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Published on: Apr 04, 2020
3 minute read
By: Dr Rajan Choudhary

Developing A Vaccine For COVID-19? Part 1

It is often stated vaccination has made the greatest contribution to global health of any human discovery, other than clean water and sanitation, and their impact on everyday life is immediately evident. We have managed to completely eradicate two major infections from existence (smallpox and rinderpest) , and the WHO are working towards adding polio to that list.

In these cases the numbers speak for themselves. It is estimated that the eradication of smallpox in 1980 has saved 5 million lives per year, adding up to 150 to 200 million by 2018. Common vaccination programmes for polio, measles, mumps, rubella, rabies and hepatitis A have prevented nearly 200 million cases from occurring in the US alone over the past 50 years, and 4.5 billion instances of the diseases worldwide.

We have achieved a 99% immunisation rate against polio, preventing children from suffering crippling paralysis, and only 3 countries remain. Sadly, around 1.4 million children under 5 still die from preventable diseases each year as they do not have access to these life saving vaccines, but charities and public health organisations around the world are working hard to improve access.

So what are vaccines? And how will they help is in the face of the latest pandemic? Here we will go into the challenges behind making vaccines, and why a vaccine against COVID-19 is unlikely to be ready in the next few months, or even this year.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4024226/ contribution of vaccination

https://www.who.int/features/factfiles/polio/en/ polio eradication

https://www.sciencedaily.com/releases/2017/03/170303163208.htm study article

WHAT IS A VACCINE

The human body’s immune system is incredibly smart. It is able to distinguish between infective organisms, such as bacteria, viruses and parasites, from our own body’s cells, target these invaders for destruction and keep our bodies healthy. Even better, the body remembers any previous infections it has had before, recognise these previous infections even quicker and even eradicate the disease before we know we are infected.

Vaccines target the immune system’s memory by presenting them with pieces of these infective diseases. The small amounts do not cause any infective symptoms, but if the person is infected later in life their body will mount a quicker response and prevent them from falling ill. These vaccines can contain broken up parts of the organisms, “dead” organisms or “live” versions that have been severely weakened so they cannot cause any harm.

In summary, medicines treat us when we get an infection. Vaccines make sure we never suffer from an infection in the first place.

https://www.chop.edu/centers-programs/vaccine-education-center/making-vaccines/how-are-vaccines-made Making Vaccines

THE HURDLES WE FACE IN RESEARCH

Making a vaccine is a difficult process, one that can take 3–5 years and cost hundreds of millions of dollars, sometimes billions of dollars. This is because there are many difficult steps to be taken in the process of creating a vaccine that is effective, but more importantly one that is safe.

To start with the troubling organism has to be identified. For COVID-19 it took a few weeks to recognise the virus responsible, and some time more to understand its genetic code and grow the virus in lab conditions. We then have to understand the virus, how it infects, how it causes symptoms, and how it has mutated compared to the coronaviruses responsible for SARS and MERS.

After this, we have to isolate parts of the virus our immune system will recognise. This is usually the outside coat of the virus. The DNA responsible for making these parts need to be found in the virus’ genetic code, and put inside other “skeleton” viruses. This will force the dummy virus to look like coronavirus, without the ability to infect and kill someone.

These dummy viruses can be injected into animals to see if it causes an immune reaction, whether the immune system recognises it as the coronavirus responsible for COVID-19, and whether it will protect the animal from the real COVID-19. Up to now the research has likely cost a few million dollars. The next step is when the price inflates up to billions.

If the vaccine appears safe in animals, it can be tested in humans. This can be dangerous at first, since we don’t know whether a vaccine that works in an animal will work in a human. And we don’t know if there will be any side effects to the vaccine. Human testing has to be very thorough, very careful, and safe for use. If you give too much of the virus it might make the person sick, too little and it wont immunise the person. These clinical trials can take years, and if the vaccine fails at this point its back to the drawing board, to try another step.

https://www.theatlantic.com/politics/archive/2014/10/how-to-make-an-ebola-vaccine-5-simplified-steps/454443/ ebola vaccine

Now we have a basic understanding of what vaccines are and why it takes so long to make a vaccine. In the next part we will look at why viral vaccines can cause even more problems, and how far we have come with the COVID-19 vaccine,

Dr Rajan Choudhary, London UK

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Role of Nutrition in Disease Prevention: How Food Choices Shape Long-Term Health

Disease prevention is no longer limited to vaccinations and medical screenings. Modern healthcare increasingly recognises nutrition as one of the most powerful tools for preventing illness before it begins. The role of nutrition in disease prevention is especially important in India, where lifestyle-related diseases account for a large share of premature illness and mortality.

According to the Indian Council of Medical Research (ICMR) and the National Family Health Survey (NFHS-5), poor dietary patterns contribute significantly to rising cases of diabetes, heart disease, obesity and hypertension. Unlike genetic factors, nutrition is a modifiable risk factor, meaning everyday food choices can actively protect health.

