• Published on: May 31, 2021
  • 1 minute read
  • By: Dr Rajan Choudhary

REGN-COV2 – Artificial "antibody Cocktail" 

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REGN-COV2 – Artificial "antibody cocktail" 

Recently a new drug was approved for use in COVID patients in India. Known as REGN-COV2, this new therapy is based on monoclonal antibodies targeting the SARS-CoV-2 virus responsible for COVID. So how does it work? And is there any evidence behind the treatment?

Monoclonal antibodies are made from components of the human immune system. When the human body recognizes a bacteria or virus in the body, the immune system recognizes and processes proteins on the surface of that bacteria or virus. This is presented to the adaptive immune system, and antibodies have produced that lock onto these surface proteins, neutralizing their function and also tagging them for destruction by other white blood cells.

If we identify antibodies capable of efficiently tagging and neutralizing a certain virus, we can identify the cell capable of producing that antibody, clone it and produce it in vast quantities. The antibodies produced from this cloned cell line will be able to target the virus at the same efficiency and have the same ability to neutralize the virus. Just like with vaccines, there is a risk of mutations developing, resulting in changes in the surface protein that reduce binding and neutralizing effects of the antibodies, allowing them to escape and continue to cause disease

REGN-COV2 uses two neutralizing antibodies (Casirivimab/imdevimab), in an effort to minimize the ability of a mutant virus to develop resistance against the antibody cocktail, as the virus would need to develop mutations canceling both antibodies out at once. These antibodies neutralize the receptor-binding domain of SARS-CoV-2 spike protein, preventing viral entry through ACE2 receptors.

In a study published in the New England Journal of Medicine (one of the most prestigious journals in the medical field) data from 275 patients showed a drastic reduction in viral load in patients treated with REGN-COV2. This is clinically significant as hospitalized patients with severe symptoms have higher viral counts than non-hospitalized or asymptomatic patients, suggesting the hypoxaemic, shortness of breath symptoms are related to the viral count and resulting exaggerated immune response.

Based off this result the European Medicines Agency approved the use of REGN-COV2 antibody cocktail in patients who do not require supplemental oxygen but are at high risk of progressing to severe COVID-19.

FDA regulations currently recommend it for patients who are COVID positive with risk factors that may result in their hospitalization but do not recommend it for patients who are already hospitalized, requiring O2 therapy because of COVID or need chronic O2 therapy.

Those that fall into the high-risk categories include patients with a high BMI (over 35), diabetes, on immunosuppressive treatment or with an immunosuppressive disease, over 65 years of age or those with chronic diseases such as renal disease, cardiovascular disease, COPD, or other developmental disorders.

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Digestive

Digestive System Disorders: Common Causes, Symptoms, and Prevention Tips

The digestive system plays a vital role in overall health by breaking down food, absorbing nutrients and eliminating waste. When this system does not function properly, it can lead to discomfort, poor nutrition and chronic illness. Digestive system disorders are increasingly common due to modern lifestyles, dietary habits and stress. Understanding their causes, symptoms and prevention strategies is essential for maintaining long-term gut health.

Public health research shows that a large proportion of adults experience digestive symptoms at some point in their lives, yet many delay seeking care until problems become severe.

 

What Are Digestive System Disorders?

Digestive system disorders are conditions that affect:

  • the oesophagus
     

  • stomach
     

  • intestines
     

  • liver
     

  • pancreas
     

  • gallbladder
     

They may be temporary or chronic and range from mild functional issues to serious inflammatory or structural diseases.

 

Common Digestive System Disorders

Acid Reflux and GERD

Gastroesophageal reflux disease (GERD) occurs when stomach acid flows back into the oesophagus.

Symptoms include:

  • heartburn
     

  • chest discomfort
     

  • sour taste in mouth
     

  • difficulty swallowing
     

Long-term reflux can damage the oesophagus if untreated.

 

Irritable Bowel Syndrome (IBS)

IBS is a functional bowel disorder.

Symptoms include:

  • abdominal pain
     

  • bloating
     

  • diarrhoea or constipation
     

  • alternating bowel habits
     

Stress and diet often trigger symptoms.

 

Constipation

Constipation involves infrequent or difficult bowel movements.

Causes include:

  • low fibre intake
     

  • dehydration
     

  • sedentary lifestyle
     

Chronic constipation affects comfort and gut function.

 

Diarrhoea

Diarrhoea results from rapid bowel movements.

Common causes include:

  • infections
     

  • food intolerance
     

  • medication side effects
     

Persistent diarrhoea may lead to dehydration and nutrient loss.

