Call
+918447748545

Published on: Oct 28, 2020
2 minute read
By: Dr Rajan ( Medical Second Opinion Cell)

Hepatitis C Nobel Prize

Earlier this month the Nobel Prize in Physiology and Medicine was jointly awarded to Harvey J Alter, Michael Houghton and Charles M Rice for the discovery of the Hepatitis C virus. This helped push our understanding of blood-borne hepatitis, a major global health problem that is one of the leading causes of cirrhosis and liver cancer alongside Hepatitis B. It led the way in introducing new tests for chronic hepatitis as well as new treatments that have saved the lives of millions.

HEPATITIS

Hepatitis is the inflammation of your liver, the largest solid organ in your body. Though there are numerous other causes of hepatitis, including alcohol abuse, drugs and toxins (including paracetamol overdose), and autoimmune disorders (such as Wilson’s disease), viral infections are the most common worldwide causes for hepatitis. Hepatitis A was the first to be discovered, transmitted by polluted food and water, and results in a short-term transient hepatitis. Hepatitis B on the other hand is transmitted through blood and is more of an issue as it can lead to chronic cirrhosis and possible liver cancer. It can remain indolent in a person, causing disease long after the initial infection.

Blood borne hepatitis was first discovered in the 1960s, when it was found that some patients would become ill after receiving blood transfusions. Despite this discovery and new tests for Hepatitis B reducing the number of transfusion related hepatitis, a large number of cases remained.

NOT A, NOT B

Harvey Alter, working at the US National Institute of Health, was studying the occurrence of hepatitis in blood transfusion patients. His team showed that blood from these infected patients could transmit the disease to chimpanzees, resulting in hepatitis. This agent had the properties of a virus, one that was “non-A, non B” hepatitis.

Further investigation into the virus would require the input of Michael Houghton, working for Chiron pharmaceutical. His team created a collection of DNA fragments found in the blood of infected chimpanzees. Though the majority of these fragments were from the chimpanzee, enough were from the virus. They were able to utilise this information to identify antibodies against the suspected virus, and ultimately identify it as the flavivirus Hepatitis C.

The final piece of the puzzle was shown by Charles M Rice, a researcher at Washington University, St Louis – could the virus alone cause hepatitis. He studied the RNA of Hepatitis C to identify regions that may be used for replication, and areas that might hinder replication. This was key as the virus can lay dormant for years, replicating at a slow rate before causing damage to the liver. For researchers, this was an issue as it was not feasible to wait years and see if the suspected virus caused hepatitis. By genetically engineering the viral genome, he developed a variant of Hepatitis C that would only multiple rapidly and have no mechanism to inactivate itself for dormancy. This strain caused rapid changes to the livers of infected chimpanzees; the same changes seen in hepatitis patients.

. ;.,hrvxzThe impact was significant. Prior to this, receiving a blood transfusion was like Russian Roulette. You were receiving life saving therapy, but it coZuld also be a hidden death sentence. Now that hepatitis had been discovered, it became possible to screen patients prior to donation, to screen blood transfusion bags, and to start developing treatments for the virus.

The fight is not over yet. There are still over 70 million people who still live with the virus, and it still kills around 400,000 a year. Its only very recently that we have found treatments that can reduce the viral load in patients to levels that they are considered cured. This treatment remains expensive, and we are very far away from eradication itself.

Read Blog

Weekly Health Roundup Newsletter: India’s Trusted Source for Preventive Wellness Insights

Health information today is abundant, but not always reliable. With countless articles, social media trends, home remedies and conflicting opinions, individuals often struggle to separate credible medical advice from misinformation. This challenge becomes especially significant in India, where rising lifestyle diseases, nutritional gaps and limited public health awareness create a pressing need for accurate guidance.

The Weekly Health Roundup Newsletter by SecondMedic addresses this gap by offering a clear, expert-driven and accessible summary of everything people need to know about their health each week. Designed for families, patients, caregivers and wellness-focused readers, it transforms medical updates into practical, everyday insights.