Why Nutrition Is Central to Disease Prevention

1. Nutrition regulates metabolic health

Balanced diets help maintain:

healthy blood sugar levels
optimal cholesterol balance
stable blood pressure

Disruption in these systems increases disease risk.

2. Nutrition strengthens immunity

WHO highlights that immune function depends heavily on adequate intake of vitamins, minerals and protein.

3. Nutrition controls inflammation

Chronic low-grade inflammation is linked to most lifestyle diseases. Diets rich in whole foods reduce inflammatory markers.

Major Diseases Influenced by Nutrition

Diabetes and Prediabetes

Excess refined carbohydrates and sugar drive insulin resistance.

Preventive nutrition focuses on:

whole grains
fibre-rich vegetables
adequate protein
controlled portion sizes

ICMR data shows that dietary modification can delay or prevent type 2 diabetes in high-risk individuals.

Cardiovascular Disease

Heart disease remains a leading cause of death in India.

Nutrition impacts:

cholesterol levels
blood pressure
arterial inflammation

Diets low in trans fats and high in fibre significantly reduce cardiovascular risk, as confirmed by WHO and Lancet studies.

Obesity

Obesity increases the risk of multiple chronic diseases.

Preventive nutrition addresses:

calorie density
food quality
satiety regulation

NFHS-5 reports a steady rise in overweight and obesity across age groups.

Hypertension

High sodium intake and low potassium intake contribute to high blood pressure.

Preventive dietary strategies include:

reducing processed foods
increasing fruits and vegetables
maintaining mineral balance

Certain Cancers

Diet influences cancer risk through:

antioxidant intake
fibre consumption
reduced exposure to carcinogenic compounds

WHO estimates that a significant percentage of cancers are preventable through diet and lifestyle changes.

Key Nutrients That Support Disease Prevention

Fibre

Supports gut health, blood sugar control and cholesterol reduction.

Protein

Essential for muscle health, immune function and metabolic balance.

Healthy Fats

Omega-3 fats reduce inflammation and protect heart health.

Micronutrients

Iron, zinc, vitamin D and B vitamins are essential for metabolic and immune regulation.

NFHS-5 highlights widespread micronutrient deficiencies in India, increasing disease vulnerability.

Role of Gut Health in Prevention

The gut microbiome plays a major role in:

immune regulation
inflammation control
nutrient absorption

Fermented foods and fibre-rich diets support healthy gut bacteria, strengthening disease resistance.

Why Preventive Nutrition Works Best Early

Nutrition is most effective when applied:

before disease onset
during pre-disease stages
alongside regular health screening

Once disease progresses, nutrition remains supportive but may not reverse damage fully.

Nutrition vs Medication in Prevention

Medication treats disease; nutrition reduces risk.

WHO and NITI Aayog emphasize that:

preventive nutrition reduces disease incidence
lifestyle modification lowers healthcare burden
early nutrition changes reduce dependency on long-term medication

Both approaches work best when combined appropriately.

Workplace and Community Role in Preventive Nutrition

Structured nutrition programs at workplaces and communities:

improve awareness
support behaviour change
reduce population-level disease burden

Lancet studies show that group-based nutrition interventions improve long-term adherence.

Common Myths About Nutrition and Disease Prevention

Myth 1: Supplements replace healthy food

Whole foods provide better long-term protection.

Myth 2: Prevention requires extreme diets

Consistency matters more than restriction.

Myth 3: Nutrition only matters after diagnosis

Early nutrition is most effective before disease develops.

Building a Preventive Nutrition Routine

Effective preventive nutrition includes:

regular meals
diverse food groups
portion awareness
minimal processed foods
hydration

Small daily choices compound into long-term health benefits.

Long-Term Impact of Preventive Nutrition

Consistent healthy eating leads to:

reduced disease risk
improved energy and productivity
better immune resilience
lower healthcare costs
improved quality of life

NITI Aayog identifies nutrition as a cornerstone of sustainable healthcare systems.

Conclusion

Understanding the role of nutrition in disease prevention empowers individuals to take control of their health long before illness develops. Balanced, consistent nutrition reduces inflammation, supports immunity and protects against chronic diseases that burden India’s healthcare system. Preventive nutrition is not about short-term fixes but about building lifelong habits that support health, resilience and longevity.

References

ICMR – Nutrition and Lifestyle Disease Prevention Reports
National Family Health Survey (NFHS-5) – Dietary and Metabolic Health Data
NITI Aayog – Preventive Healthcare and Nutrition Strategy Reports
WHO – Diet, Nutrition and Chronic Disease Prevention Guidelines
Lancet – Nutrition and Disease Risk Reduction Studies
Statista – Dietary Trends and Health Outcomes India
EY-FICCI – Preventive Healthcare and Nutrition Economics

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