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Published on: Apr 04, 2020
3 minute read
By: Dr Rajan Choudhary

Developing A Vaccine For COVID-19? Part 1

It is often stated vaccination has made the greatest contribution to global health of any human discovery, other than clean water and sanitation, and their impact on everyday life is immediately evident. We have managed to completely eradicate two major infections from existence (smallpox and rinderpest) , and the WHO are working towards adding polio to that list.

In these cases the numbers speak for themselves. It is estimated that the eradication of smallpox in 1980 has saved 5 million lives per year, adding up to 150 to 200 million by 2018. Common vaccination programmes for polio, measles, mumps, rubella, rabies and hepatitis A have prevented nearly 200 million cases from occurring in the US alone over the past 50 years, and 4.5 billion instances of the diseases worldwide.

We have achieved a 99% immunisation rate against polio, preventing children from suffering crippling paralysis, and only 3 countries remain. Sadly, around 1.4 million children under 5 still die from preventable diseases each year as they do not have access to these life saving vaccines, but charities and public health organisations around the world are working hard to improve access.

So what are vaccines? And how will they help is in the face of the latest pandemic? Here we will go into the challenges behind making vaccines, and why a vaccine against COVID-19 is unlikely to be ready in the next few months, or even this year.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4024226/ contribution of vaccination

https://www.who.int/features/factfiles/polio/en/ polio eradication

https://www.sciencedaily.com/releases/2017/03/170303163208.htm study article

WHAT IS A VACCINE

The human body’s immune system is incredibly smart. It is able to distinguish between infective organisms, such as bacteria, viruses and parasites, from our own body’s cells, target these invaders for destruction and keep our bodies healthy. Even better, the body remembers any previous infections it has had before, recognise these previous infections even quicker and even eradicate the disease before we know we are infected.

Vaccines target the immune system’s memory by presenting them with pieces of these infective diseases. The small amounts do not cause any infective symptoms, but if the person is infected later in life their body will mount a quicker response and prevent them from falling ill. These vaccines can contain broken up parts of the organisms, “dead” organisms or “live” versions that have been severely weakened so they cannot cause any harm.

In summary, medicines treat us when we get an infection. Vaccines make sure we never suffer from an infection in the first place.

https://www.chop.edu/centers-programs/vaccine-education-center/making-vaccines/how-are-vaccines-made Making Vaccines

THE HURDLES WE FACE IN RESEARCH

Making a vaccine is a difficult process, one that can take 3–5 years and cost hundreds of millions of dollars, sometimes billions of dollars. This is because there are many difficult steps to be taken in the process of creating a vaccine that is effective, but more importantly one that is safe.

To start with the troubling organism has to be identified. For COVID-19 it took a few weeks to recognise the virus responsible, and some time more to understand its genetic code and grow the virus in lab conditions. We then have to understand the virus, how it infects, how it causes symptoms, and how it has mutated compared to the coronaviruses responsible for SARS and MERS.

After this, we have to isolate parts of the virus our immune system will recognise. This is usually the outside coat of the virus. The DNA responsible for making these parts need to be found in the virus’ genetic code, and put inside other “skeleton” viruses. This will force the dummy virus to look like coronavirus, without the ability to infect and kill someone.

These dummy viruses can be injected into animals to see if it causes an immune reaction, whether the immune system recognises it as the coronavirus responsible for COVID-19, and whether it will protect the animal from the real COVID-19. Up to now the research has likely cost a few million dollars. The next step is when the price inflates up to billions.

If the vaccine appears safe in animals, it can be tested in humans. This can be dangerous at first, since we don’t know whether a vaccine that works in an animal will work in a human. And we don’t know if there will be any side effects to the vaccine. Human testing has to be very thorough, very careful, and safe for use. If you give too much of the virus it might make the person sick, too little and it wont immunise the person. These clinical trials can take years, and if the vaccine fails at this point its back to the drawing board, to try another step.

https://www.theatlantic.com/politics/archive/2014/10/how-to-make-an-ebola-vaccine-5-simplified-steps/454443/ ebola vaccine

Now we have a basic understanding of what vaccines are and why it takes so long to make a vaccine. In the next part we will look at why viral vaccines can cause even more problems, and how far we have come with the COVID-19 vaccine,

Dr Rajan Choudhary, London UK

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common health problems during seasonal change

Seasonal changes bring relief from extreme weather, but they also pose unique challenges to human health. Transitions between summer, monsoon and winter often trigger a rise in illnesses. The body requires time to adapt to changing temperature, humidity and environmental conditions. During this adjustment period, immunity may weaken, making individuals more vulnerable to infections and other health problems.

