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Published on: Oct 28, 2020
2 minute read
By: Dr Rajan ( Medical Second Opinion Cell)

Hepatitis C Nobel Prize

Earlier this month the Nobel Prize in Physiology and Medicine was jointly awarded to Harvey J Alter, Michael Houghton and Charles M Rice for the discovery of the Hepatitis C virus. This helped push our understanding of blood-borne hepatitis, a major global health problem that is one of the leading causes of cirrhosis and liver cancer alongside Hepatitis B. It led the way in introducing new tests for chronic hepatitis as well as new treatments that have saved the lives of millions.

HEPATITIS

Hepatitis is the inflammation of your liver, the largest solid organ in your body. Though there are numerous other causes of hepatitis, including alcohol abuse, drugs and toxins (including paracetamol overdose), and autoimmune disorders (such as Wilson’s disease), viral infections are the most common worldwide causes for hepatitis. Hepatitis A was the first to be discovered, transmitted by polluted food and water, and results in a short-term transient hepatitis. Hepatitis B on the other hand is transmitted through blood and is more of an issue as it can lead to chronic cirrhosis and possible liver cancer. It can remain indolent in a person, causing disease long after the initial infection.

Blood borne hepatitis was first discovered in the 1960s, when it was found that some patients would become ill after receiving blood transfusions. Despite this discovery and new tests for Hepatitis B reducing the number of transfusion related hepatitis, a large number of cases remained.

NOT A, NOT B

Harvey Alter, working at the US National Institute of Health, was studying the occurrence of hepatitis in blood transfusion patients. His team showed that blood from these infected patients could transmit the disease to chimpanzees, resulting in hepatitis. This agent had the properties of a virus, one that was “non-A, non B” hepatitis.

Further investigation into the virus would require the input of Michael Houghton, working for Chiron pharmaceutical. His team created a collection of DNA fragments found in the blood of infected chimpanzees. Though the majority of these fragments were from the chimpanzee, enough were from the virus. They were able to utilise this information to identify antibodies against the suspected virus, and ultimately identify it as the flavivirus Hepatitis C.

The final piece of the puzzle was shown by Charles M Rice, a researcher at Washington University, St Louis – could the virus alone cause hepatitis. He studied the RNA of Hepatitis C to identify regions that may be used for replication, and areas that might hinder replication. This was key as the virus can lay dormant for years, replicating at a slow rate before causing damage to the liver. For researchers, this was an issue as it was not feasible to wait years and see if the suspected virus caused hepatitis. By genetically engineering the viral genome, he developed a variant of Hepatitis C that would only multiple rapidly and have no mechanism to inactivate itself for dormancy. This strain caused rapid changes to the livers of infected chimpanzees; the same changes seen in hepatitis patients.

. ;.,hrvxzThe impact was significant. Prior to this, receiving a blood transfusion was like Russian Roulette. You were receiving life saving therapy, but it coZuld also be a hidden death sentence. Now that hepatitis had been discovered, it became possible to screen patients prior to donation, to screen blood transfusion bags, and to start developing treatments for the virus.

The fight is not over yet. There are still over 70 million people who still live with the virus, and it still kills around 400,000 a year. Its only very recently that we have found treatments that can reduce the viral load in patients to levels that they are considered cured. This treatment remains expensive, and we are very far away from eradication itself.

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How Lack of Sleep Weakens Immunity: Why Poor Sleep Makes You Fall Sick More Often

Sleep is one of the most powerful yet overlooked pillars of health. While nutrition and exercise receive significant attention, sleep often takes a back seat in modern lifestyles. Understanding how lack of sleep weakens immunity reveals why people who sleep poorly fall sick more often, take longer to recover and experience chronic inflammation.

In India, late-night work culture, excessive screen time and irregular schedules have made sleep deprivation increasingly common across age groups.

The Link Between Sleep and the Immune System

The immune system relies on sleep for:

repair and regeneration
immune cell production
inflammation control

During deep sleep, the body releases cytokines and antibodies that protect against infections.

What Happens to Immunity During Sleep

While sleeping:

immune cells identify pathogens
inflammatory responses are regulated
memory T-cells strengthen immune memory

This nightly process prepares the body to fight infections effectively.

How Sleep Deprivation Disrupts Immune Function

When sleep is inadequate:

immune cell activity decreases
antibody production drops
inflammation increases

WHO studies confirm that sleep deprivation weakens immune defence mechanisms.

Increased Risk of Infections

People who sleep less than 6 hours regularly:

fall sick more often
catch colds and flu easily
recover slower from illness

Lancet research shows a strong link between sleep duration and infection susceptibility.

Impact on Inflammation

Poor sleep increases inflammatory markers.

Chronic inflammation:

weakens immune response
increases risk of chronic diseases

ICMR reports highlight sleep deprivation as a contributor to low-grade systemic inflammation.

Effect on Vaccine Response

Sleep quality affects how well vaccines work.

Studies show:

poor sleep reduces antibody response
adequate sleep improves vaccine effectiveness

Sleep is essential for immune memory formation.

Hormonal Changes That Affect Immunity

Sleep regulates hormones such as:

cortisol
melatonin

Lack of sleep increases cortisol, which suppresses immune function.

Stress, Sleep and Immunity

Sleep deprivation and stress reinforce each other.

High stress:

disrupts sleep
suppresses immune cells

This cycle weakens overall resistance to illness.

Impact on Gut Immunity

The gut hosts a major part of the immune system.

Poor sleep:

disrupts gut microbiome
weakens gut immunity

Lancet studies link sleep deprivation to gut-related immune dysfunction.

Why Children and Older Adults Are More Vulnerable

Sleep deprivation affects:

children’s developing immune systems
older adults’ already weakened immunity

Adequate sleep is especially important in these age groups.

Signs Your Immunity Is Affected by Poor Sleep

Warning signs include:

frequent infections
slow wound healing
constant fatigue
increased allergies

These symptoms indicate compromised immune defence.

Long-Term Health Risks of Poor Sleep

Chronic sleep deprivation increases risk of:

infections
autoimmune disorders
metabolic diseases
heart disease

Sleep loss affects nearly every body system.

Role of Preventive Health Awareness

Preventive healthcare emphasises:

sleep as a foundation of immunity
early lifestyle correction

NITI Aayog recognises sleep hygiene as essential for population health.

How to Improve Sleep for Better Immunity

Effective strategies include:

fixed sleep and wake times
limiting screen exposure before bed
avoiding caffeine late in the day
creating a dark, quiet sleep environment

Consistency matters more than duration alone.

Myths About Sleep and Immunity

Myth: You can catch up on sleep later
Fact: Chronic sleep debt harms immunity.

Myth: Sleeping pills improve immunity
Fact: Natural sleep is more beneficial.

Why Sleep Is a Preventive Medicine

Sleep:

costs nothing
requires no equipment
delivers powerful immune protection

It is one of the most effective preventive health tools.

Conclusion

Understanding how lack of sleep weakens immunity highlights the critical role of sleep in protecting the body from infections and chronic disease. Poor sleep disrupts immune cell function, increases inflammation and reduces resistance to illness. Prioritising consistent, quality sleep is not optional—it is essential for strong immunity, faster recovery and long-term health. Protecting sleep today strengthens immune defence for tomorrow.

References

Indian Council of Medical Research (ICMR) – Sleep, Immunity and Inflammation Studies
World Health Organization (WHO) – Sleep and Immune Health Guidelines
National Institutes of Health – Sleep Deprivation and Immunity
Lancet – Sleep Duration and Infection Risk
NITI Aayog – Preventive Health and Lifestyle Recommendations

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