• Published on: Jul 22, 2020
  • 2 minute read
  • By: Dr Rajan Choudhary

The Oxford Vaccine

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Recently we wrote a blog on the success of an RNA vaccine against SARS-CoV-2, the virus responsible for COVID-19. Within just a few weeks of that incredible research breakthrough, researchers at Oxford University’s Jenner Institute have announced a COVID vaccine that has induced remarkable immune response against the virus.

This study was published in the Lancet, one of the most prestigious medical journals in the world, and a simple summary suggests the vaccine has no early safety concern and is able to induce a strong immune response with both T cells and B cell/antibodies.

THE VACCINE

ChAdOx1 nCoV-19, now known as AZD1222, was co-developed by the University of Oxford and one of its spin-off companies, Vaccitech. The vaccine uses a viral vector based on a common cold virus (adenovirus). This carries genetic material for the SARS-CoV-2 spike protein. In our previous blog, we saw how the spike proteins are used by the virus to target and fuse with our target cells, allowing the virus to invade, replicate and ultimately cause the disease known as COVID. It is also a good target for the human immune system to recognize and attack.

The viral vector delivers the genetic material inside our cells. The spike protein is then produced by our cells, recognized by the immune system as a viral target, and an immune response is created against it. This can be antibodies, which recognize, attach to and mark the virus in our blood, allowing for other white blood cells to destroy the virus.

In this case, the vaccine also produced a T cell response. T cells can recognize cells infected by a virus-based on the markers present on the surface of infected cells. They can tell an infected cell to destroy itself, thereby destroying the virus within without spreading the infection. They also have other functions that we will not discuss in this blog.

THE STUDY

This study was a Phase I/II trial that started in April using the vaccine named ChAdOx1 nCoV-19. This vaccine development started in January 2020, and progress on development has been incredibly rapid. Whilst our previous study had just 45 people, this study looked reviewed over 1,000 healthy adults. 10 of these participants received two doses of the vaccine.

In a study the more participants there are, the greater the power of the study. If the vaccine has any side effects, even ones that rarely occur, it is more likely to be picked up in studies with more people. Similarly having more people helps show that the vaccine is effective, and the strong responses are not merely a fluke or accident. Another benefit of this study is it was able to compare the vaccine against a control group. This shows the results were not simply a placebo and allowed comparison of side effects as well.

The majority of side effects were feeling feverish, chills, muscle ache, headache, and malaise, all symptoms treatable with paracetamol. None of the participants had any serious side effects. It took just 14 days to create a T cell response, and  28 days to make strong antibodies. In 91% of patients, this was enough to neutralize the COVID coronavirus. Receiving two doses gave an even stronger antibody response, and all participants were able to stop the virus.

 

WHAT NEXT

The news from the University of Oxford is needed, as infection rate and mortality continue to increase in countries such as the US and Brazil. The ability to induce an antibody response without causing harm to the patient shows we have made huge progress in the fight against COVID-19. Further Large scale Phase III trials been set up through a global partnership, and include studies in the US with over 30,000 patients, studies in children as well as some in low to middle-income countries.

If successful a vaccine would be essential in preventing a second wave of COVID in the winter when the elderly population is most at risk. And it would be the key to restarting the economy and getting our everyday lives back to where it was pre-pandemic.

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Vitamin D

Vitamin D Deficiency Symptoms: Signs Your Body May Be Lacking Vitamin D

Vitamin D is an essential nutrient that plays a vital role in maintaining strong bones, supporting the immune system and regulating several important functions in the body. Despite its importance, vitamin D deficiency is one of the most common nutritional deficiencies worldwide.

In India, vitamin D deficiency has become increasingly prevalent due to lifestyle factors such as limited sunlight exposure, indoor working environments and dietary habits. According to the Indian Council of Medical Research (ICMR), a significant percentage of the population may have insufficient vitamin D levels.

Recognizing the symptoms of vitamin D deficiency early is important because prolonged deficiency can lead to serious health complications affecting bones, muscles and overall wellbeing.

What Is Vitamin D and Why Is It Important?

Vitamin D is often called the “sunshine vitamin” because the body produces it when the skin is exposed to sunlight. It plays a key role in calcium absorption, which is essential for maintaining healthy bones and teeth.

In addition to bone health, vitamin D supports several important functions including:

immune system regulation
muscle function
inflammation control
hormonal balance

Low levels of vitamin D can disrupt these functions and contribute to various health problems.

Common Symptoms of Vitamin D Deficiency

Vitamin D deficiency can manifest through several symptoms, many of which are often overlooked or mistaken for other health issues.

Persistent Fatigue

Constant tiredness or low energy levels may be one of the earliest signs of vitamin D deficiency. Even after adequate rest, individuals with low vitamin D levels may continue to feel exhausted.

