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Published on: Oct 28, 2020
2 minute read
By: Dr Rajan ( Medical Second Opinion Cell)

Hepatitis C Nobel Prize

Earlier this month the Nobel Prize in Physiology and Medicine was jointly awarded to Harvey J Alter, Michael Houghton and Charles M Rice for the discovery of the Hepatitis C virus. This helped push our understanding of blood-borne hepatitis, a major global health problem that is one of the leading causes of cirrhosis and liver cancer alongside Hepatitis B. It led the way in introducing new tests for chronic hepatitis as well as new treatments that have saved the lives of millions.

HEPATITIS

Hepatitis is the inflammation of your liver, the largest solid organ in your body. Though there are numerous other causes of hepatitis, including alcohol abuse, drugs and toxins (including paracetamol overdose), and autoimmune disorders (such as Wilson’s disease), viral infections are the most common worldwide causes for hepatitis. Hepatitis A was the first to be discovered, transmitted by polluted food and water, and results in a short-term transient hepatitis. Hepatitis B on the other hand is transmitted through blood and is more of an issue as it can lead to chronic cirrhosis and possible liver cancer. It can remain indolent in a person, causing disease long after the initial infection.

Blood borne hepatitis was first discovered in the 1960s, when it was found that some patients would become ill after receiving blood transfusions. Despite this discovery and new tests for Hepatitis B reducing the number of transfusion related hepatitis, a large number of cases remained.

NOT A, NOT B

Harvey Alter, working at the US National Institute of Health, was studying the occurrence of hepatitis in blood transfusion patients. His team showed that blood from these infected patients could transmit the disease to chimpanzees, resulting in hepatitis. This agent had the properties of a virus, one that was “non-A, non B” hepatitis.

Further investigation into the virus would require the input of Michael Houghton, working for Chiron pharmaceutical. His team created a collection of DNA fragments found in the blood of infected chimpanzees. Though the majority of these fragments were from the chimpanzee, enough were from the virus. They were able to utilise this information to identify antibodies against the suspected virus, and ultimately identify it as the flavivirus Hepatitis C.

The final piece of the puzzle was shown by Charles M Rice, a researcher at Washington University, St Louis – could the virus alone cause hepatitis. He studied the RNA of Hepatitis C to identify regions that may be used for replication, and areas that might hinder replication. This was key as the virus can lay dormant for years, replicating at a slow rate before causing damage to the liver. For researchers, this was an issue as it was not feasible to wait years and see if the suspected virus caused hepatitis. By genetically engineering the viral genome, he developed a variant of Hepatitis C that would only multiple rapidly and have no mechanism to inactivate itself for dormancy. This strain caused rapid changes to the livers of infected chimpanzees; the same changes seen in hepatitis patients.

. ;.,hrvxzThe impact was significant. Prior to this, receiving a blood transfusion was like Russian Roulette. You were receiving life saving therapy, but it coZuld also be a hidden death sentence. Now that hepatitis had been discovered, it became possible to screen patients prior to donation, to screen blood transfusion bags, and to start developing treatments for the virus.

The fight is not over yet. There are still over 70 million people who still live with the virus, and it still kills around 400,000 a year. Its only very recently that we have found treatments that can reduce the viral load in patients to levels that they are considered cured. This treatment remains expensive, and we are very far away from eradication itself.

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5K Run for a Cause: How Community Fitness Drives Preventive Health Awareness

Physical activity is one of the most effective tools for disease prevention, yet it remains underutilised in everyday life. Community-based fitness initiatives such as a 5K Run for a Cause play a powerful role in bridging this gap by making movement accessible, meaningful and socially engaging. These events combine the benefits of exercise with awareness-building, creating lasting impact on public health.

In India, lifestyle-related diseases such as diabetes, heart disease and obesity are rising rapidly. According to the Indian Council of Medical Research (ICMR) and National Family Health Survey (NFHS-5), physical inactivity is a major contributor to this growing burden. Events that encourage structured, enjoyable physical activity help counter this trend.

What Is a 5K Run for a Cause?

A 5K Run for a Cause is a short-distance running or walking event designed to promote fitness while supporting a health, social or community objective. Participants may run, jog or walk the 5-kilometre distance, making the event inclusive for people of varying fitness levels.

