Call
+918447748545

Published on: Oct 28, 2020
2 minute read
By: Dr Rajan ( Medical Second Opinion Cell)

Hepatitis C Nobel Prize

Earlier this month the Nobel Prize in Physiology and Medicine was jointly awarded to Harvey J Alter, Michael Houghton and Charles M Rice for the discovery of the Hepatitis C virus. This helped push our understanding of blood-borne hepatitis, a major global health problem that is one of the leading causes of cirrhosis and liver cancer alongside Hepatitis B. It led the way in introducing new tests for chronic hepatitis as well as new treatments that have saved the lives of millions.

HEPATITIS

Hepatitis is the inflammation of your liver, the largest solid organ in your body. Though there are numerous other causes of hepatitis, including alcohol abuse, drugs and toxins (including paracetamol overdose), and autoimmune disorders (such as Wilson’s disease), viral infections are the most common worldwide causes for hepatitis. Hepatitis A was the first to be discovered, transmitted by polluted food and water, and results in a short-term transient hepatitis. Hepatitis B on the other hand is transmitted through blood and is more of an issue as it can lead to chronic cirrhosis and possible liver cancer. It can remain indolent in a person, causing disease long after the initial infection.

Blood borne hepatitis was first discovered in the 1960s, when it was found that some patients would become ill after receiving blood transfusions. Despite this discovery and new tests for Hepatitis B reducing the number of transfusion related hepatitis, a large number of cases remained.

NOT A, NOT B

Harvey Alter, working at the US National Institute of Health, was studying the occurrence of hepatitis in blood transfusion patients. His team showed that blood from these infected patients could transmit the disease to chimpanzees, resulting in hepatitis. This agent had the properties of a virus, one that was “non-A, non B” hepatitis.

Further investigation into the virus would require the input of Michael Houghton, working for Chiron pharmaceutical. His team created a collection of DNA fragments found in the blood of infected chimpanzees. Though the majority of these fragments were from the chimpanzee, enough were from the virus. They were able to utilise this information to identify antibodies against the suspected virus, and ultimately identify it as the flavivirus Hepatitis C.

The final piece of the puzzle was shown by Charles M Rice, a researcher at Washington University, St Louis – could the virus alone cause hepatitis. He studied the RNA of Hepatitis C to identify regions that may be used for replication, and areas that might hinder replication. This was key as the virus can lay dormant for years, replicating at a slow rate before causing damage to the liver. For researchers, this was an issue as it was not feasible to wait years and see if the suspected virus caused hepatitis. By genetically engineering the viral genome, he developed a variant of Hepatitis C that would only multiple rapidly and have no mechanism to inactivate itself for dormancy. This strain caused rapid changes to the livers of infected chimpanzees; the same changes seen in hepatitis patients.

. ;.,hrvxzThe impact was significant. Prior to this, receiving a blood transfusion was like Russian Roulette. You were receiving life saving therapy, but it coZuld also be a hidden death sentence. Now that hepatitis had been discovered, it became possible to screen patients prior to donation, to screen blood transfusion bags, and to start developing treatments for the virus.

The fight is not over yet. There are still over 70 million people who still live with the virus, and it still kills around 400,000 a year. Its only very recently that we have found treatments that can reduce the viral load in patients to levels that they are considered cured. This treatment remains expensive, and we are very far away from eradication itself.

Read Blog

Remote Cardiac Monitoring India: Transforming Heart Health Through Continuous Digital Tracking

Heart disease remains one of the leading causes of death in India. According to the Indian Council of Medical Research (ICMR), cardiovascular diseases account for nearly 28% of total deaths in the country. With rising stress levels, sedentary lifestyles, air pollution exposure, diabetes, hypertension, and delayed diagnosis, the need for better cardiac monitoring has grown significantly. Remote cardiac monitoring India is emerging as a powerful solution to monitor heart health in real time and detect abnormalities before they turn into emergencies.

Remote cardiac monitoring involves wearable or portable ECG devices that track heart signals continuously or at regular intervals. These devices transmit data securely to cardiologists or AI-based systems, enabling early detection of arrhythmias, rhythm abnormalities, ischemic patterns, and fluctuations in heart rate variability (HRV). SecondMedic brings cutting-edge remote monitoring options that help patients manage heart-related risks effectively, anytime and anywhere.

Why Remote Cardiac Monitoring Is Becoming Essential in India

India has a disproportionately high cardiac burden. Reports by WHO show that Indians suffer heart attacks at a younger age compared to global averages. Additionally, more than 50% of cardiac patients in India do not recognize early warning signs and reach hospitals late.

Remote cardiac monitoring helps solve these challenges by offering:

Early arrhythmia detection
Timely identification of heart stress
Post-surgery cardiac recovery supervision
Reduced hospital dependency
Continuous heart rhythm tracking
Better outcomes for chronic heart patients

With easy access to digital ECG devices, monitoring is no longer limited to hospitals.

