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Published on: Jul 22, 2020
2 minute read
By: Dr Rajan Choudhary

The Oxford Vaccine

Recently we wrote a blog on the success of an RNA vaccine against SARS-CoV-2, the virus responsible for COVID-19. Within just a few weeks of that incredible research breakthrough, researchers at Oxford University’s Jenner Institute have announced a COVID vaccine that has induced remarkable immune response against the virus.

This study was published in the Lancet, one of the most prestigious medical journals in the world, and a simple summary suggests the vaccine has no early safety concern and is able to induce a strong immune response with both T cells and B cell/antibodies.

THE VACCINE

ChAdOx1 nCoV-19, now known as AZD1222, was co-developed by the University of Oxford and one of its spin-off companies, Vaccitech. The vaccine uses a viral vector based on a common cold virus (adenovirus). This carries genetic material for the SARS-CoV-2 spike protein. In our previous blog, we saw how the spike proteins are used by the virus to target and fuse with our target cells, allowing the virus to invade, replicate and ultimately cause the disease known as COVID. It is also a good target for the human immune system to recognize and attack.

The viral vector delivers the genetic material inside our cells. The spike protein is then produced by our cells, recognized by the immune system as a viral target, and an immune response is created against it. This can be antibodies, which recognize, attach to and mark the virus in our blood, allowing for other white blood cells to destroy the virus.

In this case, the vaccine also produced a T cell response. T cells can recognize cells infected by a virus-based on the markers present on the surface of infected cells. They can tell an infected cell to destroy itself, thereby destroying the virus within without spreading the infection. They also have other functions that we will not discuss in this blog.

THE STUDY

This study was a Phase I/II trial that started in April using the vaccine named ChAdOx1 nCoV-19. This vaccine development started in January 2020, and progress on development has been incredibly rapid. Whilst our previous study had just 45 people, this study looked reviewed over 1,000 healthy adults. 10 of these participants received two doses of the vaccine.

In a study the more participants there are, the greater the power of the study. If the vaccine has any side effects, even ones that rarely occur, it is more likely to be picked up in studies with more people. Similarly having more people helps show that the vaccine is effective, and the strong responses are not merely a fluke or accident. Another benefit of this study is it was able to compare the vaccine against a control group. This shows the results were not simply a placebo and allowed comparison of side effects as well.

The majority of side effects were feeling feverish, chills, muscle ache, headache, and malaise, all symptoms treatable with paracetamol. None of the participants had any serious side effects. It took just 14 days to create a T cell response, and 28 days to make strong antibodies. In 91% of patients, this was enough to neutralize the COVID coronavirus. Receiving two doses gave an even stronger antibody response, and all participants were able to stop the virus.

WHAT NEXT

The news from the University of Oxford is needed, as infection rate and mortality continue to increase in countries such as the US and Brazil. The ability to induce an antibody response without causing harm to the patient shows we have made huge progress in the fight against COVID-19. Further Large scale Phase III trials been set up through a global partnership, and include studies in the US with over 30,000 patients, studies in children as well as some in low to middle-income countries.

If successful a vaccine would be essential in preventing a second wave of COVID in the winter when the elderly population is most at risk. And it would be the key to restarting the economy and getting our everyday lives back to where it was pre-pandemic.

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Health Risks of Irregular Eating Habits: How Skipping Meals Affects Your Body

Maintaining a balanced and consistent diet is essential for good health. However, modern lifestyles often lead to irregular eating patterns due to busy schedules, work stress and changing daily routines. Many people skip meals, eat late at night or consume food at inconsistent times.

Understanding the health risks of irregular eating habits is important for maintaining metabolic balance and overall wellbeing. Consistent meal timing plays a key role in supporting digestion, energy levels and long-term health.

What Are Irregular Eating Habits?

Irregular eating habits refer to inconsistent or unpredictable meal patterns.

