• Published on: May 31, 2021
  • 1 minute read
  • By: Dr Rajan Choudhary

REGN-COV2 – Artificial "antibody Cocktail" 

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REGN-COV2 – Artificial "antibody cocktail" 

Recently a new drug was approved for use in COVID patients in India. Known as REGN-COV2, this new therapy is based on monoclonal antibodies targeting the SARS-CoV-2 virus responsible for COVID. So how does it work? And is there any evidence behind the treatment?

Monoclonal antibodies are made from components of the human immune system. When the human body recognizes a bacteria or virus in the body, the immune system recognizes and processes proteins on the surface of that bacteria or virus. This is presented to the adaptive immune system, and antibodies have produced that lock onto these surface proteins, neutralizing their function and also tagging them for destruction by other white blood cells.

If we identify antibodies capable of efficiently tagging and neutralizing a certain virus, we can identify the cell capable of producing that antibody, clone it and produce it in vast quantities. The antibodies produced from this cloned cell line will be able to target the virus at the same efficiency and have the same ability to neutralize the virus. Just like with vaccines, there is a risk of mutations developing, resulting in changes in the surface protein that reduce binding and neutralizing effects of the antibodies, allowing them to escape and continue to cause disease

REGN-COV2 uses two neutralizing antibodies (Casirivimab/imdevimab), in an effort to minimize the ability of a mutant virus to develop resistance against the antibody cocktail, as the virus would need to develop mutations canceling both antibodies out at once. These antibodies neutralize the receptor-binding domain of SARS-CoV-2 spike protein, preventing viral entry through ACE2 receptors.

In a study published in the New England Journal of Medicine (one of the most prestigious journals in the medical field) data from 275 patients showed a drastic reduction in viral load in patients treated with REGN-COV2. This is clinically significant as hospitalized patients with severe symptoms have higher viral counts than non-hospitalized or asymptomatic patients, suggesting the hypoxaemic, shortness of breath symptoms are related to the viral count and resulting exaggerated immune response.

Based off this result the European Medicines Agency approved the use of REGN-COV2 antibody cocktail in patients who do not require supplemental oxygen but are at high risk of progressing to severe COVID-19.

FDA regulations currently recommend it for patients who are COVID positive with risk factors that may result in their hospitalization but do not recommend it for patients who are already hospitalized, requiring O2 therapy because of COVID or need chronic O2 therapy.

Those that fall into the high-risk categories include patients with a high BMI (over 35), diabetes, on immunosuppressive treatment or with an immunosuppressive disease, over 65 years of age or those with chronic diseases such as renal disease, cardiovascular disease, COPD, or other developmental disorders.

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5K Run for a Cause: How Community Fitness Drives Preventive Health Awareness

5K Run for a Cause: How Community Fitness Drives Preventive Health Awareness

Physical activity is one of the most effective tools for disease prevention, yet it remains underutilised in everyday life. Community-based fitness initiatives such as a 5K Run for a Cause play a powerful role in bridging this gap by making movement accessible, meaningful and socially engaging. These events combine the benefits of exercise with awareness-building, creating lasting impact on public health.

In India, lifestyle-related diseases such as diabetes, heart disease and obesity are rising rapidly. According to the Indian Council of Medical Research (ICMR) and National Family Health Survey (NFHS-5), physical inactivity is a major contributor to this growing burden. Events that encourage structured, enjoyable physical activity help counter this trend.

 

What Is a 5K Run for a Cause?

A 5K Run for a Cause is a short-distance running or walking event designed to promote fitness while supporting a health, social or community objective. Participants may run, jog or walk the 5-kilometre distance, making the event inclusive for people of varying fitness levels.

Beyond physical activity, these runs aim to:

  • raise awareness about preventive health
     

  • encourage active lifestyles
     

  • build community participation
     

  • support wellness-driven causes
     

 

Why 5K Is an Ideal Distance

The 5-kilometre distance is widely recognised as:

  • achievable for beginners
     

  • challenging enough to promote fitness
     

  • safe for most age groups with minimal training
     

WHO physical activity guidelines support moderate-intensity exercise like running or brisk walking for improving cardiovascular and metabolic health.

