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Published on: Apr 04, 2020
2 minute read
By: Dr Rajan Choudhary

THE CHALLENGES FACED IN MAKING A VACCINE FOR COVID-19 — Part 2

Previously we’ve seen the difficulties researches face in trying to make a vaccine. But even if we make a vaccine, that’s just half the battle. Viruses are unique because they can mutate, and they can mutate to astonishing degrees. In humans mutations to tiny parts of our DNA can cause severe diseases or even death. In viruses mutations can change their structure, making them more infective and giving them a new coat. It gives them a survival advantage, the ability to evade our immune system and make our vaccines ineffective. This is why we need a new flu vaccine every year.

If it takes months to a year to develop a vaccine, it will be based off the virus found in December 2019. By this time the virus may have spread and mutated to such a degree that it is not effective. This does not mean all the effort was for nothing. Going through the steps and understanding the issues faced with making a COVID-19 vaccine can make the process quicker for subsequent vaccines against its mutated versions.

https://www.sciencealert.com/who-says-a-coronavirus-vaccine-is-18-months-away So Long to Develop a Vaccine

FAILURES FROM THE PAST

These issues were faced during the Ebola and Zika virus epidemics, and many large companies are understandably hesitant to develop vaccines for COVID-19. Ebola first broke out in 2014, and it was only in December 2019 that the first vaccine was approved for use by the European Commission and the United States. This is despite multiple large institutes in Canada and the UK working together to develop it.

13 different Ebola vaccine candidates had been identified soon after the outbreak, but none had been tested on humans. Unfortunately this is the most expensive part of development, and the area biopharmecuticals stand to loose the most money. Return on investments is also low, since epidemics usually take place in poorer countries, and the potential customers are unable to pay the high prices for these brand new treatments. It is an unfortunate realisation that research into medicines is driven by rich countries, for diseases that affect the rich.

https://newint.org/features/web-exclusive/2016/06/16/why-did-the-market-fail-to-produce-an-ebola-vaccine Ebola

WHERE ARE WE NOW?

This is all well and good, but what does it mean for COVID-19? We know we cannot rush a vaccine, because a poorly designed vaccine with unknown side effects can cause more harm than good, especially if given to children or the elderly. Currently the WHO are tracking 31 different attempts at making a COVID-19 vaccine, using different methods as discussed before. All of these are currently in the pre-clinical stage, focusing on isolating parts of the virus and creating a target the body will recognise and react to.

Researchers at the University of Queensland were one of the first to start using the genetic code of COVID-19, released openly by Chinese researchers. They have developed a test vaccine within 6 weeks using state-of-the-art genetic techniques, used for the first time. If animal models prove successful then human testing might begin within 6 months. In the pharmaceutical industry advancements this quick are almost unheard of.

Additionally over 293 clinical trials are taking place in China using existing drugs on the market. The advantage is we already know these drugs are safe to use in humans, but we are trying to work out if they will work against COVID-19. Some scientists are also looking at medications that were initially developed against SARS and MERS, but never completed because these outbreaks died down and the medication was no longer required.

https://www.aljazeera.com/news/2020/03/china-recovered-develop-effective-covid-19-treatments-200302082850237.html COVID-19 treatments

https://www.who.int/blueprint/priority-diseases/key-action/novel-coronavirus-landscape-ncov.pdf?ua=1 WHO news

https://www.theverge.com/2020/2/28/21156385/covid-coronavirus-vaccine-treatment-moderna-remdesivir-research COVID-19 treatment

Its not all doom and gloom. Challenges drive innovation, and we are already benefitting from this. New forms of genetic sequencing, new methods for extracting viral proteins, new techniques in creating a vaccine. These innovations are already benefitting us on the drive to create an effective vaccine for COVID-19, and they will benefit us in the future when the next pandemic hits.

Dr Rajan Choudhary, Product Manager Second Medic UK

www.secondmedic.com

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Digestive System Disorders: Common Causes, Symptoms, and Prevention Tips

The digestive system plays a vital role in overall health by breaking down food, absorbing nutrients and eliminating waste. When this system does not function properly, it can lead to discomfort, poor nutrition and chronic illness. Digestive system disorders are increasingly common due to modern lifestyles, dietary habits and stress. Understanding their causes, symptoms and prevention strategies is essential for maintaining long-term gut health.

Public health research shows that a large proportion of adults experience digestive symptoms at some point in their lives, yet many delay seeking care until problems become severe.

What Are Digestive System Disorders?

Digestive system disorders are conditions that affect:

the oesophagus
stomach
intestines
liver
pancreas
gallbladder

They may be temporary or chronic and range from mild functional issues to serious inflammatory or structural diseases.

