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Published on: Jul 22, 2020
2 minute read
By: Dr Rajan Choudhary

The Oxford Vaccine

Recently we wrote a blog on the success of an RNA vaccine against SARS-CoV-2, the virus responsible for COVID-19. Within just a few weeks of that incredible research breakthrough, researchers at Oxford University’s Jenner Institute have announced a COVID vaccine that has induced remarkable immune response against the virus.

This study was published in the Lancet, one of the most prestigious medical journals in the world, and a simple summary suggests the vaccine has no early safety concern and is able to induce a strong immune response with both T cells and B cell/antibodies.

THE VACCINE

ChAdOx1 nCoV-19, now known as AZD1222, was co-developed by the University of Oxford and one of its spin-off companies, Vaccitech. The vaccine uses a viral vector based on a common cold virus (adenovirus). This carries genetic material for the SARS-CoV-2 spike protein. In our previous blog, we saw how the spike proteins are used by the virus to target and fuse with our target cells, allowing the virus to invade, replicate and ultimately cause the disease known as COVID. It is also a good target for the human immune system to recognize and attack.

The viral vector delivers the genetic material inside our cells. The spike protein is then produced by our cells, recognized by the immune system as a viral target, and an immune response is created against it. This can be antibodies, which recognize, attach to and mark the virus in our blood, allowing for other white blood cells to destroy the virus.

In this case, the vaccine also produced a T cell response. T cells can recognize cells infected by a virus-based on the markers present on the surface of infected cells. They can tell an infected cell to destroy itself, thereby destroying the virus within without spreading the infection. They also have other functions that we will not discuss in this blog.

THE STUDY

This study was a Phase I/II trial that started in April using the vaccine named ChAdOx1 nCoV-19. This vaccine development started in January 2020, and progress on development has been incredibly rapid. Whilst our previous study had just 45 people, this study looked reviewed over 1,000 healthy adults. 10 of these participants received two doses of the vaccine.

In a study the more participants there are, the greater the power of the study. If the vaccine has any side effects, even ones that rarely occur, it is more likely to be picked up in studies with more people. Similarly having more people helps show that the vaccine is effective, and the strong responses are not merely a fluke or accident. Another benefit of this study is it was able to compare the vaccine against a control group. This shows the results were not simply a placebo and allowed comparison of side effects as well.

The majority of side effects were feeling feverish, chills, muscle ache, headache, and malaise, all symptoms treatable with paracetamol. None of the participants had any serious side effects. It took just 14 days to create a T cell response, and 28 days to make strong antibodies. In 91% of patients, this was enough to neutralize the COVID coronavirus. Receiving two doses gave an even stronger antibody response, and all participants were able to stop the virus.

WHAT NEXT

The news from the University of Oxford is needed, as infection rate and mortality continue to increase in countries such as the US and Brazil. The ability to induce an antibody response without causing harm to the patient shows we have made huge progress in the fight against COVID-19. Further Large scale Phase III trials been set up through a global partnership, and include studies in the US with over 30,000 patients, studies in children as well as some in low to middle-income countries.

If successful a vaccine would be essential in preventing a second wave of COVID in the winter when the elderly population is most at risk. And it would be the key to restarting the economy and getting our everyday lives back to where it was pre-pandemic.

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Lifestyle Disease Prevention India: Protecting Health Through Proactive Care

Lifestyle diseases, also known as non-communicable diseases (NCDs), have become one of India’s most pressing health challenges. Conditions such as diabetes, hypertension, obesity, heart disease, thyroid disorders, fatty liver, and high cholesterol now affect millions-often starting at younger ages compared to previous generations. According to the Indian Council of Medical Research (ICMR), NCDs account for more than 60 percent of deaths in India. The good news: most lifestyle diseases are preventable with awareness, screening, and timely intervention.

SecondMedic supports a national shift from reactive to preventive healthcare through early detection, nutrition planning, lifestyle improvement, and chronic risk monitoring.

