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Published on: Apr 17, 2020
4 minute read
By: Dr Rajan Choudhary

Vitamin D In Reducing The Risk Of COVID 19

Why Vitamin D is the only supplement we will recommend for you.

Most of our blogs have looked at theories posted on social media, and shown how they are usually not true, or have no factual basis behind them. But here we will show some evidence that supports something truly interesting, especially during the time of this pandemic.

For a number of years research has shown a possible link between vitamin D and illnesses, specifically respiratory infections. In our previous blogs we have shown that vitamin supplementation is unnecessary, except for vitamin D. Here we will show why supplementation may be in your best interest for reducing the risk of COVID.

Now I’ll be honest. Vitamin D and immunity was not something we were taught at medical school, or in medical practice. The fact that such a large amount of research exists on this topic is certainly interesting, and whilst researching this topic I have certainly learnt a lot myself, enough to change my own medical practice. And it is because of the high quality of evidence present that I feel confident in supporting the claims below.

SUMMARY

Many people are low in Vitamin D due to various risk factors (see our blog on vitamin D)
Vitamin D appears to have a role in modulating immune function
Low Vitamin D levels appear to increase the severity of autoimmune disorders
Low Vitamin D levels appear to increase the risk of getting respiratory infections
Vitamin D supplementation appears to reduce the risk of getting respiratory infections
Those who are at risk of having low vitamin D should take low dose supplementations.

If you want the good stuff, skip to the section on SUPPLEMENTATION

IMMUNE FUNCTIONS

As we’ve discussed, vitamin D is key in maintaining the right balance of calcium, ensuring the right amount is taken up from the food we eat, integrated into our bones, and removed in our urine if not required. We know that there are some people who are at risk of vitamin D deficiency, and this is more common in countries closer to the poles and with cloudy weather.

But there also appears to be a role for vitamin D in modulating the immune system. We have found many more cells in our body other than bone, intestine and kidney that possess the vitamin D receptor. These include immune cells, and one role may be to promote proliferation of these cells as well as promote their protective immunity.

AUTOIMMUNE

Due to its role in immune function, studies have been performed to see whether there is a link between autoimmune diseases and vitamin D. Common autoimmune disorders (and the organs the affect) include multiple sclerosis (nerves), rheumatoid arthritis (joints), diabetes mellitus (pancreas), inflammatory bowel disease (bowels) and systemic lupus erythematous (the entire body). All of these diseases lead to loss in function of an organ or system as the immune system recognises the organ as an “invader” and begins to destroy it.

One study looked at 161 patients with early forms of autoimmune diseases over 2 years. Out of them, 35 went on to develop full blown autoimmune disorders (like rheumatoid and lupus). Whilst the two groups of patients were mostly similar, vitamin D was noticeably lower in the group that progressed to disease. But this is one study, with a small number of patients.

Other studies have looked at vitamin D levels in patients across the globe, and the majority of them have shown there to be a correlation between low vitamin D or severe deficiency, and the severity of autoimmune disorder they have. We will not go into them in detail because this is beyond the scope of this blog, but it certainly is interesting and supports this new role for vitamin D.

RESPIRATORY INFECTIONS

We have unknowingly tried to use Vitamin D to treat infections prior to the advent of antibiotics. A common treatment for tuberculosis was to send patients to sanatoriums, where treatments included exposure to sunlight, and provision of cod liver oil, a rich source of vitamin D.

Large population studies done in the 1980s and 1990s involving 19,000 people showed that those with low vitamin D levels were more likely to self report recent upper respiratory tract infections than those with normal levels. This was true even if age, gender, season and race were accounted for. Similar studies have shown similar results when looking at rates of influenza, bacterial vaginosis and HIV.

Normally we are very skeptical with such studies, and look for weaknesses in their methodology and conclusions. After all, we could just cherry pick the studies that show a benefit. Furthermore, just because there is a trend with vitamin D levels and infection, this does not imply a direct link. More evidence is required. However, the fact 19,000 people were surveyed provides this study with good statistical power, and lends it validity. But lets look for more.

