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Published on: Oct 28, 2020
2 minute read
By: Dr Rajan ( Medical Second Opinion Cell)

Hepatitis C Nobel Prize

Earlier this month the Nobel Prize in Physiology and Medicine was jointly awarded to Harvey J Alter, Michael Houghton and Charles M Rice for the discovery of the Hepatitis C virus. This helped push our understanding of blood-borne hepatitis, a major global health problem that is one of the leading causes of cirrhosis and liver cancer alongside Hepatitis B. It led the way in introducing new tests for chronic hepatitis as well as new treatments that have saved the lives of millions.

HEPATITIS

Hepatitis is the inflammation of your liver, the largest solid organ in your body. Though there are numerous other causes of hepatitis, including alcohol abuse, drugs and toxins (including paracetamol overdose), and autoimmune disorders (such as Wilson’s disease), viral infections are the most common worldwide causes for hepatitis. Hepatitis A was the first to be discovered, transmitted by polluted food and water, and results in a short-term transient hepatitis. Hepatitis B on the other hand is transmitted through blood and is more of an issue as it can lead to chronic cirrhosis and possible liver cancer. It can remain indolent in a person, causing disease long after the initial infection.

Blood borne hepatitis was first discovered in the 1960s, when it was found that some patients would become ill after receiving blood transfusions. Despite this discovery and new tests for Hepatitis B reducing the number of transfusion related hepatitis, a large number of cases remained.

NOT A, NOT B

Harvey Alter, working at the US National Institute of Health, was studying the occurrence of hepatitis in blood transfusion patients. His team showed that blood from these infected patients could transmit the disease to chimpanzees, resulting in hepatitis. This agent had the properties of a virus, one that was “non-A, non B” hepatitis.

Further investigation into the virus would require the input of Michael Houghton, working for Chiron pharmaceutical. His team created a collection of DNA fragments found in the blood of infected chimpanzees. Though the majority of these fragments were from the chimpanzee, enough were from the virus. They were able to utilise this information to identify antibodies against the suspected virus, and ultimately identify it as the flavivirus Hepatitis C.

The final piece of the puzzle was shown by Charles M Rice, a researcher at Washington University, St Louis – could the virus alone cause hepatitis. He studied the RNA of Hepatitis C to identify regions that may be used for replication, and areas that might hinder replication. This was key as the virus can lay dormant for years, replicating at a slow rate before causing damage to the liver. For researchers, this was an issue as it was not feasible to wait years and see if the suspected virus caused hepatitis. By genetically engineering the viral genome, he developed a variant of Hepatitis C that would only multiple rapidly and have no mechanism to inactivate itself for dormancy. This strain caused rapid changes to the livers of infected chimpanzees; the same changes seen in hepatitis patients.

. ;.,hrvxzThe impact was significant. Prior to this, receiving a blood transfusion was like Russian Roulette. You were receiving life saving therapy, but it coZuld also be a hidden death sentence. Now that hepatitis had been discovered, it became possible to screen patients prior to donation, to screen blood transfusion bags, and to start developing treatments for the virus.

The fight is not over yet. There are still over 70 million people who still live with the virus, and it still kills around 400,000 a year. Its only very recently that we have found treatments that can reduce the viral load in patients to levels that they are considered cured. This treatment remains expensive, and we are very far away from eradication itself.

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Health Risks of Irregular Eating Habits: How Skipping Meals Affects Your Body

Maintaining a balanced and consistent diet is essential for good health. However, modern lifestyles often lead to irregular eating patterns due to busy schedules, work stress and changing daily routines. Many people skip meals, eat late at night or consume food at inconsistent times.

Understanding the health risks of irregular eating habits is important for maintaining metabolic balance and overall wellbeing. Consistent meal timing plays a key role in supporting digestion, energy levels and long-term health.

What Are Irregular Eating Habits?

Irregular eating habits refer to inconsistent or unpredictable meal patterns.

