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Published on: Jan 23, 2022
3 minute read
By: Second Medic Expert

Diagnostics: Kidney Function Test

Diagnostics: Kidney function Test

Blood and urine tests are done to check kidney function.

Blood tests that can help assess kidney function include creatinine level, blood urea nitrogen level, and estimated glomerular filtration rate (eGFR).

Urine tests that can help assess kidney function include urine protein test, urine specific gravity test, and urine creatinine test.

What tests are done to check kidney function?

The most common tests to check kidney function are a blood test called creatinine and a urine test called albumin.

Creatinine is a waste product that is released into the blood when the muscle is damaged. So if the kidneys are not working properly, creatinine levels will go up. Albumin is a protein that is found in the urine. If the kidneys are not working properly, more albumin will leak out of the kidneys and into the urine.

Other tests that may be done to check kidney function include:

-A blood test to measure creatinine clearance. This measures how well the kidneys are filtering creatinine from the blood.

-A urine test to measure protein levels. High protein levels

When a doctor checks kidney function, they will order a blood test to check creatinine levels and blood urea nitrogen levels. These tests give an indication of how well the kidneys are working. If the creatinine or BUN levels are high, it means that the kidneys are not working properly. The doctor may also order a urine test to look for albumin in the urine. Albumin is a protein that is normally filtered out by the kidneys. If there is albumin in the urine, it means that the kidneys are not working properly.

What is the most accurate test for kidney function?

The most accurate test for kidney function is a creatinine blood test. It measures the level of creatinine in your blood. Creatinine is a waste product that is released when muscle tissue is damaged. So the higher your creatinine level, the more damage your kidneys have sustained.

Other tests that can be used to measure kidney function include a BUN (blood urea nitrogen) test and urine analysis. However, both tests are less accurate than the creatinine blood test.

What is a normal kidney function level?

Normal kidney function is when the kidneys filter wastes and excess fluid from the blood to make urine. The normal range for creatinine, a waste product that is filtered out by the kidneys, is 0.5 to 1.1 mg/dL for women and 0.6 to 1.2 mg/dL for men. Urine output should be about 600 to 800 mL per day. If you have symptoms such as foamy urine, swelling in your legs, shortness of breath, or chest pain, see your doctor right away because they may be signs of a problem with your kidneys.

Normal kidney function is defined as a creatinine level below 1.5 mg/dL in men and below 1.4 mg/dL in women. Creatinine is a waste product that is eliminated from the body through the kidneys. When the kidneys are functioning properly, they filter creatinine and other waste products from the blood and excrete them in urine. A creatinine level that is higher than normal indicates that the kidneys are not filtering blood as efficiently as they should be. This can be a sign of many different diseases or conditions, including kidney disease, liver disease, heart failure, and diabetes.

What are the first signs of kidney disease?

The first signs of kidney disease are usually subtle and can be easily missed. Here are five common early signs of kidney disease:

1) Changes in urine output, such as a decrease in the amount of urine produced or an increase in the amount of time needed to produce a full bladder

2) Increased thirst and urination, caused by the body's efforts to get rid of excess fluid by increasing urine production

3) Foamy or bubbly urine, a sign that protein is spilling over into the urine from damaged kidneys

4) Swelling in feet, ankles, and legs, caused by buildup of fluid called edema

5) Feeling tired and sluggish all the time, possibly due to anemia

Can a blood test detect kidney problems?

Yes. A blood test can detect kidney problems by looking for biomarkers in the blood that indicate a problem with the kidneys.

Some common biomarkers that may be detected in a blood test include creatinine, urea nitrogen, and albumin. If any of these biomarkers are elevated, it may indicate that there is a problem with the kidneys.

Kidney problems can be detected through blood tests, although the specific tests used will vary depending on the nature of the kidney problem.

Some common blood tests used to detect kidney problems include:

-A creatinine level, which measures how well your kidneys are filtering waste products from your blood

-A BUN level, which measures how much urea (a breakdown product of protein) is in your blood

-An albumin level, which measures how much albumin (a type of protein) is in your urine

-A creatinine clearance test, which measures how much creatinine is cleared from your blood per minute

Read Blog

Difference Between Sadness and Depression: Understanding Normal Emotions vs Mental Illness

Feeling low or unhappy is a part of being human. However, not all low moods are the same. Many people confuse sadness with depression, which can delay proper support and treatment. Understanding the difference between sadness and depression is crucial for mental health awareness, early intervention and reducing stigma.