Why India Needs a Weekly Health Roundup

1. Growing Lifestyle Disease Burden

ICMR and NFHS-5 highlight significant increases in:

Diabetes
Heart disease
Thyroid disorders
Obesity
PCOS

A weekly educational resource empowers individuals to make preventive choices before complications arise.

2. Overload of Health Information

Millions of Indians rely on social media for health advice, leading to confusion and misinformation.
A curated newsletter ensures accuracy.

3. Rising Interest in Preventive Healthcare

People want to understand their bodies better, track health metrics and adopt healthier lifestyles.
The newsletter provides guidance supported by medical evidence.

4. Technological Growth in Healthcare

AI-based tools, wearables and digital monitoring are reshaping healthcare.
Readers learn how to use them effectively.

What the Weekly Health Roundup Covers

• Medical Research Summaries

Digestible versions of new findings from:

ICMR
WHO
Lancet
NITI Aayog
Global medical journals

• Nutrition and Lifestyle Guidance

Includes:

Balanced diets
Myth-busting
Portion control
Affordable nutrition ideas for Indian households

• Chronic Disease Management Tips

Expert insights on:

Diabetes control
Heart health
Blood pressure
Hormonal disorders

• Mental Wellbeing

Stress reduction, emotional resilience and sleep optimisation tips.

• Fitness Recommendations

Simple routines, mobility tips, strength guidance and step-based activity recommendations.

• Seasonal Health Alerts

Information on:

Pollution
Heatwaves
Monsoon infections
Viral outbreaks

• Digital Health Education

Guidance on:

AI health tools
Wearable devices
Teleconsultation benefits
Remote monitoring

How SecondMedic Ensures Accuracy and Quality

Expert Verification

Doctors, nutritionists, physiotherapists and mental health specialists review every issue.

Evidence-Based Approach

Content uses:

Peer-reviewed studies
Real-world health data
National and global guidelines

Personalised Relevance

Topics are selected based on what Indian families most commonly search, ask or struggle with.

Preventive Care Focus

Instead of addressing illness alone, the newsletter promotes long-term lifestyle improvement.

How Readers Benefit

1. Improved Health Literacy

People understand conditions earlier and seek help at the right time.

2. Practical, Actionable Advice

The newsletter offers:

Simple diet swaps
Daily routine tips
Easy-to-follow health habits

3. Early Detection Support

By recognizing symptoms and risk patterns, individuals can prevent complications.

4. Better Use of Digital Tools

Readers learn how AI health guides and wearables support monitoring and early intervention.

5. Family-Centered Wellness

Content is relevant to:

Children
Working adults
Elderly individuals
Chronic disease patients

Example Weekly Topics

A sample edition may include:

"New Findings on Vitamin D Deficiency in Indian Adults"
"How to Interpret Your Blood Sugar Patterns"
"5 AI Tools That Improve Home Health Monitoring"
"Early Signs of Heart Disease You Shouldn’t Ignore"
"Preventive Care Checklist for Busy Professionals"

Conclusion

The Weekly Health Roundup Newsletter is more than just a health update-it is a practical wellness companion. With expert insights, scientific clarity and personalised relevance, it empowers people across India to make smarter health decisions every week.

By turning complex medical knowledge into everyday guidance, SecondMedic strengthens India’s preventive healthcare movement one newsletter at a time.

References

• ICMR - Lifestyle Disease Burden & Research Updates
• NFHS-5 - National Health Indicators & Wellness Trends
• NITI Aayog - Digital Health & Preventive Care Framework
• WHO - Global Wellness & Preventive Healthcare Guidelines
• Lancet - Public Health Research & Behaviour Studies
• Statista India - Digital Health Usage & Reader Behaviour
• EY-FICCI - Health Awareness & Preventive Care Landscape

Request A Callback

+91

By using this website/app, I confirm that I am at least 18 years old and consent to the processing of my personal data in accordance with the Terms of Service, Privacy Policy, and Declaration.