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Published on: Apr 25, 2021
2 minute read
By: Dr Rajan Choudhary

COVID 19 Mutations: An Update

COVID 19 Mutations: an update

India is currently experiencing a very high rate of infections across the country, resulting in record hospitalisations, ICU admissions and now a severe shortage of oxygen. How did this happen? As with all things, it is likely multifactorial, and blame cannot be associated with one single issue. Socioeconomic issues preventing effective lockdown, stretched healthcare resources, poor communication and maintenance of social distancing and mask use. And of course, viral variants, something we will be discussing below.

GENETIC MUTATIONS

Mutations are integrated deeply into the backbone of genetics. When DNA replicates, its two strands split apart and are used as blueprints to create two new strands, each containing half the original DNA. Mutation’s sneak into the replication phase, and can change the proteins the DNA encodes. If these mutations are compatible with life, they survive and may be passed down the generations. If the mutations provide an evolutionary benefit that improves the survival of the organism and allows it to outcompete other organisms, its descendants will survive, and the mutation will flourish.

Complex organisms such as plants and animals have inherent DNA repair mechanisms that reduce the rate of mutations. This is because most mutations are incompatible with life, as they destroy critical proteins required for the most basic functions of cell function and life. Cancer is evidence of what happens when these repair mechanisms fail. Viruses do not have such protection; when the high mutation rate is combined with the high replication rate, viral variants are inevitable.

COVID MUTATIONS

Scientists have been tracking mutations of the SARS-CoV-2 virus closely. Countries across the world are basing the re-opening and recovery of their societies on reducing infection rates and preventing re-infections through vaccination programmes. If the virus mutates, it can result in increased infectivity, mortality, and potentially the ability to escape from natural immunity offered by antibodies.

Indian genome scientists first detected the “double variant” of the novel coronavirus in October 2020, and in the UK in Feb 2021. It has been on the rise, and B.1.617 accounts for almost 70% of genomes submitted by India to the global database GISAID. It has a total of 13 mutations, which in turn lead to the change in multiple amino acids. B.1.617 has multiple mutations and describing it as a “double mutant” virus is therefore inaccurate.

L452R

B1617 s more contagious because of a mutation in the spike protein known as L452R.This mutation has been studied as it has also been found in variants identified in California (including apes in San Diego Zoo). It is thought this improves the binding to the ACE2 receptors in the lung and may also have some ability to escape from neutralising antibodies.

E484Q

The second mutation is E484Q, which also affects the spike protein to make it less susceptible to pre-existing antibodies, though there is limited evidence for this. Looking at convalescent plasma donated by people it appears to have weaker neutralisation of B.1.617 in some people, though this isn’t a consistent finding.

Mutations at position 484 have also been found in other global variants, though these E484K mutations lead to different functions. One study looking at the UK B.1.1.7 variant looked at how this E484K mutation affected viral interactions in vaccinated patients. Patients who have been vaccinated produce antibodies with a wide range of actions targeting multiple sections of the spike protein. When these patient serums were exposed to the B.1.1.7 mutation, it was found to have decreased neutralisation. This raised the risk of reduced vaccine efficacy and threatened the vaccine programme. Currently, public health officials are confident our vaccine programmes cover the emerging variants.

CONCERNS

Whilst B.1.617 is concerning, it currently accounts for about 20% of cases in Maharashtra, and likely a low percentage of total infections in the country. There is not yet enough evidence to classify it as a “variant of concern”, and further research is required. Though it has increased potential for spreading, currently the UK variant B.1.1.7 may be on the rise, and more concerning. It has over 50% increased transmissibility and 60% lethality and contributed to the UK’s most recent wave of infections. Genomic studies have shown it is now the dominant form of the virus in the Indian state of Punjab.

What is most concerning, however, is the risk of more variants emerging. As the infection spreads unimpeded through the population, viral replication remains at an all-time high, which in turn increases the risk of mutations. Current mutations are covered by vaccines, future mutations may not be. This is why we need to lower infection rates as soon as possible.

Social distancing, use of masks, vaccinations, lockdowns, and quarantine when expressing symptoms. We have to follow public health advice, to prevent our infection rates from spiralling further out of control

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Walking Meetings via Voice Chat: A Smarter Way to Boost Health and Productivity in Remote Teams

Remote work has transformed how teams collaborate, but it has also increased sedentary behaviour. Long hours of sitting in front of screens contribute to fatigue, musculoskeletal pain and reduced mental focus. In this context, walking meetings conducted via voice chat have emerged as a simple yet effective corporate wellness practice that aligns productivity with health.