SUPPLEMENTATION

Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data – Martineau 2017, British Medical Journal

A systematic review and meta analysis is the highest level of evidence in the realm of medical research. It is the absolute pinnacle of thorough research, looking and comparing other studies with very close scrutiny to see whether we have conducted enough research worldwide to support a theory. In this case this systematic review was published in the British Medical Journal, a highly reputable source that again scrutinises any study submitted thoroughly before accepting it for publication. In my eyes, this is some of the best evidence we will have on this topic. And it is a far sight better than any WhatsApp forwards.

So what does this say?

Vitamin D supplementation was safe and it protected against acute respiratory tract infection overall. Patients who were very vitamin D deficient and those not receiving bolus doses experienced the most benefit.

I don’t think I could have summarised it better myself. If you wish to read the study yourself you can use this link: https://www.bmj.com/content/356/bmj.i6583 Vitamin D supplementation to prevent acute respiratory tract infections

WHAT DOES THIS MEAN FOR ME?

If you are someone who may be at risk of vitamin D deficiency, then low dose supplements (NOT treatment dose) may be beneficial in reducing the risk of getting a respiratory infection. Since COVID is caused by a respiratory virus, we can extrapolate that Vitamin D supplementations may reduce your risk of getting COVID. This is not a cure, and it is not a guaranteed protection. If you already have a balanced diet and are not low in Vit D, it may be less beneficial.

Dr Rajan Choudhary, UK, Chief Product Officer, Second Medic Inc

www.secondmedic.com

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Stroke Warning Signs for Indians Over 40: Early Detection Can Save Lives

Introduction

Stroke is a major health issue in India — both as a cause of death and lifelong disability. For people over 40, the risk climbs sharply. The earlier a stroke is recognized and treated, the better the chances of recovery. In this post, we’ll look at the warning signs of stroke especially relevant in Indians over 40, backed by real survey data, the risk factors common in India, what to do, and how to act fast. Understanding these can help you or your loved ones catch a stroke early and reduce damage.

How Big Is the Problem in India, Especially After 40

According to a 2024 study using Global Burden of Disease data, stroke incidence in India has increased from 76 per 100,000 people in 1990 to ??88 per 100,000 in 2021 for all ages.
Stroke incidence and burden are especially high among people aged 50-69 and over 70.
Another study in North India showed that a large number of adults over 45 lacked awareness about warning signs of stroke: nearly 46% didn’t know warning signs.
Among hypertensive patients (~mean age 54) from Western Rajasthan, about 75% recognized at least one stroke symptom like slurred speech or body-weakness, but 25-30% still lacked awareness.

These figures show that though awareness is improving, there is a significant gap in recognition of warning signs among people over 40 — a high-risk group.

Warning Signs of Stroke (What to Look Out For)

In Indians over 40, common symptoms are similar globally, but here are those particularly reported in Indian surveys:

Sudden Weakness or Numbness on One Side
Many people identified “paralysis of one side of the body” or weakness in an arm or leg. In a Tamil Nadu hospital-based survey, 56% of respondents recognized this symptom.
Facial Droop or Deviation
One side of face droops or mouth slants. In the same survey, ~20% noted deviation of the mouth.
Speech Problems
Slurring, garbled speech, or trouble understanding what others are saying. ~16% in that survey recognized speech impairment.
Vision Disturbance
Sudden trouble with sight in one or both eyes (blurring, loss of vision). Awareness of this is lower: about 53% recognized vision disturbances in a Kerala survey.
Loss of Balance, Dizziness, Severe Headache
Sudden loss of balance or coordination, dizziness, confusion, or sudden, severe headache are also warning signs. Surveys show these are less well recognized compared to motor or speech symptoms but still important.