Understanding common health problems during seasonal change helps individuals take preventive measures and seek timely care.

Why Seasonal Change Affects Health

Seasonal transitions impact the body in several ways:

sudden temperature fluctuations stress the immune system
humidity changes promote pathogen growth
allergens become more prevalent
lifestyle habits shift with weather

These factors collectively increase illness risk.

1. Respiratory Infections

Respiratory infections are among the most common health problems during seasonal change.

Causes

viral and bacterial growth in changing weather
increased indoor crowding
weakened respiratory defences

Symptoms

cough
sore throat
fever
nasal congestion

Children and elderly individuals are particularly vulnerable.

2. Common Cold and Flu

Seasonal transitions often coincide with cold and flu outbreaks.

Why They Increase

viruses survive longer in certain climates
immunity temporarily weakens
exposure increases during travel and gatherings

Symptoms

runny nose
sneezing
body aches
fatigue

3. Allergies

Seasonal allergies become prominent during weather shifts.

Common Triggers

pollen
dust
mould
air pollution

Symptoms

sneezing
itchy eyes
nasal congestion
throat irritation

Allergic symptoms can mimic infections and are often overlooked.

4. Digestive Problems

Digestive issues such as acidity, gas and indigestion are common during seasonal change.

Contributing Factors

altered eating patterns
contaminated food or water
reduced digestion efficiency

Symptoms

bloating
abdominal discomfort
nausea

5. Skin Problems

Changes in humidity and temperature affect skin health.

Common Issues

dryness
fungal infections
rashes

Poor skin barrier function increases infection risk.

6. Viral Fevers

Viral fevers are common during monsoon and post-monsoon periods.

Symptoms

sudden fever
body pain
headache
weakness

Early rest and hydration are essential.

7. Joint and Body Pain

Seasonal change may worsen joint stiffness and body aches, especially in individuals with arthritis.

Causes

cold weather
reduced physical activity
inflammation

Why Immunity Drops During Seasonal Change

Immunity may weaken due to:

temperature stress
vitamin deficiencies
poor sleep
increased stress

According to Indian Council of Medical Research data, immunity-related illnesses increase during transitional seasons.

Who Is Most at Risk?

High-risk groups include:

infants and children
elderly individuals
pregnant women
people with chronic diseases
individuals with low immunity

Extra care is required for these groups.
people with diabetes, heart disease,lung disease, kidney disease

Prevention of Seasonal Health Problems

Maintain Good Hygiene

Frequent handwashing reduces infection spread.

Support Immune Health

Balanced nutrition, hydration and adequate sleep strengthen immunity.

Stay Physically Active

Regular movement supports circulation and immune function.

Eat Fresh and Safe Food

Avoid stale or contaminated food during high-risk seasons.

Stay Vaccinated

Vaccination helps prevent seasonal flu and related complications.

Manage Allergens

Keep living spaces clean and well-ventilated.
mask use in crowded places, safe water, mosquito protection in monsoon.

Early Warning Signs Not to Ignore

Seek medical advice if experiencing:

persistent fever
breathing difficulty
severe weakness
worsening symptoms

Early intervention prevents complications.

Role of Preventive Healthcare

Preventive care focuses on:

early detection
risk reduction
long-term health protection

Seasonal health awareness is a key part of preventive medicine.

Long-Term Impact of Ignoring Seasonal Illness

Repeated seasonal illnesses may lead to:

chronic respiratory problems
weakened immunity
reduced quality of life

Prevention protects long-term health.

Conclusion

Common health problems during seasonal change include respiratory infections, colds, allergies, digestive issues and viral fevers. These conditions arise due to sudden weather changes, weakened immunity and increased exposure to pathogens. By understanding the causes and symptoms and adopting preventive measures such as good hygiene, balanced nutrition, adequate rest and timely medical care, individuals can significantly reduce seasonal illness risk. Seasonal transitions are inevitable, but proactive health practices ensure smoother adaptation and better wellbeing throughout the year.

References

Indian Council of Medical Research (ICMR) – Seasonal Disease Surveillance Report
National Family Health Survey (NFHS-5) – Immunity and Morbidity Data
World Health Organization (WHO) – Seasonal Illness Prevention Guideline
NITI Aayog – Preventive Healthcare and Climate Health Reports
Lancet – Climate Change and Seasonal Disease Patterns
Statista – Seasonal Illness Trends and Public Health Data

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