• Published on: May 05, 2024
  • 2 minute read
  • By: SecondMedic Expert

Role Of Kidney Function Tests In Chronic Kidney Disease (CKD)

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The progressive loss of kidney function over time is the hallmark of chronic kidney disease (CKD). In order to limit the progression of CKD and avoid complications, it is essential to recognize the condition early and monitor it regularly. Renal function tests, also referred to as kidney function tests or KFTs (Kidney Function Tests), are essential for the diagnosis and treatment of chronic kidney disease (CKD). This article examines the role that kidney function tests play in the evaluation of chronic kidney disease (CKD) phases and the importance of test results in the efficient management of this illness.

Importance of Kidney Function Tests in CKD Diagnosis

A series of blood and urine tests known as kidney function tests are used to evaluate the kidneys' overall health. By assessing certain indicators including creatinine, blood urea nitrogen (BUN), estimated glomerular filtration rate (eGFR), and urine protein levels, these tests offer insightful information on kidney health. Kidney function tests aid in the diagnosis of chronic kidney disease (CKD) by detecting changes in kidney function prior to the onset of symptoms.

Key Markers in Kidney Function Tests

Creatinine: The kidneys' capacity to remove waste from the blood is reflected in the levels of serum creatinine. High levels of creatinine signify compromised kidney function, a characteristic of chronic renal disease.
Blood Urea Nitrogen (BUN): Urea is a waste product of protein metabolism. BUN levels indicate how much nitrogen is derived from urea in the blood. Reduced renal function may be indicated by elevated BUN levels.
Age, gender, race, and creatinine levels are used to calculate the estimated glomerular filtration rate, or eGFR. It calculates the kidneys' efficiency at removing waste from the blood. When CKD is staged, a low eGFR is indicative of diminished kidney function.
Urine Protein (Proteinuria): Proteinuria is a symptom of renal disease that can be identified by urine tests. A high protein level in the urine is indicative of a compromised kidney's filtration capacity.

Stages of CKD Based on Kidney Function Tests

Based on eGFR scores, kidney function tests are essential for classifying CKD into stages:
Stage 1 (Kidney Damage with Normal eGFR): eGFR (>90 mL/min/1.73 m2) is normal despite the presence of kidney damage.
Stage 2 (moderately impaired eGFR): eGFR 60-89 mL/min/1.73 m?2; indicates a moderately impaired kidney function.
Stage 3 (Moderately Reduced eGFR): eGFR of 30-59 mL/min/1.73 m?2; indicates a moderate decline in kidney function.
Severe loss in kidney function (eGFR 15-29 mL/min/1.73 m2) is shown in Stage 4 (Severely Reduced eGFR).
Kidney function is severely compromised or failed in Stage 5 (Kidney Failure) (eGFR <15>

Monitoring CKD Progression and Treatment

Tracking the course of CKD and directing treatment choices need routine monitoring of kidney function tests. The pace of loss in kidney function can be determined with great accuracy by monitoring changes in urine protein levels, eGFR, and creatinine over time. Through lifestyle changes, medicine, and, in more severe cases, renal replacement therapy (dialysis or kidney transplantation), treatment techniques for chronic kidney disease (CKD) seek to decrease the illness's course, manage its consequences, and preserve kidney function.

Conclusion

To sum up, renal function tests are essential diagnostic and surveillance instruments for chronic kidney disease (CKD). Based on kidney function measurements, these tests aid in the staging of chronic kidney disease (CKD), enabling individualized treatment plans to impede the illness's advancement and enhance patient outcomes. The key to maintaining kidney function and improving general health in those with chronic kidney disease (CKD) is early detection and routine monitoring of the condition using kidney function testing. For those with CKD, routine follow-up appointments with medical professionals are advised in order to assess kidney health and modify treatment plans as necessary.

Renal function tests must be included in regular health screenings in order to diagnose chronic renal disease early and treat it effectively. People can safeguard their kidney health and general well-being by being proactive and learning the role that kidney function tests play in the diagnosis and monitoring of chronic kidney disease (CKD).

Read FAQs


A. Common kidney function tests include serum creatinine, blood urea nitrogen (BUN), estimated glomerular filtration rate (eGFR), urine albumin-to-creatinine ratio (ACR), and urine protein test.

A. Kidney function tests measure levels of substances like creatinine and urea in the blood and proteins in urine. Abnormal levels indicate kidney damage and help stage CKD.

A. The estimated glomerular filtration rate (eGFR) reflects the kidneys' filtering capacity. Lower eGFR values indicate reduced kidney function, a hallmark of Chronic Kidney Disease (CKD).

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Sleep disorders

Sleep Disorder Treatment: Effective Ways to Restore Healthy Sleep

Sleep is a fundamental biological process essential for physical restoration, mental clarity and emotional balance. Despite its importance, sleep disorders are increasingly common across all age groups. Millions of people struggle with poor sleep quality, difficulty falling asleep or frequent nighttime awakenings, often without seeking help.

Effective sleep disorder treatment plays a critical role in restoring healthy sleep patterns and preventing long-term health complications.

 

Understanding Sleep Disorders

Sleep disorders are conditions that disrupt normal sleep patterns, affecting the ability to fall asleep, stay asleep or achieve restorative sleep. They can be short-term or chronic and may occur due to lifestyle factors, medical conditions or psychological stress.

