Call
+918447748545

Published on: Apr 25, 2021
2 minute read
By: Dr Rajan Choudhary

COVID 19 Mutations: An Update

COVID 19 Mutations: an update

India is currently experiencing a very high rate of infections across the country, resulting in record hospitalisations, ICU admissions and now a severe shortage of oxygen. How did this happen? As with all things, it is likely multifactorial, and blame cannot be associated with one single issue. Socioeconomic issues preventing effective lockdown, stretched healthcare resources, poor communication and maintenance of social distancing and mask use. And of course, viral variants, something we will be discussing below.

GENETIC MUTATIONS

Mutations are integrated deeply into the backbone of genetics. When DNA replicates, its two strands split apart and are used as blueprints to create two new strands, each containing half the original DNA. Mutation’s sneak into the replication phase, and can change the proteins the DNA encodes. If these mutations are compatible with life, they survive and may be passed down the generations. If the mutations provide an evolutionary benefit that improves the survival of the organism and allows it to outcompete other organisms, its descendants will survive, and the mutation will flourish.

Complex organisms such as plants and animals have inherent DNA repair mechanisms that reduce the rate of mutations. This is because most mutations are incompatible with life, as they destroy critical proteins required for the most basic functions of cell function and life. Cancer is evidence of what happens when these repair mechanisms fail. Viruses do not have such protection; when the high mutation rate is combined with the high replication rate, viral variants are inevitable.

COVID MUTATIONS

Scientists have been tracking mutations of the SARS-CoV-2 virus closely. Countries across the world are basing the re-opening and recovery of their societies on reducing infection rates and preventing re-infections through vaccination programmes. If the virus mutates, it can result in increased infectivity, mortality, and potentially the ability to escape from natural immunity offered by antibodies.

Indian genome scientists first detected the “double variant” of the novel coronavirus in October 2020, and in the UK in Feb 2021. It has been on the rise, and B.1.617 accounts for almost 70% of genomes submitted by India to the global database GISAID. It has a total of 13 mutations, which in turn lead to the change in multiple amino acids. B.1.617 has multiple mutations and describing it as a “double mutant” virus is therefore inaccurate.

L452R

B1617 s more contagious because of a mutation in the spike protein known as L452R.This mutation has been studied as it has also been found in variants identified in California (including apes in San Diego Zoo). It is thought this improves the binding to the ACE2 receptors in the lung and may also have some ability to escape from neutralising antibodies.

E484Q

The second mutation is E484Q, which also affects the spike protein to make it less susceptible to pre-existing antibodies, though there is limited evidence for this. Looking at convalescent plasma donated by people it appears to have weaker neutralisation of B.1.617 in some people, though this isn’t a consistent finding.

Mutations at position 484 have also been found in other global variants, though these E484K mutations lead to different functions. One study looking at the UK B.1.1.7 variant looked at how this E484K mutation affected viral interactions in vaccinated patients. Patients who have been vaccinated produce antibodies with a wide range of actions targeting multiple sections of the spike protein. When these patient serums were exposed to the B.1.1.7 mutation, it was found to have decreased neutralisation. This raised the risk of reduced vaccine efficacy and threatened the vaccine programme. Currently, public health officials are confident our vaccine programmes cover the emerging variants.

CONCERNS

Whilst B.1.617 is concerning, it currently accounts for about 20% of cases in Maharashtra, and likely a low percentage of total infections in the country. There is not yet enough evidence to classify it as a “variant of concern”, and further research is required. Though it has increased potential for spreading, currently the UK variant B.1.1.7 may be on the rise, and more concerning. It has over 50% increased transmissibility and 60% lethality and contributed to the UK’s most recent wave of infections. Genomic studies have shown it is now the dominant form of the virus in the Indian state of Punjab.

What is most concerning, however, is the risk of more variants emerging. As the infection spreads unimpeded through the population, viral replication remains at an all-time high, which in turn increases the risk of mutations. Current mutations are covered by vaccines, future mutations may not be. This is why we need to lower infection rates as soon as possible.

Social distancing, use of masks, vaccinations, lockdowns, and quarantine when expressing symptoms. We have to follow public health advice, to prevent our infection rates from spiralling further out of control

Read Blog

Clothing Drives for Secondhand Donation: Serving Society Sustainably

Clothing is a basic human need, yet millions of people across India lack access to adequate apparel, especially during extreme weather conditions. At the same time, urban households discard large volumes of wearable clothing each year. Clothing drives for secondhand donation bridge this gap by connecting surplus with need in a dignified, sustainable manner.

