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Published on: Apr 04, 2020
2 minute read
By: Dr Rajan Choudhary

THE CHALLENGES FACED IN MAKING A VACCINE FOR COVID-19 — Part 2

Previously we’ve seen the difficulties researches face in trying to make a vaccine. But even if we make a vaccine, that’s just half the battle. Viruses are unique because they can mutate, and they can mutate to astonishing degrees. In humans mutations to tiny parts of our DNA can cause severe diseases or even death. In viruses mutations can change their structure, making them more infective and giving them a new coat. It gives them a survival advantage, the ability to evade our immune system and make our vaccines ineffective. This is why we need a new flu vaccine every year.

If it takes months to a year to develop a vaccine, it will be based off the virus found in December 2019. By this time the virus may have spread and mutated to such a degree that it is not effective. This does not mean all the effort was for nothing. Going through the steps and understanding the issues faced with making a COVID-19 vaccine can make the process quicker for subsequent vaccines against its mutated versions.

https://www.sciencealert.com/who-says-a-coronavirus-vaccine-is-18-months-away So Long to Develop a Vaccine

FAILURES FROM THE PAST

These issues were faced during the Ebola and Zika virus epidemics, and many large companies are understandably hesitant to develop vaccines for COVID-19. Ebola first broke out in 2014, and it was only in December 2019 that the first vaccine was approved for use by the European Commission and the United States. This is despite multiple large institutes in Canada and the UK working together to develop it.

13 different Ebola vaccine candidates had been identified soon after the outbreak, but none had been tested on humans. Unfortunately this is the most expensive part of development, and the area biopharmecuticals stand to loose the most money. Return on investments is also low, since epidemics usually take place in poorer countries, and the potential customers are unable to pay the high prices for these brand new treatments. It is an unfortunate realisation that research into medicines is driven by rich countries, for diseases that affect the rich.

https://newint.org/features/web-exclusive/2016/06/16/why-did-the-market-fail-to-produce-an-ebola-vaccine Ebola

WHERE ARE WE NOW?

This is all well and good, but what does it mean for COVID-19? We know we cannot rush a vaccine, because a poorly designed vaccine with unknown side effects can cause more harm than good, especially if given to children or the elderly. Currently the WHO are tracking 31 different attempts at making a COVID-19 vaccine, using different methods as discussed before. All of these are currently in the pre-clinical stage, focusing on isolating parts of the virus and creating a target the body will recognise and react to.

Researchers at the University of Queensland were one of the first to start using the genetic code of COVID-19, released openly by Chinese researchers. They have developed a test vaccine within 6 weeks using state-of-the-art genetic techniques, used for the first time. If animal models prove successful then human testing might begin within 6 months. In the pharmaceutical industry advancements this quick are almost unheard of.

Additionally over 293 clinical trials are taking place in China using existing drugs on the market. The advantage is we already know these drugs are safe to use in humans, but we are trying to work out if they will work against COVID-19. Some scientists are also looking at medications that were initially developed against SARS and MERS, but never completed because these outbreaks died down and the medication was no longer required.

https://www.aljazeera.com/news/2020/03/china-recovered-develop-effective-covid-19-treatments-200302082850237.html COVID-19 treatments

https://www.who.int/blueprint/priority-diseases/key-action/novel-coronavirus-landscape-ncov.pdf?ua=1 WHO news

https://www.theverge.com/2020/2/28/21156385/covid-coronavirus-vaccine-treatment-moderna-remdesivir-research COVID-19 treatment

Its not all doom and gloom. Challenges drive innovation, and we are already benefitting from this. New forms of genetic sequencing, new methods for extracting viral proteins, new techniques in creating a vaccine. These innovations are already benefitting us on the drive to create an effective vaccine for COVID-19, and they will benefit us in the future when the next pandemic hits.

Dr Rajan Choudhary, Product Manager Second Medic UK

www.secondmedic.com

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How Cold Weather Affects Health: Understanding Winter’s Impact on the Body

Seasonal changes influence human health more than most people realise. Cold weather, in particular, places unique stress on the body and can worsen existing health conditions while increasing susceptibility to new illnesses. Understanding how cold weather affects health is essential for preventing seasonal complications and maintaining wellbeing during winter months.

In India, winter-related health issues vary by region but commonly include respiratory infections, cardiovascular strain and joint discomfort. According to the Indian Council of Medical Research (ICMR) and World Health Organization (WHO), cold exposure is associated with increased morbidity, especially among older adults and people with chronic conditions.

