The Oxford Vaccine

Recently we wrote a blog on the success of an RNA vaccine against SARS-CoV-2, the virus responsible for COVID-19. Within just a few weeks of that incredible research breakthrough, researchers at Oxford University’s Jenner Institute have announced a COVID vaccine that has induced remarkable immune response against the virus.

This study was published in the Lancet, one of the most prestigious medical journals in the world, and a simple summary suggests the vaccine has no early safety concern and is able to induce a strong immune response with both T cells and B cell/antibodies.

THE VACCINE

ChAdOx1 nCoV-19, now known as AZD1222, was co-developed by the University of Oxford and one of its spin-off companies, Vaccitech. The vaccine uses a viral vector based on a common cold virus (adenovirus). This carries genetic material for the SARS-CoV-2 spike protein. In our previous blog, we saw how the spike proteins are used by the virus to target and fuse with our target cells, allowing the virus to invade, replicate and ultimately cause the disease known as COVID. It is also a good target for the human immune system to recognize and attack.

The viral vector delivers the genetic material inside our cells. The spike protein is then produced by our cells, recognized by the immune system as a viral target, and an immune response is created against it. This can be antibodies, which recognize, attach to and mark the virus in our blood, allowing for other white blood cells to destroy the virus.

In this case, the vaccine also produced a T cell response. T cells can recognize cells infected by a virus-based on the markers present on the surface of infected cells. They can tell an infected cell to destroy itself, thereby destroying the virus within without spreading the infection. They also have other functions that we will not discuss in this blog.

THE STUDY

This study was a Phase I/II trial that started in April using the vaccine named ChAdOx1 nCoV-19. This vaccine development started in January 2020, and progress on development has been incredibly rapid. Whilst our previous study had just 45 people, this study looked reviewed over 1,000 healthy adults. 10 of these participants received two doses of the vaccine.

In a study the more participants there are, the greater the power of the study. If the vaccine has any side effects, even ones that rarely occur, it is more likely to be picked up in studies with more people. Similarly having more people helps show that the vaccine is effective, and the strong responses are not merely a fluke or accident. Another benefit of this study is it was able to compare the vaccine against a control group. This shows the results were not simply a placebo and allowed comparison of side effects as well.

The majority of side effects were feeling feverish, chills, muscle ache, headache, and malaise, all symptoms treatable with paracetamol. None of the participants had any serious side effects. It took just 14 days to create a T cell response, and 28 days to make strong antibodies. In 91% of patients, this was enough to neutralize the COVID coronavirus. Receiving two doses gave an even stronger antibody response, and all participants were able to stop the virus.

WHAT NEXT

The news from the University of Oxford is needed, as infection rate and mortality continue to increase in countries such as the US and Brazil. The ability to induce an antibody response without causing harm to the patient shows we have made huge progress in the fight against COVID-19. Further Large scale Phase III trials been set up through a global partnership, and include studies in the US with over 30,000 patients, studies in children as well as some in low to middle-income countries.

If successful a vaccine would be essential in preventing a second wave of COVID in the winter when the elderly population is most at risk. And it would be the key to restarting the economy and getting our everyday lives back to where it was pre-pandemic.

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Why Recurring Sore Throat Can Be a Serious Issue

A sore throat is a common complaint. Most of us experience it during seasonal changes, after a cold, or when we catch the flu. But what if your sore throat keeps coming back again and again? While many people dismiss it as a minor irritation, a recurring sore throat can actually signal more serious health issues that require proper attention.

What is a recurring sore throat?

A recurring sore throat refers to repeated or persistent throat discomfort that comes back multiple times in a year or lasts longer than usual. Normally, a viral sore throat improves within a week. If the problem lingers beyond 10 days or returns frequently, it falls into the category of chronic or recurring sore throat.

Why is it serious?

Undiagnosed infections
A single sore throat from a virus is not concerning. But if bacterial infections like strep throat keep coming back, they may damage the throat and spread to other parts of the body if untreated.
Inflammation and tissue damage
Constant irritation from allergies or acid reflux can harm the delicate tissues of the throat. Over time, this may affect your voice and overall throat function.
Underlying medical conditions
Recurring sore throat can be linked to issues like gastroesophageal reflux disease (GERD), allergies, tonsil problems, or immune system weakness. In some cases, it may also be an early warning sign of more serious diseases such as tumors.
Complications
Recurrent infections can lead to abscesses around the tonsils, ear infections, or sinus problems. Inadequate or repeated antibiotic use can also cause resistance.
Impact on daily life
A constant sore throat affects your eating, speaking, sleeping, and quality of life. It leads to repeated doctor visits, discomfort, and stress.

Common causes of recurring sore throat

Bacterial infections like strep throat or chronic tonsillitis
Viral infections that linger or reactivate
Allergies that trigger postnasal drip and throat irritation
Acid reflux or GERD causing stomach acid to irritate the throat
Environmental irritants such as smoke, dust, and pollution
Mouth breathing during sleep due to nasal blockage
Immune weakness making you prone to repeated infections

Warning signs to watch for

You should never ignore these symptoms if they accompany a recurring sore throat:

Sore throat lasting longer than 2–3 weeks
Difficulty swallowing or breathing
Lump or swelling in the throat or neck
Persistent hoarseness or voice changes
Unexplained weight loss
Blood in saliva or phlegm
Fever with night sweats

These are red flags that need immediate medical evaluation.

How lab tests help

Lab tests play a critical role in finding out why you have a recurring sore throat. Some useful investigations include:

Throat swab or culture to identify bacterial infections
Rapid antigen test for strep for quick diagnosis
Complete Blood Count (CBC) to detect infection or immune problems
CRP and ESR to check inflammation
Allergy tests to identify triggers like dust or pollen
Thyroid function tests to rule out thyroid-related throat problems
Reflux evaluation if GERD is suspected
Immune status tests if infections are unusually frequent

Through SecondMedic/Thyrocare, these tests can be arranged easily, giving you faster results and treatment planning.

Treatment and prevention

The treatment of recurring sore throat depends on its cause:

Bacterial infections are treated with antibiotics prescribed by a doctor. Completing the full course is essential.
Viral infections usually require rest, hydration, and symptom management.
Acid reflux can be controlled with lifestyle changes like avoiding late meals, reducing spicy foods, and medications if required.
Allergies can be managed by identifying and avoiding triggers, along with prescribed medicines.
Tonsil problems may require surgical removal if infections are frequent and severe.

Preventive steps include:

Staying hydrated
Avoiding smoking and exposure to polluted air
Maintaining good throat hygiene
Managing acid reflux through diet and posture
Strengthening immunity with balanced nutrition and rest

When to see a doctor

If you suffer from frequent sore throats or if your symptoms come with any red flags, consult a healthcare professional without delay. Early evaluation prevents complications and ensures better outcomes.

Conclusion

Recurring sore throat is more than just an inconvenience. It is often a signal from your body that something is not right. Identifying the cause early and undergoing the right tests can help you recover faster and avoid long-term damage.

At SecondMedic, you can access lab tests, doctor consultations, and treatment guidance all in one place. Don’t ignore a sore throat that keeps returning — take charge of your health today and book your tests with SecondMedic/Thyrocare for accurate results and expert support.

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