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Published on: Apr 28, 2020
4 minute read
By: Dr Rajan Choudhary

Strokes In The Young And How COVID Causing Clotting Disorders?

Strokes in the young and healthy: how is COVID causing clotting disorders?

In the news, there has been a rush in stories linking Strokes in young and healthy patients, patients who also have COIVD-19. This is certainly worrying news, and at first glance, it is difficult to explain. How does a respiratory virus, one that is very similar to the coronavirus responsible for the common cold, cause such serious issues in a completely unrelated organ system? In this two-part series we will first go over the basics of clotting and its function, how clotting can cause problems, and finally how COVID can lead to clotting disorders.

STROKES

Before we progress, if you or a family member are having any of the following symptoms, contact your local emergency services immediately. Strokes can be devastating, and treatment needs to be given as soon as possible to save as much of the brain as we can. Early recognition can be the difference between manageable long term effects and crippling disability.

Remember, act F.A.S.T

Facial Droop on one side
Arm or hand on one side feels numb or weak with reduced power (same in one leg)
Slurred speech making it difficult to understand
Time to phone an ambulance

Other symptoms can include sudden loss in balance, sudden loss in vision in one eye, problems swallowing, and more.

PLUGGING A HOLE

We have an intricate network of vessels to transport oxygen, nutrients, and signals to cells and organs across our bodies. Damage to these blood vessels causes blood loss, reduction in oxygen and nutrient delivery to these cells, and organ damage if the issue isn’t rectified. Failure in multiple organ systems across the body will eventually lead to death. Our blood has cells and proteins that work together to form a clot at the site of injury. This acts as a plug to physically stop the leak, but also encourages repair of the blood vessel and surrounding tissue.

A clot can be triggered in three different ways: blood stasis (pooling up in one area), exposure of blood vessel lining, and pro-coagulant factors released into the blood. When triggered a coagulation cascade occurs to form the building blocks of a clot – it works so well that even a small trigger can create a response big enough to repair the damage. These form a mesh trapping platelets and other blood cells into a plug. Immune cells also arrive to destroy any organisms that might enter from the trauma site that caused the injury, and these immune cells also instruct nearby cells to begin the repair process.

As with everything in our body the whole process is very tightly regulated. The cascade has triggers and accelerators, but it also has brakes. These brakes stop a clot from growing too big, or from clots forming spontaneously when they are not needed. They also help dissolve a clot once the vessel is repaired and it isn’t needed.

WHEN IT GOES WRONG

Heart attacks and strokes. These devastating cardiovascular diseases are well recognized by the public as a leading cause of disability and death. Both can be caused by abnormal clotting. How does our finely tuned clotting cascade turn abnormal? Let's go back to the three triggers of blood clotting.

Vessel damage: Eating a high fat and cholesterol diet can cause fatty plaques to build up in our arteries. This is known as atherosclerosis, and it is extremely common. The plaques can narrow your arteries and reduce blood flow. If this happens in your coronary arteries supplying your heart muscles, your heart might not receive enough oxygen when you exercise or exert yourself. This can cause chest pain, known as angina.

If the plaques burst open it can expose the vessel lining, causing a large clot to form. This clot can become dislodged and be carried away by the blood. It will eventually get lodged in a narrow artery, blocking it and stopping blood from entering. The tissue and cells supplied by that artery will not receive oxygen and eventually die. If this happens in the coronary arteries it can cause a heart attack. In the arteries supplying the brain, it can cause a stroke, leading to neurological deficits.

THIS IS THE MOST IMPORTANT LEARNING POINT, and this is why a healthy diet low in fat and sugars is so important.

Stasis: Our heart pumps blood at high pressures through the arteries. But in the veins, there is very little pressure to drive the blood back to the heart. In our arms and head, gravity helps blood flow down to the heart. But from our legs? When we walk the muscles in our legs squeeze the veins and move the blood. Valves make sure this flow is only one way, back to the heart.

