Call
+918447748545

Published on: Apr 06, 2020
2 minute read
By: Dr Rajan Choudhary

MicroRNA That Makes Them Fight COVID Better ?

Recently you may have read a New Delhi based International Center for Genetic Engineering and Biotechnology (ICGEB) sequenced the genome (genetic data) of SARS-COV-2 (coronavirus) from India, Italy, US, Nepal and Wuhan, China. They found that the Indian variant of SARS-CoV2 has the potential to be targeted by antiviral RNA within host cells, a feature that is unique to the Indian strain.

This amazing finding has been published on blogs, newspapers and other media as proof that Indians may not suffer as much as the rest of the world when the COVID-19 pandemic hits the country. One headline touted “MicroRNA in Indians may reduce severity of corona attack”, stating “Indians have comparatively better immunity compared to other countries”. Of course this article is being forwarded on WhatsApp, and enough people may take it as gospel. Is it true?

No.

If you want to know why, just look on the Journal’s website:

“these are preliminary reports that have not been peer-reviewed. They should NOT be regarded as conclusive, guide clinical practice/health-related behaviour, or be reported in news media as established information.”

Research is not easy. I could write a very long explanation for why, but I have summarised it below.

SUMMARY:

- To prove x causes y up to a high scientific standard is incredibly difficult

- Even if you think x causes y, someone might find a flaw in your study

- Numbers can be manipulated by statistics to show what you want to believe

- Reporters might not understand the study and mis-report it

- We all want to believe there is a magic cure that will protect us, that makes us special, immune to this disaster so we can get on with our lives. Unfortunately there simply isn’t one. And believing in them without fact checking can cause more harm than good.

IMMUNITY AGAINST COVID

So what about this study? Firstly it is looking at one tiny mechanism in a cell, when a cell can have millions of proteins responsible for a billion different functions in just the cell itself. Secondly it is not peer reviewed. This means no one has fact checked the study to check whether the design is valid, whether the statistics hold up, whether they have missed something or are making incorrect conclusions based off their data. Peer-reviewing a recent paper showing SARS-CoV-2 and HIV were extremely similar disproved this paper as false.

In the authors defence he acknowledges this:

“In our study, which is a purely computational one, we predicted that this microRNA binds to the SARS-Cov2 genome submitted from India. However, it is too early to comment on it because there is only one high coverage sequence from India, so far,”

Thirdly, the news article says that Indians have better immunity because of this “microRNA”. This is wrong. The study sequenced the genome of the virus, not of the Indian population. Antiviral microRNA is found in all people. The study simply suggests that this might be more effective at targeting the Indian strain of COVID, but it does not make any concrete claims that Indians are protected from COVID.

Again, the journal even states this:

“These are preliminary reports that have not been peer-reviewed. They should not be regarded as conclusive, guide clinical practice/health-related behavior, or be reported in news media as established information.”

But most importantly, even if the paper suggests that the Indian strain may be less potent, it does not give us an excuse to be reckless. We have to adhere to social distancing, hygiene, lockdown principles in order to prevent infection. Because what happens if you take the article stating “Indians have comparatively better immunity compared to other countries” as fact, use this as an excuse to go about your regular daily lives, and it actually turns out that the microRNA has little to no effect on COVID. This endangers yourself and those around you.

Be sensible. Listen to public health officials.

Dr Rajan Choudhary, UK, Chief Product Officer, Second Medic Inc

www.secondmedic.com

Read Blog

How Poor Hydration Affects Joint Health: Why Water Matters for Mobility

Water is essential for nearly every function in the human body, yet many people underestimate its importance for joint health. While hydration is commonly associated with digestion and skin health, it also plays a crucial role in maintaining smooth and pain-free joint movement.

Understanding how poor hydration affects joint health can help prevent stiffness, discomfort and long-term mobility issues.

The Role of Water in Joint Function

Joints are where two bones meet, allowing movement and flexibility. Healthy joints rely on:

Cartilage
Synovial fluid
Ligaments
Tendons

Cartilage, which cushions bones, contains a high percentage of water. Synovial fluid acts as a lubricant, reducing friction during movement.

Proper hydration ensures these components function effectively.

What Happens When You Are Dehydrated?

When the body lacks sufficient water:

Synovial fluid production may decrease
Cartilage may lose elasticity
Joint cushioning becomes less effective

This can result in stiffness and discomfort.

1. Reduced Joint Lubrication

Synovial fluid requires adequate hydration to maintain volume and viscosity.

Without enough water:

Friction between bones increases
Movement becomes less smooth
Risk of wear and tear rises

2. Increased Joint Stiffness

Dehydration may cause joints to feel tight, especially:

In the morning
After prolonged sitting
During physical activity

Stiffness may limit flexibility.

3. Higher Risk of Injury

Poorly lubricated joints may be more prone to:

Sprains
Strains
Cartilage damage

Hydration supports tissue resilience.

4. Worsening of Existing Joint Conditions

Individuals with conditions such as osteoarthritis may experience increased discomfort if hydration is inadequate.

While water does not cure arthritis, it supports overall joint function.

5. Reduced Nutrient Delivery

Water helps transport nutrients to joint tissues.

Dehydration may impair circulation and nutrient exchange, slowing tissue repair.

Signs of Dehydration That May Affect Joints

Dry mouth
Dark urine
Fatigue
Headaches
Muscle cramps
Joint stiffness

Recognizing early dehydration signs prevents complications.

How Much Water Do You Need?

Hydration needs vary depending on:

Body weight
Climate
Physical activity level
Health conditions

On average, adults may require 2–3 liters of water daily.

In hot climates such as India, higher intake may be necessary due to increased sweating.

Tips to Maintain Proper Hydration

1. Drink Water Regularly

Do not wait until you feel thirsty.

2. Eat Water-Rich Foods

Include:

Cucumbers
Watermelon
Oranges
Tomatoes

3. Limit Excessive Caffeine and Alcohol

These may contribute to fluid loss.

4. Carry a Water Bottle

Keeping water accessible encourages consistent intake.

5. Hydrate Before and After Exercise

Physical activity increases fluid loss through sweat.

Hydration and Joint Health in India

In India’s hot and humid climate, dehydration is common, especially during summer months.

Outdoor workers, athletes and elderly individuals are particularly vulnerable.

Maintaining adequate hydration supports not only joint health but overall wellbeing.

When to Consult a Doctor

Seek medical advice if you experience:

Persistent joint pain
Swelling
Limited range of motion
Redness or warmth around joints

These may indicate underlying joint disorders requiring evaluation.

Conclusion

Poor hydration can negatively affect joint health by reducing lubrication, increasing stiffness and raising injury risk. Since cartilage and synovial fluid depend heavily on water, maintaining adequate hydration is essential for smooth movement and long-term mobility.

Drinking sufficient water daily is a simple yet powerful step toward protecting joint health. Combined with regular exercise and balanced nutrition, proper hydration supports active and pain-free living.

Small daily hydration habits can make a significant difference in how your joints feel and function.

References

Indian Council of Medical Research – Hydration Guidelines
World Health Organization – Water and Health Resources
Indian Journal of Orthopaedics – Joint Health Studies
National Institute of Nutrition India – Fluid Intake Recommendations
Journal of Sports Medicine – Hydration and Musculoskeletal Health Research

Request A Callback

+91

By using this website/app, I confirm that I am at least 18 years old and consent to the processing of my personal data in accordance with the Terms of Service, Privacy Policy, and Declaration.