Why Lifestyle Disease Prevention Matters in India

1. Rising NCD Burden

Rapid urbanization, longer working hours, stress, and processed foods have accelerated lifestyle disease growth.

2. Younger Population at Risk

More Indians in their 20s and 30s are developing prediabetes, fatty liver, and high cholesterol.

3. Silent Disease Progression

Many conditions show no symptoms in the early stages.

4. High Long-Term Medical Cost

Treatment for advanced diabetes or heart disease is expensive compared to prevention.

5. Impact on Productivity

Organizations face rising health-related absenteeism and reduced performance.

Prevention is not optional-it is a necessity.

Major Lifestyle Diseases in India

1. Diabetes & Prediabetes

India has over 10 crore diabetics, with many unaware of their condition.

2. Hypertension

Known as the “silent killer,” it increases risk for heart attack and stroke.

3. Heart Disease

India sees one of the highest premature heart attack rates globally.

4. Obesity & Metabolic Syndrome

Poor diet and inactivity contribute to dangerous fat accumulation.

5. Fatty Liver Disease

Highly common even among non-alcoholic individuals.

6. Thyroid Disorders

Thyroid imbalances affect metabolism, weight, and mental health.

7. Stress & Sleep Disorders

Impact emotional stability and long-term health.

SecondMedic offers preventive screenings tailored for each of these risk areas.

Early Detection Through Preventive Health Checkups

Preventive checkups help detect abnormalities before they turn into chronic disease.

SecondMedic’s packages include:

CBC
Lipid profile
HbA1c
Thyroid panel
Liver function tests
Kidney profile
Cardiac markers
Vitamin D & B12
Hormone tests
ECG

These tests provide a comprehensive health snapshot.

Lifestyle Disease Prevention Strategies

1. Nutrition Management

A healthy diet is the foundation of prevention.
SecondMedic dietitians design personalized nutrition plans based on:

Age
Weight
Activity
Medical history

2. Regular Physical Activity

Movement reduces blood sugar, strengthens the heart, and improves metabolism.

3. Stress Management

Chronic stress increases cortisol, causing diabetes and weight gain.
SecondMedic offers:

Online mental health counselling
Anxiety management
Sleep routines

4. Avoiding Tobacco & Alcohol

These significantly increase risk of cancer, fatty liver, and heart disease.

5. Healthy Weight Maintenance

Targeted routines help maintain optimal BMI and waist circumference.

6. Adequate Sleep

Poor sleep leads to hormonal imbalance and weak immunity.

7. Regular Health Checkups

Monitoring every 6-12 months helps track changes early.

Technology in Lifestyle Disease Prevention

India’s digital health ecosystem supports smarter prevention through:

Wearables
Fitness trackers
AI-based risk prediction
Digital symptom assessment
Remote monitoring devices

SecondMedic integrates these tools for continuous care.

Why SecondMedic for Lifestyle Disease Prevention

1. Comprehensive Screening

All major biomarkers, organ function tests, and metabolic indicators.

2. Expert Interpretation

Doctors analyze results and provide actionable insights.

3. Personalized Health Plans

Nutrition + fitness + lifestyle guidance.

4. Continuous Monitoring

Follow-ups ensure long-term success.

5. Integrated Telemedicine Support

Patients can speak to specialists anytime.

Conclusion

Lifestyle disease prevention India is crucial for improving long-term health and reducing the national burden of chronic diseases. Through early screening, targeted intervention, better nutrition, exercise routines, and continuous monitoring, individuals can dramatically reduce their risk. SecondMedic offers a complete ecosystem of preventive healthcare to help Indians stay healthy and proactive.

To begin your preventive health journey, visit www.secondmedic.com

References

ICMR - India NCD burden
WHO - Global NCD prevention guidelines
Statista - Lifestyle disease trends in India
NITI Aayog - Preventive health model
SecondMedic preventive care insights

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