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Published on: Oct 28, 2020
2 minute read
By: Dr Rajan ( Medical Second Opinion Cell)

Hepatitis C Nobel Prize

Earlier this month the Nobel Prize in Physiology and Medicine was jointly awarded to Harvey J Alter, Michael Houghton and Charles M Rice for the discovery of the Hepatitis C virus. This helped push our understanding of blood-borne hepatitis, a major global health problem that is one of the leading causes of cirrhosis and liver cancer alongside Hepatitis B. It led the way in introducing new tests for chronic hepatitis as well as new treatments that have saved the lives of millions.

HEPATITIS

Hepatitis is the inflammation of your liver, the largest solid organ in your body. Though there are numerous other causes of hepatitis, including alcohol abuse, drugs and toxins (including paracetamol overdose), and autoimmune disorders (such as Wilson’s disease), viral infections are the most common worldwide causes for hepatitis. Hepatitis A was the first to be discovered, transmitted by polluted food and water, and results in a short-term transient hepatitis. Hepatitis B on the other hand is transmitted through blood and is more of an issue as it can lead to chronic cirrhosis and possible liver cancer. It can remain indolent in a person, causing disease long after the initial infection.

Blood borne hepatitis was first discovered in the 1960s, when it was found that some patients would become ill after receiving blood transfusions. Despite this discovery and new tests for Hepatitis B reducing the number of transfusion related hepatitis, a large number of cases remained.

NOT A, NOT B

Harvey Alter, working at the US National Institute of Health, was studying the occurrence of hepatitis in blood transfusion patients. His team showed that blood from these infected patients could transmit the disease to chimpanzees, resulting in hepatitis. This agent had the properties of a virus, one that was “non-A, non B” hepatitis.

Further investigation into the virus would require the input of Michael Houghton, working for Chiron pharmaceutical. His team created a collection of DNA fragments found in the blood of infected chimpanzees. Though the majority of these fragments were from the chimpanzee, enough were from the virus. They were able to utilise this information to identify antibodies against the suspected virus, and ultimately identify it as the flavivirus Hepatitis C.

The final piece of the puzzle was shown by Charles M Rice, a researcher at Washington University, St Louis – could the virus alone cause hepatitis. He studied the RNA of Hepatitis C to identify regions that may be used for replication, and areas that might hinder replication. This was key as the virus can lay dormant for years, replicating at a slow rate before causing damage to the liver. For researchers, this was an issue as it was not feasible to wait years and see if the suspected virus caused hepatitis. By genetically engineering the viral genome, he developed a variant of Hepatitis C that would only multiple rapidly and have no mechanism to inactivate itself for dormancy. This strain caused rapid changes to the livers of infected chimpanzees; the same changes seen in hepatitis patients.

. ;.,hrvxzThe impact was significant. Prior to this, receiving a blood transfusion was like Russian Roulette. You were receiving life saving therapy, but it coZuld also be a hidden death sentence. Now that hepatitis had been discovered, it became possible to screen patients prior to donation, to screen blood transfusion bags, and to start developing treatments for the virus.

The fight is not over yet. There are still over 70 million people who still live with the virus, and it still kills around 400,000 a year. Its only very recently that we have found treatments that can reduce the viral load in patients to levels that they are considered cured. This treatment remains expensive, and we are very far away from eradication itself.

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Neurobion Forte: Benefits for Nerve Health and Vitamin B Deficiency

Vitamin deficiencies are a common but often overlooked health issue. Among them, vitamin B deficiency is particularly significant because of its direct impact on nerve function, energy metabolism and overall neurological health. Neurobion Forte is a widely used vitamin B-complex supplement designed to address these deficiencies and support nerve health.

Understanding how Neurobion Forte works and when it is beneficial helps individuals make informed decisions about their nutritional and neurological wellbeing.

What Is Neurobion Forte?

Neurobion Forte is a combination supplement containing essential B vitamins, primarily:

vitamin B1 (thiamine)
vitamin B6 (pyridoxine)
vitamin B12 (cobalamin)

These vitamins play a vital role in nerve signal transmission, energy production and maintenance of the nervous system.

