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Published on: Jul 22, 2020
2 minute read
By: Dr Rajan Choudhary

The Oxford Vaccine

Recently we wrote a blog on the success of an RNA vaccine against SARS-CoV-2, the virus responsible for COVID-19. Within just a few weeks of that incredible research breakthrough, researchers at Oxford University’s Jenner Institute have announced a COVID vaccine that has induced remarkable immune response against the virus.

This study was published in the Lancet, one of the most prestigious medical journals in the world, and a simple summary suggests the vaccine has no early safety concern and is able to induce a strong immune response with both T cells and B cell/antibodies.

THE VACCINE

ChAdOx1 nCoV-19, now known as AZD1222, was co-developed by the University of Oxford and one of its spin-off companies, Vaccitech. The vaccine uses a viral vector based on a common cold virus (adenovirus). This carries genetic material for the SARS-CoV-2 spike protein. In our previous blog, we saw how the spike proteins are used by the virus to target and fuse with our target cells, allowing the virus to invade, replicate and ultimately cause the disease known as COVID. It is also a good target for the human immune system to recognize and attack.

The viral vector delivers the genetic material inside our cells. The spike protein is then produced by our cells, recognized by the immune system as a viral target, and an immune response is created against it. This can be antibodies, which recognize, attach to and mark the virus in our blood, allowing for other white blood cells to destroy the virus.

In this case, the vaccine also produced a T cell response. T cells can recognize cells infected by a virus-based on the markers present on the surface of infected cells. They can tell an infected cell to destroy itself, thereby destroying the virus within without spreading the infection. They also have other functions that we will not discuss in this blog.

THE STUDY

This study was a Phase I/II trial that started in April using the vaccine named ChAdOx1 nCoV-19. This vaccine development started in January 2020, and progress on development has been incredibly rapid. Whilst our previous study had just 45 people, this study looked reviewed over 1,000 healthy adults. 10 of these participants received two doses of the vaccine.

In a study the more participants there are, the greater the power of the study. If the vaccine has any side effects, even ones that rarely occur, it is more likely to be picked up in studies with more people. Similarly having more people helps show that the vaccine is effective, and the strong responses are not merely a fluke or accident. Another benefit of this study is it was able to compare the vaccine against a control group. This shows the results were not simply a placebo and allowed comparison of side effects as well.

The majority of side effects were feeling feverish, chills, muscle ache, headache, and malaise, all symptoms treatable with paracetamol. None of the participants had any serious side effects. It took just 14 days to create a T cell response, and 28 days to make strong antibodies. In 91% of patients, this was enough to neutralize the COVID coronavirus. Receiving two doses gave an even stronger antibody response, and all participants were able to stop the virus.

WHAT NEXT

The news from the University of Oxford is needed, as infection rate and mortality continue to increase in countries such as the US and Brazil. The ability to induce an antibody response without causing harm to the patient shows we have made huge progress in the fight against COVID-19. Further Large scale Phase III trials been set up through a global partnership, and include studies in the US with over 30,000 patients, studies in children as well as some in low to middle-income countries.

If successful a vaccine would be essential in preventing a second wave of COVID in the winter when the elderly population is most at risk. And it would be the key to restarting the economy and getting our everyday lives back to where it was pre-pandemic.

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Flexible Work Schedules with Telehealth Support: A Smarter Approach to Employee Wellbeing

The modern workplace is undergoing a significant transformation. Rigid office hours and traditional healthcare access models are giving way to flexible work schedules and digital health solutions. One of the most impactful combinations emerging in corporate wellness is flexible work schedules with telehealth support.

This integrated approach addresses two critical challenges faced by today’s workforce: work-life imbalance and delayed healthcare access.

Why Workplace Health Models Need to Change

According to NITI Aayog and EY-FICCI workforce reports, Indian employees face rising levels of:

work-related stress
lifestyle diseases
burnout
absenteeism

Long working hours, commuting stress and limited time for medical visits worsen health outcomes. Flexible work arrangements and telehealth support directly address these gaps.

What Are Flexible Work Schedules?

Flexible work schedules allow employees to:

adjust start and end times
work remotely or in hybrid formats
manage personal commitments alongside work

Flexibility empowers employees to align work with their physical and mental health needs.

Understanding Telehealth Support

Telehealth uses digital platforms to deliver healthcare services such as:

online doctor consultations
follow-up care
preventive health advice
mental health support

It eliminates geographical and time barriers to healthcare.

Why Combining Flexibility with Telehealth Works

Individually, flexibility and telehealth are beneficial. Together, they create a powerful wellness ecosystem.

This combination allows employees to:

consult doctors without taking leave
manage chronic conditions proactively
address early symptoms promptly
reduce healthcare delays

Health Benefits for Employees

Reduced Stress and Burnout

Flexible schedules reduce time pressure, while telehealth removes healthcare-related anxiety.

Improved Access to Preventive Care

Employees are more likely to seek early consultations when care is convenient.

Better Management of Chronic Conditions

Conditions like hypertension, diabetes and thyroid disorders require regular follow-up, which telehealth supports efficiently.

Enhanced Mental Wellbeing

Tele-mental health services enable confidential and timely support.

Improved Work-Life Balance

Employees can prioritise health without compromising job responsibilities.

Productivity Benefits for Employers

Reduced Absenteeism

Quick access to care reduces prolonged sick leave.

Improved Employee Engagement

Health-supported employees show higher motivation and loyalty.

Lower Healthcare Costs

Preventive care reduces long-term medical claims.

Strong Employer Branding

Wellness-focused policies attract and retain talent.

Evidence Supporting Flexible Work and Telehealth

According to WHO and Lancet workplace health studies:

flexible work reduces stress-related disorders
telehealth improves healthcare utilisation
preventive care lowers chronic disease burden

Indian corporate data mirrors these findings, especially in hybrid work environments.

Role in Preventive Healthcare

Preventive healthcare focuses on early risk identification and lifestyle management.

Flexible schedules with telehealth support:

encourage routine checkups
support ongoing health monitoring
enable early intervention

This aligns with India’s preventive healthcare priorities outlined by NITI Aayog.

Addressing Common Concerns

Productivity Loss Myth

Multiple studies show flexible work improves output rather than reducing it.

Quality of Telehealth

Telehealth is effective for most primary care and follow-up needs.

Data Security

Modern telehealth platforms follow strict privacy and data protection standards.

Ideal Use Cases in the Workplace

This model is particularly effective for:

IT and corporate offices
remote and hybrid teams
organisations with distributed workforce
high-stress work environments

Implementation Best Practices

To maximise impact:

set clear flexibility guidelines
integrate telehealth access into HR benefits
promote preventive consultations
track wellness metrics

Leadership support is key to adoption.

Long-Term Organisational Impact

Organisations adopting this model report:

improved employee health indicators
reduced burnout
stronger workplace culture
sustainable productivity gains

Wellbeing becomes a strategic advantage.

Conclusion

Flexible work schedules with telehealth support represent the future of employee wellbeing. By removing barriers to healthcare access and allowing employees control over their work routines, this approach promotes preventive care, reduces stress and enhances productivity. As workplaces evolve, integrating flexibility with digital health support is not just an employee benefit—it is a strategic investment in long-term organisational health and resilience.

References

World Health Organization (WHO) – Workplace Health Promotion Framework
Indian Council of Medical Research (ICMR) – Lifestyle Disease and Workforce Health Studies
NITI Aayog – Digital Health and Workplace Wellness Reports
Lancet – Telehealth and Workforce Productivity Research
EY-FICCI – Corporate Wellness and Future of Work Reports
Statista – Telehealth Adoption and Workforce Trends

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