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Published on: May 31, 2021
1 minute read
By: Dr Rajan Choudhary

REGN-COV2 – Artificial "antibody Cocktail"

REGN-COV2 – Artificial "antibody cocktail"

Recently a new drug was approved for use in COVID patients in India. Known as REGN-COV2, this new therapy is based on monoclonal antibodies targeting the SARS-CoV-2 virus responsible for COVID. So how does it work? And is there any evidence behind the treatment?

Monoclonal antibodies are made from components of the human immune system. When the human body recognizes a bacteria or virus in the body, the immune system recognizes and processes proteins on the surface of that bacteria or virus. This is presented to the adaptive immune system, and antibodies have produced that lock onto these surface proteins, neutralizing their function and also tagging them for destruction by other white blood cells.

If we identify antibodies capable of efficiently tagging and neutralizing a certain virus, we can identify the cell capable of producing that antibody, clone it and produce it in vast quantities. The antibodies produced from this cloned cell line will be able to target the virus at the same efficiency and have the same ability to neutralize the virus. Just like with vaccines, there is a risk of mutations developing, resulting in changes in the surface protein that reduce binding and neutralizing effects of the antibodies, allowing them to escape and continue to cause disease

REGN-COV2 uses two neutralizing antibodies (Casirivimab/imdevimab), in an effort to minimize the ability of a mutant virus to develop resistance against the antibody cocktail, as the virus would need to develop mutations canceling both antibodies out at once. These antibodies neutralize the receptor-binding domain of SARS-CoV-2 spike protein, preventing viral entry through ACE2 receptors.

In a study published in the New England Journal of Medicine (one of the most prestigious journals in the medical field) data from 275 patients showed a drastic reduction in viral load in patients treated with REGN-COV2. This is clinically significant as hospitalized patients with severe symptoms have higher viral counts than non-hospitalized or asymptomatic patients, suggesting the hypoxaemic, shortness of breath symptoms are related to the viral count and resulting exaggerated immune response.

Based off this result the European Medicines Agency approved the use of REGN-COV2 antibody cocktail in patients who do not require supplemental oxygen but are at high risk of progressing to severe COVID-19.

FDA regulations currently recommend it for patients who are COVID positive with risk factors that may result in their hospitalization but do not recommend it for patients who are already hospitalized, requiring O2 therapy because of COVID or need chronic O2 therapy.

Those that fall into the high-risk categories include patients with a high BMI (over 35), diabetes, on immunosuppressive treatment or with an immunosuppressive disease, over 65 years of age or those with chronic diseases such as renal disease, cardiovascular disease, COPD, or other developmental disorders.

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Lifestyle Disease Prevention India: Protecting Health Through Proactive Care

Lifestyle diseases, also known as non-communicable diseases (NCDs), have become one of India’s most pressing health challenges. Conditions such as diabetes, hypertension, obesity, heart disease, thyroid disorders, fatty liver, and high cholesterol now affect millions-often starting at younger ages compared to previous generations. According to the Indian Council of Medical Research (ICMR), NCDs account for more than 60 percent of deaths in India. The good news: most lifestyle diseases are preventable with awareness, screening, and timely intervention.

SecondMedic supports a national shift from reactive to preventive healthcare through early detection, nutrition planning, lifestyle improvement, and chronic risk monitoring.

Why Lifestyle Disease Prevention Matters in India

1. Rising NCD Burden

Rapid urbanization, longer working hours, stress, and processed foods have accelerated lifestyle disease growth.

2. Younger Population at Risk

More Indians in their 20s and 30s are developing prediabetes, fatty liver, and high cholesterol.

3. Silent Disease Progression

Many conditions show no symptoms in the early stages.

4. High Long-Term Medical Cost

Treatment for advanced diabetes or heart disease is expensive compared to prevention.

5. Impact on Productivity

Organizations face rising health-related absenteeism and reduced performance.

Prevention is not optional-it is a necessity.

Major Lifestyle Diseases in India

1. Diabetes & Prediabetes

India has over 10 crore diabetics, with many unaware of their condition.

2. Hypertension

Known as the “silent killer,” it increases risk for heart attack and stroke.

3. Heart Disease

India sees one of the highest premature heart attack rates globally.

4. Obesity & Metabolic Syndrome

Poor diet and inactivity contribute to dangerous fat accumulation.

5. Fatty Liver Disease

Highly common even among non-alcoholic individuals.

6. Thyroid Disorders

Thyroid imbalances affect metabolism, weight, and mental health.

7. Stress & Sleep Disorders

Impact emotional stability and long-term health.

SecondMedic offers preventive screenings tailored for each of these risk areas.

Early Detection Through Preventive Health Checkups

Preventive checkups help detect abnormalities before they turn into chronic disease.

SecondMedic’s packages include:

CBC
Lipid profile
HbA1c
Thyroid panel
Liver function tests
Kidney profile
Cardiac markers
Vitamin D & B12
Hormone tests
ECG

These tests provide a comprehensive health snapshot.

Lifestyle Disease Prevention Strategies

1. Nutrition Management

A healthy diet is the foundation of prevention.
SecondMedic dietitians design personalized nutrition plans based on:

Age
Weight
Activity
Medical history

2. Regular Physical Activity

Movement reduces blood sugar, strengthens the heart, and improves metabolism.

3. Stress Management

Chronic stress increases cortisol, causing diabetes and weight gain.
SecondMedic offers:

Online mental health counselling
Anxiety management
Sleep routines

4. Avoiding Tobacco & Alcohol

These significantly increase risk of cancer, fatty liver, and heart disease.

5. Healthy Weight Maintenance

Targeted routines help maintain optimal BMI and waist circumference.

6. Adequate Sleep

Poor sleep leads to hormonal imbalance and weak immunity.

7. Regular Health Checkups

Monitoring every 6-12 months helps track changes early.

Technology in Lifestyle Disease Prevention

India’s digital health ecosystem supports smarter prevention through:

Wearables
Fitness trackers
AI-based risk prediction
Digital symptom assessment
Remote monitoring devices

SecondMedic integrates these tools for continuous care.

Why SecondMedic for Lifestyle Disease Prevention

1. Comprehensive Screening

All major biomarkers, organ function tests, and metabolic indicators.

2. Expert Interpretation

Doctors analyze results and provide actionable insights.

3. Personalized Health Plans

Nutrition + fitness + lifestyle guidance.

4. Continuous Monitoring

Follow-ups ensure long-term success.

5. Integrated Telemedicine Support

Patients can speak to specialists anytime.

Conclusion

Lifestyle disease prevention India is crucial for improving long-term health and reducing the national burden of chronic diseases. Through early screening, targeted intervention, better nutrition, exercise routines, and continuous monitoring, individuals can dramatically reduce their risk. SecondMedic offers a complete ecosystem of preventive healthcare to help Indians stay healthy and proactive.

To begin your preventive health journey, visit www.secondmedic.com

References

ICMR - India NCD burden
WHO - Global NCD prevention guidelines
Statista - Lifestyle disease trends in India
NITI Aayog - Preventive health model
SecondMedic preventive care insights

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