According to global and Indian health data, sleep disorders are underdiagnosed despite their strong association with chronic diseases.

 

Common Types of Sleep Disorders

Insomnia

Insomnia is the most common sleep disorder.

It involves:

  • difficulty falling asleep
     

  • frequent awakenings
     

  • early morning waking
     

  • non-restorative sleep
     

Chronic insomnia significantly affects daily functioning.

 

Sleep Apnea

Sleep apnea is a serious condition where breathing repeatedly stops during sleep.

Symptoms include:

  • loud snoring
     

  • daytime sleepiness
     

  • morning headaches
     

Untreated sleep apnea increases cardiovascular risk.

 

Restless Leg Syndrome

This condition causes uncomfortable leg sensations and an urge to move the legs, especially at night.

It disrupts sleep continuity and quality.

 

Circadian Rhythm Disorders

These occur when the body’s internal clock is misaligned with daily schedules, common in shift workers and frequent travellers.

 

Why Sleep Disorders Should Not Be Ignored

Chronic sleep problems increase the risk of:

  • heart disease
     

  • hypertension
     

  • diabetes
     

  • obesity
     

  • depression and anxiety
     

  • reduced immunity
     

Poor sleep affects both physical and mental health.

 

Causes of Sleep Disorders

Sleep disorders often result from multiple factors, including:

  • chronic stress
     

  • irregular sleep schedules
     

  • excessive screen exposure
     

  • caffeine or alcohol use
     

  • medical conditions
     

  • mental health disorders
     

Identifying root causes is essential for effective treatment.

 

Diagnosis of Sleep Disorders

Diagnosis involves:

  • detailed sleep history
     

  • lifestyle assessment
     

  • medical evaluation
     

  • sleep studies in selected cases
     

Accurate diagnosis guides appropriate treatment.

 

Sleep Disorder Treatment Approaches

Behavioural and Cognitive Therapy

Cognitive Behavioural Therapy for Insomnia (CBT-I) is a highly effective non-drug treatment.

It focuses on:

  • correcting sleep-related thoughts
     

  • improving sleep routines
     

  • reducing anxiety around sleep
     

CBT-I is recommended as first-line treatment for chronic insomnia.

 

Lifestyle and Sleep Hygiene Measures

Good sleep hygiene includes:

  • maintaining regular sleep timings
     

  • limiting screen exposure before bedtime
     

  • creating a comfortable sleep environment
     

  • avoiding heavy meals late at night
     

These measures support natural sleep regulation.

 

Medical Management

Medications may be used:

  • short-term for severe symptoms
     

  • under medical supervision
     

Medication is often combined with behavioural therapy rather than used alone.

 

Treatment for Sleep Apnea

Management may include:

  • weight management
     

  • positional therapy
     

  • continuous positive airway pressure (CPAP) devices
     

  • treating underlying conditions
     

Early treatment reduces cardiovascular risk.

 

Role of Mental Health in Sleep Disorders

Sleep and mental health are closely connected.

Conditions such as anxiety and depression:

  • disrupt sleep architecture
     

  • worsen insomnia
     

  • require integrated treatment
     

Addressing mental health improves sleep outcomes.

 

Importance of Consistency in Treatment

Sleep disorder treatment requires:

  • patience
     

  • consistency
     

  • follow-up
     

Improvement may take weeks, but sustained effort yields lasting results.

 

Preventing Sleep Disorders

Preventive strategies include:

  • stress management
     

  • physical activity
     

  • balanced nutrition
     

  • limiting stimulants
     

  • maintaining work-life balance
     

Prevention is more effective than treatment alone.

 

Impact of Technology on Sleep

Excessive screen use affects melatonin production and delays sleep onset.

Reducing nighttime screen exposure significantly improves sleep quality.

 

When to Seek Professional Help

Consult a healthcare provider if:

  • sleep problems persist beyond two weeks
     

  • daytime functioning is affected
     

  • snoring and breathing pauses are noticed
     

  • sleepiness interferes with safety
     

Early treatment prevents complications.

 

Long-Term Benefits of Treating Sleep Disorders

Effective sleep disorder treatment leads to:

  • improved energy and concentration
     

  • better mood and emotional stability
     

  • reduced chronic disease risk
     

  • enhanced quality of life
     

Healthy sleep supports overall wellbeing.

 

Conclusion

Sleep disorder treatment is essential for restoring physical health, mental clarity and emotional balance. While sleep problems are common, they are not normal or harmless. Insomnia, sleep apnea and other sleep disorders can be effectively managed through behavioural therapy, lifestyle changes and medical care when needed. Early recognition and consistent treatment not only improve sleep quality but also protect long-term health. Prioritising sleep is a powerful step toward a healthier and more productive life.

 

References

  • Indian Council of Medical Research (ICMR) – Sleep Health and Lifestyle Studies
  • World Health Organization (WHO) – Sleep and Mental Health Guidelines
  • National Institute of Mental Health and Neurosciences (NIMHANS) – Sleep Disorders Research
  • Lancet Psychiatry – Sleep Disorders and Chronic Disease Risk
  • NITI Aayog – Mental Health and Preventive Healthcare Reports
  • Statista – Global Sleep Disorder Prevalence and Trends

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