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Published on: Jul 22, 2020
2 minute read
By: Dr Rajan Choudhary

The Oxford Vaccine

Recently we wrote a blog on the success of an RNA vaccine against SARS-CoV-2, the virus responsible for COVID-19. Within just a few weeks of that incredible research breakthrough, researchers at Oxford University’s Jenner Institute have announced a COVID vaccine that has induced remarkable immune response against the virus.

This study was published in the Lancet, one of the most prestigious medical journals in the world, and a simple summary suggests the vaccine has no early safety concern and is able to induce a strong immune response with both T cells and B cell/antibodies.

THE VACCINE

ChAdOx1 nCoV-19, now known as AZD1222, was co-developed by the University of Oxford and one of its spin-off companies, Vaccitech. The vaccine uses a viral vector based on a common cold virus (adenovirus). This carries genetic material for the SARS-CoV-2 spike protein. In our previous blog, we saw how the spike proteins are used by the virus to target and fuse with our target cells, allowing the virus to invade, replicate and ultimately cause the disease known as COVID. It is also a good target for the human immune system to recognize and attack.

The viral vector delivers the genetic material inside our cells. The spike protein is then produced by our cells, recognized by the immune system as a viral target, and an immune response is created against it. This can be antibodies, which recognize, attach to and mark the virus in our blood, allowing for other white blood cells to destroy the virus.

In this case, the vaccine also produced a T cell response. T cells can recognize cells infected by a virus-based on the markers present on the surface of infected cells. They can tell an infected cell to destroy itself, thereby destroying the virus within without spreading the infection. They also have other functions that we will not discuss in this blog.

THE STUDY

This study was a Phase I/II trial that started in April using the vaccine named ChAdOx1 nCoV-19. This vaccine development started in January 2020, and progress on development has been incredibly rapid. Whilst our previous study had just 45 people, this study looked reviewed over 1,000 healthy adults. 10 of these participants received two doses of the vaccine.

In a study the more participants there are, the greater the power of the study. If the vaccine has any side effects, even ones that rarely occur, it is more likely to be picked up in studies with more people. Similarly having more people helps show that the vaccine is effective, and the strong responses are not merely a fluke or accident. Another benefit of this study is it was able to compare the vaccine against a control group. This shows the results were not simply a placebo and allowed comparison of side effects as well.

The majority of side effects were feeling feverish, chills, muscle ache, headache, and malaise, all symptoms treatable with paracetamol. None of the participants had any serious side effects. It took just 14 days to create a T cell response, and 28 days to make strong antibodies. In 91% of patients, this was enough to neutralize the COVID coronavirus. Receiving two doses gave an even stronger antibody response, and all participants were able to stop the virus.

WHAT NEXT

The news from the University of Oxford is needed, as infection rate and mortality continue to increase in countries such as the US and Brazil. The ability to induce an antibody response without causing harm to the patient shows we have made huge progress in the fight against COVID-19. Further Large scale Phase III trials been set up through a global partnership, and include studies in the US with over 30,000 patients, studies in children as well as some in low to middle-income countries.

If successful a vaccine would be essential in preventing a second wave of COVID in the winter when the elderly population is most at risk. And it would be the key to restarting the economy and getting our everyday lives back to where it was pre-pandemic.

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Zincovit Tablets: Uses, Benefits, Dosage, and Side Effects Explained

Nutritional deficiencies are common in India due to irregular diets, stress, fast-paced lifestyles and increased health demands. Multivitamin supplements are often recommended to support overall health, immunity and energy levels. One commonly prescribed supplement is Zincovit tablets.

This comprehensive guide explains what Zincovit is, its uses, benefits, dosage recommendations and potential side effects.

What Are Zincovit Tablets?

Zincovit is a multivitamin and multimineral supplement that contains:

Zinc
Vitamin C
B-complex vitamins
Vitamin A
Vitamin D
Vitamin E
Selenium and other antioxidants

It is commonly prescribed to address nutritional deficiencies and support immune function.

Uses of Zincovit Tablets

Zincovit may be recommended for:

1. Nutritional Deficiencies

Helps replenish low vitamin and mineral levels due to poor diet or illness.

2. Weak Immunity

Zinc and vitamin C support immune system function.

3. Recovery After Illness

Often prescribed during recovery from infections, surgery or prolonged weakness.

4. Fatigue and Low Energy

B vitamins help improve energy metabolism.

5. Hair and Skin Health

Zinc and antioxidants may support healthy skin and hair.

Benefits of Zincovit Tablets

Immune Support

Zinc plays a vital role in immune cell function.

Antioxidant Protection

Vitamins C and E help reduce oxidative stress.

Improved Energy Levels

B-complex vitamins aid in converting food into energy.

Better Nutritional Balance

Supports individuals with dietary gaps.

Support During Stress

Stress can deplete nutrients; supplementation may help maintain balance.

Recommended Dosage

Adults: Usually one tablet daily after meals
Children: Only if prescribed by a pediatrician
Duration: As advised by healthcare professional

Do not exceed recommended dosage without medical guidance.

How to Take Zincovit

Take after food to prevent stomach irritation
Swallow whole with water
Avoid taking with high-calcium foods unless advised

Consistency improves effectiveness.

Possible Side Effects

Zincovit is generally well tolerated. However, some individuals may experience:

Nausea
Mild stomach discomfort
Metallic taste
Constipation or diarrhea (rare)

Severe allergic reactions are uncommon but require immediate medical attention.

Who Should Use Caution?

Consult a doctor before taking Zincovit if you have:

Kidney disorders
Liver disease
Thyroid problems
Known allergies to supplement components

Pregnant and breastfeeding women should seek medical advice before use.

Can Zincovit Be Taken Long-Term?

Short-term use for deficiency correction is common. Long-term use should be monitored by a healthcare provider to avoid excessive intake of certain vitamins or minerals.

Excess zinc intake may interfere with copper absorption if taken excessively over time.

Zincovit and Immunity in India

With increasing concern about immunity and viral infections, supplements containing zinc and antioxidants have gained popularity. However, supplements should complement — not replace — a balanced diet rich in:

Fruits
Vegetables
Whole grains
Protein sources

Healthy lifestyle habits remain essential.

When to Consult a Doctor

Seek medical advice if you experience:

Persistent fatigue
Recurrent infections
Unexplained weight loss
Severe weakness

These may indicate underlying medical conditions beyond nutritional deficiency.

Balanced Nutrition Still Matters

Supplements cannot substitute a healthy diet. Combine Zincovit with:

Proper hydration
Regular exercise
Adequate sleep
Stress management

This ensures overall wellness.

Conclusion

Zincovit tablets are widely used multivitamin supplements that support immunity, energy levels and overall nutritional balance. When taken in recommended doses, they are generally safe and beneficial for individuals with dietary deficiencies or increased nutritional needs.

However, supplements should be used responsibly and under medical guidance, especially for long-term use. Maintaining a healthy diet and lifestyle remains the foundation of good health.

If you are unsure whether Zincovit is right for you, consult a healthcare professional for personalized advice.

References

Indian Council of Medical Research – Nutrient Guidelines
World Health Organization – Micronutrient Recommendations
National Health Portal India – Supplement Safety
Journal of Clinical Nutrition – Zinc and Immunity Studies
National Institute of Nutrition India – Dietary Guidelines

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