How Remote Cardiac Monitoring Works

Remote cardiac monitoring uses smart ECG patches, chest straps, handheld ECG devices, and even AI-driven wearables. These devices record heart electrical activity or rhythm patterns and transmit the data to:

Cardiologists
Digital dashboards
AI algorithms
Care teams

The real-time nature of the data allows immediate response in case of abnormalities.

Core parameters captured include:

ECG waveform
Heart rate variability (HRV)
Arrhythmias (AFib, SVT, PVCs)
Tachycardia or bradycardia
QT interval abnormalities
Stress-related heart rhythm changes

SecondMedic ensures that the captured data is clinically relevant and accessible to both patients and doctors.

Patients Who Benefit Most from Remote Cardiac Monitoring

1. Post-Cardiac Surgery Patients

After angioplasty, bypass surgery, pacemaker implantation, or stent placement, patients require strict monitoring for weeks or months. Remote devices track recovery trends.

2. Individuals With Arrhythmia

Conditions like atrial fibrillation (AFib) require continuous monitoring, as episodes may come and go unpredictably.

3. Patients With Heart Failure

Monitoring helps evaluate worsening symptoms or cardiac stress.

4. High-Risk Individuals

Patients with diabetes, hypertension, obesity, or family history of heart disease benefit from early detection.

5. Elderly and Homebound Patients

Remote monitoring eliminates frequent hospital visits for routine ECG checks.

6. People Experiencing Palpitations

Intermittent symptoms can be captured and analyzed with wearable monitors.

Key Advantages of Remote Cardiac Monitoring

Early Detection Saves Lives

Abnormal rhythms such as atrial fibrillation can go unnoticed and lead to stroke. Remote monitoring detects these in real time.

Avoids Emergency Situations

AI alerts allow doctors to intervene early before symptoms worsen.

Better Long-Term Cardiac Care

Continuous data provides better insights than occasional clinic-based ECGs.

High Accuracy

Medical-grade ECG wearables match hospital-level precision for diagnosis.

Patient Convenience

Patients can monitor their heart health from home, office, or while traveling.

Improved Doctor Decisions

Trend-based cardiac data supports more accurate treatment planning.

Role of AI in Remote Cardiac Monitoring

AI and machine learning models analyze patterns collected from ECG devices.

AI enhances care by:

Identifying subtle abnormalities
Predicting arrhythmia events
Detecting ischemic trends early
Classifying ECG signal types
Reducing manual interpretation burden

SecondMedic integrates AI-assisted analysis to strengthen cardiac risk evaluation.

Post-Surgery and Rehabilitation Monitoring

Cardiac rehabilitation is crucial after major procedures. Remote monitoring provides:

Heart rate control
Blood pressure trend tracking
Rhythm abnormality detection
Activity monitoring
Medication adherence support

This reduces readmission rates and supports safer recovery.

Remote Cardiac Monitoring in Rural India

Many small towns lack cardiology specialists or advanced ECG equipment. Remote monitoring bridges this gap by:

Connecting patients to cardiologists virtually
Providing ECG analysis without hospital visits
Reducing delay in diagnosis
Supporting long-term monitoring at home

SecondMedic helps democratize heart care access across India.

Challenges and Solutions

Device Accuracy Variability

Solution: Use medical-grade, certified ECG wearables.

Digital Literacy Issues

Solution: Simple interfaces, guided onboarding, multilingual instructions.

Data Security

Solution: End-to-end encrypted data under DPDP Act compliance.

Connectivity Challenges

Solution: Devices with offline sync capabilities.

Future of Remote Cardiac Monitoring in India

The next decade will bring significant advancements:

Patch-based continuous ECG devices
AI-driven early warning scores
Smart pacemaker data integration
Multi-day continuous ECG monitoring
Predictive arrhythmia detection algorithms
Tele-ICU support for remote patients

SecondMedic is actively working to integrate next-generation cardiac monitoring tools into its platform.

Conclusion

Remote cardiac monitoring India is transforming heart care by enabling real-time ECG tracking, early abnormality detection, and continuous cardiologist oversight. This digital-first approach empowers high-risk patients, improves outcomes, and ensures safer long-term cardiac management. SecondMedic’s integrated digital heart monitoring solutions allow patients across India to access expert cardiac care anytime.

To explore remote cardiac monitoring solutions, visit www.secondmedic.com

References

ICMR - Cardiovascular disease burden
WHO - Early cardiac risk detection
NITI Aayog - Digital health innovation in India
ABDM - Unified digital health mission
Statista - Wearable and ECG device adoption India
SecondMedic cardiac care insights

Request A Callback

+91

By using this website/app, I confirm that I am at least 18 years old and consent to the processing of my personal data in accordance with the Terms of Service, Privacy Policy, and Declaration.