Why Vitamin B Is Essential for Nerve Health

B vitamins are crucial for:

nerve impulse transmission
myelin sheath formation
energy metabolism in nerve cells

Deficiency can impair nerve function, leading to discomfort and neurological symptoms.

Common Causes of Vitamin B Deficiency

Vitamin B deficiency may occur due to:

inadequate dietary intake
poor absorption
chronic illnesses
long-term medication use
alcohol misuse

Vegetarians and elderly individuals are particularly at risk of vitamin B12 deficiency.

Symptoms of Vitamin B Deficiency

Early symptoms may include:

fatigue
weakness
numbness or tingling in hands and feet
poor concentration

If untreated, deficiency may progress to more serious neurological problems.

How Neurobion Forte Supports Nerve Health

Supports Nerve Repair

Vitamin B12 contributes to nerve regeneration and maintenance of nerve fibres.

Improves Nerve Signal Transmission

Vitamin B1 supports proper nerve impulse conduction.

Reduces Nerve Irritation

Vitamin B6 helps regulate neurotransmitter synthesis, reducing nerve-related discomfort.

Supports Energy Metabolism

B vitamins help convert food into energy, supporting overall nerve and muscle function.

Role of Neurobion Forte in Nerve Pain

Nerve pain caused by vitamin deficiency may present as:

burning sensation
tingling
numbness
shooting pain

In such cases, correcting the deficiency through supplementation may help relieve symptoms over time.

Conditions Where Neurobion Forte Is Commonly Used

Neurobion Forte may be prescribed or recommended in cases such as:

peripheral neuropathy
diabetic neuropathy (as supportive care)
nutritional deficiency-related nerve symptoms
general weakness associated with vitamin B deficiency

It is not a painkiller but supports underlying nutritional correction.

Importance of Medical Guidance

While vitamin supplements are widely available, inappropriate or excessive use may cause side effects.

Medical guidance ensures:

correct diagnosis
appropriate dosage
monitoring of response

Self-medication should be avoided, especially for long-term use.

Diet and Vitamin B Intake

Dietary sources of B vitamins include:

whole grains
legumes
dairy products
eggs
meat and fish

Balanced nutrition remains the foundation of vitamin sufficiency.

Who May Benefit Most from Neurobion Forte?

Individuals who may benefit include:

those with confirmed vitamin B deficiency
people with nerve-related symptoms
elderly individuals with poor nutrient absorption
individuals with restricted diets

Supplementation should complement dietary improvement.

Possible Side Effects and Precautions

When taken as advised, Neurobion Forte is generally well tolerated.

However:

excessive vitamin B6 intake may cause nerve symptoms
allergic reactions are rare but possible

Always follow professional advice.

How Long Does It Take to See Benefits?

Improvement depends on:

severity of deficiency
duration of symptoms
individual health status

Some people notice symptom improvement within weeks, while others require longer support.

Neurobion Forte and Overall Wellbeing

Correcting vitamin B deficiency supports:

nerve health
energy levels
cognitive function
overall vitality

Supplementation is most effective when combined with healthy lifestyle habits.

Conclusion

Neurobion Forte plays an important role in managing vitamin B deficiency and supporting nerve health. By supplying essential B vitamins, it helps restore nerve function, reduce deficiency-related symptoms and improve overall neurological wellbeing. While it can be highly beneficial when deficiency is present, its use should always be guided by medical advice to ensure safety and effectiveness. Balanced nutrition, early diagnosis and appropriate supplementation together form the foundation of healthy nerve function.

References

World Health Organization (WHO) – Micronutrients and Neurological Health
Indian Council of Medical Research (ICMR) – Nutrient Deficiency Guidelines
National Institute of Nutrition (NIN) – Vitamin B and Nerve Function Reports
Lancet Neurology – Vitamin Deficiency and Neuropathy Studies
Indian Journal of Clinical Nutrition – Vitamin B Supplementation Researc
Statista – Dietary Supplement Usage Trends

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