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Published on: Jul 22, 2020
2 minute read
By: Dr Rajan Choudhary

The Oxford Vaccine

Recently we wrote a blog on the success of an RNA vaccine against SARS-CoV-2, the virus responsible for COVID-19. Within just a few weeks of that incredible research breakthrough, researchers at Oxford University’s Jenner Institute have announced a COVID vaccine that has induced remarkable immune response against the virus.

This study was published in the Lancet, one of the most prestigious medical journals in the world, and a simple summary suggests the vaccine has no early safety concern and is able to induce a strong immune response with both T cells and B cell/antibodies.

THE VACCINE

ChAdOx1 nCoV-19, now known as AZD1222, was co-developed by the University of Oxford and one of its spin-off companies, Vaccitech. The vaccine uses a viral vector based on a common cold virus (adenovirus). This carries genetic material for the SARS-CoV-2 spike protein. In our previous blog, we saw how the spike proteins are used by the virus to target and fuse with our target cells, allowing the virus to invade, replicate and ultimately cause the disease known as COVID. It is also a good target for the human immune system to recognize and attack.

The viral vector delivers the genetic material inside our cells. The spike protein is then produced by our cells, recognized by the immune system as a viral target, and an immune response is created against it. This can be antibodies, which recognize, attach to and mark the virus in our blood, allowing for other white blood cells to destroy the virus.

In this case, the vaccine also produced a T cell response. T cells can recognize cells infected by a virus-based on the markers present on the surface of infected cells. They can tell an infected cell to destroy itself, thereby destroying the virus within without spreading the infection. They also have other functions that we will not discuss in this blog.

THE STUDY

This study was a Phase I/II trial that started in April using the vaccine named ChAdOx1 nCoV-19. This vaccine development started in January 2020, and progress on development has been incredibly rapid. Whilst our previous study had just 45 people, this study looked reviewed over 1,000 healthy adults. 10 of these participants received two doses of the vaccine.

In a study the more participants there are, the greater the power of the study. If the vaccine has any side effects, even ones that rarely occur, it is more likely to be picked up in studies with more people. Similarly having more people helps show that the vaccine is effective, and the strong responses are not merely a fluke or accident. Another benefit of this study is it was able to compare the vaccine against a control group. This shows the results were not simply a placebo and allowed comparison of side effects as well.

The majority of side effects were feeling feverish, chills, muscle ache, headache, and malaise, all symptoms treatable with paracetamol. None of the participants had any serious side effects. It took just 14 days to create a T cell response, and 28 days to make strong antibodies. In 91% of patients, this was enough to neutralize the COVID coronavirus. Receiving two doses gave an even stronger antibody response, and all participants were able to stop the virus.

WHAT NEXT

The news from the University of Oxford is needed, as infection rate and mortality continue to increase in countries such as the US and Brazil. The ability to induce an antibody response without causing harm to the patient shows we have made huge progress in the fight against COVID-19. Further Large scale Phase III trials been set up through a global partnership, and include studies in the US with over 30,000 patients, studies in children as well as some in low to middle-income countries.

If successful a vaccine would be essential in preventing a second wave of COVID in the winter when the elderly population is most at risk. And it would be the key to restarting the economy and getting our everyday lives back to where it was pre-pandemic.

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Walking Meetings via Voice Chat: A Smarter Way to Boost Health and Productivity in Remote Teams

Remote work has transformed how teams collaborate, but it has also increased sedentary behaviour. Long hours of sitting in front of screens contribute to fatigue, musculoskeletal pain and reduced mental focus. In this context, walking meetings conducted via voice chat have emerged as a simple yet effective corporate wellness practice that aligns productivity with health.

Walking meetings do not require additional time, special equipment or complex planning. They simply reimagine how meetings are conducted.

