enzyme that is involved in metabolizing amino acids. When your liver is damaged or inflamed, it releases Jazz hands advertising internships high levels of ALT into your bloodstream. The ALT test can be used to detect liver damage or disease. The normal range for ALT varies depending on your age and sex, but it is generally between 20 and 40 IU/L

There are a number of different liver function tests that can be performed, each of which can give useful information about the status of the liver. The most common liver function tests are the serum glycated albumin test, the serum alkaline phosphatase test, and the serum glutamic-oxaloacetic transaminase (SGOT)test.

The glycated albumin test measures the level of a specific type of sugar (glucose) that is bound to albumin, a protein found in the blood. This test provides an indication of how well the liver is able to process glucose.

The alkaline phosphatase test measures the level of an enzyme that is produced by the liver. This The liver function test is a blood test that measures the levels of certain enzymes and proteins in your liver. These substances are normally present in the liver in small amounts. But if your liver is damaged, these substances can leak into your bloodstream and increase the level of certain enzymes and proteins in your blood.

There are several different liver function tests, each of which measures different enzymes or proteins. The most common liver function tests are the alkaline phosphatase (ALP) test, the aspartate aminotransferase (AST) test, and the alanine aminotransferase (ALT) test.

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Sleep Debt and Its Impact on the Body: Hidden Risks of Chronic Sleep Loss

Sleep is not a luxury; it is a biological necessity. Yet in today’s fast-paced world, many people consistently sacrifice sleep due to work demands, screen time and stress. Over time, insufficient sleep accumulates into what is known as sleep debt. Understanding sleep debt and its impact on the body is essential because chronic sleep loss silently affects nearly every organ system.

According to the World Health Organization and global sleep research, chronic sleep deprivation is associated with increased risk of cardiovascular disease, metabolic disorders and mental health conditions.

What Is Sleep Debt?

Sleep debt refers to the cumulative effect of not getting enough sleep.

For example:

if you need 8 hours but sleep 6 hours daily
you accumulate 2 hours of sleep debt per night

Over a week, that equals 14 hours of lost sleep.

This deficit places strain on the body.

Why Sleep Is Critical for Health

Sleep supports:

brain function
immune response
hormonal regulation
tissue repair
memory consolidation

Without adequate sleep, these processes become impaired.

Immediate Effects of Sleep Debt

Short-term consequences include:

daytime fatigue
poor concentration
mood swings
irritability
reduced reaction time

Even one night of poor sleep affects cognitive performance.

Sleep Debt and Hormonal Imbalance

Sleep regulates several key hormones.

Chronic sleep loss disrupts:

cortisol
insulin
leptin and ghrelin (hunger hormones)

This imbalance affects appetite, stress and metabolism.

Impact on Metabolic Health

Sleep debt increases:

insulin resistance
blood sugar fluctuations
abdominal fat accumulation

ICMR and NFHS-5 data show rising metabolic disorders in India, partly linked to lifestyle patterns including poor sleep.

Increased Risk of Obesity

When sleep is insufficient:

appetite hormones increase
cravings for high-calorie foods rise
impulse control weakens

Sleep deprivation promotes weight gain.

Sleep Debt and Immunity

The immune system relies heavily on sleep.

Chronic sleep loss:

reduces infection-fighting cells
increases inflammation
slows recovery from illness

Lancet research confirms that sleep deprivation weakens immune response.

Cardiovascular Consequences

Sleep debt increases risk of:

hypertension
heart disease
stroke

Poor sleep affects blood pressure regulation and vascular health.

Mental Health Impact

Sleep and mental health are deeply connected.

Sleep debt contributes to:

anxiety
depression
emotional instability

Chronic insomnia is both a cause and consequence of mental health disorders.

Cognitive Decline and Brain Health

Lack of sleep impairs:

memory
attention
decision-making

Over time, chronic sleep deprivation may increase risk of neurodegenerative disorders.

Sleep Debt and Inflammation

Chronic sleep loss elevates inflammatory markers.

Persistent inflammation contributes to:

metabolic syndrome
cardiovascular disease
autoimmune conditions

Preventing sleep debt reduces systemic inflammation.

Can Sleep Debt Be Recovered?

Short-term sleep debt can be partially recovered through:

consistent longer sleep
improved sleep hygiene

However, chronic sleep deprivation requires long-term behavioural changes.

Weekend “catch-up sleep” offers temporary relief but does not fully reverse long-standing sleep debt.

Warning Signs of Sleep Debt

Common indicators include:

reliance on caffeine
difficulty waking up
daytime drowsiness
poor focus
frequent illness

Persistent symptoms require lifestyle correction.

Practical Strategies to Reduce Sleep Debt

Maintain a Consistent Sleep Schedule

Go to bed and wake up at the same time daily.

Limit Screen Exposure Before Bed

Blue light suppresses melatonin production.

Create a Sleep-Friendly Environment

Dark, quiet and cool environments improve sleep quality.

Manage Stress

Relaxation techniques reduce cortisol levels and support sleep.

Avoid Heavy Meals and Caffeine at Night

These disrupt sleep cycles.

Role of Preventive Health Checkups

Screening helps detect:

hypertension
metabolic imbalance
stress-related conditions

Sleep quality assessment should be part of preventive care.

Long-Term Benefits of Adequate Sleep

Restorative sleep supports:

stable mood
strong immunity
healthy weight
improved productivity
reduced disease risk

Sleep is foundational to wellness.

Conclusion

Understanding sleep debt and its impact on the body highlights the critical role sleep plays in maintaining physical and mental health. Chronic sleep loss disrupts hormones, weakens immunity, increases metabolic risk and affects heart health. While occasional sleep loss may be manageable, consistent deprivation carries serious long-term consequences. Prioritising adequate, high-quality sleep is one of the most powerful steps toward protecting overall health and preventing chronic disease.

References

World Health Organization (WHO) – Sleep and Non-Communicable Diseases
Indian Council of Medical Research (ICMR) – Lifestyle Disorders and Sleep Patterns
National Family Health Survey (NFHS-5) – Adult Health Indicators
Lancet – Sleep Deprivation and Chronic Disease Research
NITI Aayog – Preventive Healthcare and Lifestyle Risk Factors

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