REGN-COV2 – Artificial "antibody Cocktail"

REGN-COV2 – Artificial "antibody cocktail"

Recently a new drug was approved for use in COVID patients in India. Known as REGN-COV2, this new therapy is based on monoclonal antibodies targeting the SARS-CoV-2 virus responsible for COVID. So how does it work? And is there any evidence behind the treatment?

Monoclonal antibodies are made from components of the human immune system. When the human body recognizes a bacteria or virus in the body, the immune system recognizes and processes proteins on the surface of that bacteria or virus. This is presented to the adaptive immune system, and antibodies have produced that lock onto these surface proteins, neutralizing their function and also tagging them for destruction by other white blood cells.

If we identify antibodies capable of efficiently tagging and neutralizing a certain virus, we can identify the cell capable of producing that antibody, clone it and produce it in vast quantities. The antibodies produced from this cloned cell line will be able to target the virus at the same efficiency and have the same ability to neutralize the virus. Just like with vaccines, there is a risk of mutations developing, resulting in changes in the surface protein that reduce binding and neutralizing effects of the antibodies, allowing them to escape and continue to cause disease

REGN-COV2 uses two neutralizing antibodies (Casirivimab/imdevimab), in an effort to minimize the ability of a mutant virus to develop resistance against the antibody cocktail, as the virus would need to develop mutations canceling both antibodies out at once. These antibodies neutralize the receptor-binding domain of SARS-CoV-2 spike protein, preventing viral entry through ACE2 receptors.

In a study published in the New England Journal of Medicine (one of the most prestigious journals in the medical field) data from 275 patients showed a drastic reduction in viral load in patients treated with REGN-COV2. This is clinically significant as hospitalized patients with severe symptoms have higher viral counts than non-hospitalized or asymptomatic patients, suggesting the hypoxaemic, shortness of breath symptoms are related to the viral count and resulting exaggerated immune response.

Based off this result the European Medicines Agency approved the use of REGN-COV2 antibody cocktail in patients who do not require supplemental oxygen but are at high risk of progressing to severe COVID-19.

FDA regulations currently recommend it for patients who are COVID positive with risk factors that may result in their hospitalization but do not recommend it for patients who are already hospitalized, requiring O2 therapy because of COVID or need chronic O2 therapy.

Those that fall into the high-risk categories include patients with a high BMI (over 35), diabetes, on immunosuppressive treatment or with an immunosuppressive disease, over 65 years of age or those with chronic diseases such as renal disease, cardiovascular disease, COPD, or other developmental disorders.

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From Weight Loss to Heart Health: The Comprehensive Benefits of Eating Figs

Introduction to the Health Benefits of Figs

Figs are a delicious and nutritious fruit that have been enjoyed for centuries. Packed with vitamins, minerals, antioxidants, and dietary fiber, figs offer numerous health benefits. Whether you eat them fresh or dried, figs can be a valuable addition to your diet. In this blog, we will explore the many advantages of eating figs, from aiding weight loss to improving heart health.

Figs for Weight Loss Benefits

If you're looking to shed some pounds, figs can be a fantastic addition to your weight loss plan. Figs are low in calories but high in dietary fiber, which helps you feel full longer and reduces overall calorie intake. The fiber content in figs promotes satiety, making you less likely to overeat.

Additionally, figs have a natural sweetness that can satisfy your sugar cravings without the added calories of processed sweets. Incorporating figs into your weight loss diet is easy. Enjoy them as a snack, add them to your salads, or blend them into your morning smoothie. The benefits of eating figs for weight loss are truly impressive, making them a great choice for anyone aiming to achieve a healthier weight.

Figs for Heart Disease Prevention

Heart disease is a leading cause of death worldwide, but the good news is that figs can help protect your heart. Figs are rich in antioxidants, which help combat oxidative stress and reduce inflammation, two major factors in heart disease. The nutrients in figs, such as potassium and magnesium, are also essential for heart health.

Potassium helps regulate blood pressure, while magnesium supports healthy heart function. Studies have shown that consuming figs can improve heart health by lowering blood pressure and improving blood vessel function. By including figs in your diet, you can reduce your risk of heart disease and enjoy better overall cardiovascular health.

Figs for Cholesterol Reduction

High cholesterol levels can lead to serious health problems, but figs can help keep your cholesterol in check. Figs are packed with soluble fiber, which is known to lower LDL (bad cholesterol) levels while raising HDL (good cholesterol) levels. This balance is crucial for maintaining healthy cholesterol levels and preventing heart disease.

Incorporating figs into a heart-healthy diet is simple. Add them to your oatmeal, mix them into yogurt, or use them as a topping for desserts. The benefits of eating figs for cholesterol reduction make them a valuable food for anyone looking to improve their heart health.

Figs for Blood Pressure Regulation

Maintaining healthy blood pressure levels is essential for overall health, and figs can play a significant role in this. Figs are high in potassium, a mineral that helps regulate blood pressure by balancing the effects of sodium in your body. This balance is crucial for preventing hypertension and reducing the risk of stroke and heart disease.

The benefits of eating figs for blood pressure regulation are supported by research, which shows that potassium-rich foods like figs can help maintain healthy blood pressure levels. Incorporate figs into your diet by enjoying them as part of a balanced meal with other potassium-rich foods like bananas and spinach.

Other Advantages of Eating Figs

Beyond their benefits for weight loss and heart health, figs offer numerous other health advantages. Figs are excellent for digestive health due to their high fiber content, which helps promote regular bowel movements and prevent constipation. They also contain prebiotics, which support a healthy gut microbiome.

Figs are beneficial for bone health as well. They are rich in calcium and magnesium, two minerals essential for strong bones. Regular consumption of figs can help prevent bone-related conditions like osteoporosis.

Additionally, figs are great for skin health. The antioxidants and vitamins in figs help protect your skin from damage caused by free radicals, promoting a healthy and youthful complexion.

How to Add Figs to Your Daily Diet

Adding figs to your daily diet is easy and delicious. Here are some simple recipes and serving suggestions:

Snack on Fresh Figs: Enjoy fresh figs on their own for a quick and nutritious snack.
Fig and Walnut Salad: Toss sliced figs with walnuts, arugula, and a balsamic vinaigrette for a tasty salad.
Fig Smoothie: Blend figs with your favorite fruits and a splash of almond milk for a refreshing smoothie.
Fig Bars: Make homemade fig bars using dried figs, oats, and honey for a healthy treat.
Fig Chutney: Use figs to make a savory chutney that pairs well with cheese and crackers.

When choosing figs, opt for fresh, ripe figs for the best flavor and nutritional benefits. If fresh figs are not available, dried figs are a great alternative. Store figs in a cool, dry place and enjoy them regularly to reap their many health benefits.

Conclusion

In conclusion, figs are a powerhouse of nutrition and offer a wide range of health benefits. From aiding weight loss to preventing heart disease and regulating blood pressure, the advantages of eating figs are vast. Incorporate figs into your daily diet to improve your overall health and well-being. This makes them a must-have fruit for anyone looking to enhance their health naturally.