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Published on: May 31, 2021
1 minute read
By: Dr Rajan Choudhary

REGN-COV2 – Artificial "antibody Cocktail"

REGN-COV2 – Artificial "antibody cocktail"

Recently a new drug was approved for use in COVID patients in India. Known as REGN-COV2, this new therapy is based on monoclonal antibodies targeting the SARS-CoV-2 virus responsible for COVID. So how does it work? And is there any evidence behind the treatment?

Monoclonal antibodies are made from components of the human immune system. When the human body recognizes a bacteria or virus in the body, the immune system recognizes and processes proteins on the surface of that bacteria or virus. This is presented to the adaptive immune system, and antibodies have produced that lock onto these surface proteins, neutralizing their function and also tagging them for destruction by other white blood cells.

If we identify antibodies capable of efficiently tagging and neutralizing a certain virus, we can identify the cell capable of producing that antibody, clone it and produce it in vast quantities. The antibodies produced from this cloned cell line will be able to target the virus at the same efficiency and have the same ability to neutralize the virus. Just like with vaccines, there is a risk of mutations developing, resulting in changes in the surface protein that reduce binding and neutralizing effects of the antibodies, allowing them to escape and continue to cause disease

REGN-COV2 uses two neutralizing antibodies (Casirivimab/imdevimab), in an effort to minimize the ability of a mutant virus to develop resistance against the antibody cocktail, as the virus would need to develop mutations canceling both antibodies out at once. These antibodies neutralize the receptor-binding domain of SARS-CoV-2 spike protein, preventing viral entry through ACE2 receptors.

In a study published in the New England Journal of Medicine (one of the most prestigious journals in the medical field) data from 275 patients showed a drastic reduction in viral load in patients treated with REGN-COV2. This is clinically significant as hospitalized patients with severe symptoms have higher viral counts than non-hospitalized or asymptomatic patients, suggesting the hypoxaemic, shortness of breath symptoms are related to the viral count and resulting exaggerated immune response.

Based off this result the European Medicines Agency approved the use of REGN-COV2 antibody cocktail in patients who do not require supplemental oxygen but are at high risk of progressing to severe COVID-19.

FDA regulations currently recommend it for patients who are COVID positive with risk factors that may result in their hospitalization but do not recommend it for patients who are already hospitalized, requiring O2 therapy because of COVID or need chronic O2 therapy.

Those that fall into the high-risk categories include patients with a high BMI (over 35), diabetes, on immunosuppressive treatment or with an immunosuppressive disease, over 65 years of age or those with chronic diseases such as renal disease, cardiovascular disease, COPD, or other developmental disorders.

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How Lack of Sleep Weakens Immunity: Why Poor Sleep Makes You Fall Sick More Often

Sleep is one of the most powerful yet overlooked pillars of health. While nutrition and exercise receive significant attention, sleep often takes a back seat in modern lifestyles. Understanding how lack of sleep weakens immunity reveals why people who sleep poorly fall sick more often, take longer to recover and experience chronic inflammation.

In India, late-night work culture, excessive screen time and irregular schedules have made sleep deprivation increasingly common across age groups.

The Link Between Sleep and the Immune System

The immune system relies on sleep for:

repair and regeneration
immune cell production
inflammation control

During deep sleep, the body releases cytokines and antibodies that protect against infections.

What Happens to Immunity During Sleep

While sleeping:

immune cells identify pathogens
inflammatory responses are regulated
memory T-cells strengthen immune memory

This nightly process prepares the body to fight infections effectively.

How Sleep Deprivation Disrupts Immune Function

When sleep is inadequate:

immune cell activity decreases
antibody production drops
inflammation increases

WHO studies confirm that sleep deprivation weakens immune defence mechanisms.

Increased Risk of Infections

People who sleep less than 6 hours regularly:

fall sick more often
catch colds and flu easily
recover slower from illness

Lancet research shows a strong link between sleep duration and infection susceptibility.

Impact on Inflammation

Poor sleep increases inflammatory markers.

Chronic inflammation:

weakens immune response
increases risk of chronic diseases

ICMR reports highlight sleep deprivation as a contributor to low-grade systemic inflammation.

Effect on Vaccine Response

Sleep quality affects how well vaccines work.

Studies show:

poor sleep reduces antibody response
adequate sleep improves vaccine effectiveness

Sleep is essential for immune memory formation.

Hormonal Changes That Affect Immunity

Sleep regulates hormones such as:

cortisol
melatonin

Lack of sleep increases cortisol, which suppresses immune function.

Stress, Sleep and Immunity

Sleep deprivation and stress reinforce each other.

High stress:

disrupts sleep
suppresses immune cells

This cycle weakens overall resistance to illness.

Impact on Gut Immunity

The gut hosts a major part of the immune system.

Poor sleep:

disrupts gut microbiome
weakens gut immunity

Lancet studies link sleep deprivation to gut-related immune dysfunction.

Why Children and Older Adults Are More Vulnerable

Sleep deprivation affects:

children’s developing immune systems
older adults’ already weakened immunity

Adequate sleep is especially important in these age groups.

Signs Your Immunity Is Affected by Poor Sleep

Warning signs include:

frequent infections
slow wound healing
constant fatigue
increased allergies

These symptoms indicate compromised immune defence.

Long-Term Health Risks of Poor Sleep

Chronic sleep deprivation increases risk of:

infections
autoimmune disorders
metabolic diseases
heart disease

Sleep loss affects nearly every body system.

Role of Preventive Health Awareness

Preventive healthcare emphasises:

sleep as a foundation of immunity
early lifestyle correction

NITI Aayog recognises sleep hygiene as essential for population health.

How to Improve Sleep for Better Immunity

Effective strategies include:

fixed sleep and wake times
limiting screen exposure before bed
avoiding caffeine late in the day
creating a dark, quiet sleep environment

Consistency matters more than duration alone.

Myths About Sleep and Immunity

Myth: You can catch up on sleep later
Fact: Chronic sleep debt harms immunity.

Myth: Sleeping pills improve immunity
Fact: Natural sleep is more beneficial.

Why Sleep Is a Preventive Medicine

Sleep:

costs nothing
requires no equipment
delivers powerful immune protection

It is one of the most effective preventive health tools.

Conclusion

Understanding how lack of sleep weakens immunity highlights the critical role of sleep in protecting the body from infections and chronic disease. Poor sleep disrupts immune cell function, increases inflammation and reduces resistance to illness. Prioritising consistent, quality sleep is not optional—it is essential for strong immunity, faster recovery and long-term health. Protecting sleep today strengthens immune defence for tomorrow.

References

Indian Council of Medical Research (ICMR) – Sleep, Immunity and Inflammation Studies
World Health Organization (WHO) – Sleep and Immune Health Guidelines
National Institutes of Health – Sleep Deprivation and Immunity
Lancet – Sleep Duration and Infection Risk
NITI Aayog – Preventive Health and Lifestyle Recommendations

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