Call
+918447748545

Published on: Jul 22, 2020
2 minute read
By: Dr Rajan Choudhary

The Oxford Vaccine

Recently we wrote a blog on the success of an RNA vaccine against SARS-CoV-2, the virus responsible for COVID-19. Within just a few weeks of that incredible research breakthrough, researchers at Oxford University’s Jenner Institute have announced a COVID vaccine that has induced remarkable immune response against the virus.

This study was published in the Lancet, one of the most prestigious medical journals in the world, and a simple summary suggests the vaccine has no early safety concern and is able to induce a strong immune response with both T cells and B cell/antibodies.

THE VACCINE

ChAdOx1 nCoV-19, now known as AZD1222, was co-developed by the University of Oxford and one of its spin-off companies, Vaccitech. The vaccine uses a viral vector based on a common cold virus (adenovirus). This carries genetic material for the SARS-CoV-2 spike protein. In our previous blog, we saw how the spike proteins are used by the virus to target and fuse with our target cells, allowing the virus to invade, replicate and ultimately cause the disease known as COVID. It is also a good target for the human immune system to recognize and attack.

The viral vector delivers the genetic material inside our cells. The spike protein is then produced by our cells, recognized by the immune system as a viral target, and an immune response is created against it. This can be antibodies, which recognize, attach to and mark the virus in our blood, allowing for other white blood cells to destroy the virus.

In this case, the vaccine also produced a T cell response. T cells can recognize cells infected by a virus-based on the markers present on the surface of infected cells. They can tell an infected cell to destroy itself, thereby destroying the virus within without spreading the infection. They also have other functions that we will not discuss in this blog.

THE STUDY

This study was a Phase I/II trial that started in April using the vaccine named ChAdOx1 nCoV-19. This vaccine development started in January 2020, and progress on development has been incredibly rapid. Whilst our previous study had just 45 people, this study looked reviewed over 1,000 healthy adults. 10 of these participants received two doses of the vaccine.

In a study the more participants there are, the greater the power of the study. If the vaccine has any side effects, even ones that rarely occur, it is more likely to be picked up in studies with more people. Similarly having more people helps show that the vaccine is effective, and the strong responses are not merely a fluke or accident. Another benefit of this study is it was able to compare the vaccine against a control group. This shows the results were not simply a placebo and allowed comparison of side effects as well.

The majority of side effects were feeling feverish, chills, muscle ache, headache, and malaise, all symptoms treatable with paracetamol. None of the participants had any serious side effects. It took just 14 days to create a T cell response, and 28 days to make strong antibodies. In 91% of patients, this was enough to neutralize the COVID coronavirus. Receiving two doses gave an even stronger antibody response, and all participants were able to stop the virus.

WHAT NEXT

The news from the University of Oxford is needed, as infection rate and mortality continue to increase in countries such as the US and Brazil. The ability to induce an antibody response without causing harm to the patient shows we have made huge progress in the fight against COVID-19. Further Large scale Phase III trials been set up through a global partnership, and include studies in the US with over 30,000 patients, studies in children as well as some in low to middle-income countries.

If successful a vaccine would be essential in preventing a second wave of COVID in the winter when the elderly population is most at risk. And it would be the key to restarting the economy and getting our everyday lives back to where it was pre-pandemic.

Read Blog

Early Signs of a Weakened Immune System: Symptoms You Should Not Ignore

The immune system is the body’s natural defense mechanism against infections, bacteria and viruses. It works continuously to identify and eliminate harmful pathogens that may threaten health. However, when the immune system becomes weakened, the body becomes more vulnerable to illness and infections.

Recognizing the early signs of a weakened immune system is essential for maintaining overall health and preventing serious complications. Early awareness allows individuals to make lifestyle changes and seek medical advice if necessary.

Understanding the Immune System

The immune system is composed of:

White blood cells
Antibodies
Lymph nodes
Bone marrow
The spleen and thymus

These components work together to detect and destroy harmful organisms. When immunity is compromised, this protective mechanism becomes less effective.

