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Published on: Apr 04, 2020
3 minute read
By: Dr Rajan Choudhary

Developing A Vaccine For COVID-19? Part 1

It is often stated vaccination has made the greatest contribution to global health of any human discovery, other than clean water and sanitation, and their impact on everyday life is immediately evident. We have managed to completely eradicate two major infections from existence (smallpox and rinderpest) , and the WHO are working towards adding polio to that list.

In these cases the numbers speak for themselves. It is estimated that the eradication of smallpox in 1980 has saved 5 million lives per year, adding up to 150 to 200 million by 2018. Common vaccination programmes for polio, measles, mumps, rubella, rabies and hepatitis A have prevented nearly 200 million cases from occurring in the US alone over the past 50 years, and 4.5 billion instances of the diseases worldwide.

We have achieved a 99% immunisation rate against polio, preventing children from suffering crippling paralysis, and only 3 countries remain. Sadly, around 1.4 million children under 5 still die from preventable diseases each year as they do not have access to these life saving vaccines, but charities and public health organisations around the world are working hard to improve access.

So what are vaccines? And how will they help is in the face of the latest pandemic? Here we will go into the challenges behind making vaccines, and why a vaccine against COVID-19 is unlikely to be ready in the next few months, or even this year.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4024226/ contribution of vaccination

https://www.who.int/features/factfiles/polio/en/ polio eradication

https://www.sciencedaily.com/releases/2017/03/170303163208.htm study article

WHAT IS A VACCINE

The human body’s immune system is incredibly smart. It is able to distinguish between infective organisms, such as bacteria, viruses and parasites, from our own body’s cells, target these invaders for destruction and keep our bodies healthy. Even better, the body remembers any previous infections it has had before, recognise these previous infections even quicker and even eradicate the disease before we know we are infected.

Vaccines target the immune system’s memory by presenting them with pieces of these infective diseases. The small amounts do not cause any infective symptoms, but if the person is infected later in life their body will mount a quicker response and prevent them from falling ill. These vaccines can contain broken up parts of the organisms, “dead” organisms or “live” versions that have been severely weakened so they cannot cause any harm.

In summary, medicines treat us when we get an infection. Vaccines make sure we never suffer from an infection in the first place.

https://www.chop.edu/centers-programs/vaccine-education-center/making-vaccines/how-are-vaccines-made Making Vaccines

THE HURDLES WE FACE IN RESEARCH

Making a vaccine is a difficult process, one that can take 3–5 years and cost hundreds of millions of dollars, sometimes billions of dollars. This is because there are many difficult steps to be taken in the process of creating a vaccine that is effective, but more importantly one that is safe.

To start with the troubling organism has to be identified. For COVID-19 it took a few weeks to recognise the virus responsible, and some time more to understand its genetic code and grow the virus in lab conditions. We then have to understand the virus, how it infects, how it causes symptoms, and how it has mutated compared to the coronaviruses responsible for SARS and MERS.

After this, we have to isolate parts of the virus our immune system will recognise. This is usually the outside coat of the virus. The DNA responsible for making these parts need to be found in the virus’ genetic code, and put inside other “skeleton” viruses. This will force the dummy virus to look like coronavirus, without the ability to infect and kill someone.

These dummy viruses can be injected into animals to see if it causes an immune reaction, whether the immune system recognises it as the coronavirus responsible for COVID-19, and whether it will protect the animal from the real COVID-19. Up to now the research has likely cost a few million dollars. The next step is when the price inflates up to billions.

If the vaccine appears safe in animals, it can be tested in humans. This can be dangerous at first, since we don’t know whether a vaccine that works in an animal will work in a human. And we don’t know if there will be any side effects to the vaccine. Human testing has to be very thorough, very careful, and safe for use. If you give too much of the virus it might make the person sick, too little and it wont immunise the person. These clinical trials can take years, and if the vaccine fails at this point its back to the drawing board, to try another step.

https://www.theatlantic.com/politics/archive/2014/10/how-to-make-an-ebola-vaccine-5-simplified-steps/454443/ ebola vaccine

Now we have a basic understanding of what vaccines are and why it takes so long to make a vaccine. In the next part we will look at why viral vaccines can cause even more problems, and how far we have come with the COVID-19 vaccine,

Dr Rajan Choudhary, London UK

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Neurobion Forte: Benefits for Nerve Health and Vitamin B Deficiency

Vitamin deficiencies are a common but often overlooked health issue. Among them, vitamin B deficiency is particularly significant because of its direct impact on nerve function, energy metabolism and overall neurological health. Neurobion Forte is a widely used vitamin B-complex supplement designed to address these deficiencies and support nerve health.

