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Published on: Nov 10, 2021
2 minute read
By: Second Medic Expert

Understanding Hemogram

A hemogram can tell you a lot about your blood. For instance, red and white blood cells, as well as platelets (also called thrombocytes), will be counted and examined for size, shape, volume, and degree of organization. Specific factors that may affect these parameters include a total number of erythrocyte progenitor stem cells; RBC membrane stiffness; frequency of RBC production; distribution and frequency of phagocytosis (cellular breakdown); distribution and type of leukocytes (white blood cells) in circulation; vitamin deficiencies like folic acid or B12 deficiency. The number of toxic substances such as lead poisoning can also be analyzed from a hemogram.

Your hemoglobin levels should be high and your white cell count should be low. It's very important to have a blood test done when you're pregnant to make sure that you don't have any type of disease that the blood could transmit to the baby through the placenta, such as hepatitis B or C, HIV/AIDS, syphilis, or other diseases.

It's also important when giving birth if one is Rh-negative and hasn't been vaccinated against it (if they can't remember their past). If they were exposed in pregnancy and gave birth with an Rh-positive partner, there's a chance for their newborn baby to receive too many RBCs from mom and develop jaundice/anemia;

A hemogram is a blood test that measures the hematocrit, hemoglobin levels, and other substances in the blood (such as total protein and red blood cells). Hemograms can be differential or comprehensive. Comprehensive: performs a complete analysis of all forms of an organism's entire circulating cellular mass. Differential: analyzes two sources from one specimen- for example, plasma and white cells, platelets and red cells, prothrombin time combined with partial thromboplastin time (PTT), D-dimer level with complete lipid profile to provide a clear diagnosis of possible metabolic liver problems.

A blood count measures the number of each type of cell found in one cubic millimeter (1/10th of a teaspoon) or 500 microliters (a little less than half a cup) of whole blood. The numbers are reported as cells per cubic millimeter, so you need to know how many millions there are to divide by 10 to get the actual headcount. In this way, for example, someone under 20 could have 1.0x1012 neutrophils and have a CBC that says they have 10x109 neutrophils per cubic millimeter."

The blood count may reveal, for example, an abnormally high number of red blood cells (confirmatory diagnosis) or determinations made by routine inspection that are not obvious without the additional information present in the hemogram. A hemogram is typically conducted to investigate an abnormal indication on a CBC. For instance, if you have very low white counts and no cause for this can be determined using other lab tests like a peripheral smear or bone marrow biopsy, it's possible that your doctor will perform a complete hemogram. Most often abnormalities are seen on the CBC.

When you're involved in extreme sports like skateboarding, your chances of getting injured are much greater than if you're at the pool or sipping tea. Hematoma is a condition that usually arises from some form of blunt force or direct trauma-related injury to the muscles and/or bones due to the high blood vessels around those areas. This injury can cause swelling which creates pressure on these vessels causing red blood cells to either leak into the soft tissue, tissues fluids, or even lead to a blocked flow of fresh oxygenated blood through these vessels if not treated promptly with an incision.

A hematocrit test analyzes the volume of red blood cells in one cubic millimeter of blood. Red blood cells contain hemoglobin, which carries oxygen and carbon dioxide to and from tissues and organs. The more severely an individual is afflicted with anemia, the lower the percentage of red blood cells they would have in one cubic millimeter of their own cardiac tissue.

If you endure a deep cut on your arm, your body will release stress hormones such as cortisol or epinephrine that prepare your immune system for increased levels of intense activity. These types of stress hormones also trigger a large release of iron from storage sites on red blood cells so that enough iron is available to help form new erythrocytes.

A haemogram is a study of the cellular inclusions in one's blood based on their shape, color, size, and specific gene expression. This process involves pumping a person's blood through a machine (this machine includes some spinning disks that separate out each type of cell for study). However, this test is not commonly done. Instead, analysis is usually limited to basic counts of red and white blood cells as well as platelets.

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Yellow Eyes and Skin Symptoms: Causes, Warning Signs and When to Seek Care

Yellowing of the eyes and skin is one of the most noticeable physical changes a person can experience. Often referred to as jaundice, this symptom is not a disease by itself but a sign of underlying health conditions. Understanding yellow eyes and skin symptoms is essential because they frequently indicate problems involving the liver, blood or bile ducts and may require urgent medical attention.

In India, jaundice is a common presentation across age groups due to infections, liver disease and metabolic disorders.