These initiatives are not merely charitable activities. They represent a structured approach to social responsibility, environmental stewardship and community wellbeing.

The Growing Need for Clothing Donation in India

India faces significant socio-economic disparity.

According to government and NGO data:

millions live below the poverty line
seasonal weather exposes vulnerable populations to health risks
access to basic clothing remains inconsistent

Clothing insecurity directly affects dignity, health and social participation.

Environmental Impact of Textile Waste

The fashion and textile industry is among the largest contributors to environmental pollution.

Textile waste leads to:

landfill accumulation
water pollution from dyes
increased carbon footprint

Reusing clothing through donation significantly reduces environmental strain.

Why Secondhand Clothing Matters

Secondhand clothing extends the lifecycle of garments.

Benefits include:

reduced demand for new production
conservation of water and energy
lower environmental emissions

According to sustainability studies, reuse has a far lower environmental cost than recycling or disposal.

Social Impact of Clothing Drives

Clothing donation drives provide:

protection from heat, cold and rain
improved hygiene and comfort
enhanced dignity and self-esteem

For recipients, clean, appropriate clothing supports physical health and social inclusion.

Role of Clothing Drives in Community Wellbeing

Community-based donation drives:

encourage collective responsibility
foster empathy and awareness
strengthen social bonds

When organised locally, they ensure relevance and timely distribution.

Corporate and Institutional Participation

Many organisations integrate clothing drives into CSR initiatives.

Benefits for organisations include:

measurable social impact
employee engagement
alignment with sustainability goals

EY-FICCI CSR reports highlight employee-driven social initiatives as highly effective engagement tools.

How to Organise an Effective Clothing Drive

Successful drives follow structured processes.

Key steps include:

clear communication on donation guidelines
segregation by size, gender and season
quality checks for usability
hygienic packing and storage

Organisation ensures dignity for recipients.

Importance of Quality and Dignity

Donations should always respect the recipient.

Essential guidelines:

clothes must be clean and wearable
damaged or unusable items should be excluded
culturally appropriate clothing should be prioritised

Dignified donation builds trust and respect.

Seasonal Relevance of Clothing Drives

Seasonal drives maximise impact.

Examples include:

winter clothing drives
monsoon protection apparel
school clothing collections

Timing ensures practical usefulness.

Health and Wellbeing Benefits

Adequate clothing reduces:

exposure-related illnesses
skin infections
respiratory conditions during cold weather

WHO recognises appropriate clothing as a basic determinant of health.

Sustainability and Circular Economy

Clothing drives support a circular economy by:

keeping materials in use longer
reducing waste generation
encouraging responsible consumption

They align with global sustainability goals.

Community Partnerships and NGOs

Collaborating with NGOs ensures:

efficient distribution
identification of genuine needs
transparency and accountability

Partnerships amplify reach and impact.

Measuring the Impact of Clothing Drives

Impact can be assessed through:

number of beneficiaries
quantity of clothing reused
environmental waste reduction
community feedback

Data-driven evaluation improves future initiatives.

Challenges and How to Address Them

Common challenges include:

poor-quality donations
storage and logistics issues
uneven distribution

Clear guidelines and partnerships help overcome these barriers.

Long-Term Value of Sustainable Donation Drives

Regular clothing drives:

normalise responsible disposal habits
build sustainable communities
encourage conscious consumption

They move society from waste to welfare.

Integrating Clothing Drives with Broader Wellness Initiatives

Clothing drives complement:

health camps
nutrition programs
community wellness initiatives

Holistic approaches improve overall social wellbeing.

Conclusion

Clothing drives for secondhand donation represent a powerful intersection of compassion and sustainability. By redirecting wearable clothing to those who need it most, these initiatives protect dignity, improve health outcomes and reduce environmental impact. In a society striving for sustainable development, organised clothing donation drives serve as practical, high-impact actions that benefit communities and the planet alike. When individuals and organisations come together to serve responsibly, small acts of reuse create lasting social change.

References

World Health Organization (WHO) – Social Determinants of Health Reports
Indian Council of Medical Research (ICMR) – Environmental and Community Health Studies
NITI Aayog – Sustainability and Social Impact Frameworks
EY-FICCI – Corporate Social Responsibility and Sustainability Reports
Statista – Textile Waste and Sustainability Data
UN Environment Programme – Sustainable Consumption and Circular Economy

Request A Callback

+91

By using this website/app, I confirm that I am at least 18 years old and consent to the processing of my personal data in accordance with the Terms of Service, Privacy Policy, and Declaration.