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Published on: Jul 22, 2020
2 minute read
By: Dr Rajan Choudhary

The Oxford Vaccine

Recently we wrote a blog on the success of an RNA vaccine against SARS-CoV-2, the virus responsible for COVID-19. Within just a few weeks of that incredible research breakthrough, researchers at Oxford University’s Jenner Institute have announced a COVID vaccine that has induced remarkable immune response against the virus.

This study was published in the Lancet, one of the most prestigious medical journals in the world, and a simple summary suggests the vaccine has no early safety concern and is able to induce a strong immune response with both T cells and B cell/antibodies.

THE VACCINE

ChAdOx1 nCoV-19, now known as AZD1222, was co-developed by the University of Oxford and one of its spin-off companies, Vaccitech. The vaccine uses a viral vector based on a common cold virus (adenovirus). This carries genetic material for the SARS-CoV-2 spike protein. In our previous blog, we saw how the spike proteins are used by the virus to target and fuse with our target cells, allowing the virus to invade, replicate and ultimately cause the disease known as COVID. It is also a good target for the human immune system to recognize and attack.

The viral vector delivers the genetic material inside our cells. The spike protein is then produced by our cells, recognized by the immune system as a viral target, and an immune response is created against it. This can be antibodies, which recognize, attach to and mark the virus in our blood, allowing for other white blood cells to destroy the virus.

In this case, the vaccine also produced a T cell response. T cells can recognize cells infected by a virus-based on the markers present on the surface of infected cells. They can tell an infected cell to destroy itself, thereby destroying the virus within without spreading the infection. They also have other functions that we will not discuss in this blog.

THE STUDY

This study was a Phase I/II trial that started in April using the vaccine named ChAdOx1 nCoV-19. This vaccine development started in January 2020, and progress on development has been incredibly rapid. Whilst our previous study had just 45 people, this study looked reviewed over 1,000 healthy adults. 10 of these participants received two doses of the vaccine.

In a study the more participants there are, the greater the power of the study. If the vaccine has any side effects, even ones that rarely occur, it is more likely to be picked up in studies with more people. Similarly having more people helps show that the vaccine is effective, and the strong responses are not merely a fluke or accident. Another benefit of this study is it was able to compare the vaccine against a control group. This shows the results were not simply a placebo and allowed comparison of side effects as well.

The majority of side effects were feeling feverish, chills, muscle ache, headache, and malaise, all symptoms treatable with paracetamol. None of the participants had any serious side effects. It took just 14 days to create a T cell response, and 28 days to make strong antibodies. In 91% of patients, this was enough to neutralize the COVID coronavirus. Receiving two doses gave an even stronger antibody response, and all participants were able to stop the virus.

WHAT NEXT

The news from the University of Oxford is needed, as infection rate and mortality continue to increase in countries such as the US and Brazil. The ability to induce an antibody response without causing harm to the patient shows we have made huge progress in the fight against COVID-19. Further Large scale Phase III trials been set up through a global partnership, and include studies in the US with over 30,000 patients, studies in children as well as some in low to middle-income countries.

If successful a vaccine would be essential in preventing a second wave of COVID in the winter when the elderly population is most at risk. And it would be the key to restarting the economy and getting our everyday lives back to where it was pre-pandemic.

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Clothing Drives for Secondhand Donation: Serving Society Sustainably

Clothing is a basic human need, yet millions of people across India lack access to adequate apparel, especially during extreme weather conditions. At the same time, urban households discard large volumes of wearable clothing each year. Clothing drives for secondhand donation bridge this gap by connecting surplus with need in a dignified, sustainable manner.

These initiatives are not merely charitable activities. They represent a structured approach to social responsibility, environmental stewardship and community wellbeing.

The Growing Need for Clothing Donation in India

India faces significant socio-economic disparity.

According to government and NGO data:

millions live below the poverty line
seasonal weather exposes vulnerable populations to health risks
access to basic clothing remains inconsistent

Clothing insecurity directly affects dignity, health and social participation.

