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Published on: Nov 17, 2023
3 minute read
By: Secondmedic Expert

Exploring New Drugs Show Potential Promise In Lowering Cholesterol

In the realm of medical advancements, a spotlight has recently been cast on groundbreaking cholesterol drugs, promising new avenues for treatment. This comprehensive guide will delve into the intricacies of these potential breakthroughs, shedding light on their implications, challenges, and the expert perspectives shaping their journey.

Understanding the Landscape:

Recent research has introduced VERVE-101, a novel cholesterol drug, sparking interest and optimism within the medical community. However, experts caution that, despite promising initial results, both VERVE-101 and similar treatments have a substantial journey ahead before potential approval.

Dr. Wesley Milks, a seasoned cardiologist specializing in cardiovascular disease prevention and lipid disorders at the Ohio State University Wexner Medical Center, emphasizes the need for extensive testing. He notes that a small proof-of-concept study may be intriguing, but a more extensive patient pool is required to establish the safety and effectiveness of such therapies. Regulatory bodies like the FDA would demand rigorous evidence before considering approval.

Potential Downsides of Genetic-Level Intervention:

While the prospects of genetic-level interventions offer exciting possibilities, concerns arise regarding the permanence of DNA editing. Dr. Milks underlines that the irreversibility of such therapies might deter both patients and healthcare providers. Assurance of minimal off-target or unintended genetic disturbances becomes paramount before recommending CRISPR gene editing therapy on a broader scale.

As we venture into the uncharted territory of genetic-level intervention for cholesterol management, the cautionary notes from Dr. Milks highlight the complexities and ethical considerations associated with altering the fundamental building blocks of our genetic code.

Considerations for Approval:

Dr. Rekha Kumar, Chief Medical Officer of Found, a weight loss program, and former Medical Director of the American Board of Obesity Medicine, adds valuable insights. She acknowledges the novelty of these potential drugs, targeting specific genetic abnormalities related to cholesterol metabolism. However, she emphasizes that despite their unique mechanisms, these drugs are far from everyday use.

As these drugs move towards personalized therapies, there's a potential downside - cost. Dr. Kumar notes that highly personalized drugs often come with a hefty price tag. This raises concerns about accessibility, as many individuals may not be aware of underlying cholesterol disorders or have access to appropriate testing for genetic abnormalities.

The balance between innovation and practicality becomes apparent in Dr. Kumar's observations. While the drugs hold promise in addressing specific genetic abnormalities, the challenge lies in ensuring that these treatments are not only effective but also accessible to those who need them.

The Road to Approval:

The journey from groundbreaking research to everyday use is multifaceted. Beyond providing safety and effectiveness, regulatory bodies evaluate the cost-effectiveness and accessibility of these treatments. Dr. Kumar's mention of the significant development towards personalized therapies reinforces the idea that these drugs, when approved, might cater to a specific population with genetic abnormalities related to cholesterol metabolism.

The regulatory pathway for novel treatments is often lengthy and intricate. As these potential cholesterol drugs navigate through clinical trials and regulatory scrutiny, the healthcare landscape evolves. The hope is that these therapies, when approved, become part of a broader strategy to address cholesterol disorders, especially in those with specific genetic susceptibilities.

Addressing Accessibility Concerns:

Dr. Kumar's concerns about the potential high cost of personalized drugs align with broader discussions on healthcare accessibility. As drugs become more tailored to specific genetic profiles, there is a risk of excluding individuals who may not be able to afford these specialized treatments.

The intersection of science, economics, and public health becomes evident in the discourse around accessibility. While breakthrough treatments offer promise, their true impact lies in their reach. The healthcare industry faces the ongoing challenge of ensuring that advancements in medical science translate into tangible benefits for diverse populations.

The Balancing Act: Safety, Cost, and Accessibility:

Balancing safety, cost, and accessibility is a delicate act in the pharmaceutical landscape. The potential permanence of genetic-level interventions, coupled with the financial considerations associated with highly personalized drugs, underscores the need for a meticulous and inclusive approach to healthcare.

The delicate equilibrium between scientific innovation and practical application is at the heart of the healthcare debate. Striking the right balance ensures that advancements in medicine are not only groundbreaking but also socially responsible.

Navigating Uncertainties and Promising Futures:

In conclusion, the journey of emerging cholesterol drugs, exemplified by VERVE-101, is marked by both promise and caution. While the potential for groundbreaking treatments is undeniable, the road to widespread acceptance involves addressing critical considerations—safety, permanence, cost, and accessibility.

As medical researchers and professionals continue to unveil the mysteries of genetic-level interventions, collaboration between scientists, regulatory bodies, and healthcare providers becomes imperative. The hope is that these strides in personalized therapies lead to advancements that benefit a broader spectrum of individuals, ensuring that the promise of innovative treatments aligns with principles of safety, affordability, and accessibility.

Remember, the path from discovery to everyday use is a collective journey—one that requires diligence, scrutiny, and a commitment to improving health outcomes for all. In navigating uncertainties, we chart a course towards a future where groundbreaking treatments are not just possibilities in a lab but accessible realities for those in need.

Read FAQs

A. Statins are widely considered the most successful drugs for lowering cholesterol. Common statins include atorvastatin, simvastatin, and rosuvastatin. They effectively reduce LDL (low-density lipoprotein) cholesterol levels and are often prescribed to lower the risk of cardiovascular events.

