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Published on: Oct 28, 2020
2 minute read
By: Dr Rajan ( Medical Second Opinion Cell)

Hepatitis C Nobel Prize

Earlier this month the Nobel Prize in Physiology and Medicine was jointly awarded to Harvey J Alter, Michael Houghton and Charles M Rice for the discovery of the Hepatitis C virus. This helped push our understanding of blood-borne hepatitis, a major global health problem that is one of the leading causes of cirrhosis and liver cancer alongside Hepatitis B. It led the way in introducing new tests for chronic hepatitis as well as new treatments that have saved the lives of millions.

HEPATITIS

Hepatitis is the inflammation of your liver, the largest solid organ in your body. Though there are numerous other causes of hepatitis, including alcohol abuse, drugs and toxins (including paracetamol overdose), and autoimmune disorders (such as Wilson’s disease), viral infections are the most common worldwide causes for hepatitis. Hepatitis A was the first to be discovered, transmitted by polluted food and water, and results in a short-term transient hepatitis. Hepatitis B on the other hand is transmitted through blood and is more of an issue as it can lead to chronic cirrhosis and possible liver cancer. It can remain indolent in a person, causing disease long after the initial infection.

Blood borne hepatitis was first discovered in the 1960s, when it was found that some patients would become ill after receiving blood transfusions. Despite this discovery and new tests for Hepatitis B reducing the number of transfusion related hepatitis, a large number of cases remained.

NOT A, NOT B

Harvey Alter, working at the US National Institute of Health, was studying the occurrence of hepatitis in blood transfusion patients. His team showed that blood from these infected patients could transmit the disease to chimpanzees, resulting in hepatitis. This agent had the properties of a virus, one that was “non-A, non B” hepatitis.

Further investigation into the virus would require the input of Michael Houghton, working for Chiron pharmaceutical. His team created a collection of DNA fragments found in the blood of infected chimpanzees. Though the majority of these fragments were from the chimpanzee, enough were from the virus. They were able to utilise this information to identify antibodies against the suspected virus, and ultimately identify it as the flavivirus Hepatitis C.

The final piece of the puzzle was shown by Charles M Rice, a researcher at Washington University, St Louis – could the virus alone cause hepatitis. He studied the RNA of Hepatitis C to identify regions that may be used for replication, and areas that might hinder replication. This was key as the virus can lay dormant for years, replicating at a slow rate before causing damage to the liver. For researchers, this was an issue as it was not feasible to wait years and see if the suspected virus caused hepatitis. By genetically engineering the viral genome, he developed a variant of Hepatitis C that would only multiple rapidly and have no mechanism to inactivate itself for dormancy. This strain caused rapid changes to the livers of infected chimpanzees; the same changes seen in hepatitis patients.

. ;.,hrvxzThe impact was significant. Prior to this, receiving a blood transfusion was like Russian Roulette. You were receiving life saving therapy, but it coZuld also be a hidden death sentence. Now that hepatitis had been discovered, it became possible to screen patients prior to donation, to screen blood transfusion bags, and to start developing treatments for the virus.

The fight is not over yet. There are still over 70 million people who still live with the virus, and it still kills around 400,000 a year. Its only very recently that we have found treatments that can reduce the viral load in patients to levels that they are considered cured. This treatment remains expensive, and we are very far away from eradication itself.

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Add Indoor Cycles or Scooters at Large Offices – Promote Movement During the Day

Corporate offices today are larger, more digitally connected and more sedentary than ever before. Employees spend extended hours seated at desks, in meetings or on screens. According to the World Health Organization, physical inactivity is among the top risk factors for global mortality. In India, rapid urbanisation and desk-based jobs have significantly increased sedentary behaviour.

One innovative workplace wellness strategy is to Add Indoor Cycles or Scooters at Large Offices – Promote movement during the day. This simple yet impactful initiative encourages daily physical activity within the office environment, helping reduce long-term health risks.

