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Published on: Jan 02, 2021
2 minute read
By: Dr Rajan Choudhary

COVID-19 Variant: What We Know About This New Mutation

COVID-19 Variant: What we know about this new mutation

In early December a new variant of COVID -19 was detected in the UK, raising concerns across the world. SARS-CoV-2 has already significantly impacted the world, with 84 million cases worldwide and nearly 2 million deaths. Could the new variant cause further havoc? Is it something we should be worried about? Today we will have a look at what we know so far about the virus.

MUTAGENESIS

To start with we should go over viral mutations. Unlike complex organisms, viruses are highly prone to genetic mutations, even more than bacteria. All organisms including humans, birds, even worms, are prone to mutations as well. However due to their complexity, there is much higher risk of mutations causing significant problems with their cellular and genetic processes, problems that are often incompatible with life, or lead to cancer. For this reason, there are significant genetic roadblocks present to prevent such mutations from occurring.

Viruses on the other hand have genetic replication machinery of poor “quality”, prone to introducing mutations. Since they replicate quickly, with little care on which viral particles survive, it matters little if hundreds of viruses do not survive, as further thousands will and continue to spread in their host. It is for this reason we have such difficulty treating viruses or making viruses against them .

COVID VARIANT

The variant was first picked up by the COVID-19 Genomics UK consortium, which undertakes random genetic sequencing of positive COVID-19 samples across the UK. Since April they have sequenced 140,000 virus genomes, to identify and track outbreaks across the UK. The strain was first identified in September and sequenced in early October. However, the significance of this strain was not realized until the end of the year. By 13th December 1108 cases had been identified across 60 different locations, though the true number is likely much higher. In Norfolk, it accounts for nearly 20% of all samples.

17 Variations have been identified, most significantly in the spike protein the virus uses to bind to the ACE2 receptor found in the lungs. Changes in this protein may have resulted in it being more infectious and spreading more quickly between people. A review of current evidence has shown the rate of transmission was 71% higher than the other variants and may also have a much higher viral load. This has given it an advantage over the other COVID-19 strains- it has already been detected in South Africa, Europe, and America, and it is likely to become the dominant global strain in the near future.

It appears children are more susceptible to catching this virus. The virus propagated at a time when schools were open and running, whilst the rest of the country remained in lockdown. This may have provided a larger pool of children for the virus to spread in, resulting in this change. However, this does not mean that the virus “attacks” children, rather it is able to attach to ACE2 receptors in children’s lungs with greater ease and spread quickly.

VACCINE

The most important question on everyone’s mind – will the vaccine be effective against this new strain? If not, lockdown rules may be extended until new vaccines are discovered, and by then newer strains may leapfrog ahead and make the new vaccines irrelevant again.

So far experts believe that the new variant is unlikely to make vaccines ineffective. The vaccines all produce antibodies against the viral spike protein, but so far it appears the mutation has not changed the shape or function of the spike protein enough for antibodies to fail against it. The antibodies should be able to recognize enough sites on the spike protein to successfully attach, neuter the protein, and present the virus for destruction by the body’s immune system. Unfortunately, it will take some time to fully understand the effects of the mutation, though we can remain hopeful for now

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Chest Pain While Breathing: Causes, Warning Signs, and When to Seek Urgent Care

Chest pain is one of the most alarming symptoms a person can experience, especially when it worsens during breathing. Chest pain while breathing, also known as pleuritic chest pain, often indicates involvement of the lungs, chest wall or surrounding structures. While some causes are mild, others can be life-threatening and require immediate medical attention.

In India, respiratory infections, air pollution, sedentary lifestyles and delayed medical care contribute significantly to chest-related symptoms.

What Does Chest Pain While Breathing Mean?

Chest pain while breathing refers to pain that:

worsens with deep inhalation or exhalation
may feel sharp, stabbing or burning
can be localized or spread across the chest

Pain intensity often increases with coughing or movement.

