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Published on: Aug 03, 2021
2 minute read
By: Second Medic Pulmonologist

What Is Mucormycosis & COVID-19 Associated With Mucormycosis ?

Mucormycosis is a rare but serious infectious disease that can be caused by inhaling spores from the ubiquitous fungi. These organisms, commonly found in soil and composts are also present on fallen leaves or animal dung. Less contagious than other types of infections, mucormycosis mainly affects people who have weakened immune systems because it cannot spread like others that do not need an outside source to enter one's body via open wounds or cuts. Mucoromyces mean "fuzz," which describes their appearance when seen under a microscope with long branching filaments called pseudohistiocysts arising off these branched threads (hyphae).

Mucormycosis is a rare but serious angio-invasive infection caused by ubiquitous fungi. The spores of these fungi can be inhaled and then infect the lungs, sinuses, or extend into brain tissue to cause mucormycosis in people who are immunocompromised. Mucoromyces has been found all over Earth with it mainly affecting those living on farms due to contact from animal dung containing high quantities of this fungus type as well as compost piles where fresh manure falls leaves cover vegetable gardening beds that may have fallen nearby leading most cases occurring near woodland areas such before dorms at college campuses were previously thought responsible for respiratory infections since they might contain bacteria like tuberculosis which also needs oxygenated.

Fungal infections, including mucormycosis, aspergillosis and invasive candidiasis, have been reported in patients with severe COVID-19 or those recovering from the disease and are associated with a high risk of serious illness. India has recently seen an increase in cases that present this way when compared to other countries where these types of fungus thrive. Prevention needs to focus on making sure people who suffer from Covid-19 maintain better glycemic control so they do not develop any fungal infection like Mucoromyces Cerealis (a subtype found more often outside India) which can cause pneumonia if untreated or brain damage if left too long without treatment because it is resistant both systemic corticosteroids/other.

Mucormycosis, an invasive fungal infection that can lead to death, has been reported in patients with severe COVID-19. The Indian government recently noted a surge of cases and the spread of this dangerous condition is attributed largely to poor glycemic control among those living with the disease or recovering from it.

Fungal infections, including mucormycosis and invasive candidiasis, have been reported in patients with severe COVID-19 or those recovering from the disease. India has seen an uptick of cases due to fungal infection caused by COVID-19 along with a surge in people who are severely affected because they were not diagnosed early on while fighting off the virus. Prevention for this type of fungus is increased monitoring when trying to apply systemic corticosteroids/other immunomodulating drugs on these patients just as much as it would be if there was no sign that someone had ARDS (acute respiratory distress syndrome).

Mucormycosis is not contagious and does not spread by contact from person to person. This fungus has been found in the environment, but transmission occurs through inhalation or ingestion of spores from the environment. Although most cases are sporadic, healthcare-associated outbreaks have occurred after the use of adhesive bandages made out wood tongue depressors as well as linens with lackadaisical hygiene standards at hospitals that result in fungal exposure on surfaces like walls and floors which can lead to airborne infection if those areas aren't properly cleaned up soon enough. Mucormicosis primarily affects sinuses or lungs after inhaling spores from air when it's breathed directly into them.

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How Lack of Sleep Weakens Immunity: Why Poor Sleep Makes You Fall Sick More Often

Sleep is one of the most powerful yet overlooked pillars of health. While nutrition and exercise receive significant attention, sleep often takes a back seat in modern lifestyles. Understanding how lack of sleep weakens immunity reveals why people who sleep poorly fall sick more often, take longer to recover and experience chronic inflammation.

In India, late-night work culture, excessive screen time and irregular schedules have made sleep deprivation increasingly common across age groups.

The Link Between Sleep and the Immune System

The immune system relies on sleep for:

repair and regeneration
immune cell production
inflammation control

During deep sleep, the body releases cytokines and antibodies that protect against infections.

What Happens to Immunity During Sleep

While sleeping:

immune cells identify pathogens
inflammatory responses are regulated
memory T-cells strengthen immune memory

This nightly process prepares the body to fight infections effectively.

How Sleep Deprivation Disrupts Immune Function

When sleep is inadequate:

immune cell activity decreases
antibody production drops
inflammation increases

WHO studies confirm that sleep deprivation weakens immune defence mechanisms.

Increased Risk of Infections

People who sleep less than 6 hours regularly:

fall sick more often
catch colds and flu easily
recover slower from illness

Lancet research shows a strong link between sleep duration and infection susceptibility.

Impact on Inflammation

Poor sleep increases inflammatory markers.

Chronic inflammation:

weakens immune response
increases risk of chronic diseases

ICMR reports highlight sleep deprivation as a contributor to low-grade systemic inflammation.

Effect on Vaccine Response

Sleep quality affects how well vaccines work.

Studies show:

poor sleep reduces antibody response
adequate sleep improves vaccine effectiveness

Sleep is essential for immune memory formation.

Hormonal Changes That Affect Immunity

Sleep regulates hormones such as:

cortisol
melatonin

Lack of sleep increases cortisol, which suppresses immune function.

Stress, Sleep and Immunity

Sleep deprivation and stress reinforce each other.

High stress:

disrupts sleep
suppresses immune cells

This cycle weakens overall resistance to illness.

Impact on Gut Immunity

The gut hosts a major part of the immune system.

Poor sleep:

disrupts gut microbiome
weakens gut immunity

Lancet studies link sleep deprivation to gut-related immune dysfunction.

Why Children and Older Adults Are More Vulnerable

Sleep deprivation affects:

children’s developing immune systems
older adults’ already weakened immunity

Adequate sleep is especially important in these age groups.

Signs Your Immunity Is Affected by Poor Sleep

Warning signs include:

frequent infections
slow wound healing
constant fatigue
increased allergies

These symptoms indicate compromised immune defence.

Long-Term Health Risks of Poor Sleep

Chronic sleep deprivation increases risk of:

infections
autoimmune disorders
metabolic diseases
heart disease

Sleep loss affects nearly every body system.

Role of Preventive Health Awareness

Preventive healthcare emphasises:

sleep as a foundation of immunity
early lifestyle correction

NITI Aayog recognises sleep hygiene as essential for population health.

How to Improve Sleep for Better Immunity

Effective strategies include:

fixed sleep and wake times
limiting screen exposure before bed
avoiding caffeine late in the day
creating a dark, quiet sleep environment

Consistency matters more than duration alone.

Myths About Sleep and Immunity

Myth: You can catch up on sleep later
Fact: Chronic sleep debt harms immunity.

Myth: Sleeping pills improve immunity
Fact: Natural sleep is more beneficial.

Why Sleep Is a Preventive Medicine

Sleep:

costs nothing
requires no equipment
delivers powerful immune protection

It is one of the most effective preventive health tools.

Conclusion

Understanding how lack of sleep weakens immunity highlights the critical role of sleep in protecting the body from infections and chronic disease. Poor sleep disrupts immune cell function, increases inflammation and reduces resistance to illness. Prioritising consistent, quality sleep is not optional—it is essential for strong immunity, faster recovery and long-term health. Protecting sleep today strengthens immune defence for tomorrow.

References

Indian Council of Medical Research (ICMR) – Sleep, Immunity and Inflammation Studies
World Health Organization (WHO) – Sleep and Immune Health Guidelines
National Institutes of Health – Sleep Deprivation and Immunity
Lancet – Sleep Duration and Infection Risk
NITI Aayog – Preventive Health and Lifestyle Recommendations

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