 

Peptic Ulcer Disease

Ulcers are sores in the stomach or intestinal lining.

Symptoms include:

  • burning stomach pain
     

  • nausea
     

  • bloating
     

They are often linked to infections or long-term medication use.

 

Inflammatory Bowel Disease (IBD)

IBD includes conditions like Crohn’s disease and ulcerative colitis.

Symptoms include:

  • chronic diarrhoea
     

  • abdominal pain
     

  • weight loss
     

  • fatigue
     

IBD requires long-term medical management.

Common Symptoms of Digestive Disorders

Digestive system disorders often present with:

  • abdominal pain or cramps
     

  • bloating and gas
     

  • nausea or vomiting
     

  • constipation or diarrhoea
     

  • heartburn
     

  • unexplained weight changes
     

Symptoms may fluctuate and worsen with stress or poor diet.

 

Causes of Digestive System Disorders

Poor Dietary Habits

Diets high in:

  • processed foods
     

  • refined sugars
     

  • unhealthy fats
     

strain the digestive system and alter gut microbiota.

 

Stress and Mental Health

Chronic stress affects gut-brain communication, worsening digestive symptoms.

 

Infections

Bacterial, viral or parasitic infections disrupt gut function.

 

Food Intolerances

Lactose, gluten or other intolerances cause digestive distress.

 

Sedentary Lifestyle

Lack of physical activity slows digestion and bowel movement.

 

Medication Use

Certain medications irritate the stomach lining or alter gut flora.

 

Who Is at Higher Risk?

People at increased risk include:

  • individuals with poor diet
     

  • those under chronic stress
     

  • older adults
     

  • people with family history of gut disease
     

  • individuals with sedentary lifestyles
     

Early lifestyle correction reduces risk significantly.

 

Diagnosis of Digestive Disorders

Evaluation may include:

  • medical history
     

  • physical examination
     

  • blood tests
     

  • stool tests
     

  • imaging or endoscopy
     

Diagnosis depends on symptom severity and duration.

 

Treatment Approaches

Medical Management

Treatment varies by condition and may include:

  • acid suppressants
     

  • anti-inflammatory medications
     

  • probiotics
     

  • antibiotics when needed
     

 

Dietary Modifications

  • increase fibre intake
     

  • limit trigger foods
     

  • eat regular meals
     

  • avoid excessive alcohol
     

Diet plays a central role in gut health.

 

Lifestyle Changes

  • manage stress
     

  • exercise regularly
     

  • stay hydrated
     

  • maintain sleep routine
     

Healthy habits support digestive function.

 

Prevention Tips for Digestive Health

Eat a Balanced Diet

Include fruits, vegetables, whole grains and lean proteins.

 

Stay Hydrated

Water supports digestion and prevents constipation.

 

Manage Stress

Mindfulness and relaxation techniques improve gut-brain balance.

 

Be Physically Active

Movement stimulates bowel activity and gut motility.

 

Avoid Smoking and Excess Alcohol

These irritate the digestive tract and worsen symptoms.

 

Seek Early Medical Advice

Early care prevents complications and chronic disease.

 

Long-Term Impact of Ignoring Digestive Problems

Untreated digestive disorders may lead to:

  • nutrient deficiencies
     

  • chronic inflammation
     

  • poor quality of life
     

  • increased disease complications
     

Early intervention is more effective and less invasive.

 

When to Consult a Doctor

Medical advice is recommended if:

  • symptoms persist beyond weeks
     

  • pain is severe
     

  • blood appears in stool
     

  • unexplained weight loss occurs
     

Prompt evaluation ensures safe management.

 

Conclusion

Digestive system disorders are common but often underestimated health issues. Symptoms such as bloating, pain, constipation and heartburn may seem minor initially but can signal deeper problems if ignored. Understanding causes, recognising early symptoms and adopting preventive habits help protect digestive health. With timely care, balanced nutrition and healthy lifestyle choices, most digestive disorders can be effectively managed, allowing the digestive system to function smoothly and support overall wellbeing.

 

References

  • Indian Council of Medical Research (ICMR) – Digestive Health and Nutrition Reports

  • World Health Organization (WHO) – Digestive Disorders and Gut Health Guideline

  •  National Institute of Nutrition (NIN) – Dietary Fibre and Gut Health Researc

  •  Lancet – Gastrointestinal Disease and Prevention Studies

  •  Indian Journal of Gastroenterology – Digestive Disorder Research

  •  Statista – Digestive Health Trends and Lifestyle Factors

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