Common Causes of Chest Pain While Breathing

Lung Infections (Pneumonia)

Pneumonia inflames lung tissue and surrounding membranes.

Symptoms include:

chest pain while breathing
fever
cough
breathlessness

ICMR data identifies pneumonia as a major cause of respiratory illness in India.

Pleuritis (Inflammation of Lung Lining)

The pleura are thin membranes surrounding the lungs.

When inflamed:

breathing causes friction
sharp chest pain occurs

Pleuritis often follows viral infections or pneumonia.

Pulmonary Embolism

A blood clot in the lungs causes:

sudden chest pain
rapid breathing
severe breathlessness

This is a medical emergency requiring immediate care.

Chest Wall Muscle Strain

Muscle strain due to:

heavy lifting
intense coughing
poor posture

can cause pain during breathing or movement.

Costochondritis

Inflammation of rib cartilage causes:

localized chest pain
pain worsened by breathing or pressing on the chest

This condition is painful but not life-threatening.

Pneumothorax (Collapsed Lung)

Air leakage into the chest cavity causes:

sudden sharp chest pain
breathlessness

Often seen after trauma or in individuals with lung disease.

Heart-Related Causes

Though heart pain usually does not worsen with breathing, conditions such as:

pericarditis (heart lining inflammation)

can cause chest pain that changes with respiration.

Acid Reflux and Esophageal Spasm

Gastrointestinal causes may mimic chest pain.

However:

pain usually relates to meals
breathing-related pain should be evaluated carefully

Anxiety and Panic Disorders

Anxiety can cause:

chest tightness
rapid breathing
discomfort while breathing

Medical causes must be ruled out before attributing pain to anxiety.

Warning Signs That Require Emergency Attention

Seek immediate medical care if chest pain while breathing is associated with:

sudden onset
severe breathlessness
bluish lips or fingers
dizziness or fainting
sweating
coughing up blood

These may indicate life-threatening conditions.

Risk Factors for Serious Chest Pain

Higher risk occurs in people with:

smoking history
recent surgery or long travel
lung disease
heart disease
clotting disorders

Early evaluation is critical.

Diagnostic Evaluation

Doctors may recommend:

physical examination
chest X-ray
ECG
blood tests
CT scan

Timely diagnosis saves lives.

Why Chest Pain Should Not Be Ignored

Ignoring chest pain can lead to:

delayed treatment
worsening respiratory failure
preventable complications

WHO emphasises early symptom recognition for better outcomes.

Impact of Air Pollution and Lifestyle

Air pollution increases:

lung inflammation
infection risk

Sedentary habits reduce lung capacity, worsening symptoms.

Preventive Measures

Helpful preventive steps include:

avoiding smoking
staying physically active
managing respiratory infections early
maintaining good posture
staying hydrated

Preventive care reduces risk.

Role of Preventive Health Checkups

Regular health screening helps detect:

early lung disease
heart risk factors
chronic inflammation

Early intervention prevents emergencies.

When Chest Pain Is Less Likely Serious

Pain may be less concerning if:

localized
reproducible on touch
improves with rest

However, medical confirmation is still necessary.

Importance of Timely Medical Consultation

Chest pain should always be evaluated by a healthcare professional.

Delaying care can:

increase complications
raise mortality risk

Early action saves lives.

Conclusion

Chest pain while breathing is a critical symptom that should never be ignored. While causes range from muscle strain and infections to serious lung and heart conditions, only proper medical evaluation can determine the exact cause. Early diagnosis, timely treatment and preventive care are essential to protect respiratory and cardiovascular health. When it comes to chest pain, it is always safer to act early than to wait.

References

Indian Council of Medical Research (ICMR) – Respiratory and Cardiovascular Health Reports
World Health Organization (WHO) – Chest Pain and Respiratory Symptoms Guidelines
National Family Health Survey (NFHS-5) – Adult Respiratory Health Data
Lancet – Pulmonary Embolism and Chest Pain Research
NITI Aayog – Preventive Healthcare and Early Symptom Recognition

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