The Sedentary Workplace Problem

Large office campuses often require:

long walks between departments
elevator use for multiple floors
extended desk time

However, most employees still remain seated for more than 6–8 hours daily.

ICMR and NFHS-5 data show increasing prevalence of:

obesity
hypertension
diabetes

Sedentary habits contribute significantly to these conditions.

Why Movement During the Day Matters

Prolonged sitting affects:

metabolism
circulation
posture
heart health

Short bursts of activity improve:

blood flow
oxygen delivery
mental alertness

Encouraging movement throughout the day prevents metabolic slowdown.

How Indoor Cycles and Scooters Help

1. Break the Sitting Cycle

Indoor cycles placed in designated zones allow employees to:

pedal for 5–10 minutes
refresh during breaks
reduce continuous sitting

Scooters in large campuses encourage movement between departments.

2. Boost Energy Levels

Light physical activity stimulates:

endorphin release
improved circulation
mental clarity

Employees return to tasks with renewed focus.

3. Improve Cardiovascular Health

Regular low-intensity cycling helps:

regulate blood pressure
improve heart function
manage weight

Consistent activity reduces risk of heart disease.

4. Encourage Active Office Culture

Visible wellness initiatives create:

positive peer influence
cultural shift toward health
higher engagement

When movement becomes normalised, participation increases.

Impact on Productivity

Contrary to concerns, movement breaks:

improve concentration
reduce fatigue
enhance creativity

Research cited by global workplace health reports shows that active employees demonstrate better cognitive performance.

Suitable for Large Office Campuses

Large offices with:

multiple floors
wide corridors
campus layouts

can safely integrate scooters for short-distance mobility.

Indoor cycling stations can be placed in:

wellness corners
break rooms
near cafeterias

Accessibility encourages usage.

Addressing Safety and Practicality

To ensure safety:

provide clear guidelines
designate riding zones
encourage voluntary participation
maintain equipment regularly

Structured implementation ensures smooth integration.

Mental Health Benefits

Movement during the workday:

reduces stress
lowers cortisol levels
improves mood

Stress reduction contributes to better overall wellbeing.

Supporting Preventive Healthcare

Regular physical activity helps prevent:

metabolic syndrome
obesity
type 2 diabetes
hypertension

Preventive workplace initiatives reduce long-term health costs.

Encouraging Participation

Organisations can:

track voluntary participation
organise friendly cycling challenges
reward consistent engagement

Gamification increases motivation.

Complementing Other Wellness Initiatives

Indoor cycles and scooters can integrate with:

standing desks
walking meetings
stretch breaks
health screening programs

A multi-layered approach maximises impact.

Measuring Success

Metrics may include:

employee feedback
reduced absenteeism
improved wellness survey results
increased engagement scores

Data supports long-term continuation.

Economic Benefits for Employers

Preventive activity reduces:

sick leave
burnout
productivity loss

Healthy employees contribute more consistently.

Creating a Culture of Movement

Leadership participation encourages adoption.

When managers model active behaviour, employees follow.

Wellness becomes embedded in organisational identity.

Long-Term Impact

Encouraging daily movement leads to:

better cardiovascular health
improved metabolic function
reduced stress
enhanced workplace morale

Small, consistent actions create sustainable change.

Conclusion

Add Indoor Cycles or Scooters at Large Offices – Promote movement during the day is a forward-thinking corporate wellness strategy. By addressing sedentary habits directly within the workplace environment, organisations can reduce lifestyle disease risk, enhance productivity and foster a culture of health. Movement is not just exercise—it is preventive healthcare in action. When offices actively design for motion, they invest in the long-term wellbeing of their workforce.

References

World Health Organization (WHO) – Physical Activity and Health Reports
Indian Council of Medical Research (ICMR) – Lifestyle Disease Data
National Family Health Survey (NFHS-5) – Obesity and Hypertension Trends
NITI Aayog – Preventive Healthcare Strategy Reports
Lancet – Sedentary Behaviour and Chronic Disease Research

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