• Published on: Jul 22, 2020
  • 2 minute read
  • By: Dr Rajan Choudhary

The Oxford Vaccine

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Recently we wrote a blog on the success of an RNA vaccine against SARS-CoV-2, the virus responsible for COVID-19. Within just a few weeks of that incredible research breakthrough, researchers at Oxford University’s Jenner Institute have announced a COVID vaccine that has induced remarkable immune response against the virus.

This study was published in the Lancet, one of the most prestigious medical journals in the world, and a simple summary suggests the vaccine has no early safety concern and is able to induce a strong immune response with both T cells and B cell/antibodies.

THE VACCINE

ChAdOx1 nCoV-19, now known as AZD1222, was co-developed by the University of Oxford and one of its spin-off companies, Vaccitech. The vaccine uses a viral vector based on a common cold virus (adenovirus). This carries genetic material for the SARS-CoV-2 spike protein. In our previous blog, we saw how the spike proteins are used by the virus to target and fuse with our target cells, allowing the virus to invade, replicate and ultimately cause the disease known as COVID. It is also a good target for the human immune system to recognize and attack.

The viral vector delivers the genetic material inside our cells. The spike protein is then produced by our cells, recognized by the immune system as a viral target, and an immune response is created against it. This can be antibodies, which recognize, attach to and mark the virus in our blood, allowing for other white blood cells to destroy the virus.

In this case, the vaccine also produced a T cell response. T cells can recognize cells infected by a virus-based on the markers present on the surface of infected cells. They can tell an infected cell to destroy itself, thereby destroying the virus within without spreading the infection. They also have other functions that we will not discuss in this blog.

THE STUDY

This study was a Phase I/II trial that started in April using the vaccine named ChAdOx1 nCoV-19. This vaccine development started in January 2020, and progress on development has been incredibly rapid. Whilst our previous study had just 45 people, this study looked reviewed over 1,000 healthy adults. 10 of these participants received two doses of the vaccine.

In a study the more participants there are, the greater the power of the study. If the vaccine has any side effects, even ones that rarely occur, it is more likely to be picked up in studies with more people. Similarly having more people helps show that the vaccine is effective, and the strong responses are not merely a fluke or accident. Another benefit of this study is it was able to compare the vaccine against a control group. This shows the results were not simply a placebo and allowed comparison of side effects as well.

The majority of side effects were feeling feverish, chills, muscle ache, headache, and malaise, all symptoms treatable with paracetamol. None of the participants had any serious side effects. It took just 14 days to create a T cell response, and  28 days to make strong antibodies. In 91% of patients, this was enough to neutralize the COVID coronavirus. Receiving two doses gave an even stronger antibody response, and all participants were able to stop the virus.

 

WHAT NEXT

The news from the University of Oxford is needed, as infection rate and mortality continue to increase in countries such as the US and Brazil. The ability to induce an antibody response without causing harm to the patient shows we have made huge progress in the fight against COVID-19. Further Large scale Phase III trials been set up through a global partnership, and include studies in the US with over 30,000 patients, studies in children as well as some in low to middle-income countries.

If successful a vaccine would be essential in preventing a second wave of COVID in the winter when the elderly population is most at risk. And it would be the key to restarting the economy and getting our everyday lives back to where it was pre-pandemic.

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Insomnia in Teens and How to Manage It

Insomnia in Teens and How to Manage It

Sleep is essential for growing teens, yet many struggle to get enough of it. From school stress to social media scrolling, teenagers today face multiple challenges that affect their sleep. One of the most common sleep disorders among adolescents is insomnia—the inability to fall asleep, stay asleep, or wake up feeling rested.

In this blog, we’ll break down the causes, effects, and simple strategies to handle insomnia in teens and how to manage it naturally.

 

What is Insomnia?

Insomnia is a sleep disorder that makes it hard to fall asleep, stay asleep, or get quality rest. Teens with insomnia often feel tired during the day, even if they’ve spent enough time in bed.

There are two main types:

  • Short-term insomnia: Lasts for a few days or weeks, often triggered by stress or changes in routine.
     

  • Chronic insomnia: Occurs at least three times a week for over three months.
     

 

Why Is Insomnia Common in Teens?