Why Cold Weather Impacts the Body

The human body works constantly to maintain core temperature. In cold environments:

blood vessels constrict to conserve heat
energy expenditure increases
immune responses may weaken
organs work harder to maintain balance

These adaptations, while protective, also create health vulnerabilities.

Increased Risk of Infections

Weakened Immune Response

Cold weather can suppress immune function, making it harder for the body to fight infections.

Factors contributing to winter infections include:

reduced vitamin D due to less sunlight
dry air affecting mucosal defenses
closer indoor contact

Common winter infections include colds, flu and respiratory illnesses.

Respiratory Health Problems

Cold air irritates the respiratory tract.

This can lead to:

worsening asthma symptoms
bronchitis flare-ups
increased cough and breathlessness

WHO reports higher hospital admissions for respiratory illnesses during colder months.

Impact on Heart Health

Cold temperatures affect cardiovascular function.

Blood Vessel Constriction

Cold causes blood vessels to narrow, increasing:

blood pressure
heart workload

This raises the risk of:

heart attacks
strokes

People with existing heart disease are particularly vulnerable.

Joint and Muscle Pain

Cold weather affects musculoskeletal health.

Common complaints include:

joint stiffness
muscle aches
worsening arthritis pain

Lower temperatures reduce joint lubrication and increase sensitivity to pain.

Metabolic and Weight Changes

Winter often leads to:

reduced physical activity
increased calorie intake
metabolic slowdown

These changes contribute to weight gain and worsen metabolic conditions such as diabetes.

Skin and Hydration Issues

Cold air holds less moisture.

This leads to:

dry skin
cracked lips
worsening eczema

Dehydration is also common as thirst perception reduces in cold weather.

Mental Health Effects

Seasonal changes can influence mental wellbeing.

Cold weather is associated with:

low mood
reduced motivation
seasonal affective symptoms

Limited sunlight affects circadian rhythm and serotonin levels.

Cold Weather and Older Adults

Elderly individuals face higher risks due to:

reduced temperature regulation
weaker immunity
existing chronic conditions

Winter-related complications are a significant cause of hospitalisation in older populations.

Why Chronic Diseases Worsen in Winter

Conditions such as:

hypertension
arthritis
asthma
diabetes

often worsen due to reduced activity, stress on organs and infection risk.

Preventive Strategies for Winter Health

Maintain Body Warmth

Layered clothing and warm environments reduce cold stress.

Support Immunity

Adequate nutrition, vitamin intake and sleep strengthen immune defences.

Stay Physically Active

Indoor exercises and regular movement prevent stiffness and metabolic decline.

Manage Chronic Conditions

Regular monitoring and medication adherence are critical during winter.

Hydration and Skin Care

Drinking fluids and using moisturisers prevent dehydration and skin damage.

Role of Preventive Healthcare

Preventive healthcare helps:

identify seasonal risk factors
adjust treatment plans
prevent winter complications

NITI Aayog highlights seasonal preparedness as an important public health strategy.

When to Seek Medical Help

Medical attention is necessary if:

infections persist or worsen
chest pain or breathlessness occurs
joint pain limits mobility
mental health symptoms interfere with daily life

Early care prevents serious outcomes.

Long-Term Impact of Ignoring Winter Health Risks

Ignoring cold weather effects may lead to:

severe infections
cardiovascular events
chronic pain progression
reduced quality of life

Seasonal awareness plays a critical role in long-term health.

Conclusion

Understanding how cold weather affects health allows individuals to take timely preventive measures. Winter increases the risk of infections, heart strain, respiratory problems, joint pain and mental health challenges. With proper warmth, nutrition, activity and preventive healthcare, most cold-related health issues are manageable and preventable. Seasonal care is not optional—it is essential for protecting health and wellbeing throughout the colder months.

References

ICMR – Seasonal Health and Infectious Disease Reports
National Family Health Survey (NFHS-5) – Seasonal Morbidity Data
NITI Aayog – Preventive Healthcare and Seasonal Preparedness Strategy
WHO – Cold Weather and Health Impact Guideline
Lancet – Seasonal Variation in Cardiovascular and Respiratory Diseases
Statista – Winter Health Trends and Illness Data
Indian Journal of Public Health – Climate and Health Studies

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