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Published on: Aug 05, 2020
2 minute read
By: Dr Rajan Choudhary

Diagnosing Cancers Through A Blood Test

Diagnosing cancer is difficult.

Cancer is a group of diseases in which healthy cells in our body undergo DNA changes. This affects the cell's programming, and instead of performing its regular functions, it begins to divide. Uncontrollably. This division causes greater and greater growth that uses up valuable resources and nutrition, destroys the healthy organs around it, and ultimately puts the body under so much strain it can cause death.

How do we diagnose cancer? If we are lucky we may notice unusual new symptoms. Unintended weight loss, excessive tiredness, bleeding from unusual places, difficulty breathing. It depends on the type of cancer. For some cancers, we have screening programmes, where we look for signs of cancer in people we know are at higher risk. But most of the time the symptoms are only detected when the cancer is advanced enough to cause damage to the body.

In some cases it can already be too late. Pancreatic cancer is notorious for not showing signs until the cancer is too advanced to operate, leaving patients with just 3-6 months of life expectancy.

If we recognise the symptoms we still need to run scans to see the size of the tumour, where it is, and obtain biopsies. Biopsies are vital in figuring out exactly what type of cancer is present, what medications would work against it and what the patients prognosis may be. Whether its by cutting out parts of the tumour directly, with a needle or with endoscopes, biopsy procedures are invasive, uncomfortable and sometimes painful.

What if there was a different way? What if you could take a blood sample and find out if a person has cancer? This dream is becoming slowly more and more real.

CIRCULATING TUMOUR DNA

Circulating Tumour DNA (ctDNA) is found in the blood and refers to DNA that comes from cancerous cells and tumours. Normally this is contained within the centre of a cell, in its nucleus. As a tumour grows, some cancerous cells can die and break apart. When this happens the contents of the cell are released into the blood, including pieces of the mutated DNA. Detecting this DNA is helpful for many reasons.

It can diagnose a tumour based off the mutations present on the DNA. Different cancers will have different mutations, and matching these up can show whether cancer is present before it starts showing symptoms
If we know cancer is present, we can use the DNA to create personalised medical therapy that is specific to one particular cancer in that particular individual. In the future, this could lead to a therapy that does not have as many side effects as chemo and radiotherapy
Repeated blood tests during treatment to look at levels of ctDNA could show whether the treatment is working. A decrease in ctDNA levels would correspond to a decrease in tumour size
Similarly, a lack of ctDNA would show treatment was successful, and the patient is remission free.

This all seems too good to be true. One blood test and you could know if you have cancer years before your symptoms start forming.

In July 2020 an international team of researchers published a study showing a non-invasive blood test was able to detect whether a person had one of five common types of cancer, up to four years before cancer would otherwise have been detected through our current methods. Stomach, oesophageal, colorectal, lung and liver cancer were the types included in the study.

It had a 91% success rate in patients who were otherwise asymptomatic, and 88% successful in detecting cancer in patients who were known to have cancer. If the test states you don’t have cancer, it was shown to be 95?curate.

This incredible study took over 10 years to conduct with over 120,000 participants who gave blood samples at regular intervals, as well as regular check in with physicians to monitor symptoms. Over 1.6 million specimens were collected and archived for this gargantuan project.

Specialists not involved with the research project have praised it, saying its methods are robust and the test is an essential first step towards commercial cancer screening. Of course, we still have many years and lots more research to do before we can achieve this goal, but the results are exciting nonetheless.

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Sleep Disorder Treatment: Effective Ways to Restore Healthy Sleep

Sleep is a fundamental biological process essential for physical restoration, mental clarity and emotional balance. Despite its importance, sleep disorders are increasingly common across all age groups. Millions of people struggle with poor sleep quality, difficulty falling asleep or frequent nighttime awakenings, often without seeking help.

Effective sleep disorder treatment plays a critical role in restoring healthy sleep patterns and preventing long-term health complications.

Understanding Sleep Disorders

Sleep disorders are conditions that disrupt normal sleep patterns, affecting the ability to fall asleep, stay asleep or achieve restorative sleep. They can be short-term or chronic and may occur due to lifestyle factors, medical conditions or psychological stress.

According to global and Indian health data, sleep disorders are underdiagnosed despite their strong association with chronic diseases.

Common Types of Sleep Disorders

Insomnia

Insomnia is the most common sleep disorder.

