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Published on: Apr 04, 2020
3 minute read
By: Dr Rajan Choudhary

Developing A Vaccine For COVID-19? Part 1

It is often stated vaccination has made the greatest contribution to global health of any human discovery, other than clean water and sanitation, and their impact on everyday life is immediately evident. We have managed to completely eradicate two major infections from existence (smallpox and rinderpest) , and the WHO are working towards adding polio to that list.

In these cases the numbers speak for themselves. It is estimated that the eradication of smallpox in 1980 has saved 5 million lives per year, adding up to 150 to 200 million by 2018. Common vaccination programmes for polio, measles, mumps, rubella, rabies and hepatitis A have prevented nearly 200 million cases from occurring in the US alone over the past 50 years, and 4.5 billion instances of the diseases worldwide.

We have achieved a 99% immunisation rate against polio, preventing children from suffering crippling paralysis, and only 3 countries remain. Sadly, around 1.4 million children under 5 still die from preventable diseases each year as they do not have access to these life saving vaccines, but charities and public health organisations around the world are working hard to improve access.

So what are vaccines? And how will they help is in the face of the latest pandemic? Here we will go into the challenges behind making vaccines, and why a vaccine against COVID-19 is unlikely to be ready in the next few months, or even this year.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4024226/ contribution of vaccination

https://www.who.int/features/factfiles/polio/en/ polio eradication

https://www.sciencedaily.com/releases/2017/03/170303163208.htm study article

WHAT IS A VACCINE

The human body’s immune system is incredibly smart. It is able to distinguish between infective organisms, such as bacteria, viruses and parasites, from our own body’s cells, target these invaders for destruction and keep our bodies healthy. Even better, the body remembers any previous infections it has had before, recognise these previous infections even quicker and even eradicate the disease before we know we are infected.

Vaccines target the immune system’s memory by presenting them with pieces of these infective diseases. The small amounts do not cause any infective symptoms, but if the person is infected later in life their body will mount a quicker response and prevent them from falling ill. These vaccines can contain broken up parts of the organisms, “dead” organisms or “live” versions that have been severely weakened so they cannot cause any harm.

In summary, medicines treat us when we get an infection. Vaccines make sure we never suffer from an infection in the first place.

https://www.chop.edu/centers-programs/vaccine-education-center/making-vaccines/how-are-vaccines-made Making Vaccines

THE HURDLES WE FACE IN RESEARCH

Making a vaccine is a difficult process, one that can take 3–5 years and cost hundreds of millions of dollars, sometimes billions of dollars. This is because there are many difficult steps to be taken in the process of creating a vaccine that is effective, but more importantly one that is safe.

To start with the troubling organism has to be identified. For COVID-19 it took a few weeks to recognise the virus responsible, and some time more to understand its genetic code and grow the virus in lab conditions. We then have to understand the virus, how it infects, how it causes symptoms, and how it has mutated compared to the coronaviruses responsible for SARS and MERS.

After this, we have to isolate parts of the virus our immune system will recognise. This is usually the outside coat of the virus. The DNA responsible for making these parts need to be found in the virus’ genetic code, and put inside other “skeleton” viruses. This will force the dummy virus to look like coronavirus, without the ability to infect and kill someone.

These dummy viruses can be injected into animals to see if it causes an immune reaction, whether the immune system recognises it as the coronavirus responsible for COVID-19, and whether it will protect the animal from the real COVID-19. Up to now the research has likely cost a few million dollars. The next step is when the price inflates up to billions.

If the vaccine appears safe in animals, it can be tested in humans. This can be dangerous at first, since we don’t know whether a vaccine that works in an animal will work in a human. And we don’t know if there will be any side effects to the vaccine. Human testing has to be very thorough, very careful, and safe for use. If you give too much of the virus it might make the person sick, too little and it wont immunise the person. These clinical trials can take years, and if the vaccine fails at this point its back to the drawing board, to try another step.

https://www.theatlantic.com/politics/archive/2014/10/how-to-make-an-ebola-vaccine-5-simplified-steps/454443/ ebola vaccine

Now we have a basic understanding of what vaccines are and why it takes so long to make a vaccine. In the next part we will look at why viral vaccines can cause even more problems, and how far we have come with the COVID-19 vaccine,

Dr Rajan Choudhary, London UK

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Importance of Regular Health Checkups: Early Detection Saves Lives

In today’s fast-paced lifestyle, many individuals prioritise work and family responsibilities while neglecting their own health. However, understanding the importance of regular health checkups is critical for preventing serious medical conditions. Many diseases develop silently without noticeable symptoms, making routine screening essential for early diagnosis and effective treatment.

