Call
+918447748545

Published on: Jul 22, 2020
2 minute read
By: Dr Rajan Choudhary

The Oxford Vaccine

Recently we wrote a blog on the success of an RNA vaccine against SARS-CoV-2, the virus responsible for COVID-19. Within just a few weeks of that incredible research breakthrough, researchers at Oxford University’s Jenner Institute have announced a COVID vaccine that has induced remarkable immune response against the virus.

This study was published in the Lancet, one of the most prestigious medical journals in the world, and a simple summary suggests the vaccine has no early safety concern and is able to induce a strong immune response with both T cells and B cell/antibodies.

THE VACCINE

ChAdOx1 nCoV-19, now known as AZD1222, was co-developed by the University of Oxford and one of its spin-off companies, Vaccitech. The vaccine uses a viral vector based on a common cold virus (adenovirus). This carries genetic material for the SARS-CoV-2 spike protein. In our previous blog, we saw how the spike proteins are used by the virus to target and fuse with our target cells, allowing the virus to invade, replicate and ultimately cause the disease known as COVID. It is also a good target for the human immune system to recognize and attack.

The viral vector delivers the genetic material inside our cells. The spike protein is then produced by our cells, recognized by the immune system as a viral target, and an immune response is created against it. This can be antibodies, which recognize, attach to and mark the virus in our blood, allowing for other white blood cells to destroy the virus.

In this case, the vaccine also produced a T cell response. T cells can recognize cells infected by a virus-based on the markers present on the surface of infected cells. They can tell an infected cell to destroy itself, thereby destroying the virus within without spreading the infection. They also have other functions that we will not discuss in this blog.

THE STUDY

This study was a Phase I/II trial that started in April using the vaccine named ChAdOx1 nCoV-19. This vaccine development started in January 2020, and progress on development has been incredibly rapid. Whilst our previous study had just 45 people, this study looked reviewed over 1,000 healthy adults. 10 of these participants received two doses of the vaccine.

In a study the more participants there are, the greater the power of the study. If the vaccine has any side effects, even ones that rarely occur, it is more likely to be picked up in studies with more people. Similarly having more people helps show that the vaccine is effective, and the strong responses are not merely a fluke or accident. Another benefit of this study is it was able to compare the vaccine against a control group. This shows the results were not simply a placebo and allowed comparison of side effects as well.

The majority of side effects were feeling feverish, chills, muscle ache, headache, and malaise, all symptoms treatable with paracetamol. None of the participants had any serious side effects. It took just 14 days to create a T cell response, and 28 days to make strong antibodies. In 91% of patients, this was enough to neutralize the COVID coronavirus. Receiving two doses gave an even stronger antibody response, and all participants were able to stop the virus.

WHAT NEXT

The news from the University of Oxford is needed, as infection rate and mortality continue to increase in countries such as the US and Brazil. The ability to induce an antibody response without causing harm to the patient shows we have made huge progress in the fight against COVID-19. Further Large scale Phase III trials been set up through a global partnership, and include studies in the US with over 30,000 patients, studies in children as well as some in low to middle-income countries.

If successful a vaccine would be essential in preventing a second wave of COVID in the winter when the elderly population is most at risk. And it would be the key to restarting the economy and getting our everyday lives back to where it was pre-pandemic.

Read Blog

Pale Skin Symptoms: Causes, Health Conditions, and When to Seek Medical Care

Skin colour provides important clues about internal health. When the skin becomes noticeably lighter than usual, it may indicate an underlying medical condition. Pale skin symptoms, also referred to as pallor, are commonly associated with reduced blood flow, low hemoglobin levels or impaired oxygen delivery to tissues.

In India, pale skin is frequently linked to anemia, nutritional deficiencies and chronic illnesses, making early recognition essential.

What Is Pale Skin?

Pale skin refers to:

lighter-than-normal skin tone
reduced redness
pale appearance of lips, gums or nail beds

It can affect the entire body or specific areas such as the face or hands.

