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Published on: Jul 22, 2020
2 minute read
By: Dr Rajan Choudhary

The Oxford Vaccine

Recently we wrote a blog on the success of an RNA vaccine against SARS-CoV-2, the virus responsible for COVID-19. Within just a few weeks of that incredible research breakthrough, researchers at Oxford University’s Jenner Institute have announced a COVID vaccine that has induced remarkable immune response against the virus.

This study was published in the Lancet, one of the most prestigious medical journals in the world, and a simple summary suggests the vaccine has no early safety concern and is able to induce a strong immune response with both T cells and B cell/antibodies.

THE VACCINE

ChAdOx1 nCoV-19, now known as AZD1222, was co-developed by the University of Oxford and one of its spin-off companies, Vaccitech. The vaccine uses a viral vector based on a common cold virus (adenovirus). This carries genetic material for the SARS-CoV-2 spike protein. In our previous blog, we saw how the spike proteins are used by the virus to target and fuse with our target cells, allowing the virus to invade, replicate and ultimately cause the disease known as COVID. It is also a good target for the human immune system to recognize and attack.

The viral vector delivers the genetic material inside our cells. The spike protein is then produced by our cells, recognized by the immune system as a viral target, and an immune response is created against it. This can be antibodies, which recognize, attach to and mark the virus in our blood, allowing for other white blood cells to destroy the virus.

In this case, the vaccine also produced a T cell response. T cells can recognize cells infected by a virus-based on the markers present on the surface of infected cells. They can tell an infected cell to destroy itself, thereby destroying the virus within without spreading the infection. They also have other functions that we will not discuss in this blog.

THE STUDY

This study was a Phase I/II trial that started in April using the vaccine named ChAdOx1 nCoV-19. This vaccine development started in January 2020, and progress on development has been incredibly rapid. Whilst our previous study had just 45 people, this study looked reviewed over 1,000 healthy adults. 10 of these participants received two doses of the vaccine.

In a study the more participants there are, the greater the power of the study. If the vaccine has any side effects, even ones that rarely occur, it is more likely to be picked up in studies with more people. Similarly having more people helps show that the vaccine is effective, and the strong responses are not merely a fluke or accident. Another benefit of this study is it was able to compare the vaccine against a control group. This shows the results were not simply a placebo and allowed comparison of side effects as well.

The majority of side effects were feeling feverish, chills, muscle ache, headache, and malaise, all symptoms treatable with paracetamol. None of the participants had any serious side effects. It took just 14 days to create a T cell response, and 28 days to make strong antibodies. In 91% of patients, this was enough to neutralize the COVID coronavirus. Receiving two doses gave an even stronger antibody response, and all participants were able to stop the virus.

WHAT NEXT

The news from the University of Oxford is needed, as infection rate and mortality continue to increase in countries such as the US and Brazil. The ability to induce an antibody response without causing harm to the patient shows we have made huge progress in the fight against COVID-19. Further Large scale Phase III trials been set up through a global partnership, and include studies in the US with over 30,000 patients, studies in children as well as some in low to middle-income countries.

If successful a vaccine would be essential in preventing a second wave of COVID in the winter when the elderly population is most at risk. And it would be the key to restarting the economy and getting our everyday lives back to where it was pre-pandemic.

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Virtual Second Opinion Services India: Making Medical Decisions Safer, Smarter, and More Accurate

Healthcare decisions can be overwhelming, especially when dealing with serious diagnoses, complex treatment options, or long-term health conditions. In India, where diagnostic variability and specialist availability differ across regions, seeking a second medical opinion has become essential for clarity and confidence. Virtual second opinion services India allow patients to consult top specialists online, review diagnoses, validate reports, and confirm treatment plans without traveling long distances.

SecondMedic has emerged as a trusted platform for virtual second opinions, connecting users with experienced specialists across cardiology, oncology, neurology, orthopedics, nephrology, endocrinology, and other medical fields. These services empower patients with accurate information and reduce the risk of misdiagnosis or unnecessary treatments.

