• Published on: Sep 08, 2021
  • 4 minute read
  • By: Dr Rakesh Rai

What Is The Main Cause Of Hepatitis & What Happens If You Have Hepatitis?

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What is the main cause of hepatitis & What happens if you have hepatitis?

The virus is the most common cause, but auto-immune hepatitis can also occur when the body's immune system attacks and destroys its own kidney cells. Hepatitis is primarily caused by a virus, but there are many other possibilities. A viral infection is the primary cause of hepatitis. And various types of viruses can lead to hepatitis-- some fairly benign, some very serious—such as cytomegalovirus (CMV) and Epstein-Barr virus (EBV).

The main cause of hepatitis is the Hepatitis A virus (HAV). Hepatitis B virus (HBV) and Hepatitis C virus (HCV) can also cause acute hepatitis, but they are responsible for the majority of chronic cases. Chronic hepatic problems may result in the development of cirrhosis or liver cancer, which can be ultimately fatal. It's also possible for an individual to experience co-infection with HAV and HBB/HCV without knowing it since some people infected with HAV do not show any symptoms.

                                  

The human body typically gets rid of the virus in 1-3 months or so without needing any help from drugs or therapies, but about 15% to 40% of people infected with hepatitis A see their symptoms persist for 6 months to 3 years. This can be especially hard on people who are young and otherwise healthy because it often results in interruption of school or work life, not to mention the loss of self-esteem which can damage personal relationships.

Permanently resolving this requires active participation by both doctor and patient; unfortunately, many factors combine to reduce the likelihood that someone will recover completely naturally, including an existing chronic liver disease like cirrhosis (in which case

The main cause of hepatitis is bacteria, viruses, fungi, parasites and chemical substances that damage the liver. The secondary causes may be alcohol abuse or chronic fatty liver disease.

A damaged or diseased liver can lead to alcoholic cirrhosis and other diseases such as spontaneous bacterial peritonitis and encephalopathy.

Hepatitis refers broadly to any inflammatory disorder involving the liver, a diverse organ having many functions in the body. The immune system's response damages hepatocytes - cells that form bile ducts to remove toxins from the blood, produce clotting proteins for blood clots, store energy from food in glycogen so it can be used later when glucose supply from food runs low after starvation occurs.

Some viruses, but more often a drug or toxin that irritates the liver. Drugs and other toxins that can damage the liver include industrial solvents like ammonia, industrial chemicals like benzene, alcohol, acetaminophen (Tylenol), erythromycin (mostly taken to decrease antibiotic resistance), tetracycline antibiotic with surgery concurrent antibiotics), drugs for prevention of malaria such as chloroquine plus proguanil or mefloquine with surgery concurrent clindamycin plus primaquine) and ursodeoxycholic acid.

In adults, viral hepatitis is the most common cause of infectious chronic liver disease, and it's often spread by close contact. In children, foodborne outbreaks are more common. Your body's immune system is a major cause of hepatitis and can be activated by something like a viral infection.

The key to understanding liver disease comes when you realize that the immune system - via T cells and B cells; NK cells; macrophages and natural killer (NK) cells - create inflammation in your gut which ultimately drains into your liver. And when these "Do-or-Die" T lymphocytes or "natural killer" (NK) cell attacks occur it triggers scarring in various regions of your liver which leads to cirrhosis.

The main cause of hepatitis is viral, but it's important to note that there are two types of hepatic viruses that can cause this condition. The first is Hepatitis A (HAV), which comes from fecal matter and is usually spread by food or water contaminated with infected feces. The second type of virus, Hepatitis B (HBV) comes from blood contact, sexual intercourse, or childbirth; however, both types can be transmitted through blood transfusion or drug use (especially needles). According to the Centers for Disease Control and Prevention (CDC), HAV affects about 150 Americans each year; HBV affects roughly 2 million people annually.

The main cause of hepatitis is the virus. But there are other causes including bad hygiene, drinking contaminated water or using dirty injections needles. Furthermore, the hepatitis viruses may spread from an infected mother carrying the disease to her unborn child before it's even born! That can lead to two very different types of hepatitis - one that has a strong reaction where the pregnant woman develops significant liver damage and another that barely affects her at all. And then of course not surprisingly- people who already have chronic health conditions such as diabetes or cirrhosis (liver scarring) and those with weak immune systems due to age or chemotherapy for cancer patients with low white blood cell counts can be more prone to experiencing a chronic infection.

