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Published on: Apr 04, 2020
2 minute read
By: Dr Rajan Choudhary

THE CHALLENGES FACED IN MAKING A VACCINE FOR COVID-19 — Part 2

Previously we’ve seen the difficulties researches face in trying to make a vaccine. But even if we make a vaccine, that’s just half the battle. Viruses are unique because they can mutate, and they can mutate to astonishing degrees. In humans mutations to tiny parts of our DNA can cause severe diseases or even death. In viruses mutations can change their structure, making them more infective and giving them a new coat. It gives them a survival advantage, the ability to evade our immune system and make our vaccines ineffective. This is why we need a new flu vaccine every year.

If it takes months to a year to develop a vaccine, it will be based off the virus found in December 2019. By this time the virus may have spread and mutated to such a degree that it is not effective. This does not mean all the effort was for nothing. Going through the steps and understanding the issues faced with making a COVID-19 vaccine can make the process quicker for subsequent vaccines against its mutated versions.

https://www.sciencealert.com/who-says-a-coronavirus-vaccine-is-18-months-away So Long to Develop a Vaccine

FAILURES FROM THE PAST

These issues were faced during the Ebola and Zika virus epidemics, and many large companies are understandably hesitant to develop vaccines for COVID-19. Ebola first broke out in 2014, and it was only in December 2019 that the first vaccine was approved for use by the European Commission and the United States. This is despite multiple large institutes in Canada and the UK working together to develop it.

13 different Ebola vaccine candidates had been identified soon after the outbreak, but none had been tested on humans. Unfortunately this is the most expensive part of development, and the area biopharmecuticals stand to loose the most money. Return on investments is also low, since epidemics usually take place in poorer countries, and the potential customers are unable to pay the high prices for these brand new treatments. It is an unfortunate realisation that research into medicines is driven by rich countries, for diseases that affect the rich.

https://newint.org/features/web-exclusive/2016/06/16/why-did-the-market-fail-to-produce-an-ebola-vaccine Ebola

WHERE ARE WE NOW?

This is all well and good, but what does it mean for COVID-19? We know we cannot rush a vaccine, because a poorly designed vaccine with unknown side effects can cause more harm than good, especially if given to children or the elderly. Currently the WHO are tracking 31 different attempts at making a COVID-19 vaccine, using different methods as discussed before. All of these are currently in the pre-clinical stage, focusing on isolating parts of the virus and creating a target the body will recognise and react to.

Researchers at the University of Queensland were one of the first to start using the genetic code of COVID-19, released openly by Chinese researchers. They have developed a test vaccine within 6 weeks using state-of-the-art genetic techniques, used for the first time. If animal models prove successful then human testing might begin within 6 months. In the pharmaceutical industry advancements this quick are almost unheard of.

Additionally over 293 clinical trials are taking place in China using existing drugs on the market. The advantage is we already know these drugs are safe to use in humans, but we are trying to work out if they will work against COVID-19. Some scientists are also looking at medications that were initially developed against SARS and MERS, but never completed because these outbreaks died down and the medication was no longer required.

https://www.aljazeera.com/news/2020/03/china-recovered-develop-effective-covid-19-treatments-200302082850237.html COVID-19 treatments

https://www.who.int/blueprint/priority-diseases/key-action/novel-coronavirus-landscape-ncov.pdf?ua=1 WHO news

https://www.theverge.com/2020/2/28/21156385/covid-coronavirus-vaccine-treatment-moderna-remdesivir-research COVID-19 treatment

Its not all doom and gloom. Challenges drive innovation, and we are already benefitting from this. New forms of genetic sequencing, new methods for extracting viral proteins, new techniques in creating a vaccine. These innovations are already benefitting us on the drive to create an effective vaccine for COVID-19, and they will benefit us in the future when the next pandemic hits.

Dr Rajan Choudhary, Product Manager Second Medic UK

www.secondmedic.com

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Health Risks of Irregular Eating Habits: How Skipping Meals Affects Your Body

Maintaining a balanced and consistent diet is essential for good health. However, modern lifestyles often lead to irregular eating patterns due to busy schedules, work stress and changing daily routines. Many people skip meals, eat late at night or consume food at inconsistent times.