Common examples include:

Skipping breakfast or other meals
Eating meals at varying times each day
Consuming large meals late at night
Frequently replacing meals with snacks

These habits may disrupt the body’s natural metabolic rhythm.

How the Body Regulates Eating Patterns

The human body follows internal biological rhythms that regulate hunger, metabolism and digestion.

When meals occur at consistent times, the digestive system prepares enzymes and hormones needed for efficient food processing.

Irregular eating patterns may interfere with these processes.

1. Disruption of Metabolism

Metabolism refers to the process by which the body converts food into energy.

Skipping meals or eating inconsistently may slow metabolic activity, making it harder for the body to regulate energy balance.

This disruption may contribute to metabolic disorders over time.

2. Increased Risk of Weight Gain

Although skipping meals may appear to reduce calorie intake, it often leads to overeating later in the day.

Large or late meals may increase calorie consumption and contribute to weight gain.

Irregular eating may also affect hormones that regulate appetite.

3. Digestive Problems

The digestive system functions best when meals occur at regular intervals.

Irregular eating may cause symptoms such as:

Acid reflux
Bloating
Indigestion
Stomach discomfort

Consistent meal timing helps maintain digestive balance.

4. Fluctuating Energy Levels

Skipping meals can lead to sudden drops in blood sugar levels.

Low blood sugar may cause symptoms such as:

Fatigue
Dizziness
Difficulty concentrating

Regular meals help maintain steady energy throughout the day.

5. Impact on Blood Sugar Control

Irregular eating patterns may disrupt glucose regulation.

Over time, inconsistent meal timing may increase the risk of insulin resistance and type 2 diabetes.

Maintaining stable blood sugar levels is important for metabolic health.

6. Nutritional Deficiencies

Skipping meals can reduce the intake of essential nutrients required for body function.

A balanced diet provides vitamins, minerals and other nutrients needed for immunity, metabolism and overall health.

Irregular eating habits may lead to nutritional imbalances.

Irregular Eating Habits in the Indian Context

In many urban areas of India, demanding work schedules and long commuting times often lead to irregular meal patterns.

Late-night eating, fast food consumption and skipped meals have become common among professionals and students.

These lifestyle patterns may increase the risk of metabolic and digestive health problems.

Promoting regular meal timing and balanced diets is essential for improving public health.

Tips to Maintain Healthy Eating Habits

Establish Regular Meal Times

Eating meals at consistent times each day helps regulate digestion and metabolism.

Do Not Skip Breakfast

Breakfast provides essential energy for starting the day and supports metabolic activity.

Plan Balanced Meals

Include a variety of foods such as:

Whole grains
Fruits and vegetables
Lean proteins
Healthy fats

Balanced nutrition supports overall health.

Avoid Late-Night Heavy Meals

Eating large meals close to bedtime may disrupt digestion and sleep.

Stay Hydrated

Adequate hydration supports digestion and nutrient absorption.

When to Seek Medical Advice

Consult a healthcare professional if irregular eating habits lead to:

Persistent digestive problems
Unexplained weight changes
Chronic fatigue
Blood sugar irregularities

Early intervention can help prevent long-term health complications.

Conclusion

Irregular eating habits may significantly impact metabolism, digestion and overall health. Skipping meals, inconsistent meal timing and late-night eating can disrupt the body’s natural rhythms and increase the risk of metabolic disorders.

Maintaining consistent meal schedules, balanced nutrition and healthy lifestyle habits can support digestive health and stable energy levels.

By adopting regular eating routines, individuals can improve metabolic balance and reduce the risk of long-term health complications.

Healthy eating patterns are a fundamental part of maintaining overall wellbeing and long-term health.

References

Indian Council of Medical Research – Nutrition and Dietary Guidelines
World Health Organization – Healthy Diet Recommendations
National Institute of Nutrition India – Balanced Meal Guidelines
Journal of Nutrition and Metabolism – Meal Timing Research
Lancet Global Health – Nutrition and Lifestyle Studies

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