What Does Yellowing of Eyes and Skin Mean?

The yellow colour appears due to excess bilirubin in the blood.

Bilirubin is:

a yellow pigment
produced from the breakdown of red blood cells
processed and removed by the liver

When bilirubin builds up, it deposits in tissues, causing yellow discoloration.

Why the Eyes Turn Yellow First

The sclera, or white part of the eyes, contains elastic tissue that binds bilirubin easily.

This makes yellowing:

more visible in eyes
detectable before skin changes

Yellow eyes are often the earliest sign of jaundice.

Common Causes of Yellow Eyes and Skin

Liver-Related Causes

The liver plays a central role in bilirubin metabolism.

Common liver causes include:

viral hepatitis (A, B, C, E)
fatty liver disease
alcoholic liver disease
liver cirrhosis
drug-induced liver injury

ICMR reports viral hepatitis as a major cause of jaundice in India.

Bile Duct Obstruction

Blocked bile flow prevents bilirubin excretion.

Causes include:

gallstones
bile duct strictures
pancreatic or bile duct tumours

This type of jaundice is often associated with itching and pale stools.

Blood Disorders

Excess breakdown of red blood cells increases bilirubin production.

Conditions include:

hemolytic anemia
malaria
inherited blood disorders

The liver may be overwhelmed despite being healthy.

Infections

Certain infections directly affect liver function.

Examples include:

hepatitis viruses
leptospirosis
severe sepsis

WHO data highlights hepatitis as a leading infectious cause of jaundice globally.

Newborn and Pregnancy-Related Causes

While common in newborns, jaundice in adults always needs evaluation.

Pregnancy-related liver disorders can also cause yellowing.

Associated Symptoms That Provide Clues

Yellow eyes and skin are often accompanied by:

dark yellow or tea-coloured urine
pale or clay-coloured stools
itching
fatigue
abdominal pain
loss of appetite

These symptoms help identify the underlying cause.

When Yellowing Becomes Dangerous

Seek urgent medical care if yellowing is accompanied by:

high fever
severe abdominal pain
confusion or drowsiness
vomiting
rapid worsening of colour

These signs suggest severe liver or systemic disease.

Jaundice and Liver Function

The liver normally:

conjugates bilirubin
excretes it into bile

When liver cells are damaged, bilirubin accumulates.

Lancet studies confirm jaundice as a key marker of liver dysfunction.

Diagnostic Evaluation

Doctors evaluate jaundice using:

blood tests for bilirubin levels
liver function tests
viral markers
ultrasound or CT scans
additional tests based on findings

Early testing identifies reversible causes.

Impact on Daily Life

Persistent jaundice can affect:

energy levels
digestion
mental clarity
work performance

Untreated liver disease can progress silently.

Treatment Depends on the Cause

There is no single treatment for jaundice.

Management focuses on:

treating infection
relieving bile obstruction
stopping harmful medications
managing chronic liver disease

Self-medication can worsen liver injury.

Role of Preventive Healthcare

Preventive measures include:

hepatitis vaccination
safe drinking water
limiting alcohol intake
regular health checkups

NITI Aayog emphasises liver health in preventive care strategies.

Lifestyle Factors That Affect Liver Health

Risk factors include:

excessive alcohol
obesity
high-fat diets
unsafe injections

Addressing these reduces jaundice risk.

Importance of Early Detection

Early diagnosis:

prevents complications
improves recovery
reduces hospitalisation

Delays increase the risk of liver failure.

Jaundice Is a Symptom, Not a Diagnosis

Understanding this distinction is crucial.

Treating the symptom alone:

does not resolve the disease
may mask serious conditions

Medical evaluation is essential.

Conclusion

Yellow eyes and skin symptoms are visible warning signs that should never be ignored. Most often linked to jaundice, they reflect underlying problems involving the liver, bile ducts or blood. Early medical evaluation, accurate diagnosis and timely treatment are critical to prevent serious complications. Recognising these symptoms and seeking care promptly can protect liver health and save lives.

References

Indian Council of Medical Research (ICMR) – Hepatitis and Liver Disease Reports
World Health Organization (WHO) – Jaundice and Hepatitis Guidelines
National Family Health Survey (NFHS-5) – Liver and Metabolic Health Indicators
Lancet – Liver Function and Bilirubin Research
NITI Aayog – Non-Communicable Diseases and Liver Health
Statista – Liver Disease and Hepatitis Trends

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