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Published on: Apr 06, 2020
2 minute read
By: Dr Rajan Choudhary

MicroRNA That Makes Them Fight COVID Better ?

Recently you may have read a New Delhi based International Center for Genetic Engineering and Biotechnology (ICGEB) sequenced the genome (genetic data) of SARS-COV-2 (coronavirus) from India, Italy, US, Nepal and Wuhan, China. They found that the Indian variant of SARS-CoV2 has the potential to be targeted by antiviral RNA within host cells, a feature that is unique to the Indian strain.

This amazing finding has been published on blogs, newspapers and other media as proof that Indians may not suffer as much as the rest of the world when the COVID-19 pandemic hits the country. One headline touted “MicroRNA in Indians may reduce severity of corona attack”, stating “Indians have comparatively better immunity compared to other countries”. Of course this article is being forwarded on WhatsApp, and enough people may take it as gospel. Is it true?

No.

If you want to know why, just look on the Journal’s website:

“these are preliminary reports that have not been peer-reviewed. They should NOT be regarded as conclusive, guide clinical practice/health-related behaviour, or be reported in news media as established information.”

Research is not easy. I could write a very long explanation for why, but I have summarised it below.

SUMMARY:

- To prove x causes y up to a high scientific standard is incredibly difficult

- Even if you think x causes y, someone might find a flaw in your study

- Numbers can be manipulated by statistics to show what you want to believe

- Reporters might not understand the study and mis-report it

- We all want to believe there is a magic cure that will protect us, that makes us special, immune to this disaster so we can get on with our lives. Unfortunately there simply isn’t one. And believing in them without fact checking can cause more harm than good.

IMMUNITY AGAINST COVID

So what about this study? Firstly it is looking at one tiny mechanism in a cell, when a cell can have millions of proteins responsible for a billion different functions in just the cell itself. Secondly it is not peer reviewed. This means no one has fact checked the study to check whether the design is valid, whether the statistics hold up, whether they have missed something or are making incorrect conclusions based off their data. Peer-reviewing a recent paper showing SARS-CoV-2 and HIV were extremely similar disproved this paper as false.

In the authors defence he acknowledges this:

“In our study, which is a purely computational one, we predicted that this microRNA binds to the SARS-Cov2 genome submitted from India. However, it is too early to comment on it because there is only one high coverage sequence from India, so far,”

Thirdly, the news article says that Indians have better immunity because of this “microRNA”. This is wrong. The study sequenced the genome of the virus, not of the Indian population. Antiviral microRNA is found in all people. The study simply suggests that this might be more effective at targeting the Indian strain of COVID, but it does not make any concrete claims that Indians are protected from COVID.

Again, the journal even states this:

“These are preliminary reports that have not been peer-reviewed. They should not be regarded as conclusive, guide clinical practice/health-related behavior, or be reported in news media as established information.”

But most importantly, even if the paper suggests that the Indian strain may be less potent, it does not give us an excuse to be reckless. We have to adhere to social distancing, hygiene, lockdown principles in order to prevent infection. Because what happens if you take the article stating “Indians have comparatively better immunity compared to other countries” as fact, use this as an excuse to go about your regular daily lives, and it actually turns out that the microRNA has little to no effect on COVID. This endangers yourself and those around you.

Be sensible. Listen to public health officials.

Dr Rajan Choudhary, UK, Chief Product Officer, Second Medic Inc

www.secondmedic.com

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Nutritional Deficiencies in Indian Kids: Recognizing, Preventing & Overcoming “Hidden Hunger”

Every parent wants their child to grow up healthy — tall, strong, smart, and full of energy. But in India, many kids suffer from what is known as “hidden hunger.” It means that even though they are eating, their diet lacks essential nutrients. These nutritional deficiencies can affect growth, learning, immunity, and long-term health. In this blog, we’ll explore the major nutritional deficiencies in Indian kids, what causes them, how to detect them, and what parents can do. Let’s dive into nutritional deficiencies in Indian kids.

What Are the Most Common Nutritional Deficiencies?

Based on recent research and national surveys, the following are among the most widespread deficiencies in Indian children:

Iron Deficiency / Anaemia
A large percentage of Indian kids (especially under-5s) have low hemoglobin and low iron stores. Anaemia can cause tiredness, slow cognitive development, and lowered immunity. Lippincott Journals+2PMC+2
Vitamin A Deficiency
Vitamin A is essential for good vision, immunity, and healthy cells. Many children under 5 show sub-clinical deficiency; some show clinical signs like night blindness. Lippincott Journals+1
Iodine Deficiency
Iodine is critical for thyroid hormone production, which affects brain development. Lack of iodine can lead to goitre, delayed mental development, and poor school performance. Lippincott Journals+2thyrocare.com+2
Vitamin D Deficiency
Even though India is sunny, many children have low vitamin D — due to indoor living, limited sun exposure, skin coverage, or dietary gaps. This impacts bone health, growth, and risks rickets. PMC+1
Protein-Energy Malnutrition (PEM)
In poorer or marginalized communities, children may not get enough protein or calories. This leads to underweight, wasting, stunting, and weakened immunity. Lippincott Journals+2HDFC ERGO+2
Other Micronutrients (Vitamin B12, folate, zinc etc.)
Deficiencies in B12 & folate can affect cell division, blood production, nerve function; zinc deficiency weakens immunity & slows growth. PMC+2nanhedil.com+2

Why Do These Deficiencies Happen?

