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Published on: Apr 06, 2020
2 minute read
By: Dr Rajan Choudhary

MicroRNA That Makes Them Fight COVID Better ?

Recently you may have read a New Delhi based International Center for Genetic Engineering and Biotechnology (ICGEB) sequenced the genome (genetic data) of SARS-COV-2 (coronavirus) from India, Italy, US, Nepal and Wuhan, China. They found that the Indian variant of SARS-CoV2 has the potential to be targeted by antiviral RNA within host cells, a feature that is unique to the Indian strain.

This amazing finding has been published on blogs, newspapers and other media as proof that Indians may not suffer as much as the rest of the world when the COVID-19 pandemic hits the country. One headline touted “MicroRNA in Indians may reduce severity of corona attack”, stating “Indians have comparatively better immunity compared to other countries”. Of course this article is being forwarded on WhatsApp, and enough people may take it as gospel. Is it true?

No.

If you want to know why, just look on the Journal’s website:

“these are preliminary reports that have not been peer-reviewed. They should NOT be regarded as conclusive, guide clinical practice/health-related behaviour, or be reported in news media as established information.”

Research is not easy. I could write a very long explanation for why, but I have summarised it below.

SUMMARY:

- To prove x causes y up to a high scientific standard is incredibly difficult

- Even if you think x causes y, someone might find a flaw in your study

- Numbers can be manipulated by statistics to show what you want to believe

- Reporters might not understand the study and mis-report it

- We all want to believe there is a magic cure that will protect us, that makes us special, immune to this disaster so we can get on with our lives. Unfortunately there simply isn’t one. And believing in them without fact checking can cause more harm than good.

IMMUNITY AGAINST COVID

So what about this study? Firstly it is looking at one tiny mechanism in a cell, when a cell can have millions of proteins responsible for a billion different functions in just the cell itself. Secondly it is not peer reviewed. This means no one has fact checked the study to check whether the design is valid, whether the statistics hold up, whether they have missed something or are making incorrect conclusions based off their data. Peer-reviewing a recent paper showing SARS-CoV-2 and HIV were extremely similar disproved this paper as false.

In the authors defence he acknowledges this:

“In our study, which is a purely computational one, we predicted that this microRNA binds to the SARS-Cov2 genome submitted from India. However, it is too early to comment on it because there is only one high coverage sequence from India, so far,”

Thirdly, the news article says that Indians have better immunity because of this “microRNA”. This is wrong. The study sequenced the genome of the virus, not of the Indian population. Antiviral microRNA is found in all people. The study simply suggests that this might be more effective at targeting the Indian strain of COVID, but it does not make any concrete claims that Indians are protected from COVID.

Again, the journal even states this:

“These are preliminary reports that have not been peer-reviewed. They should not be regarded as conclusive, guide clinical practice/health-related behavior, or be reported in news media as established information.”

But most importantly, even if the paper suggests that the Indian strain may be less potent, it does not give us an excuse to be reckless. We have to adhere to social distancing, hygiene, lockdown principles in order to prevent infection. Because what happens if you take the article stating “Indians have comparatively better immunity compared to other countries” as fact, use this as an excuse to go about your regular daily lives, and it actually turns out that the microRNA has little to no effect on COVID. This endangers yourself and those around you.

Be sensible. Listen to public health officials.

Dr Rajan Choudhary, UK, Chief Product Officer, Second Medic Inc

www.secondmedic.com

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Lipid Profile Test – Normal Range and Risks

Keeping your heart healthy isn’t just about staying active or eating green veggies. It also means knowing what’s going on inside your body—especially your cholesterol levels. One of the best ways to track this is through a lipid profile test.

If you’re wondering what this test means, what the numbers should be, and what risks you face if they're abnormal—this blog is for you.

Let’s dive into lipid profile test – normal range and risks in easy and clear language.

What Is a Lipid Profile Test?

A lipid profile test is a blood test that measures the amount of fat (lipids) in your blood. These lipids include different types of cholesterol and triglycerides.

The test helps evaluate your risk of heart disease, stroke, and clogged arteries.

What Does the Lipid Profile Test Measure?

A complete lipid profile usually measures:

Total Cholesterol – the overall amount of cholesterol in your blood
LDL (Low-Density Lipoprotein) – the “bad” cholesterol that can block arteries
HDL (High-Density Lipoprotein) – the “good” cholesterol that protects your heart
Triglycerides – a type of fat that provides energy but can cause heart issues in high amounts

Sometimes, the test also calculates VLDL and a cholesterol/HDL ratio to better assess your health risks.

Lipid Profile – Normal Range

Understanding what your numbers mean is key. Here are the recommended normal ranges:

Test Component	Normal Range
Total Cholesterol	Less than 200 mg/dL
LDL (Bad Cholesterol)	Less than 100 mg/dL
HDL (Good Cholesterol)	40 mg/dL or more (men), 50+ (women)
Triglycerides	Less than 150 mg/dL

Note: Values may vary slightly depending on labs and age. Always consult your doctor for interpretation.

Why Is This Test Important?

High cholesterol usually shows no symptoms. That’s why it's called a silent threat.

Your arteries may slowly get clogged without you knowing it, increasing the risk of:

Heart attacks
Strokes
Peripheral artery disease
High blood pressure

A lipid profile gives an early warning so you can make timely changes to protect your heart.

Risks of Abnormal Lipid Profile

Here’s what happens when the results are not in the normal range:

High LDL Cholesterol

Builds plaque in your arteries
Increases risk of heart attack or stroke

Low HDL Cholesterol

Reduces protection for your heart
Makes it easier for bad cholesterol to stick to artery walls

High Triglycerides

Can lead to pancreatitis and diabetes
Often linked with obesity and poor lifestyle

High Total Cholesterol

General risk marker for cardiovascular diseases

Causes of High Cholesterol or Triglycerides

Unhealthy diet (high in fried, fatty, and sugary foods)
Lack of physical activity
Smoking and alcohol consumption
Obesity
Diabetes or thyroid problems
Genetic/family history of high cholesterol

How to Improve Your Lipid Profile Naturally

If your test results are abnormal, you don’t always need medicine right away. Often, small changes in your lifestyle can bring big improvements.

Eat a Heart-Healthy Diet

Choose whole grains, fruits, vegetables, and lean proteins
Avoid processed food, red meat, and fried items
Include omega-3 rich foods like fish, flaxseeds, and walnuts

Exercise Regularly

30 minutes of walking, yoga, cycling, or swimming at least 5 days a week

Quit Smoking & Limit Alcohol

These habits lower HDL and increase LDL

Maintain a Healthy Weight

Losing even 5–10% of body weight can improve lipid levels

How and When to Take the Lipid Profile Test

When to Take:

Once every 12 months for adults above 30
More often if you have heart disease, diabetes, obesity, or a family history

Fasting Required?

Yes, you should fast for 8–12 hours before giving the blood sample for the most accurate results.

Can I Get This Test at Home?

Yes! Platforms like SecondMedic.com offer home sample collection for the Lipid Profile Test, powered by trusted labs like Thyrocare.

You just book the test online, and a technician collects the sample from your doorstep. Results are available digitally within 24–48 hours.

Total cholesterol over 240 mg/dL, LDL over 160 mg/dL, and triglycerides over 200 mg/dL are considered high-risk levels.

Conclusion

A lipid profile test is a simple yet powerful tool that gives deep insights into your heart health. Knowing the normal range and understanding the risks of abnormal levels can help you take control early and live a longer, healthier life.

Stay proactive about your health. Book a lipid profile test – normal range and risks checkup today and make heart-smart choices.

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