Call
+918447748545

Published on: Apr 06, 2020
2 minute read
By: Dr Rajan Choudhary

MicroRNA That Makes Them Fight COVID Better ?

Recently you may have read a New Delhi based International Center for Genetic Engineering and Biotechnology (ICGEB) sequenced the genome (genetic data) of SARS-COV-2 (coronavirus) from India, Italy, US, Nepal and Wuhan, China. They found that the Indian variant of SARS-CoV2 has the potential to be targeted by antiviral RNA within host cells, a feature that is unique to the Indian strain.

This amazing finding has been published on blogs, newspapers and other media as proof that Indians may not suffer as much as the rest of the world when the COVID-19 pandemic hits the country. One headline touted “MicroRNA in Indians may reduce severity of corona attack”, stating “Indians have comparatively better immunity compared to other countries”. Of course this article is being forwarded on WhatsApp, and enough people may take it as gospel. Is it true?

No.

If you want to know why, just look on the Journal’s website:

“these are preliminary reports that have not been peer-reviewed. They should NOT be regarded as conclusive, guide clinical practice/health-related behaviour, or be reported in news media as established information.”

Research is not easy. I could write a very long explanation for why, but I have summarised it below.

SUMMARY:

- To prove x causes y up to a high scientific standard is incredibly difficult

- Even if you think x causes y, someone might find a flaw in your study

- Numbers can be manipulated by statistics to show what you want to believe

- Reporters might not understand the study and mis-report it

- We all want to believe there is a magic cure that will protect us, that makes us special, immune to this disaster so we can get on with our lives. Unfortunately there simply isn’t one. And believing in them without fact checking can cause more harm than good.

IMMUNITY AGAINST COVID

So what about this study? Firstly it is looking at one tiny mechanism in a cell, when a cell can have millions of proteins responsible for a billion different functions in just the cell itself. Secondly it is not peer reviewed. This means no one has fact checked the study to check whether the design is valid, whether the statistics hold up, whether they have missed something or are making incorrect conclusions based off their data. Peer-reviewing a recent paper showing SARS-CoV-2 and HIV were extremely similar disproved this paper as false.

In the authors defence he acknowledges this:

“In our study, which is a purely computational one, we predicted that this microRNA binds to the SARS-Cov2 genome submitted from India. However, it is too early to comment on it because there is only one high coverage sequence from India, so far,”

Thirdly, the news article says that Indians have better immunity because of this “microRNA”. This is wrong. The study sequenced the genome of the virus, not of the Indian population. Antiviral microRNA is found in all people. The study simply suggests that this might be more effective at targeting the Indian strain of COVID, but it does not make any concrete claims that Indians are protected from COVID.

Again, the journal even states this:

“These are preliminary reports that have not been peer-reviewed. They should not be regarded as conclusive, guide clinical practice/health-related behavior, or be reported in news media as established information.”

But most importantly, even if the paper suggests that the Indian strain may be less potent, it does not give us an excuse to be reckless. We have to adhere to social distancing, hygiene, lockdown principles in order to prevent infection. Because what happens if you take the article stating “Indians have comparatively better immunity compared to other countries” as fact, use this as an excuse to go about your regular daily lives, and it actually turns out that the microRNA has little to no effect on COVID. This endangers yourself and those around you.

Be sensible. Listen to public health officials.

Dr Rajan Choudhary, UK, Chief Product Officer, Second Medic Inc

www.secondmedic.com

Read Blog

Impact of Air Pollution on Human Health: Risks, Effects and Prevention

Air pollution has become one of the most serious public health challenges worldwide. In India, rapid urbanisation, vehicle emissions, industrial activity and seasonal factors contribute to high pollution levels, especially in metropolitan cities. Understanding the impact of air pollution on human health is essential because exposure to polluted air significantly increases the risk of chronic illness and premature death.

According to the World Health Organization, air pollution is responsible for millions of premature deaths globally each year. Studies published in The Lancet highlight India as one of the countries most affected by air quality-related health burdens.

What Is Air Pollution?

