Call
+918447748545

Published on: Oct 28, 2020
2 minute read
By: Dr Rajan ( Medical Second Opinion Cell)

Hepatitis C Nobel Prize

Earlier this month the Nobel Prize in Physiology and Medicine was jointly awarded to Harvey J Alter, Michael Houghton and Charles M Rice for the discovery of the Hepatitis C virus. This helped push our understanding of blood-borne hepatitis, a major global health problem that is one of the leading causes of cirrhosis and liver cancer alongside Hepatitis B. It led the way in introducing new tests for chronic hepatitis as well as new treatments that have saved the lives of millions.

HEPATITIS

Hepatitis is the inflammation of your liver, the largest solid organ in your body. Though there are numerous other causes of hepatitis, including alcohol abuse, drugs and toxins (including paracetamol overdose), and autoimmune disorders (such as Wilson’s disease), viral infections are the most common worldwide causes for hepatitis. Hepatitis A was the first to be discovered, transmitted by polluted food and water, and results in a short-term transient hepatitis. Hepatitis B on the other hand is transmitted through blood and is more of an issue as it can lead to chronic cirrhosis and possible liver cancer. It can remain indolent in a person, causing disease long after the initial infection.

Blood borne hepatitis was first discovered in the 1960s, when it was found that some patients would become ill after receiving blood transfusions. Despite this discovery and new tests for Hepatitis B reducing the number of transfusion related hepatitis, a large number of cases remained.

NOT A, NOT B

Harvey Alter, working at the US National Institute of Health, was studying the occurrence of hepatitis in blood transfusion patients. His team showed that blood from these infected patients could transmit the disease to chimpanzees, resulting in hepatitis. This agent had the properties of a virus, one that was “non-A, non B” hepatitis.

Further investigation into the virus would require the input of Michael Houghton, working for Chiron pharmaceutical. His team created a collection of DNA fragments found in the blood of infected chimpanzees. Though the majority of these fragments were from the chimpanzee, enough were from the virus. They were able to utilise this information to identify antibodies against the suspected virus, and ultimately identify it as the flavivirus Hepatitis C.

The final piece of the puzzle was shown by Charles M Rice, a researcher at Washington University, St Louis – could the virus alone cause hepatitis. He studied the RNA of Hepatitis C to identify regions that may be used for replication, and areas that might hinder replication. This was key as the virus can lay dormant for years, replicating at a slow rate before causing damage to the liver. For researchers, this was an issue as it was not feasible to wait years and see if the suspected virus caused hepatitis. By genetically engineering the viral genome, he developed a variant of Hepatitis C that would only multiple rapidly and have no mechanism to inactivate itself for dormancy. This strain caused rapid changes to the livers of infected chimpanzees; the same changes seen in hepatitis patients.

. ;.,hrvxzThe impact was significant. Prior to this, receiving a blood transfusion was like Russian Roulette. You were receiving life saving therapy, but it coZuld also be a hidden death sentence. Now that hepatitis had been discovered, it became possible to screen patients prior to donation, to screen blood transfusion bags, and to start developing treatments for the virus.

The fight is not over yet. There are still over 70 million people who still live with the virus, and it still kills around 400,000 a year. Its only very recently that we have found treatments that can reduce the viral load in patients to levels that they are considered cured. This treatment remains expensive, and we are very far away from eradication itself.

Read Blog

How Poor Hydration Affects Joint Health: Why Water Matters for Mobility

Water is essential for nearly every function in the human body, yet many people underestimate its importance for joint health. While hydration is commonly associated with digestion and skin health, it also plays a crucial role in maintaining smooth and pain-free joint movement.

Understanding how poor hydration affects joint health can help prevent stiffness, discomfort and long-term mobility issues.

The Role of Water in Joint Function

Joints are where two bones meet, allowing movement and flexibility. Healthy joints rely on:

Cartilage
Synovial fluid
Ligaments
Tendons

Cartilage, which cushions bones, contains a high percentage of water. Synovial fluid acts as a lubricant, reducing friction during movement.

Proper hydration ensures these components function effectively.

What Happens When You Are Dehydrated?

When the body lacks sufficient water:

Synovial fluid production may decrease
Cartilage may lose elasticity
Joint cushioning becomes less effective

This can result in stiffness and discomfort.

1. Reduced Joint Lubrication

Synovial fluid requires adequate hydration to maintain volume and viscosity.

Without enough water:

Friction between bones increases
Movement becomes less smooth
Risk of wear and tear rises

2. Increased Joint Stiffness

Dehydration may cause joints to feel tight, especially:

In the morning
After prolonged sitting
During physical activity

Stiffness may limit flexibility.

3. Higher Risk of Injury

Poorly lubricated joints may be more prone to:

Sprains
Strains
Cartilage damage

Hydration supports tissue resilience.

4. Worsening of Existing Joint Conditions

Individuals with conditions such as osteoarthritis may experience increased discomfort if hydration is inadequate.

While water does not cure arthritis, it supports overall joint function.

5. Reduced Nutrient Delivery

Water helps transport nutrients to joint tissues.

Dehydration may impair circulation and nutrient exchange, slowing tissue repair.

Signs of Dehydration That May Affect Joints

Dry mouth
Dark urine
Fatigue
Headaches
Muscle cramps
Joint stiffness

Recognizing early dehydration signs prevents complications.

How Much Water Do You Need?

Hydration needs vary depending on:

Body weight
Climate
Physical activity level
Health conditions

On average, adults may require 2–3 liters of water daily.

In hot climates such as India, higher intake may be necessary due to increased sweating.

Tips to Maintain Proper Hydration

1. Drink Water Regularly

Do not wait until you feel thirsty.

2. Eat Water-Rich Foods

Include:

Cucumbers
Watermelon
Oranges
Tomatoes

3. Limit Excessive Caffeine and Alcohol

These may contribute to fluid loss.

4. Carry a Water Bottle

Keeping water accessible encourages consistent intake.

5. Hydrate Before and After Exercise

Physical activity increases fluid loss through sweat.

Hydration and Joint Health in India

In India’s hot and humid climate, dehydration is common, especially during summer months.

Outdoor workers, athletes and elderly individuals are particularly vulnerable.

Maintaining adequate hydration supports not only joint health but overall wellbeing.

When to Consult a Doctor

Seek medical advice if you experience:

Persistent joint pain
Swelling
Limited range of motion
Redness or warmth around joints

These may indicate underlying joint disorders requiring evaluation.

Conclusion

Poor hydration can negatively affect joint health by reducing lubrication, increasing stiffness and raising injury risk. Since cartilage and synovial fluid depend heavily on water, maintaining adequate hydration is essential for smooth movement and long-term mobility.

Drinking sufficient water daily is a simple yet powerful step toward protecting joint health. Combined with regular exercise and balanced nutrition, proper hydration supports active and pain-free living.

Small daily hydration habits can make a significant difference in how your joints feel and function.

References

Indian Council of Medical Research – Hydration Guidelines
World Health Organization – Water and Health Resources
Indian Journal of Orthopaedics – Joint Health Studies
National Institute of Nutrition India – Fluid Intake Recommendations
Journal of Sports Medicine – Hydration and Musculoskeletal Health Research

Request A Callback

+91

By using this website/app, I confirm that I am at least 18 years old and consent to the processing of my personal data in accordance with the Terms of Service, Privacy Policy, and Declaration.