1. Frequent Infections

One of the most common signs of weakened immunity is experiencing frequent infections.

These may include:

Recurrent colds
Sinus infections
Ear infections
Respiratory illnesses

If infections occur repeatedly or take longer than usual to recover, it may indicate reduced immune strength.

2. Persistent Fatigue

Constant tiredness despite adequate sleep may signal an underlying immune imbalance.

When the immune system is weakened, the body uses more energy to fight potential threats, leading to prolonged fatigue.

3. Slow Wound Healing

A healthy immune system supports tissue repair and healing.

Cuts, bruises or minor injuries that take longer than usual to heal may indicate weakened immune function.

Delayed healing may also increase infection risk.

4. Digestive Problems

A significant portion of the immune system is located in the gastrointestinal tract.

Digestive symptoms such as:

Frequent diarrhea
Bloating
Constipation

may reflect imbalance in gut health and immunity.

5. Frequent Allergies or Sensitivities

A weakened immune system may overreact to harmless substances, causing allergic reactions.

Symptoms may include:

Sneezing
Skin irritation
Food sensitivities

Maintaining immune balance helps regulate these responses.

6. Recurring Fever

Frequent low-grade fever may occur when the body is constantly attempting to fight infections.

This may indicate ongoing immune stress.

7. Increased Susceptibility to Stress

Chronic stress significantly affects immune function.

Stress hormones such as cortisol may suppress immune responses, making the body more vulnerable to illness.

Common Causes of Weak Immunity

Several lifestyle and health factors can weaken the immune system:

Poor nutrition
Lack of sleep
Chronic stress
Sedentary lifestyle
Smoking or excessive alcohol consumption
Chronic illnesses

Identifying these factors is important for improving immune health.

Strengthening the Immune System Naturally

Maintain a Balanced Diet

Consume foods rich in:

Vitamin C
Vitamin D
Zinc
Antioxidants

Fruits, vegetables, nuts and whole grains support immune function.

Prioritize Sleep

Adequate sleep allows the immune system to repair and regenerate.

Adults should aim for 7–8 hours of sleep daily.

Stay Physically Active

Moderate physical activity improves circulation and supports immune response.

Regular exercise also reduces stress levels.

Manage Stress

Practices such as meditation, breathing exercises and relaxation techniques help regulate stress hormones.

Maintain Hygiene

Simple habits like handwashing reduce exposure to harmful pathogens.

Weak Immunity in the Indian Context

In India, factors such as nutritional deficiencies, pollution exposure and high stress levels contribute to weakened immunity among many individuals.

Public health initiatives increasingly emphasize balanced nutrition, vaccination and healthy lifestyle habits to improve immune resilience.

When to Consult a Doctor

Seek medical advice if you experience:

Frequent infections
Persistent fatigue
Unexplained weight loss
Recurrent fever
Slow healing wounds

Medical evaluation may identify underlying health conditions affecting immunity.

Conclusion

Recognizing the early signs of a weakened immune system is essential for protecting long-term health. Symptoms such as frequent infections, fatigue and slow wound healing may indicate that the body’s defense mechanisms need support.

By adopting healthy lifestyle habits, maintaining balanced nutrition and managing stress effectively, individuals can strengthen immune function and reduce the risk of illness.

Listening to the body’s warning signals and seeking timely medical guidance ensures better health outcomes and improved wellbeing.

A strong immune system is the foundation of a healthy life.

References

Indian Council of Medical Research – Immunity and Nutrition Reports
World Health Organization – Immune Health Guidelines
National Institute of Nutrition India – Dietary Recommendations
Journal of Clinical Immunology – Immune System Research
Lancet Global Health – Public Health and Immunity Studies

Request A Callback

+91

By using this website/app, I confirm that I am at least 18 years old and consent to the processing of my personal data in accordance with the Terms of Service, Privacy Policy, and Declaration.