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Published on: Oct 28, 2020
2 minute read
By: Dr Rajan ( Medical Second Opinion Cell)

Hepatitis C Nobel Prize

Earlier this month the Nobel Prize in Physiology and Medicine was jointly awarded to Harvey J Alter, Michael Houghton and Charles M Rice for the discovery of the Hepatitis C virus. This helped push our understanding of blood-borne hepatitis, a major global health problem that is one of the leading causes of cirrhosis and liver cancer alongside Hepatitis B. It led the way in introducing new tests for chronic hepatitis as well as new treatments that have saved the lives of millions.

HEPATITIS

Hepatitis is the inflammation of your liver, the largest solid organ in your body. Though there are numerous other causes of hepatitis, including alcohol abuse, drugs and toxins (including paracetamol overdose), and autoimmune disorders (such as Wilson’s disease), viral infections are the most common worldwide causes for hepatitis. Hepatitis A was the first to be discovered, transmitted by polluted food and water, and results in a short-term transient hepatitis. Hepatitis B on the other hand is transmitted through blood and is more of an issue as it can lead to chronic cirrhosis and possible liver cancer. It can remain indolent in a person, causing disease long after the initial infection.

Blood borne hepatitis was first discovered in the 1960s, when it was found that some patients would become ill after receiving blood transfusions. Despite this discovery and new tests for Hepatitis B reducing the number of transfusion related hepatitis, a large number of cases remained.

NOT A, NOT B

Harvey Alter, working at the US National Institute of Health, was studying the occurrence of hepatitis in blood transfusion patients. His team showed that blood from these infected patients could transmit the disease to chimpanzees, resulting in hepatitis. This agent had the properties of a virus, one that was “non-A, non B” hepatitis.

Further investigation into the virus would require the input of Michael Houghton, working for Chiron pharmaceutical. His team created a collection of DNA fragments found in the blood of infected chimpanzees. Though the majority of these fragments were from the chimpanzee, enough were from the virus. They were able to utilise this information to identify antibodies against the suspected virus, and ultimately identify it as the flavivirus Hepatitis C.

The final piece of the puzzle was shown by Charles M Rice, a researcher at Washington University, St Louis – could the virus alone cause hepatitis. He studied the RNA of Hepatitis C to identify regions that may be used for replication, and areas that might hinder replication. This was key as the virus can lay dormant for years, replicating at a slow rate before causing damage to the liver. For researchers, this was an issue as it was not feasible to wait years and see if the suspected virus caused hepatitis. By genetically engineering the viral genome, he developed a variant of Hepatitis C that would only multiple rapidly and have no mechanism to inactivate itself for dormancy. This strain caused rapid changes to the livers of infected chimpanzees; the same changes seen in hepatitis patients.

. ;.,hrvxzThe impact was significant. Prior to this, receiving a blood transfusion was like Russian Roulette. You were receiving life saving therapy, but it coZuld also be a hidden death sentence. Now that hepatitis had been discovered, it became possible to screen patients prior to donation, to screen blood transfusion bags, and to start developing treatments for the virus.

The fight is not over yet. There are still over 70 million people who still live with the virus, and it still kills around 400,000 a year. Its only very recently that we have found treatments that can reduce the viral load in patients to levels that they are considered cured. This treatment remains expensive, and we are very far away from eradication itself.

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Importance of Regular Health Checkups: Early Detection Saves Lives

In today’s fast-paced lifestyle, many individuals prioritise work and family responsibilities while neglecting their own health. However, understanding the importance of regular health checkups is critical for preventing serious medical conditions. Many diseases develop silently without noticeable symptoms, making routine screening essential for early diagnosis and effective treatment.

According to the Indian Council of Medical Research (ICMR), non-communicable diseases such as diabetes, hypertension and cardiovascular conditions are rising across India. Early detection through preventive checkups significantly reduces complications and mortality.

What Are Regular Health Checkups?

Regular health checkups involve:

routine blood tests
blood pressure monitoring
cholesterol screening
organ function tests
lifestyle risk assessments

These assessments help identify abnormalities before they progress into severe conditions.

Why Preventive Healthcare Matters

Preventive healthcare focuses on:

identifying risk factors
detecting disease early
preventing complications

The World Health Organization states that preventive care reduces long-term healthcare burden and improves life expectancy.

Early Detection of Chronic Diseases

Diabetes

India has over 100 million people living with diabetes, according to ICMR data. Many individuals are unaware until complications arise.

Early screening detects:

elevated blood sugar
insulin resistance

Hypertension

NFHS-5 reports that nearly one in four adults in India has hypertension.

Regular monitoring prevents:

stroke
heart attack
kidney damage

Heart Disease

Cholesterol screening identifies risk before symptoms appear.

Timely lifestyle modifications reduce cardiovascular events.

Cancer Screening and Survival Rates

Screenings such as:

mammograms
Pap smears
colon cancer screening

significantly improve survival when disease is detected early.

Monitoring Organ Function

Regular checkups assess:

liver health
kidney function
thyroid levels

Silent organ dysfunction can be detected early.

Benefits of Regular Health Checkups

Reduced Healthcare Costs

Treating advanced disease is more expensive than preventive care.

Improved Quality of Life

Early treatment reduces long-term complications.

Peace of Mind

Knowing health parameters are normal reduces anxiety.

Better Lifestyle Decisions

Screening results motivate healthier habits.

Who Should Get Regular Health Checkups?

adults above 30 years
individuals with family history of chronic disease
smokers
overweight individuals
sedentary professionals

High-risk groups may require more frequent testing.

Frequency of Health Screenings

General recommendation:

Annual checkup for adults
Biannual or quarterly monitoring for high-risk individuals

Doctors personalise schedules based on medical history.

Corporate Health Checkups

Many organisations conduct:

workplace screening camps
employee wellness programs

These initiatives improve workforce productivity and reduce absenteeism.

Preventive Health in India

NITI Aayog highlights preventive healthcare as essential for reducing national disease burden.

Increasing awareness about routine checkups is critical.

Common Tests in Annual Health Packages

Complete blood count
Lipid profile
Fasting blood sugar
HbA1c
Liver function test
Kidney function test
Thyroid profile
Vitamin levels

These tests provide comprehensive health insight.

Addressing Common Misconceptions

Many people avoid checkups because:

they feel healthy
they fear results
they lack time

However, absence of symptoms does not mean absence of disease.

Lifestyle Diseases and Urbanisation

Urban lifestyles contribute to:

sedentary behaviour
poor diet
stress

Regular monitoring counters these risks.

Digital Health and Screening Accessibility

Online booking platforms and home sample collection make preventive care more accessible and convenient.

Technology supports proactive health management.

Building a Culture of Preventive Health

Encouraging:

annual screenings
family health awareness
workplace initiatives

creates healthier communities.

Conclusion

Understanding the importance of regular health checkups is essential for preventing chronic disease and improving life expectancy. Early detection of diabetes, hypertension, heart disease and other conditions allows timely treatment and reduces complications. Preventive healthcare is not an expense but an investment in long-term wellbeing. Scheduling routine screenings today can protect health and save lives tomorrow.

References

Indian Council of Medical Research (ICMR) – Non-Communicable Disease Reports
National Family Health Survey (NFHS-5) – Adult Health Data
World Health Organization (WHO) – Preventive Healthcare Guidelines
NITI Aayog – National Health and Preventive Strategy Reports
Lancet – Early Detection and Disease Prevention Studies

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