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Published on: May 31, 2021
1 minute read
By: Dr Rajan Choudhary

REGN-COV2 – Artificial "antibody Cocktail"

REGN-COV2 – Artificial "antibody cocktail"

Recently a new drug was approved for use in COVID patients in India. Known as REGN-COV2, this new therapy is based on monoclonal antibodies targeting the SARS-CoV-2 virus responsible for COVID. So how does it work? And is there any evidence behind the treatment?

Monoclonal antibodies are made from components of the human immune system. When the human body recognizes a bacteria or virus in the body, the immune system recognizes and processes proteins on the surface of that bacteria or virus. This is presented to the adaptive immune system, and antibodies have produced that lock onto these surface proteins, neutralizing their function and also tagging them for destruction by other white blood cells.

If we identify antibodies capable of efficiently tagging and neutralizing a certain virus, we can identify the cell capable of producing that antibody, clone it and produce it in vast quantities. The antibodies produced from this cloned cell line will be able to target the virus at the same efficiency and have the same ability to neutralize the virus. Just like with vaccines, there is a risk of mutations developing, resulting in changes in the surface protein that reduce binding and neutralizing effects of the antibodies, allowing them to escape and continue to cause disease

REGN-COV2 uses two neutralizing antibodies (Casirivimab/imdevimab), in an effort to minimize the ability of a mutant virus to develop resistance against the antibody cocktail, as the virus would need to develop mutations canceling both antibodies out at once. These antibodies neutralize the receptor-binding domain of SARS-CoV-2 spike protein, preventing viral entry through ACE2 receptors.

In a study published in the New England Journal of Medicine (one of the most prestigious journals in the medical field) data from 275 patients showed a drastic reduction in viral load in patients treated with REGN-COV2. This is clinically significant as hospitalized patients with severe symptoms have higher viral counts than non-hospitalized or asymptomatic patients, suggesting the hypoxaemic, shortness of breath symptoms are related to the viral count and resulting exaggerated immune response.

Based off this result the European Medicines Agency approved the use of REGN-COV2 antibody cocktail in patients who do not require supplemental oxygen but are at high risk of progressing to severe COVID-19.

FDA regulations currently recommend it for patients who are COVID positive with risk factors that may result in their hospitalization but do not recommend it for patients who are already hospitalized, requiring O2 therapy because of COVID or need chronic O2 therapy.

Those that fall into the high-risk categories include patients with a high BMI (over 35), diabetes, on immunosuppressive treatment or with an immunosuppressive disease, over 65 years of age or those with chronic diseases such as renal disease, cardiovascular disease, COPD, or other developmental disorders.

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Diabetes Symptoms in Men: Early Warning Signs You Should Not Ignore

Diabetes is one of the fastest-growing health challenges worldwide, and men are particularly vulnerable to its long-term complications. In India, the burden of diabetes has increased sharply over the past two decades, driven by lifestyle changes, sedentary habits and dietary patterns. Despite this, many men remain unaware of early diabetes symptoms or delay medical consultation until complications develop.

Understanding diabetes symptoms in men is essential for early diagnosis, effective management and prevention of serious health consequences.

What Is Diabetes?

Diabetes is a chronic metabolic disorder characterised by high blood sugar levels due to:

insufficient insulin production
ineffective insulin action
or both

The most common form affecting men is type 2 diabetes, which is strongly linked to lifestyle factors.

Why Men Are at Higher Risk

Several factors increase diabetes risk in men:

higher abdominal fat accumulation
smoking and alcohol consumption
irregular eating patterns
work-related stress
lower healthcare-seeking behaviour

According to Indian Council of Medical Research data, a significant proportion of men remain undiagnosed until advanced stages.

Early Diabetes Symptoms in Men

Frequent Urination

Excess sugar in the blood causes kidneys to work harder, leading to increased urination, especially at night.

Excessive Thirst

Frequent urination leads to dehydration, causing constant thirst.

Fatigue and Weakness

Cells cannot utilise glucose efficiently, resulting in low energy levels and persistent tiredness.

Unexplained Weight Changes

Men may experience unexplained weight loss despite normal or increased appetite.

Increased Hunger

Insulin resistance prevents glucose from entering cells, triggering frequent hunger.

Diabetes Symptoms Unique or Commonly Seen in Men

Erectile Dysfunction

Diabetes damages blood vessels and nerves, leading to erectile dysfunction.

Studies show a strong association between diabetes and male sexual health problems.

Reduced Testosterone Levels

Men with diabetes often have lower testosterone, affecting libido, muscle mass and mood.

Decreased Muscle Strength

Poor glucose utilisation affects muscle health and physical stamina.

Skin and Infection-Related Symptoms

Slow-Healing Wounds

High blood sugar impairs wound healing, increasing infection risk.

Frequent Infections

Men with diabetes are more prone to:

skin infections
urinary tract infections
fungal infections

Vision and Nerve Symptoms

Blurred Vision

Fluctuating blood sugar affects eye lenses, causing blurred vision.

Tingling or Numbness

Nerve damage, known as diabetic neuropathy, causes tingling or numbness in hands and feet.

Why Diabetes Symptoms Are Often Ignored by Men

Many men dismiss symptoms as:

work-related fatigue
ageing
stress

This delay increases the risk of complications.

Long-Term Complications of Untreated Diabetes

If untreated, diabetes can lead to:

heart disease
kidney failure
nerve damage
vision loss
sexual dysfunction

According to WHO and Lancet studies, early detection significantly reduces complication risk.

Importance of Early Diagnosis

Early diagnosis allows:

better blood sugar control
lifestyle modification
prevention of organ damage

Routine screening is crucial, even in the absence of symptoms.

When Should Men Get Tested?

Men should consider testing if they:

are over 30 years old
have a family history of diabetes
are overweight
have a sedentary lifestyle
experience any warning signs

Annual screening is recommended for at-risk individuals.

Managing Diabetes After Diagnosis

Effective management includes:

healthy diet
regular physical activity
weight control
stress management
medical treatment as advised

Early management improves quality of life.

Role of Preventive Healthcare

Preventive healthcare focuses on:

early screening
lifestyle intervention
regular follow-up

According to NITI Aayog, preventive strategies are essential to control India’s diabetes burden.

Mental Health and Diabetes in Men

Diabetes can affect mental wellbeing, leading to:

stress
anxiety
depression

Addressing emotional health improves diabetes outcomes.

Breaking the Stigma Around Men’s Health

Men often avoid seeking help due to stigma.

Promoting awareness helps:

normalise health conversations
encourage timely medical care
reduce preventable complications

Conclusion

Diabetes symptoms in men often develop gradually and may go unnoticed for years. Frequent urination, fatigue, unexplained weight changes and sexual health issues should never be ignored. Early diagnosis and timely management significantly reduce the risk of serious complications and improve long-term health outcomes. Awareness, routine screening and proactive healthcare are essential steps for men to protect their health and wellbeing in an era of rising lifestyle diseases.

References

Indian Council of Medical Research (ICMR) – Diabetes Epidemiology and Risk Studies
World Health Organization (WHO) – Diabetes Prevention and Management Guidelines
National Family Health Survey (NFHS-5) – Diabetes Prevalence in Men
Lancet Diabetes & Endocrinology – Male-Specific Diabetes Outcomes
NITI Aayog – Non-Communicable Disease Prevention Reports
Statista – Global Diabetes Trends and Gender Differences

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