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Published on: May 31, 2021
1 minute read
By: Dr Rajan Choudhary

REGN-COV2 – Artificial "antibody Cocktail"

REGN-COV2 – Artificial "antibody cocktail"

Recently a new drug was approved for use in COVID patients in India. Known as REGN-COV2, this new therapy is based on monoclonal antibodies targeting the SARS-CoV-2 virus responsible for COVID. So how does it work? And is there any evidence behind the treatment?

Monoclonal antibodies are made from components of the human immune system. When the human body recognizes a bacteria or virus in the body, the immune system recognizes and processes proteins on the surface of that bacteria or virus. This is presented to the adaptive immune system, and antibodies have produced that lock onto these surface proteins, neutralizing their function and also tagging them for destruction by other white blood cells.

If we identify antibodies capable of efficiently tagging and neutralizing a certain virus, we can identify the cell capable of producing that antibody, clone it and produce it in vast quantities. The antibodies produced from this cloned cell line will be able to target the virus at the same efficiency and have the same ability to neutralize the virus. Just like with vaccines, there is a risk of mutations developing, resulting in changes in the surface protein that reduce binding and neutralizing effects of the antibodies, allowing them to escape and continue to cause disease

REGN-COV2 uses two neutralizing antibodies (Casirivimab/imdevimab), in an effort to minimize the ability of a mutant virus to develop resistance against the antibody cocktail, as the virus would need to develop mutations canceling both antibodies out at once. These antibodies neutralize the receptor-binding domain of SARS-CoV-2 spike protein, preventing viral entry through ACE2 receptors.

In a study published in the New England Journal of Medicine (one of the most prestigious journals in the medical field) data from 275 patients showed a drastic reduction in viral load in patients treated with REGN-COV2. This is clinically significant as hospitalized patients with severe symptoms have higher viral counts than non-hospitalized or asymptomatic patients, suggesting the hypoxaemic, shortness of breath symptoms are related to the viral count and resulting exaggerated immune response.

Based off this result the European Medicines Agency approved the use of REGN-COV2 antibody cocktail in patients who do not require supplemental oxygen but are at high risk of progressing to severe COVID-19.

FDA regulations currently recommend it for patients who are COVID positive with risk factors that may result in their hospitalization but do not recommend it for patients who are already hospitalized, requiring O2 therapy because of COVID or need chronic O2 therapy.

Those that fall into the high-risk categories include patients with a high BMI (over 35), diabetes, on immunosuppressive treatment or with an immunosuppressive disease, over 65 years of age or those with chronic diseases such as renal disease, cardiovascular disease, COPD, or other developmental disorders.

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Why Do You Wake Up Tired Even After 8 Hours Sleep?

Getting 8 hours of sleep is often seen as the gold standard for good health. But what if you’re still waking up feeling groggy, exhausted, and low on energy—despite clocking in those 8 hours? If that sounds like you, you’re not alone.

In this blog, we’ll explore why you wake up tired even after 8 hours sleep, the possible reasons behind it, and simple ways to fix the issue so you can start your day refreshed and energized.

Sleep Quantity vs. Sleep Quality

It’s important to understand that sleep is not just about how long you sleep, but how well you sleep.

There are different stages of sleep your body goes through:

Light Sleep (Stage 1 & 2)
Deep Sleep (Stage 3)
REM Sleep (Stage 4) – where dreams and memory processing happen

If your sleep is constantly interrupted, or if you don’t get enough deep or REM sleep, your body and brain won’t be fully rested—even after 8 hours in bed.

7 Common Reasons You Wake Up Tired After a Full Night’s Sleep

1. Poor Sleep Quality

You may be lying in bed for 8 hours, but if your sleep is light or frequently interrupted, it won’t be refreshing. Common reasons include:

Noisy environment
Uncomfortable mattress or pillow
Room too hot or too cold
Lights or electronics nearby

Fix: Try blackout curtains, keep the room cool and dark, and follow a fixed bedtime routine.

2. Undiagnosed Sleep Disorders

Conditions like sleep apnea, restless leg syndrome, or insomnia can reduce sleep quality without you even realizing it.

Sleep apnea, for example, causes you to stop breathing for short periods during sleep. You may not wake up fully, but your body doesn’t get enough oxygen—leading to morning tiredness and brain fog.

Fix: If your partner says you snore heavily or you often wake up gasping for air, consult a doctor for a sleep study.

3. Too Much Screen Time at Night

Smartphones, laptops, and TVs emit blue light, which blocks melatonin—a hormone that helps you fall asleep.

If you scroll Instagram or binge-watch shows late at night, your brain might stay active even after you fall asleep.

Fix: Stop using screens 1 hour before bedtime. Use night mode or blue light filters if necessary.

4. Eating or Drinking Close to Bedtime

Heavy meals or caffeine before bed can disturb your sleep by causing indigestion, bloating, or increased alertness.

Fix: Avoid caffeine after 5 PM, and try to have your dinner at least 2 hours before sleeping.

5. Mental Health Issues

Conditions like stress, anxiety, or depression can impact sleep quality. You may sleep for hours but still wake up tired due to mental fatigue.

Fix: Practice stress management through:

Journaling
Breathing exercises
Meditation
Seeking therapy if needed

6. Vitamin or Hormonal Imbalance

Low levels of Vitamin D, Vitamin B12, iron, or thyroid dysfunction can cause constant fatigue—even with good sleep.

Fix: A simple blood test can help detect deficiencies. You can book these tests via SecondMedic.com, powered by Thyrocare, with home sample collection.

Recommended tests:

Vitamin D Test
Vitamin B12
Thyroid Profile
CBC (Complete Blood Count)

7. Lack of Physical Activity

Not moving your body enough during the day can lead to low-quality sleep at night. Exercise helps burn excess energy and improves deep sleep.

Fix: Aim for at least 30 minutes of physical activity, like walking, yoga, or cycling daily.

Signs That You’re Not Getting Good Sleep

You hit the snooze button multiple times
You feel sleepy by mid-morning
You wake up with a heavy head or sore body
You need coffee immediately to function
You feel irritated, anxious, or unmotivated

These are signs your body is not truly rested.

Simple Tips for Better Sleep & Morning Energy

Stick to a sleep schedule: Go to bed and wake up at the same time every day—even on weekends.
Create a sleep-friendly space: Keep your bedroom cool, quiet, and dark.
Limit naps: Daytime naps should be less than 30 minutes and before 3 PM.
Stay hydrated—but not too close to bedtime: Drinking too much water late may wake you up to pee.
Practice relaxation before bed: Try reading, light stretching, or herbal tea.

Conclusion

Feeling tired despite getting enough sleep can be frustrating. But remember, quality beats quantity when it comes to sleep. By making small changes in your routine, checking for hidden health issues, and improving your lifestyle, you can wake up feeling refreshed and ready to take on the day.

If you’ve been wondering why do you wake up tired even after 8 hours sleep, now you know where to start fixing it. Begin today with a better sleep routine—and better mornings will follow.

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