If we sit or lie down in one place and don’t move, the blood isn’t pumped back and pools up in our legs, causing a clot to form. This usually happens in our calves (known as a DEEP VEIN THROMBOSIS, or DVT). The calf becomes swollen, painful, red, and hot. If this clot is dislodged, it can end up in our lungs causing a PULMONARY EMBOLISM. A large PE can block blood from entering the lungs and can be fatal. This is why you should take regular walks on long haul flights, to prevent blood from pooling.

Pro-coagulant: Sometimes the factors in our blood responsible for triggering a clot can be triggered accidentally. Cigarette smoke contains many toxins and harmful chemicals that, when inhaled, end up in your blood. These chemicals can cause damage to vessel linings, and also cause the clotting cascade to be triggered more easily. Some medications, such as the Combined Oral Contraceptive Pill, also have a similar effect, though the risk of getting a clot is still very low.

The immune system can also trigger a clot. The protein mesh formed in the blood can also capture bacteria and viruses around an infection site, making it easier for immune cells to find and destroy these invading organisms. In cancer patients, this process is sometimes triggered by unregulated cancer cells.

WHAT HAVE WE LEARNT?

Our clotting system stops us from bleeding to death from a small wound. People who have bleeding disorders are clear examples and need to be extremely careful if they injure themselves. But unregulated, our body can end up harming itself. If there is one thing you should take away from this, it is that a high sugar/high-fat diet with little exercise can directly increase your risk of having a heart attack or stroke. This is why doctors emphasize so much the importance of a good diet and exercise.

In our next blog, we will look at how this clotting problem is implicated in COVID patients.

Dr Rajan Choudhary, UK, Chief Product Officer, Second Medic Inc

www.secondmedic.com

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Genetic Testing Services India: How DNA-Based Insights Are Transforming Preventive Healthcare

Genetic testing services in India have rapidly expanded over the last decade, becoming a vital part of preventive healthcare, early diagnosis, and personalized treatment planning. As medical science advances, understanding one’s DNA has become more accessible, accurate, and meaningful. Genetic testing empowers individuals with information about hereditary risks, potential health challenges, and personalized lifestyle recommendations based on their biological blueprint.

With rising chronic disease rates, cancer cases, and lifestyle-driven health issues, India is now embracing DNA-based healthcare as an essential tool for early detection and long-term prevention. SecondMedic integrates genetic insights into its preventive care ecosystem, helping individuals and families make informed decisions about their health.

The Growing Importance of Genetic Testing in India

India has a diverse population with complex genetic structures, making genetic testing particularly valuable. Many hereditary conditions often go undiagnosed until symptoms appear, which sometimes leads to delayed treatment.

Several factors are driving the growth of genetic testing in India:

Increased awareness of hereditary diseases
Rising cancer and cardiac risk among younger populations
Demand for preventive and precision healthcare
Wider availability of DNA-testing technology
Integration of genomics into clinical practice

As people seek more personalized healthcare, genetic testing has become a powerful tool for understanding risk factors long before they cause illness.

What Genetic Testing Reveals About Your Health

Genetic testing examines specific DNA markers to determine predispositions and inherited risks. The results provide clarity about future risks, potential conditions, and biological tendencies that influence long-term health.

Genetic testing can reveal:

Predisposition to cancer
Heart disease risk
Diabetes and metabolic disorders
Thyroid and hormonal disorders
Lipid metabolism issues
Neurological and genetic syndromes
Response to medicines (pharmacogenomics)
Carrier status for inheritable conditions

This information creates a foundation for preventive action, lifestyle modification, and informed medical decisions.

Types of Genetic Testing Available in India

India’s genetic testing ecosystem offers several categories of tests designed for different health needs.

Common types include:

Hereditary cancer risk testing
Cardiac risk genetic screening
Metabolic and lifestyle-based DNA tests
Carrier screening for inheritable conditions
Pharmacogenomic testing
Newborn screening
Whole exome or genome sequencing

SecondMedic works with leading genetic laboratories to deliver clinically validated tests integrated with actionable health insights.