Vitamin D plays a role in cellular energy production, and insufficient levels may contribute to chronic fatigue.

Bone and Back Pain

One of the most well-known effects of vitamin D deficiency is bone discomfort. Vitamin D helps the body absorb calcium, which is essential for maintaining bone strength.

Low vitamin D levels may cause:

bone pain
lower back pain
increased risk of fractures

Persistent bone discomfort should be evaluated by a healthcare professional.

Muscle Weakness

Vitamin D is important for muscle health and function. Deficiency can lead to muscle weakness, cramps or general muscle fatigue.

Older adults with vitamin D deficiency may also experience reduced mobility and increased risk of falls.

Frequent Illness or Infections

Vitamin D plays a key role in supporting the immune system. Individuals with low vitamin D levels may experience frequent colds, infections or slower recovery from illness.

Research suggests that adequate vitamin D levels help strengthen immune defenses against respiratory infections.

Mood Changes and Depression

Vitamin D may influence brain function and mood regulation. Some studies have found a connection between low vitamin D levels and mood disorders such as depression or anxiety.

People experiencing persistent mood changes should consider evaluating vitamin levels as part of a broader health assessment.

Hair Loss

Severe vitamin D deficiency may contribute to hair thinning or hair loss. While hair loss can have multiple causes, nutritional deficiencies including vitamin D deficiency may play a role.

Slow Wound Healing

Vitamin D contributes to the body’s inflammatory response and tissue repair processes. Individuals with deficiency may notice slower wound healing or delayed recovery from injuries.

Who Is at Risk of Vitamin D Deficiency?

Several factors can increase the risk of vitamin D deficiency.

Limited Sun Exposure

People who spend most of their time indoors or use strong sun protection regularly may not receive enough sunlight to produce sufficient vitamin D.

Urban lifestyles and indoor work environments contribute to this problem.

Older Adults

As people age, the skin becomes less efficient at producing vitamin D from sunlight. Older adults may therefore require additional dietary intake or supplements.

Individuals with Darker Skin

Melanin reduces the skin’s ability to produce vitamin D from sunlight. Individuals with darker skin tones may require longer sun exposure to produce adequate levels.

Poor Dietary Intake

Few foods naturally contain vitamin D. Diets lacking fortified foods, dairy products or fatty fish may contribute to deficiency.

Medical Conditions

Certain medical conditions such as kidney disease, liver disease or digestive disorders can affect vitamin D absorption and metabolism.

How Is Vitamin D Deficiency Diagnosed?

Vitamin D deficiency is diagnosed through a simple blood test that measures the level of 25-hydroxyvitamin D in the bloodstream.

Doctors may recommend testing for individuals who experience symptoms of deficiency or belong to high-risk groups.

Early diagnosis allows healthcare providers to recommend appropriate treatment and lifestyle adjustments.

How to Improve Vitamin D Levels

Sunlight Exposure

Regular sunlight exposure is one of the most effective ways to increase vitamin D levels. Experts generally recommend 10 to 30 minutes of sunlight exposure several times per week, depending on skin type and location.

Dietary Sources of Vitamin D

Although limited, certain foods contain vitamin D, including:

fatty fish such as salmon and mackerel
egg yolks
fortified milk and cereals
mushrooms

Including these foods in the diet can help maintain healthy vitamin D levels.

Vitamin D Supplements

In cases of significant deficiency, doctors may recommend vitamin D supplements. The dosage depends on the individual’s vitamin levels, age and health status.

It is important to take supplements under medical supervision to avoid excessive intake.

Preventing Vitamin D Deficiency

Maintaining adequate vitamin D levels requires a balanced combination of sunlight exposure, proper nutrition and regular health monitoring.

Routine health checkups and vitamin testing can help identify deficiencies early and prevent complications.

Adopting a healthy lifestyle with balanced nutrition and outdoor activity can significantly improve vitamin D status and overall health.

Conclusion

Vitamin D deficiency is a common but often overlooked health concern. Symptoms such as fatigue, bone pain, muscle weakness and frequent infections may indicate low vitamin D levels.

Early detection and proper management are essential to prevent long-term health complications. By ensuring adequate sunlight exposure, maintaining a balanced diet and undergoing regular health checkups, individuals can support healthy vitamin D levels and improve overall wellbeing.

Recognizing the warning signs of vitamin D deficiency and seeking timely medical advice can help protect long-term health and maintain optimal body function.

References

  • Indian Council of Medical Research (ICMR) – Nutritional Deficiency Reports

  • World Health Organization (WHO) – Micronutrient Deficiency Guidelines

  • National Institute of Nutrition (NIN) India – Vitamin D Research Reports

  • Lancet Public Health – Nutritional Health Studies

  • National Institutes of Health (NIH) – Vitamin D Fact Sheets for Health Professionals

See all

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