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Published on: May 31, 2021
1 minute read
By: Dr Rajan Choudhary

REGN-COV2 – Artificial "antibody Cocktail"

REGN-COV2 – Artificial "antibody cocktail"

Recently a new drug was approved for use in COVID patients in India. Known as REGN-COV2, this new therapy is based on monoclonal antibodies targeting the SARS-CoV-2 virus responsible for COVID. So how does it work? And is there any evidence behind the treatment?

Monoclonal antibodies are made from components of the human immune system. When the human body recognizes a bacteria or virus in the body, the immune system recognizes and processes proteins on the surface of that bacteria or virus. This is presented to the adaptive immune system, and antibodies have produced that lock onto these surface proteins, neutralizing their function and also tagging them for destruction by other white blood cells.

If we identify antibodies capable of efficiently tagging and neutralizing a certain virus, we can identify the cell capable of producing that antibody, clone it and produce it in vast quantities. The antibodies produced from this cloned cell line will be able to target the virus at the same efficiency and have the same ability to neutralize the virus. Just like with vaccines, there is a risk of mutations developing, resulting in changes in the surface protein that reduce binding and neutralizing effects of the antibodies, allowing them to escape and continue to cause disease

REGN-COV2 uses two neutralizing antibodies (Casirivimab/imdevimab), in an effort to minimize the ability of a mutant virus to develop resistance against the antibody cocktail, as the virus would need to develop mutations canceling both antibodies out at once. These antibodies neutralize the receptor-binding domain of SARS-CoV-2 spike protein, preventing viral entry through ACE2 receptors.

In a study published in the New England Journal of Medicine (one of the most prestigious journals in the medical field) data from 275 patients showed a drastic reduction in viral load in patients treated with REGN-COV2. This is clinically significant as hospitalized patients with severe symptoms have higher viral counts than non-hospitalized or asymptomatic patients, suggesting the hypoxaemic, shortness of breath symptoms are related to the viral count and resulting exaggerated immune response.

Based off this result the European Medicines Agency approved the use of REGN-COV2 antibody cocktail in patients who do not require supplemental oxygen but are at high risk of progressing to severe COVID-19.

FDA regulations currently recommend it for patients who are COVID positive with risk factors that may result in their hospitalization but do not recommend it for patients who are already hospitalized, requiring O2 therapy because of COVID or need chronic O2 therapy.

Those that fall into the high-risk categories include patients with a high BMI (over 35), diabetes, on immunosuppressive treatment or with an immunosuppressive disease, over 65 years of age or those with chronic diseases such as renal disease, cardiovascular disease, COPD, or other developmental disorders.

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Only Health-Based Rewards: Why Wellness-Focused Incentives Drive Healthier Workplaces

Corporate rewards have traditionally focused on monetary incentives, gift cards or generic perks. However, organisations are increasingly realising that such rewards offer only short-lived motivation. Only health-based rewards, such as massages, gym bags and fitness trackers, represent a more effective approach to corporate wellness by reinforcing healthy behaviours that deliver long-term benefits.

In India, where lifestyle diseases are rising rapidly among working professionals, aligning rewards with health outcomes is no longer optional.

What Are Health-Based Rewards?

Health-based rewards are incentives designed specifically to improve or support employee wellbeing.

They focus on:

physical health
mental wellbeing
preventive care
recovery and stress relief

Unlike cash incentives, they encourage repeated healthy actions.

Why Traditional Rewards Fall Short

Cash rewards and generic gifts:

provide temporary satisfaction
do not influence daily habits
fail to support long-term wellbeing

Behavioural studies show that incentives disconnected from health goals have limited preventive impact.

The Case for Only Health-Based Rewards

Health-based rewards directly reinforce behaviours such as:

regular physical activity
stress management
recovery and self-care
preventive health participation

WHO workplace health guidelines emphasise incentives that promote sustained behaviour change.

Types of Effective Health-Based Rewards

Massages and Recovery Therapies

Massage therapy:

reduces muscle tension
lowers stress hormones
improves circulation

Monthly or quarterly massage rewards support physical and mental recovery.

Gym Bags and Fitness Gear

Practical fitness accessories:

encourage regular workouts
reduce barriers to exercise
promote active lifestyles

Visible gear reinforces identity as a health-conscious individual.

Fitness Trackers

Fitness trackers:

track steps, activity and sleep
create accountability
encourage daily movement

Data-driven feedback increases participation and motivation.

Psychological Impact of Health-Based Rewards

Health rewards create:

intrinsic motivation
positive habit reinforcement
long-term lifestyle shifts

Unlike cash, they associate rewards with self-care rather than consumption.

Impact on Employee Health Outcomes

Regular participation in wellness incentives leads to:

improved physical activity levels
reduced stress
better sleep patterns

ICMR data links activity-based interventions with lower lifestyle disease risk.

Benefits for Employers

Reduced Healthcare Costs

Preventive health rewards reduce chronic disease burden over time.

Improved Productivity

Healthy employees demonstrate:

better focus
fewer sick days
higher energy levels

Stronger Wellness Culture

Health-first rewards signal genuine organisational commitment.

EY-FICCI reports show preventive wellness programs deliver measurable ROI within 12–18 months.

Why Health-Based Rewards Work Better in India

Indian workplaces face:

long working hours
sedentary routines
high stress levels

Health rewards directly address these risks rather than ignoring them.

Aligning Rewards With Preventive Healthcare

Health-based rewards complement:

health screenings
fitness challenges
mental wellbeing programs

This integrated approach strengthens outcomes.

Avoiding Pitfalls in Reward Design

Effective programs:

avoid one-size-fits-all rewards
offer choice within health categories
ensure inclusivity

Poorly designed incentives reduce engagement.

Measuring Success of Health-Based Rewards

Success indicators include:

participation rates
health screening uptake
employee feedback
reduced absenteeism

Data-driven evaluation improves program effectiveness.

Long-Term Behaviour Change

Sustained wellness improvement requires:

consistency
reinforcement
meaningful incentives

Health-based rewards support gradual but lasting change.

Role of Leadership Support

Leadership participation:

increases credibility
boosts engagement
normalises wellness culture

When leaders embrace health rewards, employees follow.

Health-Based Rewards and Mental Wellbeing

Rewards such as massages and fitness trackers:

reduce burnout
improve mood
enhance resilience

Creating a Preventive Wellness Ecosystem

Only health-based rewards work best when combined with:

education
screenings
access to care

WHO emphasises integrated wellness ecosystems for maximum impact.

Conclusion

Only health-based rewards represent a strategic shift from short-term perks to long-term wellbeing investments. Incentives such as massages, gym bags and fitness trackers actively promote healthy habits, reduce lifestyle disease risk and strengthen workplace wellness culture. By aligning rewards with preventive health goals, organisations create meaningful engagement, healthier employees and sustainable productivity gains. Health-focused incentives are not just rewards—they are tools for lasting wellbeing.

References

Indian Council of Medical Research (ICMR) – Lifestyle Disease and Workplace Health Reports
World Health Organization (WHO) – Workplace Health Promotion and Incentives
National Family Health Survey (NFHS-5) – Adult Lifestyle Risk Factors
Lancet – Behavioural Incentives and Preventive Health Studies
NITI Aayog – Preventive Healthcare and Workforce Wellbeing
EY-FICCI – Corporate Wellness and Productivity Reports
Statista – Employee Wellness Incentive Trends

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