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Published on: Oct 28, 2020
2 minute read
By: Dr Rajan ( Medical Second Opinion Cell)

Hepatitis C Nobel Prize

Earlier this month the Nobel Prize in Physiology and Medicine was jointly awarded to Harvey J Alter, Michael Houghton and Charles M Rice for the discovery of the Hepatitis C virus. This helped push our understanding of blood-borne hepatitis, a major global health problem that is one of the leading causes of cirrhosis and liver cancer alongside Hepatitis B. It led the way in introducing new tests for chronic hepatitis as well as new treatments that have saved the lives of millions.

HEPATITIS

Hepatitis is the inflammation of your liver, the largest solid organ in your body. Though there are numerous other causes of hepatitis, including alcohol abuse, drugs and toxins (including paracetamol overdose), and autoimmune disorders (such as Wilson’s disease), viral infections are the most common worldwide causes for hepatitis. Hepatitis A was the first to be discovered, transmitted by polluted food and water, and results in a short-term transient hepatitis. Hepatitis B on the other hand is transmitted through blood and is more of an issue as it can lead to chronic cirrhosis and possible liver cancer. It can remain indolent in a person, causing disease long after the initial infection.

Blood borne hepatitis was first discovered in the 1960s, when it was found that some patients would become ill after receiving blood transfusions. Despite this discovery and new tests for Hepatitis B reducing the number of transfusion related hepatitis, a large number of cases remained.

NOT A, NOT B

Harvey Alter, working at the US National Institute of Health, was studying the occurrence of hepatitis in blood transfusion patients. His team showed that blood from these infected patients could transmit the disease to chimpanzees, resulting in hepatitis. This agent had the properties of a virus, one that was “non-A, non B” hepatitis.

Further investigation into the virus would require the input of Michael Houghton, working for Chiron pharmaceutical. His team created a collection of DNA fragments found in the blood of infected chimpanzees. Though the majority of these fragments were from the chimpanzee, enough were from the virus. They were able to utilise this information to identify antibodies against the suspected virus, and ultimately identify it as the flavivirus Hepatitis C.

The final piece of the puzzle was shown by Charles M Rice, a researcher at Washington University, St Louis – could the virus alone cause hepatitis. He studied the RNA of Hepatitis C to identify regions that may be used for replication, and areas that might hinder replication. This was key as the virus can lay dormant for years, replicating at a slow rate before causing damage to the liver. For researchers, this was an issue as it was not feasible to wait years and see if the suspected virus caused hepatitis. By genetically engineering the viral genome, he developed a variant of Hepatitis C that would only multiple rapidly and have no mechanism to inactivate itself for dormancy. This strain caused rapid changes to the livers of infected chimpanzees; the same changes seen in hepatitis patients.

. ;.,hrvxzThe impact was significant. Prior to this, receiving a blood transfusion was like Russian Roulette. You were receiving life saving therapy, but it coZuld also be a hidden death sentence. Now that hepatitis had been discovered, it became possible to screen patients prior to donation, to screen blood transfusion bags, and to start developing treatments for the virus.

The fight is not over yet. There are still over 70 million people who still live with the virus, and it still kills around 400,000 a year. Its only very recently that we have found treatments that can reduce the viral load in patients to levels that they are considered cured. This treatment remains expensive, and we are very far away from eradication itself.

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Why Do You Wake Up Tired Even After 8 Hours Sleep?

Getting 8 hours of sleep is often seen as the gold standard for good health. But what if you’re still waking up feeling groggy, exhausted, and low on energy—despite clocking in those 8 hours? If that sounds like you, you’re not alone.

In this blog, we’ll explore why you wake up tired even after 8 hours sleep, the possible reasons behind it, and simple ways to fix the issue so you can start your day refreshed and energized.

Sleep Quantity vs. Sleep Quality

It’s important to understand that sleep is not just about how long you sleep, but how well you sleep.