 

Health Benefits of Participating in a 5K Run

Improved Cardiovascular Health

Running and brisk walking strengthen the heart, improve circulation and lower blood pressure. Regular participation reduces the risk of heart disease and stroke.

 

Better Metabolic Health

Physical activity improves insulin sensitivity and supports weight management. ICMR data shows that regular movement significantly reduces diabetes risk.

 

Enhanced Mental Wellbeing

Exercise releases endorphins that reduce stress, anxiety and depression. Community runs add a social element that further supports mental health.

 

Improved Musculoskeletal Strength

Running strengthens muscles, bones and joints, reducing the risk of age-related mobility issues.

 

Role of 5K Runs in Preventive Healthcare

Preventive healthcare focuses on reducing disease risk before illness develops. A 5K Run for a Cause supports prevention by:

  • promoting physical activity
     

  • encouraging regular movement habits
     

  • raising awareness about lifestyle diseases
     

  • motivating health-conscious behaviour
     

NITI Aayog identifies physical activity promotion as a key pillar of preventive healthcare in India.

 

Community Impact of a 5K Run for a Cause

Building Health Awareness

Runs often highlight specific causes such as heart health, diabetes prevention or mental wellbeing, reinforcing public health messages.

Strengthening Social Bonds

Community participation fosters shared goals and mutual motivation, increasing long-term adherence to healthy habits.

Encouraging Family Participation

Inclusive events encourage families to adopt healthier lifestyles together.

 

5K Runs and Corporate Wellness Programs

Corporate wellness programs increasingly include physical activity initiatives.

Benefits for organisations include:

  • improved employee engagement
     

  • reduced absenteeism
     

  • enhanced team bonding
     

  • positive employer branding
     

EY-FICCI reports show that wellness initiatives focused on physical activity deliver strong participation and measurable health benefits.

 

Accessibility and Inclusivity

A key strength of 5K runs is inclusivity.

They accommodate:

  • first-time runners
     

  • walkers
     

  • older adults
     

  • people transitioning to active lifestyles
     

This inclusiveness reduces barriers to participation.

 

Supporting Long-Term Behaviour Change

One-time events create awareness, but their true value lies in inspiring long-term change.

Participants often:

  • continue walking or running regularly
     

  • become more conscious of fitness
     

  • seek preventive health checkups
     

Lancet studies indicate that community-based physical activity initiatives can influence long-term health behaviours.

 

Safety and Health Considerations

For safe participation:

  • individuals should assess fitness levels
     

  • warm-up and cool-down are essential
     

  • hydration should be prioritised
     

  • those with medical conditions should seek medical advice
     

Proper guidance ensures benefits without injury.

 

Role of Awareness and Education

Successful runs integrate education through:

  • health talks
     

  • informational materials
     

  • screening camps
     

  • wellness resources
     

This combination reinforces preventive health messages.

 

Measuring Impact

Impact can be assessed through:

  • participation rates
     

  • follow-up health initiatives
     

  • employee engagement metrics
     

  • community feedback
     

Data-driven evaluation improves future program design.

 

Why 5K Runs Matter in India

India faces challenges such as:

  • rising sedentary lifestyles
     

  • limited health awareness
     

  • increasing chronic disease burden
     

Community fitness events provide a scalable, low-cost solution to promote active living and prevention.

 

Conclusion

A 5K Run for a Cause is more than a fitness event—it is a preventive health movement. By combining physical activity with purpose, these runs encourage healthier lifestyles, strengthen community bonds and raise awareness about long-term wellbeing. In a country where lifestyle diseases are growing rapidly, initiatives that make movement accessible and meaningful are essential. A simple 5K run can be a powerful step toward a healthier, more active society.

 

References

  • ICMR – Physical Activity and Lifestyle Disease Prevention Reports

  • National Family Health Survey (NFHS-5) – Physical Activity and Health Data

  • NITI Aayog – Preventive Healthcare and Physical Activity Promotion Strategy

  • WHO – Physical Activity and Health Guideline

  •  Lancet – Community Fitness and Preventive Health Studies

  • Statista – Fitness Events and Participation Trends India

  • EY-FICCI – Corporate Wellness and Physical Activity Reports

See all

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