In India, mental health conditions are often misunderstood, with emotional distress frequently dismissed as temporary sadness.

What Is Sadness?

Sadness is a normal human emotion.

It usually occurs due to:

loss or disappointment
relationship issues
failure or stress
temporary life challenges

Sadness serves a psychological purpose, allowing individuals to process emotions and adapt.

Key Characteristics of Sadness

Sadness is:

situational
temporary
emotionally painful but manageable
responsive to support and positive events

A person experiencing sadness can still function, enjoy moments and feel hopeful.

What Is Depression?

Depression is a medical condition classified as a mood disorder.

It affects:

emotions
thinking patterns
behaviour
physical health

According to WHO, depression is one of the leading causes of disability worldwide.

Core Symptoms of Depression

Depression involves a combination of symptoms such as:

persistent low mood
loss of interest or pleasure
fatigue
sleep disturbances
appetite changes
feelings of worthlessness
difficulty concentrating

These symptoms last at least two weeks or longer.

Duration: A Key Difference

One major difference lies in duration.

Sadness:

lasts hours or days
improves with time

Depression:

lasts weeks or months
persists despite positive events

Duration helps distinguish emotional response from illness.

Impact on Daily Functioning

Sadness:

allows continuation of work and relationships
may reduce motivation temporarily

Depression:

interferes with work, studies and relationships
reduces self-care and productivity

Functional impairment is a defining feature of depression.

Emotional Experience: Sadness vs Depression

Sadness:

allows emotional range
moments of joy still occur

Depression:

creates emotional numbness
joy and interest disappear

People with depression often describe feeling empty rather than sad.

Physical Symptoms in Depression

Depression is not only emotional.

Physical symptoms include:

chronic fatigue
body aches
headaches
digestive issues

ICMR mental health studies highlight the physical burden of depression.

Thought Patterns and Self-Perception

Sadness:

thoughts remain realistic
self-worth is preserved

Depression:

negative self-talk dominates
feelings of guilt and worthlessness increase

These cognitive changes deepen emotional suffering.

Risk Factors for Depression

Factors increasing depression risk include:

chronic stress
trauma
family history
medical illnesses
hormonal changes

NFHS-5 data indicates rising mental health concerns among young adults.

Can Sadness Turn Into Depression?

Yes, prolonged or unresolved sadness can progress into depression.

This is more likely when:

stressors are ongoing
support systems are weak
coping mechanisms are limited

Early emotional support can prevent progression.

When to Seek Professional Help

Seek help if:

low mood lasts more than two weeks
daily functioning is affected
sleep and appetite are disturbed
thoughts of self-harm occur

Early care leads to better outcomes.

Treatment Differences

Sadness:

improves with rest, support and time

Depression:

requires psychotherapy
may need medication
benefits from structured care

WHO emphasises early treatment to reduce disability.

Role of Social Support

Support systems help both conditions but are essential for recovery.

Depression recovery improves with:

understanding family
supportive workplaces
accessible mental healthcare

Stigma reduction is key.

Mental Health Awareness in India

Mental health remains underdiagnosed in India.

NITI Aayog reports:

limited access to mental health services
low awareness
high stigma

Education helps bridge this gap.

Importance of Early Recognition

Recognising depression early:

prevents worsening
reduces suicide risk
improves quality of life

Delay increases suffering and complications.

Supporting Someone With Depression

Helpful actions include:

listening without judgement
encouraging professional help
avoiding minimising feelings

Compassion is more effective than advice.

Conclusion

Understanding the difference between sadness and depression is essential for emotional wellbeing and mental health care. Sadness is a natural, temporary response to life events, while depression is a serious medical condition that affects thoughts, emotions and daily functioning. Recognising the signs early and seeking appropriate help can prevent long-term suffering and promote recovery. Mental health deserves the same attention and care as physical health.

References

World Health Organization (WHO) – Depression and Mental Health Disorders
Indian Council of Medical Research (ICMR) – Mental Health Research and Burden
National Family Health Survey (NFHS-5) – Mental Health Indicators
Lancet – Depression, Disability and Public Health
NITI Aayog – National Mental Health Policy and Awareness Reports
Statista – Global and Indian Mental Health Trends

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