Hepatitis is an inflammation of the liver. It can be caused by either viruses or toxins, including alcohol and prescription medications. Symptoms may include fever, loss of appetite, nausea, vomiting pain in the right side below the ribs when taking deep breaths. The most common type in America is Hepatitis A which you get from sharing food or drinks that are contaminated with tiny amounts of stool from infected people; also known as "gastroenteritis." Getting vaccinated prevents the most acute form usually found in children

Hepatitis is an inflammation of the liver caused by viruses, alcohol, medication. With hepatitis A virus - the symptoms are nausea, vomiting, diarrhea, abdominal pain, and fever. The patient may also have jaundice or low levels of proteins within their blood. Hepatitis B virus - It's usually transmitted through contact with infected blood or other sharps objects such as needles. The symptoms can take up to 6 months before showing signs and it may include dark urine and light-colored stools, joint pain in the lower part of arms and legs (joints hurt worse when pressed) personality changes together with depression phase feelings such as irritability or sadness for no reason at all fatigue along with soreness. If the infection is acute then there may be nausea, vomiting, diarrhea, stomach pain, and jaundice. If chronic then fatigue, loss of appetite, and liver damage may occur.

We recommend immunization for Hepatitis A with the appropriate protection against Hepatitis B with appropriate protection against Hepatitis C with appropriate protection against Herpes Simplex Virus 2 (genital herpes).

Hepatitis is the inflammation of the liver. If you have acute hepatitis, there are often no symptoms associated with it; if you have chronic hepatitis, the most common symptom is fatigue. You can't get Hepatitis from drinking alcohol or eating too much greasy food (unless it's cooked in oil that hasn't been cleaned). You also don't get it by sharing personal items like towels or razors with an infected person.

A person with Hepatitis may feel tired, be pale and lose weight. They may not look sick but can carry the virus that damages their liver. The symptoms of HAV (hepatitis A) last only a few weeks to a couple of months, while symptoms from Hepatitis B can last six months or more; in both cases, there is no specific treatment.

Most people recover fully, and the liver will regain its former function without any need for transplantation or medical intervention in most cases but is often permanently damaged and scarred in others with chronic infections. Hepatitis C sometimes results in severe cirrhosis after decades of infection because it does not cause symptoms until late-stage disease when signs

Hepatitis is an unfortunate and contagious liver disease that we see in at least 500,000 people every year. Hepatitis can be caused by either a virus or a toxin/irritant such as alcohol. Symptoms include jaundice (yellow skin), dark urine, sudden fever that isn't relieved with antibiotics or acetaminophen, abdominal discomfort, and pain that doesn't feel like dysentery - which are hallmarks of the toxic type of hepatitis. Many times, you'll have elevated levels of bilirubin in the blood followed by the destruction of red blood cells due to obstruction of bile ducts if not treated early on.

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Yellowing

Yellow Eyes and Skin Symptoms: Causes, Warning Signs and When to Seek Care

Yellowing of the eyes and skin is one of the most noticeable physical changes a person can experience. Often referred to as jaundice, this symptom is not a disease by itself but a sign of underlying health conditions. Understanding yellow eyes and skin symptoms is essential because they frequently indicate problems involving the liver, blood or bile ducts and may require urgent medical attention.

In India, jaundice is a common presentation across age groups due to infections, liver disease and metabolic disorders.

 

What Does Yellowing of Eyes and Skin Mean?

The yellow colour appears due to excess bilirubin in the blood.

Bilirubin is:

  • a yellow pigment

  • produced from the breakdown of red blood cells

  • processed and removed by the liver

When bilirubin builds up, it deposits in tissues, causing yellow discoloration.

 

Why the Eyes Turn Yellow First

The sclera, or white part of the eyes, contains elastic tissue that binds bilirubin easily.

This makes yellowing:

  • more visible in eyes

  • detectable before skin changes

Yellow eyes are often the earliest sign of jaundice.