Understanding how Neurobion Forte works and when it is beneficial helps individuals make informed decisions about their nutritional and neurological wellbeing.

What Is Neurobion Forte?

Neurobion Forte is a combination supplement containing essential B vitamins, primarily:

vitamin B1 (thiamine)
vitamin B6 (pyridoxine)
vitamin B12 (cobalamin)

These vitamins play a vital role in nerve signal transmission, energy production and maintenance of the nervous system.

Why Vitamin B Is Essential for Nerve Health

B vitamins are crucial for:

nerve impulse transmission
myelin sheath formation
energy metabolism in nerve cells

Deficiency can impair nerve function, leading to discomfort and neurological symptoms.

Common Causes of Vitamin B Deficiency

Vitamin B deficiency may occur due to:

inadequate dietary intake
poor absorption
chronic illnesses
long-term medication use
alcohol misuse

Vegetarians and elderly individuals are particularly at risk of vitamin B12 deficiency.

Symptoms of Vitamin B Deficiency

Early symptoms may include:

fatigue
weakness
numbness or tingling in hands and feet
poor concentration

If untreated, deficiency may progress to more serious neurological problems.

How Neurobion Forte Supports Nerve Health

Supports Nerve Repair

Vitamin B12 contributes to nerve regeneration and maintenance of nerve fibres.

Improves Nerve Signal Transmission

Vitamin B1 supports proper nerve impulse conduction.

Reduces Nerve Irritation

Vitamin B6 helps regulate neurotransmitter synthesis, reducing nerve-related discomfort.

Supports Energy Metabolism

B vitamins help convert food into energy, supporting overall nerve and muscle function.

Role of Neurobion Forte in Nerve Pain

Nerve pain caused by vitamin deficiency may present as:

burning sensation
tingling
numbness
shooting pain

In such cases, correcting the deficiency through supplementation may help relieve symptoms over time.

Conditions Where Neurobion Forte Is Commonly Used

Neurobion Forte may be prescribed or recommended in cases such as:

peripheral neuropathy
diabetic neuropathy (as supportive care)
nutritional deficiency-related nerve symptoms
general weakness associated with vitamin B deficiency

It is not a painkiller but supports underlying nutritional correction.

Importance of Medical Guidance

While vitamin supplements are widely available, inappropriate or excessive use may cause side effects.

Medical guidance ensures:

correct diagnosis
appropriate dosage
monitoring of response

Self-medication should be avoided, especially for long-term use.

Diet and Vitamin B Intake

Dietary sources of B vitamins include:

whole grains
legumes
dairy products
eggs
meat and fish

Balanced nutrition remains the foundation of vitamin sufficiency.

Who May Benefit Most from Neurobion Forte?

Individuals who may benefit include:

those with confirmed vitamin B deficiency
people with nerve-related symptoms
elderly individuals with poor nutrient absorption
individuals with restricted diets

Supplementation should complement dietary improvement.

Possible Side Effects and Precautions

When taken as advised, Neurobion Forte is generally well tolerated.

However:

excessive vitamin B6 intake may cause nerve symptoms
allergic reactions are rare but possible

Always follow professional advice.

How Long Does It Take to See Benefits?

Improvement depends on:

severity of deficiency
duration of symptoms
individual health status

Some people notice symptom improvement within weeks, while others require longer support.

Neurobion Forte and Overall Wellbeing

Correcting vitamin B deficiency supports:

nerve health
energy levels
cognitive function
overall vitality

Supplementation is most effective when combined with healthy lifestyle habits.

Conclusion

Neurobion Forte plays an important role in managing vitamin B deficiency and supporting nerve health. By supplying essential B vitamins, it helps restore nerve function, reduce deficiency-related symptoms and improve overall neurological wellbeing. While it can be highly beneficial when deficiency is present, its use should always be guided by medical advice to ensure safety and effectiveness. Balanced nutrition, early diagnosis and appropriate supplementation together form the foundation of healthy nerve function.

References

World Health Organization (WHO) – Micronutrients and Neurological Health
Indian Council of Medical Research (ICMR) – Nutrient Deficiency Guidelines
National Institute of Nutrition (NIN) – Vitamin B and Nerve Function Reports
Lancet Neurology – Vitamin Deficiency and Neuropathy Studies
Indian Journal of Clinical Nutrition – Vitamin B Supplementation Researc
Statista – Dietary Supplement Usage Trends

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