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Published on: Apr 06, 2020
2 minute read
By: Dr Rajan Choudhary

MicroRNA That Makes Them Fight COVID Better ?

Recently you may have read a New Delhi based International Center for Genetic Engineering and Biotechnology (ICGEB) sequenced the genome (genetic data) of SARS-COV-2 (coronavirus) from India, Italy, US, Nepal and Wuhan, China. They found that the Indian variant of SARS-CoV2 has the potential to be targeted by antiviral RNA within host cells, a feature that is unique to the Indian strain.

This amazing finding has been published on blogs, newspapers and other media as proof that Indians may not suffer as much as the rest of the world when the COVID-19 pandemic hits the country. One headline touted “MicroRNA in Indians may reduce severity of corona attack”, stating “Indians have comparatively better immunity compared to other countries”. Of course this article is being forwarded on WhatsApp, and enough people may take it as gospel. Is it true?

No.

If you want to know why, just look on the Journal’s website:

“these are preliminary reports that have not been peer-reviewed. They should NOT be regarded as conclusive, guide clinical practice/health-related behaviour, or be reported in news media as established information.”

Research is not easy. I could write a very long explanation for why, but I have summarised it below.

SUMMARY:

- To prove x causes y up to a high scientific standard is incredibly difficult

- Even if you think x causes y, someone might find a flaw in your study

- Numbers can be manipulated by statistics to show what you want to believe

- Reporters might not understand the study and mis-report it

- We all want to believe there is a magic cure that will protect us, that makes us special, immune to this disaster so we can get on with our lives. Unfortunately there simply isn’t one. And believing in them without fact checking can cause more harm than good.

IMMUNITY AGAINST COVID

So what about this study? Firstly it is looking at one tiny mechanism in a cell, when a cell can have millions of proteins responsible for a billion different functions in just the cell itself. Secondly it is not peer reviewed. This means no one has fact checked the study to check whether the design is valid, whether the statistics hold up, whether they have missed something or are making incorrect conclusions based off their data. Peer-reviewing a recent paper showing SARS-CoV-2 and HIV were extremely similar disproved this paper as false.

In the authors defence he acknowledges this:

“In our study, which is a purely computational one, we predicted that this microRNA binds to the SARS-Cov2 genome submitted from India. However, it is too early to comment on it because there is only one high coverage sequence from India, so far,”

Thirdly, the news article says that Indians have better immunity because of this “microRNA”. This is wrong. The study sequenced the genome of the virus, not of the Indian population. Antiviral microRNA is found in all people. The study simply suggests that this might be more effective at targeting the Indian strain of COVID, but it does not make any concrete claims that Indians are protected from COVID.

Again, the journal even states this:

“These are preliminary reports that have not been peer-reviewed. They should not be regarded as conclusive, guide clinical practice/health-related behavior, or be reported in news media as established information.”

But most importantly, even if the paper suggests that the Indian strain may be less potent, it does not give us an excuse to be reckless. We have to adhere to social distancing, hygiene, lockdown principles in order to prevent infection. Because what happens if you take the article stating “Indians have comparatively better immunity compared to other countries” as fact, use this as an excuse to go about your regular daily lives, and it actually turns out that the microRNA has little to no effect on COVID. This endangers yourself and those around you.

Be sensible. Listen to public health officials.

Dr Rajan Choudhary, UK, Chief Product Officer, Second Medic Inc

www.secondmedic.com

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Chest Pain While Breathing: Causes, Warning Signs, and When to Seek Urgent Care

Chest pain is one of the most alarming symptoms a person can experience, especially when it worsens during breathing. Chest pain while breathing, also known as pleuritic chest pain, often indicates involvement of the lungs, chest wall or surrounding structures. While some causes are mild, others can be life-threatening and require immediate medical attention.

In India, respiratory infections, air pollution, sedentary lifestyles and delayed medical care contribute significantly to chest-related symptoms.

What Does Chest Pain While Breathing Mean?

Chest pain while breathing refers to pain that:

worsens with deep inhalation or exhalation
may feel sharp, stabbing or burning
can be localized or spread across the chest

Pain intensity often increases with coughing or movement.