Environmental Impact of Textile Waste

The fashion and textile industry is among the largest contributors to environmental pollution.

Textile waste leads to:

landfill accumulation
water pollution from dyes
increased carbon footprint

Reusing clothing through donation significantly reduces environmental strain.

Why Secondhand Clothing Matters

Secondhand clothing extends the lifecycle of garments.

Benefits include:

reduced demand for new production
conservation of water and energy
lower environmental emissions

According to sustainability studies, reuse has a far lower environmental cost than recycling or disposal.

Social Impact of Clothing Drives

Clothing donation drives provide:

protection from heat, cold and rain
improved hygiene and comfort
enhanced dignity and self-esteem

For recipients, clean, appropriate clothing supports physical health and social inclusion.

Role of Clothing Drives in Community Wellbeing

Community-based donation drives:

encourage collective responsibility
foster empathy and awareness
strengthen social bonds

When organised locally, they ensure relevance and timely distribution.

Corporate and Institutional Participation

Many organisations integrate clothing drives into CSR initiatives.

Benefits for organisations include:

measurable social impact
employee engagement
alignment with sustainability goals

EY-FICCI CSR reports highlight employee-driven social initiatives as highly effective engagement tools.

How to Organise an Effective Clothing Drive

Successful drives follow structured processes.

Key steps include:

clear communication on donation guidelines
segregation by size, gender and season
quality checks for usability
hygienic packing and storage

Organisation ensures dignity for recipients.

Importance of Quality and Dignity

Donations should always respect the recipient.

Essential guidelines:

clothes must be clean and wearable
damaged or unusable items should be excluded
culturally appropriate clothing should be prioritised

Dignified donation builds trust and respect.

Seasonal Relevance of Clothing Drives

Seasonal drives maximise impact.

Examples include:

winter clothing drives
monsoon protection apparel
school clothing collections

Timing ensures practical usefulness.

Health and Wellbeing Benefits

Adequate clothing reduces:

exposure-related illnesses
skin infections
respiratory conditions during cold weather

WHO recognises appropriate clothing as a basic determinant of health.

Sustainability and Circular Economy

Clothing drives support a circular economy by:

keeping materials in use longer
reducing waste generation
encouraging responsible consumption

They align with global sustainability goals.

Community Partnerships and NGOs

Collaborating with NGOs ensures:

efficient distribution
identification of genuine needs
transparency and accountability

Partnerships amplify reach and impact.

Measuring the Impact of Clothing Drives

Impact can be assessed through:

number of beneficiaries
quantity of clothing reused
environmental waste reduction
community feedback

Data-driven evaluation improves future initiatives.

Challenges and How to Address Them

Common challenges include:

poor-quality donations
storage and logistics issues
uneven distribution

Clear guidelines and partnerships help overcome these barriers.

Long-Term Value of Sustainable Donation Drives

Regular clothing drives:

normalise responsible disposal habits
build sustainable communities
encourage conscious consumption

They move society from waste to welfare.

Integrating Clothing Drives with Broader Wellness Initiatives

Clothing drives complement:

health camps
nutrition programs
community wellness initiatives

Holistic approaches improve overall social wellbeing.

Conclusion

Clothing drives for secondhand donation represent a powerful intersection of compassion and sustainability. By redirecting wearable clothing to those who need it most, these initiatives protect dignity, improve health outcomes and reduce environmental impact. In a society striving for sustainable development, organised clothing donation drives serve as practical, high-impact actions that benefit communities and the planet alike. When individuals and organisations come together to serve responsibly, small acts of reuse create lasting social change.

References

World Health Organization (WHO) – Social Determinants of Health Reports
Indian Council of Medical Research (ICMR) – Environmental and Community Health Studies
NITI Aayog – Sustainability and Social Impact Frameworks
EY-FICCI – Corporate Social Responsibility and Sustainability Reports
Statista – Textile Waste and Sustainability Data
UN Environment Programme – Sustainable Consumption and Circular Economy

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