Genetic Testing and Preventive Medicine

Preventive healthcare becomes far more effective when guided by genetic insights. Instead of waiting for symptoms, individuals can take proactive steps based on their specific risk profile.

Genetic testing supports preventive care by:

Identifying risks early
Recommending personalized diet and exercise plans
Providing medication compatibility insights
Monitoring high-risk individuals more closely
Guiding screening schedules

This approach significantly reduces the likelihood of severe disease progression.

Integration of Genetic Testing with Precision Medicine

Precision medicine aims to deliver treatments tailored to individual biology. Genetic testing is central to this approach, helping doctors customize care.

Genetic insights influence:

Selecting the right medications
Determining accurate dosages
Avoiding harmful drug reactions
Recommending targeted therapies
Planning long-term health strategies

SecondMedic combines genetic data with electronic health records, lab reports, and lifestyle assessments to build comprehensive care plans.

Genetic Testing and Family Health Management

Understanding genetic risks does not only benefit individuals—it supports entire families. Many conditions are passed down through generations and early awareness can help protect family members.

Genetic testing helps families identify:

Hereditary cancer patterns
Recessive or dominant genetic traits
Chromosomal conditions
Diseases likely to appear later in life

SecondMedic provides family-focused genetic counseling that helps relatives assess their own risks based on shared history.

Safety, Accuracy, and Reliability of Genetic Testing

Modern genetic testing is safe, non-invasive, and highly reliable. Most tests require only a saliva sample or a painless cheek swab. Laboratories then analyze DNA using advanced sequencing technologies.

Accuracy is ensured through:

Globally validated testing panels
High-depth DNA sequencing
Cross-verified genetic markers
Clinically certified laboratories
Medical review of results

SecondMedic ensures that genetic reports are interpreted by certified experts for practical application.

The Role of Genetic Counseling in DNA-Based Healthcare

Raw DNA data alone is not enough. Patients need clear guidance on how to understand and apply genetic results. Genetic counseling helps individuals navigate results confidently and make informed decisions.

Counseling includes:

Explanation of risk levels
Genetic pattern interpretation
Clear preventive recommendations
Family planning guidance
Personalized lifestyle strategies

SecondMedic offers genetic counseling alongside reports to ensure meaningful, actionable insights.

How SecondMedic Integrates Genetic Testing into Preventive Care

SecondMedic creates a seamless experience where genetic testing becomes part of a broader health management plan. After receiving results, individuals gain access to personalized nutrition, fitness, screening schedules, and digital monitoring tools.

SecondMedic’s approach includes:

Personalized DNA-based health reports
Doctor-reviewed insights
Custom preventive health plans
Ongoing monitoring and follow-up
Integration with AI-based risk scoring
Virtual consultations with specialists

This ensures long-term support based on accurate genetic understanding.

The Future of Genetic Testing in India

Genomics is set to transform Indian healthcare in the coming years. As technology becomes more affordable and awareness grows, genetic testing will become a routine part of preventive health.

Upcoming trends include:

Widespread use of pharmacogenomics
DNA-based nutrition personalization
Expanded newborn genetic screening
AI-driven genetic interpretation
Integration with national digital health records
Genetic-based early disease prediction

SecondMedic aims to make genetic testing accessible, affordable, and clinically meaningful for individuals across India.

Conclusion

Genetic testing services in India are unlocking powerful insights that empower individuals to take control of their health. Through DNA-based risk assessment, hereditary screening, and precision medicine, genetic testing creates a pathway to informed, preventive, and personalized healthcare. SecondMedic integrates these insights into comprehensive wellness plans, giving users long-term guidance for healthier living.

To book genetic testing or explore DNA-based health programs, visit www.secondmedic.com

References

NITI Aayog – Genomics and Precision Medicine India
ICMR – Genetic Disorders in India 2024
IMARC – Indian Genetic Testing Market Report
WHO – Human Genomics in Healthcare
Nature Genetics – Global Genetic Risk Studies

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