Beyond physical activity, these runs aim to:

raise awareness about preventive health
encourage active lifestyles
build community participation
support wellness-driven causes

Why 5K Is an Ideal Distance

The 5-kilometre distance is widely recognised as:

achievable for beginners
challenging enough to promote fitness
safe for most age groups with minimal training

WHO physical activity guidelines support moderate-intensity exercise like running or brisk walking for improving cardiovascular and metabolic health.

Health Benefits of Participating in a 5K Run

Improved Cardiovascular Health

Running and brisk walking strengthen the heart, improve circulation and lower blood pressure. Regular participation reduces the risk of heart disease and stroke.

Better Metabolic Health

Physical activity improves insulin sensitivity and supports weight management. ICMR data shows that regular movement significantly reduces diabetes risk.

Enhanced Mental Wellbeing

Exercise releases endorphins that reduce stress, anxiety and depression. Community runs add a social element that further supports mental health.

Improved Musculoskeletal Strength

Running strengthens muscles, bones and joints, reducing the risk of age-related mobility issues.

Role of 5K Runs in Preventive Healthcare

Preventive healthcare focuses on reducing disease risk before illness develops. A 5K Run for a Cause supports prevention by:

promoting physical activity
encouraging regular movement habits
raising awareness about lifestyle diseases
motivating health-conscious behaviour

NITI Aayog identifies physical activity promotion as a key pillar of preventive healthcare in India.

Community Impact of a 5K Run for a Cause

Building Health Awareness

Runs often highlight specific causes such as heart health, diabetes prevention or mental wellbeing, reinforcing public health messages.

Strengthening Social Bonds

Community participation fosters shared goals and mutual motivation, increasing long-term adherence to healthy habits.

Encouraging Family Participation

Inclusive events encourage families to adopt healthier lifestyles together.

5K Runs and Corporate Wellness Programs

Corporate wellness programs increasingly include physical activity initiatives.

Benefits for organisations include:

improved employee engagement
reduced absenteeism
enhanced team bonding
positive employer branding

EY-FICCI reports show that wellness initiatives focused on physical activity deliver strong participation and measurable health benefits.

Accessibility and Inclusivity

A key strength of 5K runs is inclusivity.

They accommodate:

first-time runners
walkers
older adults
people transitioning to active lifestyles

This inclusiveness reduces barriers to participation.

Supporting Long-Term Behaviour Change

One-time events create awareness, but their true value lies in inspiring long-term change.

Participants often:

continue walking or running regularly
become more conscious of fitness
seek preventive health checkups

Lancet studies indicate that community-based physical activity initiatives can influence long-term health behaviours.

Safety and Health Considerations

For safe participation:

individuals should assess fitness levels
warm-up and cool-down are essential
hydration should be prioritised
those with medical conditions should seek medical advice

Proper guidance ensures benefits without injury.

Role of Awareness and Education

Successful runs integrate education through:

health talks
informational materials
screening camps
wellness resources

This combination reinforces preventive health messages.

Measuring Impact

Impact can be assessed through:

participation rates
follow-up health initiatives
employee engagement metrics
community feedback

Data-driven evaluation improves future program design.

Why 5K Runs Matter in India

India faces challenges such as:

rising sedentary lifestyles
limited health awareness
increasing chronic disease burden

Community fitness events provide a scalable, low-cost solution to promote active living and prevention.

Conclusion

A 5K Run for a Cause is more than a fitness event—it is a preventive health movement. By combining physical activity with purpose, these runs encourage healthier lifestyles, strengthen community bonds and raise awareness about long-term wellbeing. In a country where lifestyle diseases are growing rapidly, initiatives that make movement accessible and meaningful are essential. A simple 5K run can be a powerful step toward a healthier, more active society.

References

ICMR – Physical Activity and Lifestyle Disease Prevention Reports
National Family Health Survey (NFHS-5) – Physical Activity and Health Data
NITI Aayog – Preventive Healthcare and Physical Activity Promotion Strategy
WHO – Physical Activity and Health Guideline
Lancet – Community Fitness and Preventive Health Studies
Statista – Fitness Events and Participation Trends India
EY-FICCI – Corporate Wellness and Physical Activity Reports

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