Air pollution occurs when harmful substances such as:

particulate matter (PM2.5 and PM10)
nitrogen dioxide
sulfur dioxide
ozone
carbon monoxide

accumulate in the atmosphere at unsafe levels.

Among these, PM2.5 particles are particularly dangerous because they are small enough to penetrate deep into the lungs and bloodstream.

Respiratory Health Effects

The most immediate and visible impact of air pollution is on the lungs.

Short-Term Effects

coughing
throat irritation
wheezing
shortness of breath

Long-Term Effects

chronic bronchitis
asthma worsening
reduced lung capacity
chronic obstructive pulmonary disease (COPD)

Children and elderly individuals are especially vulnerable.

Impact on Heart Health

Air pollution does not only affect the lungs. Fine particles enter the bloodstream and trigger inflammation.

Long-term exposure increases risk of:

hypertension
heart attack
stroke
atherosclerosis

ICMR reports show cardiovascular diseases remain a leading cause of mortality in India, with pollution being a significant contributing factor.

Impact on Immune System

Constant exposure to polluted air weakens the immune response.

This leads to:

frequent respiratory infections
slower recovery from illness
increased susceptibility to viral diseases

Pollution also increases systemic inflammation.

Effect on Children’s Health

Children are particularly vulnerable because:

their lungs are still developing
they breathe more air relative to body weight
they spend time outdoors

Long-term exposure may reduce lung growth and increase asthma risk.

Impact on Pregnant Women and Infants

Research published in Lancet indicates that high pollution exposure during pregnancy increases risk of:

low birth weight
premature birth
developmental complications

Protecting pregnant women from pollution exposure is critical.

Air Pollution and Cancer Risk

Prolonged exposure to air pollution increases the risk of lung cancer.

WHO classifies outdoor air pollution as a carcinogen.

Mental Health and Cognitive Impact

Emerging research suggests pollution may contribute to:

cognitive decline
mood disorders
reduced concentration

Clean air supports brain health.

Seasonal Pollution in India

During winter months, many cities experience severe smog due to:

crop burning
temperature inversion
increased emissions

Monitoring Air Quality Index (AQI) helps individuals take precautions.

Signs of Pollution-Related Health Impact

persistent cough
chest tightness
eye irritation
unusual fatigue
worsening asthma

Individuals experiencing these symptoms should consult healthcare providers.

Preventive Measures to Reduce Exposure

Monitor AQI

Avoid outdoor activities during high pollution days.

Use Protective Masks

N95 masks filter fine particles effectively.

Indoor Air Quality

Use air purifiers and keep windows closed during peak pollution.

Avoid High-Traffic Areas

Limit time near busy roads.

Maintain Healthy Lifestyle

Strong immunity helps reduce pollution-related health risks.

Role of Preventive Healthcare

Regular screening for:

lung function
blood pressure
heart health

helps detect early damage caused by pollution.

Urban populations should prioritise routine health checkups.

Long-Term Public Health Impact

Air pollution contributes significantly to:

healthcare burden
productivity loss
economic strain

Preventive awareness and environmental policies are essential.

Conclusion

The impact of air pollution on human health is profound and far-reaching. From respiratory disorders and heart disease to immune suppression and increased cancer risk, polluted air affects nearly every organ system. In India’s urban environment, proactive measures such as monitoring AQI, using protective masks and maintaining regular health screenings are crucial. Protecting oneself from air pollution is not just about comfort—it is a vital step in preserving long-term health and preventing chronic disease.

References

World Health Organization (WHO) – Air Pollution and Health Reports
Indian Council of Medical Research (ICMR) – Environmental Health Studies
National Family Health Survey (NFHS-5) – Respiratory and Cardiovascular Data
NITI Aayog – Environmental and Preventive Health Strategy Reports
Lancet – Global Burden of Disease and Air Pollution Research

Request A Callback

+91

By using this website/app, I confirm that I am at least 18 years old and consent to the processing of my personal data in accordance with the Terms of Service, Privacy Policy, and Declaration.