Common Digestive System Disorders

Acid Reflux and GERD

Gastroesophageal reflux disease (GERD) occurs when stomach acid flows back into the oesophagus.

Symptoms include:

heartburn
chest discomfort
sour taste in mouth
difficulty swallowing

Long-term reflux can damage the oesophagus if untreated.

Irritable Bowel Syndrome (IBS)

IBS is a functional bowel disorder.

Symptoms include:

abdominal pain
bloating
diarrhoea or constipation
alternating bowel habits

Stress and diet often trigger symptoms.

Constipation

Constipation involves infrequent or difficult bowel movements.

Causes include:

low fibre intake
dehydration
sedentary lifestyle

Chronic constipation affects comfort and gut function.

Diarrhoea

Diarrhoea results from rapid bowel movements.

Common causes include:

infections
food intolerance
medication side effects

Persistent diarrhoea may lead to dehydration and nutrient loss.

Peptic Ulcer Disease

Ulcers are sores in the stomach or intestinal lining.

Symptoms include:

burning stomach pain
nausea
bloating

They are often linked to infections or long-term medication use.

Inflammatory Bowel Disease (IBD)

IBD includes conditions like Crohn’s disease and ulcerative colitis.

Symptoms include:

chronic diarrhoea
abdominal pain
weight loss
fatigue

IBD requires long-term medical management.

Common Symptoms of Digestive Disorders

Digestive system disorders often present with:

abdominal pain or cramps
bloating and gas
nausea or vomiting
constipation or diarrhoea
heartburn
unexplained weight changes

Symptoms may fluctuate and worsen with stress or poor diet.

Causes of Digestive System Disorders

Poor Dietary Habits

Diets high in:

processed foods
refined sugars
unhealthy fats

strain the digestive system and alter gut microbiota.

Stress and Mental Health

Chronic stress affects gut-brain communication, worsening digestive symptoms.

Infections

Bacterial, viral or parasitic infections disrupt gut function.

Food Intolerances

Lactose, gluten or other intolerances cause digestive distress.

Sedentary Lifestyle

Lack of physical activity slows digestion and bowel movement.

Medication Use

Certain medications irritate the stomach lining or alter gut flora.

Who Is at Higher Risk?

People at increased risk include:

individuals with poor diet
those under chronic stress
older adults
people with family history of gut disease
individuals with sedentary lifestyles

Early lifestyle correction reduces risk significantly.

Diagnosis of Digestive Disorders

Evaluation may include:

medical history
physical examination
blood tests
stool tests
imaging or endoscopy

Diagnosis depends on symptom severity and duration.

Treatment Approaches

Medical Management

Treatment varies by condition and may include:

acid suppressants
anti-inflammatory medications
probiotics
antibiotics when needed

Dietary Modifications

increase fibre intake
limit trigger foods
eat regular meals
avoid excessive alcohol

Diet plays a central role in gut health.

Lifestyle Changes

manage stress
exercise regularly
stay hydrated
maintain sleep routine

Healthy habits support digestive function.

Prevention Tips for Digestive Health

Eat a Balanced Diet

Include fruits, vegetables, whole grains and lean proteins.

Stay Hydrated

Water supports digestion and prevents constipation.

Manage Stress

Mindfulness and relaxation techniques improve gut-brain balance.

Be Physically Active

Movement stimulates bowel activity and gut motility.

Avoid Smoking and Excess Alcohol

These irritate the digestive tract and worsen symptoms.

Seek Early Medical Advice

Early care prevents complications and chronic disease.

Long-Term Impact of Ignoring Digestive Problems

Untreated digestive disorders may lead to:

nutrient deficiencies
chronic inflammation
poor quality of life
increased disease complications

Early intervention is more effective and less invasive.

When to Consult a Doctor

Medical advice is recommended if:

symptoms persist beyond weeks
pain is severe
blood appears in stool
unexplained weight loss occurs

Prompt evaluation ensures safe management.

Conclusion

Digestive system disorders are common but often underestimated health issues. Symptoms such as bloating, pain, constipation and heartburn may seem minor initially but can signal deeper problems if ignored. Understanding causes, recognising early symptoms and adopting preventive habits help protect digestive health. With timely care, balanced nutrition and healthy lifestyle choices, most digestive disorders can be effectively managed, allowing the digestive system to function smoothly and support overall wellbeing.

References

Indian Council of Medical Research (ICMR) – Digestive Health and Nutrition Reports
World Health Organization (WHO) – Digestive Disorders and Gut Health Guideline
National Institute of Nutrition (NIN) – Dietary Fibre and Gut Health Researc
Lancet – Gastrointestinal Disease and Prevention Studies
Indian Journal of Gastroenterology – Digestive Disorder Research
Statista – Digestive Health Trends and Lifestyle Factors

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