Common Pale Skin Symptoms

Typical signs include:

pale face or complexion
pale lips or tongue
light-colored gums
pale nail beds
cold hands and feet
fatigue and weakness

These symptoms often occur together.

Most Common Causes of Pale Skin

Anemia

Anemia occurs when hemoglobin levels are low.

This reduces oxygen delivery to tissues, causing:

pale skin
fatigue
breathlessness
dizziness

NFHS-5 reports anemia affects a large proportion of Indian adults, especially women.

Iron Deficiency

Iron deficiency is the leading cause of anemia.

Contributing factors include:

poor dietary intake
blood loss
absorption problems

ICMR identifies iron deficiency as a major public health issue.

Poor Blood Circulation

Reduced circulation causes:

less blood reaching the skin
visible pallor

Conditions such as heart disease or shock impair circulation.

Acute Blood Loss

Sudden blood loss from:

injury
gastrointestinal bleeding
heavy menstrual bleeding

can cause rapid pallor and weakness.

Chronic Diseases

Chronic illnesses such as:

kidney disease
liver disease
cancer

often cause anemia and pallor over time.

Infections and Inflammation

Severe infections cause:

blood vessel constriction
redistribution of blood flow

This leads to pale or clammy skin.

Nutritional Deficiencies

Deficiencies of:

vitamin B12
folate

affect red blood cell production and cause pallor.

Hormonal Imbalance

Conditions like hypothyroidism reduce metabolic activity, causing:

pale, dry skin
fatigue

Thyroid disorders are common but underdiagnosed.

Genetic Conditions

Inherited disorders such as thalassemia affect hemoglobin production, leading to chronic pallor.

Pale Skin in Children and Older Adults

Children:

may develop pallor due to iron deficiency or infections

Older adults:

often develop pallor due to chronic disease or nutritional deficiency

Both groups need careful evaluation.

Warning Signs That Need Immediate Medical Attention

Seek urgent care if pale skin is associated with:

sudden weakness
chest pain
breathlessness
fainting
rapid heartbeat

These may indicate serious medical emergencies.

How Pale Skin Affects Daily Life

Persistent pallor often causes:

low energy
reduced physical endurance
difficulty concentrating

Quality of life may decline without treatment.

Diagnostic Evaluation

Doctors may recommend:

complete blood count
iron studies
vitamin B12 and folate levels
kidney and liver function tests

Identifying the cause is critical for treatment.

Role of Preventive Health Checkups

Preventive screening helps detect:

early anemia
nutritional deficiencies
chronic disease

Early treatment prevents complications.

Management and Treatment Options

Treatment depends on cause and may include:

iron or vitamin supplementation
treatment of underlying disease
dietary correction
medical therapy for chronic conditions

Self-treatment without diagnosis should be avoided.

Lifestyle Measures to Prevent Pallor

Helpful strategies include:

balanced diet rich in iron and vitamins
adequate hydration
regular health monitoring
treating infections early

Lifestyle changes support long-term health.

Importance of Early Detection

Ignoring pale skin delays diagnosis of:

anemia
internal bleeding
chronic illness

Early recognition improves outcomes.

Conclusion

Pale skin symptoms are more than a cosmetic concern. They often signal anemia, poor circulation, nutritional deficiencies or underlying medical conditions. While temporary pallor may occur due to minor causes, persistent or sudden pale skin requires medical evaluation. Early diagnosis, preventive health screening and appropriate treatment can restore normal skin tone, improve energy levels and protect long-term health.

References

Indian Council of Medical Research (ICMR) – Anemia and Nutritional Deficiency Reports
National Family Health Survey (NFHS-5) – Anemia and Adult Health Data
World Health Organization (WHO) – Anemia and Circulatory Health
Lancet – Pallor, Anemia and Chronic Disease Research
NITI Aayog – Preventive Healthcare and Early Symptom Detection

Request A Callback

+91

By using this website/app, I confirm that I am at least 18 years old and consent to the processing of my personal data in accordance with the Terms of Service, Privacy Policy, and Declaration.