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Published on: Apr 25, 2021
2 minute read
By: Dr Rajan Choudhary

COVID 19 Mutations: An Update

COVID 19 Mutations: an update

India is currently experiencing a very high rate of infections across the country, resulting in record hospitalisations, ICU admissions and now a severe shortage of oxygen. How did this happen? As with all things, it is likely multifactorial, and blame cannot be associated with one single issue. Socioeconomic issues preventing effective lockdown, stretched healthcare resources, poor communication and maintenance of social distancing and mask use. And of course, viral variants, something we will be discussing below.

GENETIC MUTATIONS

Mutations are integrated deeply into the backbone of genetics. When DNA replicates, its two strands split apart and are used as blueprints to create two new strands, each containing half the original DNA. Mutation’s sneak into the replication phase, and can change the proteins the DNA encodes. If these mutations are compatible with life, they survive and may be passed down the generations. If the mutations provide an evolutionary benefit that improves the survival of the organism and allows it to outcompete other organisms, its descendants will survive, and the mutation will flourish.

Complex organisms such as plants and animals have inherent DNA repair mechanisms that reduce the rate of mutations. This is because most mutations are incompatible with life, as they destroy critical proteins required for the most basic functions of cell function and life. Cancer is evidence of what happens when these repair mechanisms fail. Viruses do not have such protection; when the high mutation rate is combined with the high replication rate, viral variants are inevitable.

COVID MUTATIONS

Scientists have been tracking mutations of the SARS-CoV-2 virus closely. Countries across the world are basing the re-opening and recovery of their societies on reducing infection rates and preventing re-infections through vaccination programmes. If the virus mutates, it can result in increased infectivity, mortality, and potentially the ability to escape from natural immunity offered by antibodies.

Indian genome scientists first detected the “double variant” of the novel coronavirus in October 2020, and in the UK in Feb 2021. It has been on the rise, and B.1.617 accounts for almost 70% of genomes submitted by India to the global database GISAID. It has a total of 13 mutations, which in turn lead to the change in multiple amino acids. B.1.617 has multiple mutations and describing it as a “double mutant” virus is therefore inaccurate.

L452R

B1617 s more contagious because of a mutation in the spike protein known as L452R.This mutation has been studied as it has also been found in variants identified in California (including apes in San Diego Zoo). It is thought this improves the binding to the ACE2 receptors in the lung and may also have some ability to escape from neutralising antibodies.

E484Q

The second mutation is E484Q, which also affects the spike protein to make it less susceptible to pre-existing antibodies, though there is limited evidence for this. Looking at convalescent plasma donated by people it appears to have weaker neutralisation of B.1.617 in some people, though this isn’t a consistent finding.

Mutations at position 484 have also been found in other global variants, though these E484K mutations lead to different functions. One study looking at the UK B.1.1.7 variant looked at how this E484K mutation affected viral interactions in vaccinated patients. Patients who have been vaccinated produce antibodies with a wide range of actions targeting multiple sections of the spike protein. When these patient serums were exposed to the B.1.1.7 mutation, it was found to have decreased neutralisation. This raised the risk of reduced vaccine efficacy and threatened the vaccine programme. Currently, public health officials are confident our vaccine programmes cover the emerging variants.

CONCERNS

Whilst B.1.617 is concerning, it currently accounts for about 20% of cases in Maharashtra, and likely a low percentage of total infections in the country. There is not yet enough evidence to classify it as a “variant of concern”, and further research is required. Though it has increased potential for spreading, currently the UK variant B.1.1.7 may be on the rise, and more concerning. It has over 50% increased transmissibility and 60% lethality and contributed to the UK’s most recent wave of infections. Genomic studies have shown it is now the dominant form of the virus in the Indian state of Punjab.

What is most concerning, however, is the risk of more variants emerging. As the infection spreads unimpeded through the population, viral replication remains at an all-time high, which in turn increases the risk of mutations. Current mutations are covered by vaccines, future mutations may not be. This is why we need to lower infection rates as soon as possible.