The Sedentary Challenge in Remote Work

According to WHO and ICMR data:

prolonged sitting increases the risk of heart disease, diabetes and musculoskeletal problems
remote employees often sit longer than office-based workers
screen fatigue negatively affects mental health and productivity

Traditional video meetings unintentionally reinforce inactivity.

What Are Walking Meetings?

Walking meetings are conversations held while participants walk instead of sitting.

In remote settings, these meetings:

are conducted via voice calls
eliminate the need for video screens
allow participants to move freely

They are ideal for one-on-one discussions, team check-ins and brainstorming sessions.

Why Voice Chat Works Best for Walking Meetings

Voice-only meetings:

reduce screen dependency
allow safer movement
encourage active listening

Without visual distractions, participants often engage more deeply in conversation.

Health Benefits of Walking Meetings

Reduced Sedentary Time

Even short walks help:

improve blood circulation
reduce stiffness
activate muscles

WHO recommends breaking prolonged sitting every 30–60 minutes.

Cardiovascular Support

Regular walking:

improves heart health
lowers blood pressure
supports metabolic health

Incorporating movement into meetings contributes to daily activity goals.

Musculoskeletal Relief

Walking reduces:

neck and back strain
shoulder tension
joint stiffness

This is particularly valuable for desk-bound employees.

Mental Health and Cognitive Benefits

Improved Focus and Creativity

Movement increases blood flow to the brain.

Studies cited by Lancet show that walking enhances:

problem-solving
creativity
memory recall

Many people report clearer thinking during walking discussions.

Stress Reduction

Walking helps:

lower cortisol levels
improve mood
reduce mental fatigue

This supports emotional wellbeing in high-pressure work environments.

Productivity Benefits for Organisations

Walking meetings:

reduce meeting fatigue
improve engagement
shorten meeting duration due to focused discussion

Employees often return to tasks feeling refreshed rather than drained.

Cultural Shift Toward Wellness-Oriented Work

Encouraging walking meetings signals:

trust in employees
commitment to wellbeing
flexibility in work culture

This improves morale and retention.

How to Implement Walking Meetings in Remote Teams

Simple steps include:

designating certain meetings as “audio-only”
encouraging participants to walk indoors or outdoors
keeping meetings concise
sharing agendas in advance

Clear guidelines ensure safety and effectiveness.

Safety and Practical Considerations

Best practices include:

avoiding walking in unsafe or crowded areas
using earphones for clarity
walking at a comfortable pace
pausing movement when taking notes

Inclusivity is important—walking should be optional, not mandatory.

Who Benefits Most from Walking Meetings?

Walking meetings are especially helpful for:

remote workers
hybrid teams
roles with frequent discussions
employees experiencing screen fatigue

They are less suitable for data-heavy presentations.

Walking Meetings as Part of Corporate Wellness Programs

Walking meetings complement:

ergonomics initiatives
mental health programs
physical activity challenges

They integrate wellness into daily workflows rather than adding extra tasks.

Long-Term Impact on Workplace Health

Over time, organisations adopting movement-friendly practices observe:

reduced burnout
improved energy levels
healthier work routines

Preventive health strategies are most effective when embedded into daily habits.

Role of Preventive Healthcare Awareness

NITI Aayog and WHO emphasise lifestyle modification as a core preventive health strategy.

Walking meetings align perfectly with this approach by:

reducing inactivity
promoting movement
supporting mental wellbeing

Small changes deliver cumulative benefits.

Conclusion

Walking meetings conducted via voice chat are a practical, low-cost and highly effective way to improve employee health and productivity in remote teams. By replacing sedentary meetings with movement-based conversations, organisations can reduce screen fatigue, enhance focus and support long-term wellbeing. In a remote-first world, walking meetings represent a smarter way to work—where productivity and health move forward together.

References

World Health Organization (WHO) – Physical Activity and Sedentary Behaviour Guidelines
Indian Council of Medical Research (ICMR) – Lifestyle and Non-Communicable Disease Reports
Lancet – Physical Activity, Cognition and Workplace Health Studies

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