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Published on: Jul 22, 2020
2 minute read
By: Dr Rajan Choudhary

The Oxford Vaccine

Recently we wrote a blog on the success of an RNA vaccine against SARS-CoV-2, the virus responsible for COVID-19. Within just a few weeks of that incredible research breakthrough, researchers at Oxford University’s Jenner Institute have announced a COVID vaccine that has induced remarkable immune response against the virus.

This study was published in the Lancet, one of the most prestigious medical journals in the world, and a simple summary suggests the vaccine has no early safety concern and is able to induce a strong immune response with both T cells and B cell/antibodies.

THE VACCINE

ChAdOx1 nCoV-19, now known as AZD1222, was co-developed by the University of Oxford and one of its spin-off companies, Vaccitech. The vaccine uses a viral vector based on a common cold virus (adenovirus). This carries genetic material for the SARS-CoV-2 spike protein. In our previous blog, we saw how the spike proteins are used by the virus to target and fuse with our target cells, allowing the virus to invade, replicate and ultimately cause the disease known as COVID. It is also a good target for the human immune system to recognize and attack.

The viral vector delivers the genetic material inside our cells. The spike protein is then produced by our cells, recognized by the immune system as a viral target, and an immune response is created against it. This can be antibodies, which recognize, attach to and mark the virus in our blood, allowing for other white blood cells to destroy the virus.

In this case, the vaccine also produced a T cell response. T cells can recognize cells infected by a virus-based on the markers present on the surface of infected cells. They can tell an infected cell to destroy itself, thereby destroying the virus within without spreading the infection. They also have other functions that we will not discuss in this blog.

THE STUDY

This study was a Phase I/II trial that started in April using the vaccine named ChAdOx1 nCoV-19. This vaccine development started in January 2020, and progress on development has been incredibly rapid. Whilst our previous study had just 45 people, this study looked reviewed over 1,000 healthy adults. 10 of these participants received two doses of the vaccine.

In a study the more participants there are, the greater the power of the study. If the vaccine has any side effects, even ones that rarely occur, it is more likely to be picked up in studies with more people. Similarly having more people helps show that the vaccine is effective, and the strong responses are not merely a fluke or accident. Another benefit of this study is it was able to compare the vaccine against a control group. This shows the results were not simply a placebo and allowed comparison of side effects as well.

The majority of side effects were feeling feverish, chills, muscle ache, headache, and malaise, all symptoms treatable with paracetamol. None of the participants had any serious side effects. It took just 14 days to create a T cell response, and 28 days to make strong antibodies. In 91% of patients, this was enough to neutralize the COVID coronavirus. Receiving two doses gave an even stronger antibody response, and all participants were able to stop the virus.

WHAT NEXT

The news from the University of Oxford is needed, as infection rate and mortality continue to increase in countries such as the US and Brazil. The ability to induce an antibody response without causing harm to the patient shows we have made huge progress in the fight against COVID-19. Further Large scale Phase III trials been set up through a global partnership, and include studies in the US with over 30,000 patients, studies in children as well as some in low to middle-income countries.

If successful a vaccine would be essential in preventing a second wave of COVID in the winter when the elderly population is most at risk. And it would be the key to restarting the economy and getting our everyday lives back to where it was pre-pandemic.

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Weekly Health Roundup Newsletter: India’s Trusted Source for Preventive Wellness Insights

Health information today is abundant, but not always reliable. With countless articles, social media trends, home remedies and conflicting opinions, individuals often struggle to separate credible medical advice from misinformation. This challenge becomes especially significant in India, where rising lifestyle diseases, nutritional gaps and limited public health awareness create a pressing need for accurate guidance.

The Weekly Health Roundup Newsletter by SecondMedic addresses this gap by offering a clear, expert-driven and accessible summary of everything people need to know about their health each week. Designed for families, patients, caregivers and wellness-focused readers, it transforms medical updates into practical, everyday insights.

Why India Needs a Weekly Health Roundup

1. Growing Lifestyle Disease Burden

ICMR and NFHS-5 highlight significant increases in:

Diabetes
Heart disease
Thyroid disorders
Obesity
PCOS

A weekly educational resource empowers individuals to make preventive choices before complications arise.

2. Overload of Health Information

Millions of Indians rely on social media for health advice, leading to confusion and misinformation.
A curated newsletter ensures accuracy.

3. Rising Interest in Preventive Healthcare

People want to understand their bodies better, track health metrics and adopt healthier lifestyles.
The newsletter provides guidance supported by medical evidence.

4. Technological Growth in Healthcare

AI-based tools, wearables and digital monitoring are reshaping healthcare.
Readers learn how to use them effectively.

What the Weekly Health Roundup Covers

• Medical Research Summaries

Digestible versions of new findings from:

ICMR
WHO
Lancet
NITI Aayog
Global medical journals

• Nutrition and Lifestyle Guidance

Includes:

Balanced diets
Myth-busting
Portion control
Affordable nutrition ideas for Indian households

• Chronic Disease Management Tips

Expert insights on:

Diabetes control
Heart health
Blood pressure
Hormonal disorders

• Mental Wellbeing

Stress reduction, emotional resilience and sleep optimisation tips.

• Fitness Recommendations

Simple routines, mobility tips, strength guidance and step-based activity recommendations.

• Seasonal Health Alerts

Information on:

Pollution
Heatwaves
Monsoon infections
Viral outbreaks

• Digital Health Education

Guidance on:

AI health tools
Wearable devices
Teleconsultation benefits
Remote monitoring

How SecondMedic Ensures Accuracy and Quality

Expert Verification

Doctors, nutritionists, physiotherapists and mental health specialists review every issue.

Evidence-Based Approach

Content uses:

Peer-reviewed studies
Real-world health data
National and global guidelines

Personalised Relevance

Topics are selected based on what Indian families most commonly search, ask or struggle with.

Preventive Care Focus

Instead of addressing illness alone, the newsletter promotes long-term lifestyle improvement.

How Readers Benefit

1. Improved Health Literacy

People understand conditions earlier and seek help at the right time.

2. Practical, Actionable Advice

The newsletter offers:

Simple diet swaps
Daily routine tips
Easy-to-follow health habits

3. Early Detection Support

By recognizing symptoms and risk patterns, individuals can prevent complications.

4. Better Use of Digital Tools

Readers learn how AI health guides and wearables support monitoring and early intervention.

5. Family-Centered Wellness

Content is relevant to:

Children
Working adults
Elderly individuals
Chronic disease patients

Example Weekly Topics

A sample edition may include:

"New Findings on Vitamin D Deficiency in Indian Adults"
"How to Interpret Your Blood Sugar Patterns"
"5 AI Tools That Improve Home Health Monitoring"
"Early Signs of Heart Disease You Shouldn’t Ignore"
"Preventive Care Checklist for Busy Professionals"

Conclusion

The Weekly Health Roundup Newsletter is more than just a health update-it is a practical wellness companion. With expert insights, scientific clarity and personalised relevance, it empowers people across India to make smarter health decisions every week.

By turning complex medical knowledge into everyday guidance, SecondMedic strengthens India’s preventive healthcare movement one newsletter at a time.

References

• ICMR - Lifestyle Disease Burden & Research Updates
• NFHS-5 - National Health Indicators & Wellness Trends
• NITI Aayog - Digital Health & Preventive Care Framework
• WHO - Global Wellness & Preventive Healthcare Guidelines
• Lancet - Public Health Research & Behaviour Studies
• Statista India - Digital Health Usage & Reader Behaviour
• EY-FICCI - Health Awareness & Preventive Care Landscape

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