Social distancing, use of masks, vaccinations, lockdowns, and quarantine when expressing symptoms. We have to follow public health advice, to prevent our infection rates from spiralling further out of control

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Best Home Remedies for Glowing Skin

Glowing skin is not simply a cosmetic goal. It is a visible reflection of skin health, hydration, and cellular repair. While the market is flooded with serums and treatments, dermatologists consistently observe that the most sustainable skin glow comes from consistent, simple, and evidence-supported practices. The good news is that many of the most effective ingredients are already available in an Indian kitchen.

Why Skin Loses Its Natural Glow

Before applying any remedy, understanding the root cause of dull skin is essential. Dermatologists identify the following as the most common triggers in the Indian context:

Cause	Effect on Skin
Pollution and sun exposure	Oxidative stress, pigmentation, uneven tone
Dehydration	Reduced elasticity, dryness, dullness
Poor diet and nutrient deficiency	Slowed cell renewal, loss of radiance
Disrupted sleep	Impaired skin repair, dark circles, puffiness
Hormonal imbalance	Acne, oiliness, pigmentation
Harsh skincare products	Damaged skin barrier, redness, sensitivity

Identifying and addressing the underlying cause is as important as applying any topical remedy. Skin that appears dull despite consistent care often signals an internal factor requiring dietary or medical attention.

Which Home Remedy is Best for Glowing Skin?

Among all widely used natural ingredients, raw honey combined with aloe vera gel is considered the most universally effective home remedy for glowing skin. Honey acts as a humectant, drawing moisture into the skin, while its antibacterial and antioxidant compounds protect against environmental damage. Aloe vera complements this by delivering vitamins A, C, and E directly into the skin, supporting collagen synthesis and reducing inflammation.

This combination works across all skin types, requires no preparation time, and demonstrates consistent results in clinical observations relating to skin hydration and barrier repair. Applied three times a week for 15 to 20 minutes, this remedy produces visible improvement in skin texture and brightness within two to three weeks of regular use. For individuals with oily or acne-prone skin, aloe vera used alone without honey is the preferred option as it is non-comedogenic and lightweight.

Top Home Remedies for Glowing Skin by Skin Type

One of the most significant gaps in standard advice is that remedies are rarely matched to skin type. Applying the wrong ingredient can worsen the skin condition rather than improve it. Dermatologists recommend the following skin-type specific approach:

Skin Type	Best Remedy	Key Benefit	Frequency
Dry Skin	Raw honey and milk paste	Deep hydration, lactic acid exfoliation	3 times per week
Oily Skin	Multani mitti with rose water	Sebum control, pore tightening	2 times per week
Combination Skin	Aloe vera gel	Balances moisture without clogging pores	Daily
Sensitive Skin	Oat flour and plain yogurt pack	Soothes inflammation, gentle exfoliation	2 times per week
Normal Skin	Turmeric and honey mask	Antioxidant boost, brightening	2 to 3 times per week
Dull or Pigmented Skin	Potato juice or tomato pulp	Natural kojic acid, reduces pigmentation	3 times per week

Matching the remedy to skin type is the single most important factor in achieving consistent results from any natural skincare routine.

Which Kitchen Ingredients Work Best for Skin Glow?

Several common Indian kitchen ingredients carry clinically recognised skin benefits. The mechanism behind each ingredient matters as much as the application method:

Turmeric (Haldi): Contains curcumin, a potent antioxidant and anti-inflammatory compound. Curcumin inhibits melanin synthesis, which helps reduce pigmentation and uneven skin tone over time. Used as a paste with milk or honey, turmeric is one of the most researched natural brightening agents.

Raw Milk: Contains lactic acid, a naturally occurring alpha hydroxy acid (AHA) that gently exfoliates dead skin cells, stimulates collagen production, and improves skin luminosity. Applying raw cold milk with a cotton pad and leaving it for 15 minutes is a simple and effective brightening practice.

Besan (Gram Flour): Functions as a mild physical exfoliant and oil absorber. Mixed with turmeric and rose water, besan-based face packs have been used across Indian households for generations and remain dermatologically appropriate for most skin types.