It involves:

difficulty falling asleep
frequent awakenings
early morning waking
non-restorative sleep

Chronic insomnia significantly affects daily functioning.

Sleep Apnea

Sleep apnea is a serious condition where breathing repeatedly stops during sleep.

Symptoms include:

loud snoring
daytime sleepiness
morning headaches

Untreated sleep apnea increases cardiovascular risk.

Restless Leg Syndrome

This condition causes uncomfortable leg sensations and an urge to move the legs, especially at night.

It disrupts sleep continuity and quality.

Circadian Rhythm Disorders

These occur when the body’s internal clock is misaligned with daily schedules, common in shift workers and frequent travellers.

Why Sleep Disorders Should Not Be Ignored

Chronic sleep problems increase the risk of:

heart disease
hypertension
diabetes
obesity
depression and anxiety
reduced immunity

Poor sleep affects both physical and mental health.

Causes of Sleep Disorders

Sleep disorders often result from multiple factors, including:

chronic stress
irregular sleep schedules
excessive screen exposure
caffeine or alcohol use
medical conditions
mental health disorders

Identifying root causes is essential for effective treatment.

Diagnosis of Sleep Disorders

Diagnosis involves:

detailed sleep history
lifestyle assessment
medical evaluation
sleep studies in selected cases

Accurate diagnosis guides appropriate treatment.

Sleep Disorder Treatment Approaches

Behavioural and Cognitive Therapy

Cognitive Behavioural Therapy for Insomnia (CBT-I) is a highly effective non-drug treatment.

It focuses on:

correcting sleep-related thoughts
improving sleep routines
reducing anxiety around sleep

CBT-I is recommended as first-line treatment for chronic insomnia.

Lifestyle and Sleep Hygiene Measures

Good sleep hygiene includes:

maintaining regular sleep timings
limiting screen exposure before bedtime
creating a comfortable sleep environment
avoiding heavy meals late at night

These measures support natural sleep regulation.

Medical Management

Medications may be used:

short-term for severe symptoms
under medical supervision

Medication is often combined with behavioural therapy rather than used alone.

Treatment for Sleep Apnea

Management may include:

weight management
positional therapy
continuous positive airway pressure (CPAP) devices
treating underlying conditions

Early treatment reduces cardiovascular risk.

Role of Mental Health in Sleep Disorders

Sleep and mental health are closely connected.

Conditions such as anxiety and depression:

disrupt sleep architecture
worsen insomnia
require integrated treatment

Addressing mental health improves sleep outcomes.

Importance of Consistency in Treatment

Sleep disorder treatment requires:

patience
consistency
follow-up

Improvement may take weeks, but sustained effort yields lasting results.

Preventing Sleep Disorders

Preventive strategies include:

stress management
physical activity
balanced nutrition
limiting stimulants
maintaining work-life balance

Prevention is more effective than treatment alone.

Impact of Technology on Sleep

Excessive screen use affects melatonin production and delays sleep onset.

Reducing nighttime screen exposure significantly improves sleep quality.

When to Seek Professional Help

Consult a healthcare provider if:

sleep problems persist beyond two weeks
daytime functioning is affected
snoring and breathing pauses are noticed
sleepiness interferes with safety

Early treatment prevents complications.

Long-Term Benefits of Treating Sleep Disorders

Effective sleep disorder treatment leads to:

improved energy and concentration
better mood and emotional stability
reduced chronic disease risk
enhanced quality of life

Healthy sleep supports overall wellbeing.

Conclusion

Sleep disorder treatment is essential for restoring physical health, mental clarity and emotional balance. While sleep problems are common, they are not normal or harmless. Insomnia, sleep apnea and other sleep disorders can be effectively managed through behavioural therapy, lifestyle changes and medical care when needed. Early recognition and consistent treatment not only improve sleep quality but also protect long-term health. Prioritising sleep is a powerful step toward a healthier and more productive life.

References

Indian Council of Medical Research (ICMR) – Sleep Health and Lifestyle Studies
World Health Organization (WHO) – Sleep and Mental Health Guidelines
National Institute of Mental Health and Neurosciences (NIMHANS) – Sleep Disorders Research
Lancet Psychiatry – Sleep Disorders and Chronic Disease Risk
NITI Aayog – Mental Health and Preventive Healthcare Reports
Statista – Global Sleep Disorder Prevalence and Trends

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