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Published on: May 17, 2025
3 minute read
By: Secondmedic Expert

Top 5 Blood Tests You Shouldn’t Skip After 40

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As we grow older, our bodies go through many changes — some are visible, like graying hair or slower metabolism, but others happen quietly inside. After the age of 40, the risk of lifestyle-related diseases such as diabetes, heart disease, thyroid disorders, and kidney problems increases significantly. The good news? Most of these conditions can be detected early with simple blood tests.

Regular health checkups and blood tests can help you stay ahead of potential problems. They can alert you before symptoms even begin, giving you the chance to take control of your health in time.

In this blog, we’ll look at the Top 5 blood tests you shouldn’t skip after 40, why they’re important, and how you can easily get them done — even from the comfort of your home.

1. Complete Blood Count (CBC)

What is it?
The Complete Blood Count is a common blood test that checks the levels of different cells in your blood — red blood cells, white blood cells, and platelets.

Why is it important after 40?

Detects anemia, which is common in both men and women over 40
Helps identify infections and inflammatory conditions
Can point toward more serious issues like blood cancer in rare cases

What it includes:

Hemoglobin
Hematocrit
White blood cell (WBC) count
Platelet count

How often to test:
Once a year, or as advised by your doctor.

2. Blood Sugar Tests – Fasting & HbA1c

What is it?
These tests measure the amount of glucose (sugar) in your blood. The fasting blood sugar test checks your sugar level after 8–10 hours of fasting, while the HbA1c test shows your average sugar level over the past 2-3 months.

Why is it important after 40?

Type 2 diabetes is very common in people above 40, especially in India
Early detection can prevent complications like nerve damage, eye problems, and kidney disease
Many people have prediabetes and don’t even know it

What it includes:

Fasting Blood Glucose (FBS)
Postprandial Blood Sugar (PPBS)
HbA1c

How often to test:
Every 6–12 months, or more often if you're overweight, have a family history, or symptoms of diabetes.

3. Lipid Profile (Cholesterol Test)

What is it?
A lipid profile checks the levels of different types of fats (lipids) in your blood — especially cholesterol and triglycerides.

Why is it important after 40?

Helps assess your risk of heart disease, stroke, and artery blockages
Detects high LDL ("bad cholesterol"), which builds up in arteries
Encourages healthy lifestyle changes before medications are needed

What it includes:

Total cholesterol
LDL (Low-Density Lipoprotein)
HDL (High-Density Lipoprotein)
Triglycerides

How often to test:
Once a year, or every 6 months if you're overweight, smoke, or have a family history of heart issues.

4. Liver Function Test (LFT)

What is it?
This test checks how well your liver is working. The liver is responsible for digesting food, filtering toxins, and regulating many body processes.

Why is it important after 40?

Modern lifestyle increases the risk of fatty liver disease, even in non-drinkers
Long-term use of medications, alcohol, or unhealthy diets can silently damage the liver
Detects hepatitis, jaundice, and other liver issues early

What it includes:

SGPT (ALT), SGOT (AST)
Bilirubin
Alkaline Phosphatase
Albumin

How often to test:
Once a year or as recommended, especially if you drink alcohol, are overweight, or take regular medications.

5. Kidney Function Test (KFT)

What is it?
This test checks how well your kidneys are filtering waste and balancing fluids in your body.

Why is it important after 40?

Kidneys often get damaged silently due to high blood pressure, diabetes, or painkillers
Early detection can prevent serious kidney damage or the need for dialysis
Many Indians are at risk of chronic kidney disease (CKD) without knowing it

What it includes:

Blood Urea
Serum Creatinine
Uric Acid
Electrolytes (Sodium, Potassium)
eGFR (Estimated Glomerular Filtration Rate)

How often to test:
Yearly, especially if you have diabetes, high blood pressure, or a family history of kidney problems.

Other Important Tests After 40

While the above 5 are essential, don’t ignore these additional tests:

Thyroid Function Test (TSH, T3, T4) – for energy, weight, and mood balance
Vitamin D & B12 – deficiencies are common in Indian adults
ECG or TMT – if you feel chest pain or breathlessness
Prostate Test (PSA) – for men over 45
Pap Smear & Mammogram – for women to detect cervical and breast cancer

How to Book These Tests Easily in India

Getting a blood test today is simple and stress-free. You don’t even need to visit a lab anymore.

At SecondMedic, you can:

Book blood tests online through our website
Get home sample collection by trained professionals
View your digital reports online within 24–48 hours
Consult our doctors based on your results

Conclusion

Turning 40 is a milestone — and a reminder that your health needs attention. Don’t wait for symptoms. These simple blood tests can alert you to hidden problems and help you take action before it’s too late.

Remember, good health starts with awareness. Be proactive, not reactive.

If you care about your long-term well-being, Top 5 Blood Tests You Shouldn’t Skip After 40 should be part of your annual health routine. Book them today on SecondMedic and stay a step ahead in your health journey.

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Read FAQs

A. After 40, the most important blood tests include Complete Blood Count (CBC), Fasting Blood Sugar & HbA1c, Lipid Profile, Liver Function Test (LFT), and Kidney Function Test (KFT).