A. Several classes of drugs are used to lower cholesterol levels, including: - Statins: Atorvastatin, simvastatin, rosuvastatin. - Bile acid sequestrants: Cholestyramine, colestipol. - Niacin (nicotinic acid). - Fibrates: Fenofibrate, gemfibrozil. - PCSK9 inhibitors: Evolocumab, alirocumab. The choice of medication depends on individual health factors, cholesterol profile, and overall cardiovascular risk.

A. As of my last knowledge update in January 2023, specific information about the latest cholesterol-lowering drugs introduced in 2023 is not available. The pharmaceutical landscape is continually evolving, and new drugs are periodically introduced. To stay informed about the latest developments, consult healthcare professionals or reputable sources for up-to-date information on newly approved cholesterol-lowering medications.

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Why Do You Wake Up Tired Even After 8 Hours Sleep?

Getting 8 hours of sleep is often seen as the gold standard for good health. But what if you’re still waking up feeling groggy, exhausted, and low on energy—despite clocking in those 8 hours? If that sounds like you, you’re not alone.

In this blog, we’ll explore why you wake up tired even after 8 hours sleep, the possible reasons behind it, and simple ways to fix the issue so you can start your day refreshed and energized.

Sleep Quantity vs. Sleep Quality

It’s important to understand that sleep is not just about how long you sleep, but how well you sleep.

There are different stages of sleep your body goes through:

Light Sleep (Stage 1 & 2)
Deep Sleep (Stage 3)
REM Sleep (Stage 4) – where dreams and memory processing happen

If your sleep is constantly interrupted, or if you don’t get enough deep or REM sleep, your body and brain won’t be fully rested—even after 8 hours in bed.

7 Common Reasons You Wake Up Tired After a Full Night’s Sleep

1. Poor Sleep Quality

You may be lying in bed for 8 hours, but if your sleep is light or frequently interrupted, it won’t be refreshing. Common reasons include:

Noisy environment
Uncomfortable mattress or pillow
Room too hot or too cold
Lights or electronics nearby

Fix: Try blackout curtains, keep the room cool and dark, and follow a fixed bedtime routine.

2. Undiagnosed Sleep Disorders

Conditions like sleep apnea, restless leg syndrome, or insomnia can reduce sleep quality without you even realizing it.

Sleep apnea, for example, causes you to stop breathing for short periods during sleep. You may not wake up fully, but your body doesn’t get enough oxygen—leading to morning tiredness and brain fog.

Fix: If your partner says you snore heavily or you often wake up gasping for air, consult a doctor for a sleep study.

3. Too Much Screen Time at Night

Smartphones, laptops, and TVs emit blue light, which blocks melatonin—a hormone that helps you fall asleep.

If you scroll Instagram or binge-watch shows late at night, your brain might stay active even after you fall asleep.

Fix: Stop using screens 1 hour before bedtime. Use night mode or blue light filters if necessary.

4. Eating or Drinking Close to Bedtime

Heavy meals or caffeine before bed can disturb your sleep by causing indigestion, bloating, or increased alertness.

Fix: Avoid caffeine after 5 PM, and try to have your dinner at least 2 hours before sleeping.

5. Mental Health Issues

Conditions like stress, anxiety, or depression can impact sleep quality. You may sleep for hours but still wake up tired due to mental fatigue.

Fix: Practice stress management through:

Journaling
Breathing exercises
Meditation
Seeking therapy if needed

6. Vitamin or Hormonal Imbalance

Low levels of Vitamin D, Vitamin B12, iron, or thyroid dysfunction can cause constant fatigue—even with good sleep.

Fix: A simple blood test can help detect deficiencies. You can book these tests via SecondMedic.com, powered by Thyrocare, with home sample collection.

Recommended tests:

Vitamin D Test
Vitamin B12
Thyroid Profile
CBC (Complete Blood Count)

7. Lack of Physical Activity

Not moving your body enough during the day can lead to low-quality sleep at night. Exercise helps burn excess energy and improves deep sleep.

Fix: Aim for at least 30 minutes of physical activity, like walking, yoga, or cycling daily.

Signs That You’re Not Getting Good Sleep

You hit the snooze button multiple times
You feel sleepy by mid-morning
You wake up with a heavy head or sore body
You need coffee immediately to function
You feel irritated, anxious, or unmotivated

These are signs your body is not truly rested.

Simple Tips for Better Sleep & Morning Energy

Stick to a sleep schedule: Go to bed and wake up at the same time every day—even on weekends.
Create a sleep-friendly space: Keep your bedroom cool, quiet, and dark.
Limit naps: Daytime naps should be less than 30 minutes and before 3 PM.
Stay hydrated—but not too close to bedtime: Drinking too much water late may wake you up to pee.
Practice relaxation before bed: Try reading, light stretching, or herbal tea.

Conclusion

Feeling tired despite getting enough sleep can be frustrating. But remember, quality beats quantity when it comes to sleep. By making small changes in your routine, checking for hidden health issues, and improving your lifestyle, you can wake up feeling refreshed and ready to take on the day.

If you’ve been wondering why do you wake up tired even after 8 hours sleep, now you know where to start fixing it. Begin today with a better sleep routine—and better mornings will follow.

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