 

Common Causes of Yellow Eyes and Skin

Liver-Related Causes

The liver plays a central role in bilirubin metabolism.

Common liver causes include:

  • viral hepatitis (A, B, C, E)

  • fatty liver disease

  • alcoholic liver disease

  • liver cirrhosis

  • drug-induced liver injury

ICMR reports viral hepatitis as a major cause of jaundice in India.

 

Bile Duct Obstruction

Blocked bile flow prevents bilirubin excretion.

Causes include:

  • gallstones

  • bile duct strictures

  • pancreatic or bile duct tumours

This type of jaundice is often associated with itching and pale stools.

 

Blood Disorders

Excess breakdown of red blood cells increases bilirubin production.

Conditions include:

  • hemolytic anemia

  • malaria

  • inherited blood disorders

The liver may be overwhelmed despite being healthy.

 

Infections

Certain infections directly affect liver function.

Examples include:

  • hepatitis viruses

  • leptospirosis

  • severe sepsis

WHO data highlights hepatitis as a leading infectious cause of jaundice globally.

 

Newborn and Pregnancy-Related Causes

While common in newborns, jaundice in adults always needs evaluation.

Pregnancy-related liver disorders can also cause yellowing.

 

Associated Symptoms That Provide Clues

Yellow eyes and skin are often accompanied by:

  • dark yellow or tea-coloured urine

  • pale or clay-coloured stools

  • itching

  • fatigue

  • abdominal pain

  • loss of appetite

These symptoms help identify the underlying cause.

 

When Yellowing Becomes Dangerous

Seek urgent medical care if yellowing is accompanied by:

  • high fever

  • severe abdominal pain

  • confusion or drowsiness

  • vomiting

  • rapid worsening of colour

These signs suggest severe liver or systemic disease.

 

Jaundice and Liver Function

The liver normally:

  • conjugates bilirubin

  • excretes it into bile

When liver cells are damaged, bilirubin accumulates.

Lancet studies confirm jaundice as a key marker of liver dysfunction.

 

Diagnostic Evaluation

Doctors evaluate jaundice using:

  • blood tests for bilirubin levels

  • liver function tests

  • viral markers

  • ultrasound or CT scans

  • additional tests based on findings

Early testing identifies reversible causes.

 

Impact on Daily Life

Persistent jaundice can affect:

  • energy levels

  • digestion

  • mental clarity

  • work performance

Untreated liver disease can progress silently.

 

Treatment Depends on the Cause

There is no single treatment for jaundice.

Management focuses on:

  • treating infection

  • relieving bile obstruction

  • stopping harmful medications

  • managing chronic liver disease

Self-medication can worsen liver injury.

 

Role of Preventive Healthcare

Preventive measures include:

  • hepatitis vaccination

  • safe drinking water

  • limiting alcohol intake

  • regular health checkups

NITI Aayog emphasises liver health in preventive care strategies.

 

Lifestyle Factors That Affect Liver Health

Risk factors include:

  • excessive alcohol

  • obesity

  • high-fat diets

  • unsafe injections

Addressing these reduces jaundice risk.

 

Importance of Early Detection

Early diagnosis:

  • prevents complications

  • improves recovery

  • reduces hospitalisation

Delays increase the risk of liver failure.

 

Jaundice Is a Symptom, Not a Diagnosis

Understanding this distinction is crucial.

Treating the symptom alone:

  • does not resolve the disease

  • may mask serious conditions

Medical evaluation is essential.

 

Conclusion

Yellow eyes and skin symptoms are visible warning signs that should never be ignored. Most often linked to jaundice, they reflect underlying problems involving the liver, bile ducts or blood. Early medical evaluation, accurate diagnosis and timely treatment are critical to prevent serious complications. Recognising these symptoms and seeking care promptly can protect liver health and save lives.

 

References

  • Indian Council of Medical Research (ICMR) – Hepatitis and Liver Disease Reports

  • World Health Organization (WHO) – Jaundice and Hepatitis Guidelines

  • National Family Health Survey (NFHS-5) – Liver and Metabolic Health Indicators

  • Lancet – Liver Function and Bilirubin Research

  • NITI Aayog – Non-Communicable Diseases and Liver Health

  • Statista – Liver Disease and Hepatitis Trends

See all

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