There are different stages of sleep your body goes through:

Light Sleep (Stage 1 & 2)
Deep Sleep (Stage 3)
REM Sleep (Stage 4) – where dreams and memory processing happen

If your sleep is constantly interrupted, or if you don’t get enough deep or REM sleep, your body and brain won’t be fully rested—even after 8 hours in bed.

7 Common Reasons You Wake Up Tired After a Full Night’s Sleep

1. Poor Sleep Quality

You may be lying in bed for 8 hours, but if your sleep is light or frequently interrupted, it won’t be refreshing. Common reasons include:

Noisy environment
Uncomfortable mattress or pillow
Room too hot or too cold
Lights or electronics nearby

Fix: Try blackout curtains, keep the room cool and dark, and follow a fixed bedtime routine.

2. Undiagnosed Sleep Disorders

Conditions like sleep apnea, restless leg syndrome, or insomnia can reduce sleep quality without you even realizing it.

Sleep apnea, for example, causes you to stop breathing for short periods during sleep. You may not wake up fully, but your body doesn’t get enough oxygen—leading to morning tiredness and brain fog.

Fix: If your partner says you snore heavily or you often wake up gasping for air, consult a doctor for a sleep study.

3. Too Much Screen Time at Night

Smartphones, laptops, and TVs emit blue light, which blocks melatonin—a hormone that helps you fall asleep.

If you scroll Instagram or binge-watch shows late at night, your brain might stay active even after you fall asleep.

Fix: Stop using screens 1 hour before bedtime. Use night mode or blue light filters if necessary.

4. Eating or Drinking Close to Bedtime

Heavy meals or caffeine before bed can disturb your sleep by causing indigestion, bloating, or increased alertness.

Fix: Avoid caffeine after 5 PM, and try to have your dinner at least 2 hours before sleeping.

5. Mental Health Issues

Conditions like stress, anxiety, or depression can impact sleep quality. You may sleep for hours but still wake up tired due to mental fatigue.

Fix: Practice stress management through:

Journaling
Breathing exercises
Meditation
Seeking therapy if needed

6. Vitamin or Hormonal Imbalance

Low levels of Vitamin D, Vitamin B12, iron, or thyroid dysfunction can cause constant fatigue—even with good sleep.

Fix: A simple blood test can help detect deficiencies. You can book these tests via SecondMedic.com, powered by Thyrocare, with home sample collection.

Recommended tests:

Vitamin D Test
Vitamin B12
Thyroid Profile
CBC (Complete Blood Count)

7. Lack of Physical Activity

Not moving your body enough during the day can lead to low-quality sleep at night. Exercise helps burn excess energy and improves deep sleep.

Fix: Aim for at least 30 minutes of physical activity, like walking, yoga, or cycling daily.

Signs That You’re Not Getting Good Sleep

You hit the snooze button multiple times
You feel sleepy by mid-morning
You wake up with a heavy head or sore body
You need coffee immediately to function
You feel irritated, anxious, or unmotivated

These are signs your body is not truly rested.

Simple Tips for Better Sleep & Morning Energy

Stick to a sleep schedule: Go to bed and wake up at the same time every day—even on weekends.
Create a sleep-friendly space: Keep your bedroom cool, quiet, and dark.
Limit naps: Daytime naps should be less than 30 minutes and before 3 PM.
Stay hydrated—but not too close to bedtime: Drinking too much water late may wake you up to pee.
Practice relaxation before bed: Try reading, light stretching, or herbal tea.

Conclusion

Feeling tired despite getting enough sleep can be frustrating. But remember, quality beats quantity when it comes to sleep. By making small changes in your routine, checking for hidden health issues, and improving your lifestyle, you can wake up feeling refreshed and ready to take on the day.

If you’ve been wondering why do you wake up tired even after 8 hours sleep, now you know where to start fixing it. Begin today with a better sleep routine—and better mornings will follow.

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