Walking meetings do not require additional time, special equipment or complex planning. They simply reimagine how meetings are conducted.

The Sedentary Challenge in Remote Work

According to WHO and ICMR data:

prolonged sitting increases the risk of heart disease, diabetes and musculoskeletal problems
remote employees often sit longer than office-based workers
screen fatigue negatively affects mental health and productivity

Traditional video meetings unintentionally reinforce inactivity.

What Are Walking Meetings?

Walking meetings are conversations held while participants walk instead of sitting.

In remote settings, these meetings:

are conducted via voice calls
eliminate the need for video screens
allow participants to move freely

They are ideal for one-on-one discussions, team check-ins and brainstorming sessions.

Why Voice Chat Works Best for Walking Meetings

Voice-only meetings:

reduce screen dependency
allow safer movement
encourage active listening

Without visual distractions, participants often engage more deeply in conversation.

Health Benefits of Walking Meetings

Reduced Sedentary Time

Even short walks help:

improve blood circulation
reduce stiffness
activate muscles

WHO recommends breaking prolonged sitting every 30–60 minutes.

Cardiovascular Support

Regular walking:

improves heart health
lowers blood pressure
supports metabolic health

Incorporating movement into meetings contributes to daily activity goals.

Musculoskeletal Relief

Walking reduces:

neck and back strain
shoulder tension
joint stiffness

This is particularly valuable for desk-bound employees.

Mental Health and Cognitive Benefits

Improved Focus and Creativity

Movement increases blood flow to the brain.

Studies cited by Lancet show that walking enhances:

problem-solving
creativity
memory recall

Many people report clearer thinking during walking discussions.

Stress Reduction

Walking helps:

lower cortisol levels
improve mood
reduce mental fatigue

This supports emotional wellbeing in high-pressure work environments.

Productivity Benefits for Organisations

Walking meetings:

reduce meeting fatigue
improve engagement
shorten meeting duration due to focused discussion

Employees often return to tasks feeling refreshed rather than drained.

Cultural Shift Toward Wellness-Oriented Work

Encouraging walking meetings signals:

trust in employees
commitment to wellbeing
flexibility in work culture

This improves morale and retention.

How to Implement Walking Meetings in Remote Teams

Simple steps include:

designating certain meetings as “audio-only”
encouraging participants to walk indoors or outdoors
keeping meetings concise
sharing agendas in advance

Clear guidelines ensure safety and effectiveness.

Safety and Practical Considerations

Best practices include:

avoiding walking in unsafe or crowded areas
using earphones for clarity
walking at a comfortable pace
pausing movement when taking notes

Inclusivity is important—walking should be optional, not mandatory.

Who Benefits Most from Walking Meetings?

Walking meetings are especially helpful for:

remote workers
hybrid teams
roles with frequent discussions
employees experiencing screen fatigue

They are less suitable for data-heavy presentations.

Walking Meetings as Part of Corporate Wellness Programs

Walking meetings complement:

ergonomics initiatives
mental health programs
physical activity challenges

They integrate wellness into daily workflows rather than adding extra tasks.

Long-Term Impact on Workplace Health

Over time, organisations adopting movement-friendly practices observe:

reduced burnout
improved energy levels
healthier work routines

Preventive health strategies are most effective when embedded into daily habits.

Role of Preventive Healthcare Awareness

NITI Aayog and WHO emphasise lifestyle modification as a core preventive health strategy.

Walking meetings align perfectly with this approach by:

reducing inactivity
promoting movement
supporting mental wellbeing

Small changes deliver cumulative benefits.

Conclusion

Walking meetings conducted via voice chat are a practical, low-cost and highly effective way to improve employee health and productivity in remote teams. By replacing sedentary meetings with movement-based conversations, organisations can reduce screen fatigue, enhance focus and support long-term wellbeing. In a remote-first world, walking meetings represent a smarter way to work—where productivity and health move forward together.

References

World Health Organization (WHO) – Physical Activity and Sedentary Behaviour Guidelines
Indian Council of Medical Research (ICMR) – Lifestyle and Non-Communicable Disease Reports
Lancet – Physical Activity, Cognition and Workplace Health Studies

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