According to the Indian Council of Medical Research (ICMR), non-communicable diseases such as diabetes, hypertension and cardiovascular conditions are rising across India. Early detection through preventive checkups significantly reduces complications and mortality.

What Are Regular Health Checkups?

Regular health checkups involve:

routine blood tests
blood pressure monitoring
cholesterol screening
organ function tests
lifestyle risk assessments

These assessments help identify abnormalities before they progress into severe conditions.

Why Preventive Healthcare Matters

Preventive healthcare focuses on:

identifying risk factors
detecting disease early
preventing complications

The World Health Organization states that preventive care reduces long-term healthcare burden and improves life expectancy.

Early Detection of Chronic Diseases

Diabetes

India has over 100 million people living with diabetes, according to ICMR data. Many individuals are unaware until complications arise.

Early screening detects:

elevated blood sugar
insulin resistance

Hypertension

NFHS-5 reports that nearly one in four adults in India has hypertension.

Regular monitoring prevents:

stroke
heart attack
kidney damage

Heart Disease

Cholesterol screening identifies risk before symptoms appear.

Timely lifestyle modifications reduce cardiovascular events.

Cancer Screening and Survival Rates

Screenings such as:

mammograms
Pap smears
colon cancer screening

significantly improve survival when disease is detected early.

Monitoring Organ Function

Regular checkups assess:

liver health
kidney function
thyroid levels

Silent organ dysfunction can be detected early.

Benefits of Regular Health Checkups

Reduced Healthcare Costs

Treating advanced disease is more expensive than preventive care.

Improved Quality of Life

Early treatment reduces long-term complications.

Peace of Mind

Knowing health parameters are normal reduces anxiety.

Better Lifestyle Decisions

Screening results motivate healthier habits.

Who Should Get Regular Health Checkups?

adults above 30 years
individuals with family history of chronic disease
smokers
overweight individuals
sedentary professionals

High-risk groups may require more frequent testing.

Frequency of Health Screenings

General recommendation:

Annual checkup for adults
Biannual or quarterly monitoring for high-risk individuals

Doctors personalise schedules based on medical history.

Corporate Health Checkups

Many organisations conduct:

workplace screening camps
employee wellness programs

These initiatives improve workforce productivity and reduce absenteeism.

Preventive Health in India

NITI Aayog highlights preventive healthcare as essential for reducing national disease burden.

Increasing awareness about routine checkups is critical.

Common Tests in Annual Health Packages

Complete blood count
Lipid profile
Fasting blood sugar
HbA1c
Liver function test
Kidney function test
Thyroid profile
Vitamin levels

These tests provide comprehensive health insight.

Addressing Common Misconceptions

Many people avoid checkups because:

they feel healthy
they fear results
they lack time

However, absence of symptoms does not mean absence of disease.

Lifestyle Diseases and Urbanisation

Urban lifestyles contribute to:

sedentary behaviour
poor diet
stress

Regular monitoring counters these risks.

Digital Health and Screening Accessibility

Online booking platforms and home sample collection make preventive care more accessible and convenient.

Technology supports proactive health management.

Building a Culture of Preventive Health

Encouraging:

annual screenings
family health awareness
workplace initiatives

creates healthier communities.

Conclusion

Understanding the importance of regular health checkups is essential for preventing chronic disease and improving life expectancy. Early detection of diabetes, hypertension, heart disease and other conditions allows timely treatment and reduces complications. Preventive healthcare is not an expense but an investment in long-term wellbeing. Scheduling routine screenings today can protect health and save lives tomorrow.

References

Indian Council of Medical Research (ICMR) – Non-Communicable Disease Reports
National Family Health Survey (NFHS-5) – Adult Health Data
World Health Organization (WHO) – Preventive Healthcare Guidelines
NITI Aayog – National Health and Preventive Strategy Reports
Lancet – Early Detection and Disease Prevention Studies

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