Understanding the causes helps in prevention:

Dietary Factors
Many diets are heavy in cereals or starches but low in diversity. Meals may lack fruits, vegetables, animal-source foods (meat, eggs, fish) or fortified products.
Bioavailability of Nutrients
Even when foods contain nutrients, they may not be absorbed well. For example, plant-based iron is less readily absorbed, phytates in grains and legumes can reduce absorption.
Socioeconomic Constraints
Poverty, food insecurity, access issues, lack of awareness, and sometimes traditional/cultural food beliefs limit access to nutrient-rich foods.
Living Conditions and Health
Frequent infections, parasitic infestations, poor hygiene, etc., can increase nutrient loss or demand. Also sunlight exposure (important for vitamin D) is inadequate in many cases.
Gaps in Implementation of Prevention Programs
Though India has multiple programs (fortification, supplement distribution, ICDS, National Nutrition Mission etc.), challenges remain in reach, compliance, quality, and behavioural change.

Effects of Nutritional Deficiencies

These deficiencies have short-term and long-term effects:

Growth stunting (children don’t reach their full height potential)
Wasting (low weight for height), underweight
Impaired cognitive development & learning difficulties
Weak immune system ? more infections
Delayed motor skills, poor school performance
Bone deformities (rickets, weak bones)
Poor quality of life; in severe cases, increased mortality

How to Detect & Diagnose Early

Taking action early helps avoid permanent harm. Key strategies include:

Regular growth monitoring: Checking weight, height, BMI for age
Look for signs: Pale skin or lips, tiredness, delayed milestones, frequent illness, bone pain or deformities (knees bowing, wrist/ankle enlargement)
Lab tests:
- Haemoglobin & complete blood count
- Serum ferritin for iron stores
- Serum levels for vitamin A (retinol)
- 25-OH vitamin D test
- Serum B12, folate
- Urinary iodine excretion or salt iodine test
- Protein / albumin levels

Using broad vitamin profiles (like those from Thyrocare) can help screen for multiple deficiencies in one go.

Foods, Diet & Prevention: What Parents / Caregivers Can Do

Here are practical steps parents can take:

Diversify diet: Include pulses, legumes, eggs, dairy, meat (if non-vegetarian), fish; plenty of green leafy vegetables & fruits.
Fortified foods: Use iodised salt; choose cereals / milk products fortified with vitamins & iron.
Sunlight exposure: Encourage outdoor activities; even short daily sun exposure (face, arms) helps vitamin D.
Supplementation when needed: Under doctor guidance, provide vitamin A doses, iron/folic acid, vitamin D etc., especially in high-risk children.
Hygiene & health care: Prevent worm infections, diarrhoea etc. which can drain nutrients. Ensure vaccinations.
Education & awareness: Teach families importance of nutrition, balanced meals, what local foods can provide what nutrients.

What Parents Should Ask Healthcare Providers

Ask whether your child needs screening for deficiencies (e.g., iron, vitamin A, D, B12).
If lab tests are suggested, check whether it’s comprehensive or narrow, cost, and follow-up.
Seek help for dietary planning, perhaps from nutritionists or public health bodies.
Learn about local government/NGO programs—free or subsidized supplementation or fortified food programs.

When to Seek Medical Help

If your child has:

Persistent anaemia symptoms (very pale, lethargic)
Growth issues (falling off growth charts)
Bone deformities or pain
Severe or recurrent infections
Unusual signs like night blindness, goitre

Then get a medical evaluation. Early intervention can make a big difference.

Conclusion & Call to Action

Nutritional deficiencies in Indian kids are common—but many are preventable or treatable. By recognizing risks, ensuring good diet, doing appropriate lab tests, and using supplements or fortified foods when needed, children can grow healthier, smarter, and stronger.

If you’re concerned that your child may have one or more of these deficiencies, talk to a trusted pediatrician or nutritionist, and consider getting a comprehensive vitamin & nutrition profile done (for example through Thyrocare or SecondMedic) to know exactly where improvements are needed. Don’t wait—every child deserves a strong foundation.

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