Teenagers go through many physical, emotional, and social changes. All these factors can disturb their sleep:

1. Hormonal Shifts

During puberty, the sleep hormone melatonin is released later at night. This shifts the body clock, making teens naturally want to sleep and wake up later.

2. Screen Time

Excessive use of phones, tablets, or laptops before bedtime exposes the brain to blue light, which delays melatonin release and interferes with sleep.

3. Academic Stress

Homework, exams, and performance pressure can cause anxiety and overthinking at night, preventing restful sleep.

4. Caffeine Intake

Energy drinks, tea, coffee, and cola consumed in the evening can make it difficult to fall asleep due to their stimulating effects.

5. Mental Health Issues

Anxiety, depression, and emotional distress are often linked with poor sleep in teens.

 

Signs of Insomnia in Teenagers

  • Difficulty falling asleep at night
     

  • Waking up multiple times during the night
     

  • Feeling tired or sleepy during the day
     

  • Irritability or mood swings
     

  • Trouble focusing in school
     

  • Frequent headaches or stomach issues
     

  • Increased use of stimulants (coffee, energy drinks)
     

 

How Insomnia Affects Teens

Sleep deprivation can harm a teen's physical and mental health. Here are a few ways it affects their well-being:

  • Poor concentration in school
     

  • Weakened immunity
     

  • Increased risk of depression and anxiety
     

  • Weight gain due to hormonal imbalance
     

  • Risky behaviors due to impaired judgment
     

Teens who consistently sleep less than 7–8 hours are more likely to face emotional and academic challenges.

 

Natural Ways to Manage Insomnia in Teens

Thankfully, insomnia doesn’t always need medication. Many teens can improve their sleep with simple lifestyle changes.

1. Set a Regular Sleep Schedule

Encourage going to bed and waking up at the same time every day—even on weekends. This helps reset the body’s internal clock.

2. Limit Screen Time Before Bed

Avoid phones, TVs, and tablets at least 1 hour before bedtime. Use “night mode” or blue light filters if screen use is necessary.

3. Practice Relaxation Techniques

Deep breathing, meditation, gentle yoga, or reading a book before bed can calm the mind and prepare the body for sleep.

4. Watch Food and Drink

Avoid heavy meals, sugar, or caffeine in the evening. A light snack like warm milk, bananas, or almonds can promote better sleep.

5. Get Daily Exercise

Physical activity during the day can improve sleep quality—but avoid intense workouts right before bedtime.

6. Create a Sleep-Friendly Environment

Keep the bedroom cool, dark, and quiet. Use blackout curtains, soft bedding, and remove distractions like phones or bright lights.

 

When to See a Doctor

If your teen’s insomnia lasts longer than 3 weeks or affects their daily life, school, or mood, it’s important to consult a doctor or sleep specialist. Underlying conditions like anxiety, ADHD, or depression might need professional care.

 

Lab Tests That May Help

If your teen complains of constant fatigue or disrupted sleep, you might consider lab tests to rule out medical reasons such as:

  • Thyroid Function Test (for hormonal imbalance)
     

  • Vitamin D & B12 Tests (deficiency can affect sleep)
     

  • Stress Hormone Panel (Cortisol)
     

  • Iron Levels (especially in girls)
     

These tests are available through diagnostic providers like Thyrocare on platforms like SecondMedic.

 

Helping Teens Build Healthy Sleep Habits

As a parent, here’s how you can support better sleep:

  • Encourage open conversations about school pressure or emotional issues.
     

  • Set boundaries for screen use, especially at night.
     

  • Make the home environment calm and supportive before bedtime.
     

  • Lead by example—follow healthy sleep habits yourself.
     

 

Quick Tips for Teens

  • Sleep 8–10 hours every night
     

  • Don’t study in bed
     

  • Use a sleep diary or app to track sleep patterns
     

  • Avoid naps longer than 30 minutes in the day
     

  • Try journaling to clear the mind before sleep
     

 

Conclusion

Teenage insomnia is more common than many people realize. Fortunately, with the right support, structure, and healthy routines, it can be managed without medication.

If your teen shows signs of poor sleep, don’t ignore it. Better sleep leads to better mood, focus, and health.

So, if you’re wondering how to support better sleep for your child, remember to understand insomnia in teens and how to manage it the natural way—with empathy, good habits, and expert care when needed.

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