Aloe Vera: Rich in polysaccharides that support skin hydration and mucilaginous compounds that form a protective barrier. Clinical data supports its use in reducing UV-induced skin damage and accelerating epidermal repair.

Potato Juice: Contains catecholase, an enzyme with mild skin-lightening properties. Particularly useful for reducing dark circles, tan lines, and post-inflammatory hyperpigmentation.

How to Get Glowing Skin Naturally in One Week

Most competitors list remedies without telling readers how to actually use them together. The following 7-day routine is structured to progressively address cleansing, exfoliation, hydration, and brightening within a single week:

Day	Morning	Evening
Day 1	Raw milk cotton pad cleanse	Aloe vera gel application
Day 2	Rose water toner	Honey and aloe vera mask (15 min)
Day 3	Raw milk cleanse	Turmeric and honey mask (10 min)
Day 4	Rose water toner	Aloe vera gel application
Day 5	Raw milk cleanse	Besan, turmeric and rose water pack (15 min)
Day 6	Rose water toner	Potato juice on dark spots (20 min)
Day 7	Raw milk cleanse	Honey and aloe vera mask (15 min)

This routine uses no more than three to four ingredients across the entire week, minimising the risk of ingredient overload or skin irritation. Always perform a patch test on the inner forearm before applying any new ingredient to the face.

Lifestyle Habits That Support Glowing Skin From Within

Topical remedies address the surface. Skin glow that is deep and lasting is primarily determined by internal health factors that all four competitor articles fail to address:

Hydration: Dermatologists observe that inadequate water intake is the single most common and most overlooked cause of dull skin among Indian adults. A minimum of 2.5 to 3 litres of water daily supports cellular metabolism and maintains skin turgor.

Diet: Skin cells require vitamins C, E, and A along with zinc and omega-3 fatty acids for repair and renewal. Indian dietary staples such as amla (Indian gooseberry), carrots, spinach, walnuts, and flaxseeds provide these nutrients in bioavailable forms. Reducing refined sugar intake is equally important, as excess glucose triggers glycation, a process that breaks down collagen and accelerates skin ageing.

Sleep: The skin's repair cycle peaks during deep sleep between 11 PM and 3 AM. Chronic sleep deprivation elevates cortisol, which degrades collagen and increases inflammatory skin conditions. Clinical specialists recommend seven to eight hours of uninterrupted sleep as a non-negotiable component of any skin improvement plan.

Gut Health: Emerging dermatological research on the gut-skin axis confirms that dysbiosis (imbalance of gut bacteria) is linked to acne, rosacea, and dull skin. Incorporating fermented foods such as curd and buttermilk into the daily diet supports gut microbiome balance, which in turn improves skin clarity.

Home Remedies to Avoid: What Dermatologists Warn Against

This section exists in none of the competing articles and represents the most clinically important addition to this topic. Several widely promoted "natural" skin remedies are actively harmful:

Lemon juice directly on skin: Lemon juice has a pH of approximately 2, far too acidic for direct skin application. It disrupts the skin's natural acid mantle (pH 4.5 to 5.5), causes photosensitivity, and can result in chemical burns or permanent pigmentation when skin is exposed to sunlight post-application.

Baking soda: Despite its popularity on social media, baking soda has an alkaline pH of 9, which severely disrupts the skin barrier, strips natural oils, and causes microbial imbalance on the skin surface.

Toothpaste on pimples: Toothpaste contains fluoride, menthol, and hydrogen peroxide, none of which are formulated for skin. It causes contact dermatitis, dryness, and post-inflammatory hyperpigmentation, particularly on Indian skin tones.

Undiluted essential oils: Applying undiluted tea tree oil, lavender oil, or any essential oil directly on the face without a carrier oil causes irritant contact dermatitis and skin sensitisation.

Dermatologists advise that if a remedy causes stinging, redness, or visible irritation, it should be discontinued immediately regardless of how widely it is recommended online.

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