Common examples include:

Skipping breakfast or other meals
Eating meals at varying times each day
Consuming large meals late at night
Frequently replacing meals with snacks

These habits may disrupt the body’s natural metabolic rhythm.

How the Body Regulates Eating Patterns

The human body follows internal biological rhythms that regulate hunger, metabolism and digestion.

When meals occur at consistent times, the digestive system prepares enzymes and hormones needed for efficient food processing.

Irregular eating patterns may interfere with these processes.

1. Disruption of Metabolism

Metabolism refers to the process by which the body converts food into energy.

Skipping meals or eating inconsistently may slow metabolic activity, making it harder for the body to regulate energy balance.

This disruption may contribute to metabolic disorders over time.

2. Increased Risk of Weight Gain

Although skipping meals may appear to reduce calorie intake, it often leads to overeating later in the day.

Large or late meals may increase calorie consumption and contribute to weight gain.

Irregular eating may also affect hormones that regulate appetite.

3. Digestive Problems

The digestive system functions best when meals occur at regular intervals.

Irregular eating may cause symptoms such as:

Acid reflux
Bloating
Indigestion
Stomach discomfort

Consistent meal timing helps maintain digestive balance.

4. Fluctuating Energy Levels

Skipping meals can lead to sudden drops in blood sugar levels.

Low blood sugar may cause symptoms such as:

Fatigue
Dizziness
Difficulty concentrating

Regular meals help maintain steady energy throughout the day.

5. Impact on Blood Sugar Control

Irregular eating patterns may disrupt glucose regulation.

Over time, inconsistent meal timing may increase the risk of insulin resistance and type 2 diabetes.

Maintaining stable blood sugar levels is important for metabolic health.

6. Nutritional Deficiencies

Skipping meals can reduce the intake of essential nutrients required for body function.

A balanced diet provides vitamins, minerals and other nutrients needed for immunity, metabolism and overall health.

Irregular eating habits may lead to nutritional imbalances.

Irregular Eating Habits in the Indian Context

In many urban areas of India, demanding work schedules and long commuting times often lead to irregular meal patterns.

Late-night eating, fast food consumption and skipped meals have become common among professionals and students.

These lifestyle patterns may increase the risk of metabolic and digestive health problems.

Promoting regular meal timing and balanced diets is essential for improving public health.

Tips to Maintain Healthy Eating Habits

Establish Regular Meal Times

Eating meals at consistent times each day helps regulate digestion and metabolism.

Do Not Skip Breakfast

Breakfast provides essential energy for starting the day and supports metabolic activity.

Plan Balanced Meals

Include a variety of foods such as:

Whole grains
Fruits and vegetables
Lean proteins
Healthy fats

Balanced nutrition supports overall health.

Avoid Late-Night Heavy Meals

Eating large meals close to bedtime may disrupt digestion and sleep.

Stay Hydrated

Adequate hydration supports digestion and nutrient absorption.

When to Seek Medical Advice

Consult a healthcare professional if irregular eating habits lead to:

Persistent digestive problems
Unexplained weight changes
Chronic fatigue
Blood sugar irregularities

Early intervention can help prevent long-term health complications.

Conclusion

Irregular eating habits may significantly impact metabolism, digestion and overall health. Skipping meals, inconsistent meal timing and late-night eating can disrupt the body’s natural rhythms and increase the risk of metabolic disorders.

Maintaining consistent meal schedules, balanced nutrition and healthy lifestyle habits can support digestive health and stable energy levels.

By adopting regular eating routines, individuals can improve metabolic balance and reduce the risk of long-term health complications.

Healthy eating patterns are a fundamental part of maintaining overall wellbeing and long-term health.

References

Indian Council of Medical Research – Nutrition and Dietary Guidelines
World Health Organization – Healthy Diet Recommendations
National Institute of Nutrition India – Balanced Meal Guidelines
Journal of Nutrition and Metabolism – Meal Timing Research
Lancet Global Health – Nutrition and Lifestyle Studies

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