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Published on: Jan 02, 2021
2 minute read
By: Dr Rajan Choudhary

COVID-19 Variant: What We Know About This New Mutation

COVID-19 Variant: What we know about this new mutation

In early December a new variant of COVID -19 was detected in the UK, raising concerns across the world. SARS-CoV-2 has already significantly impacted the world, with 84 million cases worldwide and nearly 2 million deaths. Could the new variant cause further havoc? Is it something we should be worried about? Today we will have a look at what we know so far about the virus.

MUTAGENESIS

To start with we should go over viral mutations. Unlike complex organisms, viruses are highly prone to genetic mutations, even more than bacteria. All organisms including humans, birds, even worms, are prone to mutations as well. However due to their complexity, there is much higher risk of mutations causing significant problems with their cellular and genetic processes, problems that are often incompatible with life, or lead to cancer. For this reason, there are significant genetic roadblocks present to prevent such mutations from occurring.

Viruses on the other hand have genetic replication machinery of poor “quality”, prone to introducing mutations. Since they replicate quickly, with little care on which viral particles survive, it matters little if hundreds of viruses do not survive, as further thousands will and continue to spread in their host. It is for this reason we have such difficulty treating viruses or making viruses against them .

COVID VARIANT

The variant was first picked up by the COVID-19 Genomics UK consortium, which undertakes random genetic sequencing of positive COVID-19 samples across the UK. Since April they have sequenced 140,000 virus genomes, to identify and track outbreaks across the UK. The strain was first identified in September and sequenced in early October. However, the significance of this strain was not realized until the end of the year. By 13th December 1108 cases had been identified across 60 different locations, though the true number is likely much higher. In Norfolk, it accounts for nearly 20% of all samples.

17 Variations have been identified, most significantly in the spike protein the virus uses to bind to the ACE2 receptor found in the lungs. Changes in this protein may have resulted in it being more infectious and spreading more quickly between people. A review of current evidence has shown the rate of transmission was 71% higher than the other variants and may also have a much higher viral load. This has given it an advantage over the other COVID-19 strains- it has already been detected in South Africa, Europe, and America, and it is likely to become the dominant global strain in the near future.

It appears children are more susceptible to catching this virus. The virus propagated at a time when schools were open and running, whilst the rest of the country remained in lockdown. This may have provided a larger pool of children for the virus to spread in, resulting in this change. However, this does not mean that the virus “attacks” children, rather it is able to attach to ACE2 receptors in children’s lungs with greater ease and spread quickly.

VACCINE

The most important question on everyone’s mind – will the vaccine be effective against this new strain? If not, lockdown rules may be extended until new vaccines are discovered, and by then newer strains may leapfrog ahead and make the new vaccines irrelevant again.

So far experts believe that the new variant is unlikely to make vaccines ineffective. The vaccines all produce antibodies against the viral spike protein, but so far it appears the mutation has not changed the shape or function of the spike protein enough for antibodies to fail against it. The antibodies should be able to recognize enough sites on the spike protein to successfully attach, neuter the protein, and present the virus for destruction by the body’s immune system. Unfortunately, it will take some time to fully understand the effects of the mutation, though we can remain hopeful for now

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Health Risks of Sedentary Lifestyle: Why Sitting Too Much Can Harm Your Health

Modern lifestyles have become increasingly sedentary. With the rise of desk jobs, digital devices and long working hours, many individuals spend a significant portion of their day sitting. While technology and convenience have improved productivity, they have also contributed to reduced physical activity.

Understanding the health risks of a sedentary lifestyle is essential for preventing chronic diseases and maintaining overall wellbeing.

What Is a Sedentary Lifestyle?

A sedentary lifestyle refers to a pattern of behavior characterized by prolonged sitting or inactivity with minimal physical movement.

Common examples include:

Sitting at a desk for long hours
Watching television for extended periods
Spending significant time on computers or smartphones
Limited engagement in physical exercise

When the body remains inactive for long durations, various physiological functions may become impaired.