Risk Factors: What Makes Stroke More Likely After Age 40

Understanding risk helps prevention:

Hypertension (High Blood Pressure) — arguably the biggest factor. Many over-40 Indians have undiagnosed or uncontrolled high BP.
Diabetes Mellitus — often co-exists; increases damage to blood vessels.
Dyslipidemia (High Cholesterol / Lipids)
Smoking & Tobacco Use — cigarettes, chewing tobacco.
Alcohol Use
Obesity / Sedentary Lifestyle
Dietary Risks — high sodium, low fruits/vegetables.
Heart Conditions — atrial fibrillation, prior heart disease.
Other — age itself, stress, sometimes air pollution.

Awareness & Knowledge: What Indian Surveys Reveal

In the Rajasthan survey among hypertensive patients (mean age ~54), around 75-80% knew at least one major warning sign (one?side weakness, speech or vision issues), but 25-30% were unaware.
In a community survey in Kerala, 94.2% identified facial weakness, 86.6% speech disturbances, 84.5% limb weakness. But only ~53% recognized vision issues as a symptom.
In a North Indian telephone survey, nearly half the participants (?46%) did not know warning signs.

So even in literate, more urban or health-aware areas, a non-trivial proportion of people over 40 are not fully aware.

Why Early Recognition Matters

Treatments like thrombolysis (clot-busting medications) are time sensitive — often must be given within a few hours (“golden hour”). Delays drastically reduce benefit.
Early hospital arrival, correct diagnosis, and starting therapy quickly can reduce severity, prevent permanent disability, reduce mortality.
Preventing recurrence: once someone has had a stroke (or mini-stroke), risk of further strokes increases. Early intervention (lifestyle, medicines) matters.

What to Do If You or Someone Over 40 Notices These Signs

Don’t Delay — If sudden facial droop, weakness on one side, speech issues, vision trouble, or sudden severe headache occurs, seek emergency medical help immediately (call ambulance / go to hospital).
Note the Time — When symptoms started. Critical for treatment options.
Diagnostic Tests may include CT/MRI brain, ECG, carotid imaging, labs (blood sugar, lipids etc.).
Medical Management — Control high blood pressure, diabetes, cholesterol; anticoagulants if needed; lifestyle changes.
Rehabilitation — Speech therapy, physiotherapy, occupational therapy if deficits remain.

Real Numbers: What Are the Outcomes / Burden

Adjusted stroke prevalence in India is estimated between 84 and 262 strokes per 100,000 in rural areas, and 334-424 per 100,000 in urban areas depending on the region.
Among those aged 55+, stroke rates jump — e.g., in Trivandrum, rate is ~7.1 per 1,000 people per year for 55+, rising to 13.3 per 1,000 for those aged 75+.
The chance of having a stroke after 55 is roughly 1 in 5 for women and 1 in 6 for men in certain studies, though this includes all adults over 55.

Challenges in India

Delays in recognising signs and reaching hospital. Many people don’t know less obvious symptoms.
Low awareness of treatments and golden period for therapy. Surveys show only a small fraction know about clot lysis or emergency window.
Access issues: hospitals with stroke care, imaging etc. may be far. Costs, transport, awareness all barriers.
Comorbidities often unmanaged (hypertension, diabetes).

Prevention: What Indians Over 40 Can Do Now

Regular health checkups: Monitor blood pressure, blood sugar, cholesterol.
Lifestyle changes: Healthy diet (low salt, more fruits/veg), active lifestyle, avoid tobacco, limit alcohol.
Stay alert to symptoms: Educate self / family about warning signs.
Emergency planning: Know nearest hospital that handles stroke, keep travel / transport options ready.
Medication adherence: If prescribed (for BP, diabetes, heart conditions), don’t skip.

Conclusion & Call to Action

Stroke warning signs for Indians over 40 are often clear—but awareness is still incomplete. Because stroke risk increases with age, recognizing the early warning signs like sudden weakness, facial droop, speech trouble, vision disturbance, and balance issues can make all the difference.

If you or someone over 40 feels any of these, act fast. Time matters. Go to the hospital immediately.

CTA: If you’re over 40, schedule a stroke risk assessment today — check your blood pressure, diabetes, cholesterol, and get informed about warning signs. A simple health check can save your life or someone you care about.

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