Why Second Opinions Are Becoming Important in India

According to WHO, nearly 20-30% of medical errors globally stem from misdiagnoses. In India, disparities in medical access and diagnostic quality can make it harder for patients to rely on a single opinion-especially for complex or high-risk conditions.

Patients seek second opinions for:

Cancer diagnosis
Cardiac issues (blockages, angioplasty recommendations)
Orthopedic surgeries
Neurological disorders
Kidney and liver conditions
Autoimmune diseases
Rare or chronic illnesses

A second opinion ensures that treatment decisions are well-informed and evidence-based.

How Virtual Second Opinion Services Work

Virtual second opinion platforms like SecondMedic make the process simple and accessible.

Steps include:

Uploading medical reports, scans, prescriptions, and lab results.
Selecting the specialty or condition.
AI tools help summarize and organize the case.
A specialist reviews the case in detail.
The patient receives a written report or video consultation explaining the recommendations.
Follow-up guidance is provided when needed.

This digital-first approach saves time and helps patients receive expert evaluations from anywhere in India.

Key Benefits of Virtual Second Opinions

1. Access to Top Specialists

Patients can connect with some of India's best doctors without needing to visit major metro hospitals.

2. Prevention of Misdiagnosis

A fresh review reduces the risk of incorrect or incomplete diagnoses.

3. Verification of Treatment Plans

Before committing to surgery or long-term therapy, patients receive reassurance and clarity.

4. Time and Cost Savings

Virtual reviews eliminate travel, long waiting lines, and high hospital consultation fees.

5. Emotional Confidence

Patients and families gain peace of mind through expert validation of medical decisions.

SecondMedic ensures case reviews are thorough, unbiased, and personalized.

Use Cases Where Second Opinions Make a Big Difference

Oncology

Cancer diagnoses often require multi-specialty inputs. Virtual tumor board reviews help patients choose the right treatment path.

Cardiology

Heart conditions like blockages, angioplasty recommendations, or arrhythmia management require accurate evaluations.

Orthopedics

Joint replacement or spine surgery recommendations often need second validation to avoid unnecessary procedures.

Neurology

Conditions like epilepsy, stroke, or movement disorders benefit from deeper case review.

Chronic Illnesses

Diabetes, hypertension, kidney disease, and thyroid disorders require long-term management strategies.

Why Virtual Second Opinion Is Better Than In-Person for Many Patients

More specialist availability
Faster review times
Ability to compare multiple expert opinions
Digital access to consolidated medical records
Better accommodation of busy schedules
Suitable for rural patients with limited access to tertiary care hospitals

Digital second opinions remove geographic barriers completely.

The Role of Technology in Second Opinions

AI enhances the clarity and accuracy of second opinions by:

Pre-sorting medical documents
Highlighting abnormalities in lab results
Summarizing doctor notes
Identifying missing tests
Flagging potential medical risks

SecondMedic combines AI insights with top specialist expertise, resulting in stronger, data-backed recommendations.

Challenges in India’s Traditional Second Opinion System

Long wait times at major hospitals
Difficulty obtaining complete medical records
Travel to metro cities
Lack of specialized doctors in Tier 2/3 cities
Inconsistent diagnostic quality

Virtual second opinion services solve all of these pain points.

Future Outlook

Virtual medical reviews will continue growing with:

AI-powered case analysis
Integration with electronic health records (EHRs)
Multi-specialty collaborative boards
Predictive diagnostics
Global doctor networks

SecondMedic aims to lead this space by offering deeper, faster, and more accurate medical reassessments.

Conclusion

Virtual second opinion services India empower patients to make informed, safe, and confident healthcare decisions. By connecting users with top specialists and leveraging AI-driven insights, SecondMedic ensures that every major medical choice is backed by expertise and clarity. This is especially valuable for complex diagnoses, chronic conditions, and surgical recommendations.

To request a virtual second opinion, visit www.secondmedic.com

References

WHO - Misdiagnosis data and clinical errors
NITI Aayog - Digital health transformation reports
ABDM - Digital health records and interoperability
Statista - Telehealth adoption in India
Lancet & NEJM - Studies on second opinions
SecondMedic clinical team insights

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