A. It's recommended to get a full set of preventive blood tests at least once a year. If you have risk factors like diabetes, hypertension, or family history of chronic disease, more frequent testing may be needed.

A. Yes, platforms like SecondMedic offer home sample collection for blood tests across India. You can book tests online and receive digital reports within 24–48 hours.

A. Most of these tests are affordable and are also available in bundled health checkup packages. Prices range from ₹500 to ₹2000 depending on the tests and provider.

A. Many chronic diseases like diabetes, kidney damage, or fatty liver show no symptoms in the early stages. Regular blood tests help detect these issues early, improving chances of effective treatment or reversal.

Read Blog

Difference Between Sadness and Depression: Understanding Normal Emotions vs Mental Illness

Feeling low or unhappy is a part of being human. However, not all low moods are the same. Many people confuse sadness with depression, which can delay proper support and treatment. Understanding the difference between sadness and depression is crucial for mental health awareness, early intervention and reducing stigma.

In India, mental health conditions are often misunderstood, with emotional distress frequently dismissed as temporary sadness.

What Is Sadness?

Sadness is a normal human emotion.

It usually occurs due to:

loss or disappointment
relationship issues
failure or stress
temporary life challenges

Sadness serves a psychological purpose, allowing individuals to process emotions and adapt.

Key Characteristics of Sadness

Sadness is:

situational
temporary
emotionally painful but manageable
responsive to support and positive events

A person experiencing sadness can still function, enjoy moments and feel hopeful.

What Is Depression?

Depression is a medical condition classified as a mood disorder.

It affects:

emotions
thinking patterns
behaviour
physical health

According to WHO, depression is one of the leading causes of disability worldwide.

Core Symptoms of Depression

Depression involves a combination of symptoms such as:

persistent low mood
loss of interest or pleasure
fatigue
sleep disturbances
appetite changes
feelings of worthlessness
difficulty concentrating

These symptoms last at least two weeks or longer.

Duration: A Key Difference

One major difference lies in duration.

Sadness:

lasts hours or days
improves with time

Depression:

lasts weeks or months
persists despite positive events

Duration helps distinguish emotional response from illness.

Impact on Daily Functioning

Sadness:

allows continuation of work and relationships
may reduce motivation temporarily

Depression:

interferes with work, studies and relationships
reduces self-care and productivity

Functional impairment is a defining feature of depression.

Emotional Experience: Sadness vs Depression

Sadness:

allows emotional range
moments of joy still occur

Depression:

creates emotional numbness
joy and interest disappear

People with depression often describe feeling empty rather than sad.

Physical Symptoms in Depression

Depression is not only emotional.

Physical symptoms include:

chronic fatigue
body aches
headaches
digestive issues

ICMR mental health studies highlight the physical burden of depression.

Thought Patterns and Self-Perception

Sadness:

thoughts remain realistic
self-worth is preserved

Depression:

negative self-talk dominates
feelings of guilt and worthlessness increase

These cognitive changes deepen emotional suffering.

Risk Factors for Depression

Factors increasing depression risk include:

chronic stress
trauma
family history
medical illnesses
hormonal changes

NFHS-5 data indicates rising mental health concerns among young adults.

Can Sadness Turn Into Depression?

Yes, prolonged or unresolved sadness can progress into depression.

This is more likely when:

stressors are ongoing
support systems are weak
coping mechanisms are limited

Early emotional support can prevent progression.

When to Seek Professional Help

Seek help if:

low mood lasts more than two weeks
daily functioning is affected
sleep and appetite are disturbed
thoughts of self-harm occur

Early care leads to better outcomes.

Treatment Differences

Sadness:

improves with rest, support and time

Depression:

requires psychotherapy
may need medication
benefits from structured care

WHO emphasises early treatment to reduce disability.

Role of Social Support

Support systems help both conditions but are essential for recovery.

Depression recovery improves with:

understanding family
supportive workplaces
accessible mental healthcare

Stigma reduction is key.

Mental Health Awareness in India

Mental health remains underdiagnosed in India.

NITI Aayog reports:

limited access to mental health services
low awareness
high stigma

Education helps bridge this gap.

Importance of Early Recognition

Recognising depression early:

prevents worsening
reduces suicide risk
improves quality of life

Delay increases suffering and complications.

Supporting Someone With Depression

Helpful actions include:

listening without judgement
encouraging professional help
avoiding minimising feelings

Compassion is more effective than advice.

Conclusion

Understanding the difference between sadness and depression is essential for emotional wellbeing and mental health care. Sadness is a natural, temporary response to life events, while depression is a serious medical condition that affects thoughts, emotions and daily functioning. Recognising the signs early and seeking appropriate help can prevent long-term suffering and promote recovery. Mental health deserves the same attention and care as physical health.

References

World Health Organization (WHO) – Depression and Mental Health Disorders
Indian Council of Medical Research (ICMR) – Mental Health Research and Burden
National Family Health Survey (NFHS-5) – Mental Health Indicators
Lancet – Depression, Disability and Public Health
NITI Aayog – National Mental Health Policy and Awareness Reports
Statista – Global and Indian Mental Health Trends

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