REGN-COV2 – Artificial "antibody Cocktail"

REGN-COV2 – Artificial "antibody cocktail"

Recently a new drug was approved for use in COVID patients in India. Known as REGN-COV2, this new therapy is based on monoclonal antibodies targeting the SARS-CoV-2 virus responsible for COVID. So how does it work? And is there any evidence behind the treatment?

Monoclonal antibodies are made from components of the human immune system. When the human body recognizes a bacteria or virus in the body, the immune system recognizes and processes proteins on the surface of that bacteria or virus. This is presented to the adaptive immune system, and antibodies have produced that lock onto these surface proteins, neutralizing their function and also tagging them for destruction by other white blood cells.

If we identify antibodies capable of efficiently tagging and neutralizing a certain virus, we can identify the cell capable of producing that antibody, clone it and produce it in vast quantities. The antibodies produced from this cloned cell line will be able to target the virus at the same efficiency and have the same ability to neutralize the virus. Just like with vaccines, there is a risk of mutations developing, resulting in changes in the surface protein that reduce binding and neutralizing effects of the antibodies, allowing them to escape and continue to cause disease

REGN-COV2 uses two neutralizing antibodies (Casirivimab/imdevimab), in an effort to minimize the ability of a mutant virus to develop resistance against the antibody cocktail, as the virus would need to develop mutations canceling both antibodies out at once. These antibodies neutralize the receptor-binding domain of SARS-CoV-2 spike protein, preventing viral entry through ACE2 receptors.

In a study published in the New England Journal of Medicine (one of the most prestigious journals in the medical field) data from 275 patients showed a drastic reduction in viral load in patients treated with REGN-COV2. This is clinically significant as hospitalized patients with severe symptoms have higher viral counts than non-hospitalized or asymptomatic patients, suggesting the hypoxaemic, shortness of breath symptoms are related to the viral count and resulting exaggerated immune response.

Based off this result the European Medicines Agency approved the use of REGN-COV2 antibody cocktail in patients who do not require supplemental oxygen but are at high risk of progressing to severe COVID-19.

FDA regulations currently recommend it for patients who are COVID positive with risk factors that may result in their hospitalization but do not recommend it for patients who are already hospitalized, requiring O2 therapy because of COVID or need chronic O2 therapy.

Those that fall into the high-risk categories include patients with a high BMI (over 35), diabetes, on immunosuppressive treatment or with an immunosuppressive disease, over 65 years of age or those with chronic diseases such as renal disease, cardiovascular disease, COPD, or other developmental disorders.

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Why Recurring Sore Throat Can Be a Serious Issue

A sore throat is a common complaint. Most of us experience it during seasonal changes, after a cold, or when we catch the flu. But what if your sore throat keeps coming back again and again? While many people dismiss it as a minor irritation, a recurring sore throat can actually signal more serious health issues that require proper attention.

What is a recurring sore throat?

A recurring sore throat refers to repeated or persistent throat discomfort that comes back multiple times in a year or lasts longer than usual. Normally, a viral sore throat improves within a week. If the problem lingers beyond 10 days or returns frequently, it falls into the category of chronic or recurring sore throat.

Why is it serious?

Undiagnosed infections
A single sore throat from a virus is not concerning. But if bacterial infections like strep throat keep coming back, they may damage the throat and spread to other parts of the body if untreated.
Inflammation and tissue damage
Constant irritation from allergies or acid reflux can harm the delicate tissues of the throat. Over time, this may affect your voice and overall throat function.
Underlying medical conditions
Recurring sore throat can be linked to issues like gastroesophageal reflux disease (GERD), allergies, tonsil problems, or immune system weakness. In some cases, it may also be an early warning sign of more serious diseases such as tumors.
Complications
Recurrent infections can lead to abscesses around the tonsils, ear infections, or sinus problems. Inadequate or repeated antibiotic use can also cause resistance.
Impact on daily life
A constant sore throat affects your eating, speaking, sleeping, and quality of life. It leads to repeated doctor visits, discomfort, and stress.

Common causes of recurring sore throat

Bacterial infections like strep throat or chronic tonsillitis
Viral infections that linger or reactivate
Allergies that trigger postnasal drip and throat irritation
Acid reflux or GERD causing stomach acid to irritate the throat
Environmental irritants such as smoke, dust, and pollution
Mouth breathing during sleep due to nasal blockage
Immune weakness making you prone to repeated infections

Warning signs to watch for

You should never ignore these symptoms if they accompany a recurring sore throat:

Sore throat lasting longer than 2–3 weeks
Difficulty swallowing or breathing
Lump or swelling in the throat or neck
Persistent hoarseness or voice changes
Unexplained weight loss
Blood in saliva or phlegm
Fever with night sweats

These are red flags that need immediate medical evaluation.

How lab tests help

Lab tests play a critical role in finding out why you have a recurring sore throat. Some useful investigations include:

Throat swab or culture to identify bacterial infections
Rapid antigen test for strep for quick diagnosis
Complete Blood Count (CBC) to detect infection or immune problems
CRP and ESR to check inflammation
Allergy tests to identify triggers like dust or pollen
Thyroid function tests to rule out thyroid-related throat problems
Reflux evaluation if GERD is suspected
Immune status tests if infections are unusually frequent

Through SecondMedic/Thyrocare, these tests can be arranged easily, giving you faster results and treatment planning.

Treatment and prevention

The treatment of recurring sore throat depends on its cause:

Bacterial infections are treated with antibiotics prescribed by a doctor. Completing the full course is essential.
Viral infections usually require rest, hydration, and symptom management.
Acid reflux can be controlled with lifestyle changes like avoiding late meals, reducing spicy foods, and medications if required.
Allergies can be managed by identifying and avoiding triggers, along with prescribed medicines.
Tonsil problems may require surgical removal if infections are frequent and severe.

Preventive steps include:

Staying hydrated
Avoiding smoking and exposure to polluted air
Maintaining good throat hygiene
Managing acid reflux through diet and posture
Strengthening immunity with balanced nutrition and rest

When to see a doctor

If you suffer from frequent sore throats or if your symptoms come with any red flags, consult a healthcare professional without delay. Early evaluation prevents complications and ensures better outcomes.

Conclusion

Recurring sore throat is more than just an inconvenience. It is often a signal from your body that something is not right. Identifying the cause early and undergoing the right tests can help you recover faster and avoid long-term damage.

At SecondMedic, you can access lab tests, doctor consultations, and treatment guidance all in one place. Don’t ignore a sore throat that keeps returning — take charge of your health today and book your tests with SecondMedic/Thyrocare for accurate results and expert support.

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