1. Increased Risk of Obesity

Physical inactivity reduces calorie expenditure.

When calorie intake exceeds the energy burned through activity, excess calories are stored as body fat.

This can lead to weight gain and increase the risk of obesity.

Obesity is a major risk factor for several chronic health conditions.

2. Higher Risk of Cardiovascular Disease

Prolonged sitting has been associated with increased risk of heart disease.

Sedentary behavior may contribute to:

Elevated blood pressure
Increased cholesterol levels
Reduced blood circulation

These factors increase the likelihood of cardiovascular complications over time.

3. Increased Risk of Type 2 Diabetes

Physical activity helps regulate blood sugar levels.

A sedentary lifestyle may impair the body’s ability to use insulin effectively, leading to insulin resistance.

Over time, this can increase the risk of developing type 2 diabetes.

4. Poor Metabolic Health

Metabolism refers to the body’s ability to convert food into energy.

Long periods of inactivity may slow metabolic processes and reduce the body’s efficiency in managing glucose and fat levels.

This can contribute to metabolic syndrome.

5. Musculoskeletal Problems

Sitting for extended periods can strain muscles and joints.

Common issues include:

Lower back pain
Neck stiffness
Shoulder discomfort
Poor posture

These problems are particularly common among office workers.

6. Reduced Mental Wellbeing

Physical activity plays a significant role in supporting mental health.

Sedentary behavior may contribute to:

Increased stress levels
Reduced mood
Lower energy levels

Regular movement helps improve mental wellbeing.

7. Increased Risk of Premature Mortality

Studies have shown that prolonged inactivity may increase the risk of early death due to chronic diseases.

Maintaining an active lifestyle significantly improves long-term health outcomes.

Sedentary Lifestyle in the Indian Context

Urbanization and technological advancements have led to more sedentary work environments in India.

Long commuting hours, desk-based professions and digital entertainment have reduced physical activity levels for many individuals.

As a result, lifestyle-related diseases such as diabetes and heart disease have increased significantly in recent years.

Public health initiatives now emphasize the importance of regular physical activity to counter these trends.

How to Reduce Sedentary Behavior

Take Frequent Movement Breaks

Stand up and stretch every 30–60 minutes during work.

Incorporate Walking into Daily Routine

Short walks during breaks can improve circulation and energy levels.

Use Active Workstations

Standing desks or adjustable workstations encourage movement.

Exercise Regularly

Engage in moderate physical activity such as walking, cycling or yoga.

Health guidelines recommend at least 150 minutes of exercise per week.

Limit Screen Time

Reducing recreational screen time encourages more active habits.

Benefits of an Active Lifestyle

Increasing daily physical activity provides several health benefits:

Improved cardiovascular health
Better weight management
Enhanced mental wellbeing
Stronger muscles and bones
Improved metabolic function

Even small lifestyle changes can make a significant difference over time.

When to Seek Medical Advice

Consult a healthcare professional if you experience:

Persistent back pain
Unexplained weight gain
Chronic fatigue
Signs of metabolic disorders

Early intervention can help manage health risks effectively.

Conclusion

A sedentary lifestyle may significantly impact physical and mental health. Prolonged sitting and lack of movement increase the risk of obesity, cardiovascular disease, diabetes and musculoskeletal problems.

Adopting an active lifestyle that includes regular movement, exercise and healthy habits is essential for maintaining overall wellbeing.

Simple changes such as standing frequently, walking regularly and engaging in physical activity can greatly reduce the health risks associated with sedentary behavior.

Maintaining an active lifestyle is one of the most effective ways to support long-term health and prevent chronic disease.

References

World Health Organization – Physical Activity Guidelines
Indian Council of Medical Research – Lifestyle Disease Reports
National Family Health Survey – Health and Lifestyle Data
Lancet Global Health – Sedentary Behavior Research
Journal of Preventive Medicine – Physical Activity Studies

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