Common Causes of Chest Pain While Breathing

Lung Infections (Pneumonia)

Pneumonia inflames lung tissue and surrounding membranes.

Symptoms include:

chest pain while breathing
fever
cough
breathlessness

ICMR data identifies pneumonia as a major cause of respiratory illness in India.

Pleuritis (Inflammation of Lung Lining)

The pleura are thin membranes surrounding the lungs.

When inflamed:

breathing causes friction
sharp chest pain occurs

Pleuritis often follows viral infections or pneumonia.

Pulmonary Embolism

A blood clot in the lungs causes:

sudden chest pain
rapid breathing
severe breathlessness

This is a medical emergency requiring immediate care.

Chest Wall Muscle Strain

Muscle strain due to:

heavy lifting
intense coughing
poor posture

can cause pain during breathing or movement.

Costochondritis

Inflammation of rib cartilage causes:

localized chest pain
pain worsened by breathing or pressing on the chest

This condition is painful but not life-threatening.

Pneumothorax (Collapsed Lung)

Air leakage into the chest cavity causes:

sudden sharp chest pain
breathlessness

Often seen after trauma or in individuals with lung disease.

Heart-Related Causes

Though heart pain usually does not worsen with breathing, conditions such as:

pericarditis (heart lining inflammation)

can cause chest pain that changes with respiration.

Acid Reflux and Esophageal Spasm

Gastrointestinal causes may mimic chest pain.

However:

pain usually relates to meals
breathing-related pain should be evaluated carefully

Anxiety and Panic Disorders

Anxiety can cause:

chest tightness
rapid breathing
discomfort while breathing

Medical causes must be ruled out before attributing pain to anxiety.

Warning Signs That Require Emergency Attention

Seek immediate medical care if chest pain while breathing is associated with:

sudden onset
severe breathlessness
bluish lips or fingers
dizziness or fainting
sweating
coughing up blood

These may indicate life-threatening conditions.

Risk Factors for Serious Chest Pain

Higher risk occurs in people with:

smoking history
recent surgery or long travel
lung disease
heart disease
clotting disorders

Early evaluation is critical.

Diagnostic Evaluation

Doctors may recommend:

physical examination
chest X-ray
ECG
blood tests
CT scan

Timely diagnosis saves lives.

Why Chest Pain Should Not Be Ignored

Ignoring chest pain can lead to:

delayed treatment
worsening respiratory failure
preventable complications

WHO emphasises early symptom recognition for better outcomes.

Impact of Air Pollution and Lifestyle

Air pollution increases:

lung inflammation
infection risk

Sedentary habits reduce lung capacity, worsening symptoms.

Preventive Measures

Helpful preventive steps include:

avoiding smoking
staying physically active
managing respiratory infections early
maintaining good posture
staying hydrated

Preventive care reduces risk.

Role of Preventive Health Checkups

Regular health screening helps detect:

early lung disease
heart risk factors
chronic inflammation

Early intervention prevents emergencies.

When Chest Pain Is Less Likely Serious

Pain may be less concerning if:

localized
reproducible on touch
improves with rest

However, medical confirmation is still necessary.

Importance of Timely Medical Consultation

Chest pain should always be evaluated by a healthcare professional.

Delaying care can:

increase complications
raise mortality risk

Early action saves lives.

Conclusion

Chest pain while breathing is a critical symptom that should never be ignored. While causes range from muscle strain and infections to serious lung and heart conditions, only proper medical evaluation can determine the exact cause. Early diagnosis, timely treatment and preventive care are essential to protect respiratory and cardiovascular health. When it comes to chest pain, it is always safer to act early than to wait.

References

Indian Council of Medical Research (ICMR) – Respiratory and Cardiovascular Health Reports
World Health Organization (WHO) – Chest Pain and Respiratory Symptoms Guidelines
National Family Health Survey (NFHS-5) – Adult Respiratory Health Data
Lancet – Pulmonary Embolism and Chest Pain Research
NITI Aayog – Preventive Healthcare and Early Symptom Recognition

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