Understanding the health risks of irregular eating habits is important for maintaining metabolic balance and overall wellbeing. Consistent meal timing plays a key role in supporting digestion, energy levels and long-term health.

What Are Irregular Eating Habits?

Irregular eating habits refer to inconsistent or unpredictable meal patterns.

Common examples include:

Skipping breakfast or other meals
Eating meals at varying times each day
Consuming large meals late at night
Frequently replacing meals with snacks

These habits may disrupt the body’s natural metabolic rhythm.

How the Body Regulates Eating Patterns

The human body follows internal biological rhythms that regulate hunger, metabolism and digestion.

When meals occur at consistent times, the digestive system prepares enzymes and hormones needed for efficient food processing.

Irregular eating patterns may interfere with these processes.

1. Disruption of Metabolism

Metabolism refers to the process by which the body converts food into energy.

Skipping meals or eating inconsistently may slow metabolic activity, making it harder for the body to regulate energy balance.

This disruption may contribute to metabolic disorders over time.

2. Increased Risk of Weight Gain

Although skipping meals may appear to reduce calorie intake, it often leads to overeating later in the day.

Large or late meals may increase calorie consumption and contribute to weight gain.

Irregular eating may also affect hormones that regulate appetite.

3. Digestive Problems

The digestive system functions best when meals occur at regular intervals.

Irregular eating may cause symptoms such as:

Acid reflux
Bloating
Indigestion
Stomach discomfort

Consistent meal timing helps maintain digestive balance.

4. Fluctuating Energy Levels

Skipping meals can lead to sudden drops in blood sugar levels.

Low blood sugar may cause symptoms such as:

Fatigue
Dizziness
Difficulty concentrating

Regular meals help maintain steady energy throughout the day.

5. Impact on Blood Sugar Control

Irregular eating patterns may disrupt glucose regulation.

Over time, inconsistent meal timing may increase the risk of insulin resistance and type 2 diabetes.

Maintaining stable blood sugar levels is important for metabolic health.

6. Nutritional Deficiencies

Skipping meals can reduce the intake of essential nutrients required for body function.

A balanced diet provides vitamins, minerals and other nutrients needed for immunity, metabolism and overall health.

Irregular eating habits may lead to nutritional imbalances.

Irregular Eating Habits in the Indian Context

In many urban areas of India, demanding work schedules and long commuting times often lead to irregular meal patterns.

Late-night eating, fast food consumption and skipped meals have become common among professionals and students.

These lifestyle patterns may increase the risk of metabolic and digestive health problems.

Promoting regular meal timing and balanced diets is essential for improving public health.

Tips to Maintain Healthy Eating Habits

Establish Regular Meal Times

Eating meals at consistent times each day helps regulate digestion and metabolism.

Do Not Skip Breakfast

Breakfast provides essential energy for starting the day and supports metabolic activity.

Plan Balanced Meals

Include a variety of foods such as:

Whole grains
Fruits and vegetables
Lean proteins
Healthy fats

Balanced nutrition supports overall health.

Avoid Late-Night Heavy Meals

Eating large meals close to bedtime may disrupt digestion and sleep.

Stay Hydrated

Adequate hydration supports digestion and nutrient absorption.

When to Seek Medical Advice

Consult a healthcare professional if irregular eating habits lead to:

Persistent digestive problems
Unexplained weight changes
Chronic fatigue
Blood sugar irregularities

Early intervention can help prevent long-term health complications.

Conclusion

Irregular eating habits may significantly impact metabolism, digestion and overall health. Skipping meals, inconsistent meal timing and late-night eating can disrupt the body’s natural rhythms and increase the risk of metabolic disorders.

Maintaining consistent meal schedules, balanced nutrition and healthy lifestyle habits can support digestive health and stable energy levels.

By adopting regular eating routines, individuals can improve metabolic balance and reduce the risk of long-term health complications.

Healthy eating patterns are a fundamental part of maintaining overall wellbeing and long-term health.

References

Indian Council of Medical Research – Nutrition and Dietary Guidelines
World Health Organization – Healthy Diet Recommendations
National Institute of Nutrition India – Balanced Meal Guidelines
Journal of Nutrition and Metabolism – Meal Timing Research
Lancet Global Health – Nutrition and Lifestyle Studies

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