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Published on: Apr 06, 2020
2 minute read
By: Dr Rajan Choudhary

MicroRNA That Makes Them Fight COVID Better ?

Recently you may have read a New Delhi based International Center for Genetic Engineering and Biotechnology (ICGEB) sequenced the genome (genetic data) of SARS-COV-2 (coronavirus) from India, Italy, US, Nepal and Wuhan, China. They found that the Indian variant of SARS-CoV2 has the potential to be targeted by antiviral RNA within host cells, a feature that is unique to the Indian strain.

This amazing finding has been published on blogs, newspapers and other media as proof that Indians may not suffer as much as the rest of the world when the COVID-19 pandemic hits the country. One headline touted “MicroRNA in Indians may reduce severity of corona attack”, stating “Indians have comparatively better immunity compared to other countries”. Of course this article is being forwarded on WhatsApp, and enough people may take it as gospel. Is it true?

No.

If you want to know why, just look on the Journal’s website:

“these are preliminary reports that have not been peer-reviewed. They should NOT be regarded as conclusive, guide clinical practice/health-related behaviour, or be reported in news media as established information.”

Research is not easy. I could write a very long explanation for why, but I have summarised it below.

SUMMARY:

- To prove x causes y up to a high scientific standard is incredibly difficult

- Even if you think x causes y, someone might find a flaw in your study

- Numbers can be manipulated by statistics to show what you want to believe

- Reporters might not understand the study and mis-report it

- We all want to believe there is a magic cure that will protect us, that makes us special, immune to this disaster so we can get on with our lives. Unfortunately there simply isn’t one. And believing in them without fact checking can cause more harm than good.

IMMUNITY AGAINST COVID

So what about this study? Firstly it is looking at one tiny mechanism in a cell, when a cell can have millions of proteins responsible for a billion different functions in just the cell itself. Secondly it is not peer reviewed. This means no one has fact checked the study to check whether the design is valid, whether the statistics hold up, whether they have missed something or are making incorrect conclusions based off their data. Peer-reviewing a recent paper showing SARS-CoV-2 and HIV were extremely similar disproved this paper as false.

In the authors defence he acknowledges this:

“In our study, which is a purely computational one, we predicted that this microRNA binds to the SARS-Cov2 genome submitted from India. However, it is too early to comment on it because there is only one high coverage sequence from India, so far,”

Thirdly, the news article says that Indians have better immunity because of this “microRNA”. This is wrong. The study sequenced the genome of the virus, not of the Indian population. Antiviral microRNA is found in all people. The study simply suggests that this might be more effective at targeting the Indian strain of COVID, but it does not make any concrete claims that Indians are protected from COVID.

Again, the journal even states this:

“These are preliminary reports that have not been peer-reviewed. They should not be regarded as conclusive, guide clinical practice/health-related behavior, or be reported in news media as established information.”

But most importantly, even if the paper suggests that the Indian strain may be less potent, it does not give us an excuse to be reckless. We have to adhere to social distancing, hygiene, lockdown principles in order to prevent infection. Because what happens if you take the article stating “Indians have comparatively better immunity compared to other countries” as fact, use this as an excuse to go about your regular daily lives, and it actually turns out that the microRNA has little to no effect on COVID. This endangers yourself and those around you.

Be sensible. Listen to public health officials.

Dr Rajan Choudhary, UK, Chief Product Officer, Second Medic Inc

www.secondmedic.com

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Diabetes Symptoms in Men: Early Warning Signs You Should Not Ignore

Diabetes is one of the fastest-growing health challenges worldwide, and men are particularly vulnerable to its long-term complications. In India, the burden of diabetes has increased sharply over the past two decades, driven by lifestyle changes, sedentary habits and dietary patterns. Despite this, many men remain unaware of early diabetes symptoms or delay medical consultation until complications develop.

Understanding diabetes symptoms in men is essential for early diagnosis, effective management and prevention of serious health consequences.

What Is Diabetes?

Diabetes is a chronic metabolic disorder characterised by high blood sugar levels due to:

insufficient insulin production
ineffective insulin action
or both

The most common form affecting men is type 2 diabetes, which is strongly linked to lifestyle factors.

Why Men Are at Higher Risk

Several factors increase diabetes risk in men:

higher abdominal fat accumulation
smoking and alcohol consumption
irregular eating patterns
work-related stress
lower healthcare-seeking behaviour

According to Indian Council of Medical Research data, a significant proportion of men remain undiagnosed until advanced stages.

Early Diabetes Symptoms in Men

Frequent Urination

Excess sugar in the blood causes kidneys to work harder, leading to increased urination, especially at night.

Excessive Thirst

Frequent urination leads to dehydration, causing constant thirst.

Fatigue and Weakness

Cells cannot utilise glucose efficiently, resulting in low energy levels and persistent tiredness.

Unexplained Weight Changes

Men may experience unexplained weight loss despite normal or increased appetite.

Increased Hunger

Insulin resistance prevents glucose from entering cells, triggering frequent hunger.

Diabetes Symptoms Unique or Commonly Seen in Men

Erectile Dysfunction

Diabetes damages blood vessels and nerves, leading to erectile dysfunction.

Studies show a strong association between diabetes and male sexual health problems.

Reduced Testosterone Levels

Men with diabetes often have lower testosterone, affecting libido, muscle mass and mood.

Decreased Muscle Strength

Poor glucose utilisation affects muscle health and physical stamina.

Skin and Infection-Related Symptoms

Slow-Healing Wounds

High blood sugar impairs wound healing, increasing infection risk.

Frequent Infections

Men with diabetes are more prone to:

skin infections
urinary tract infections
fungal infections

Vision and Nerve Symptoms

Blurred Vision

Fluctuating blood sugar affects eye lenses, causing blurred vision.

Tingling or Numbness

Nerve damage, known as diabetic neuropathy, causes tingling or numbness in hands and feet.

Why Diabetes Symptoms Are Often Ignored by Men

Many men dismiss symptoms as:

work-related fatigue
ageing
stress

This delay increases the risk of complications.

Long-Term Complications of Untreated Diabetes

If untreated, diabetes can lead to:

heart disease
kidney failure
nerve damage
vision loss
sexual dysfunction

According to WHO and Lancet studies, early detection significantly reduces complication risk.

Importance of Early Diagnosis

Early diagnosis allows:

better blood sugar control
lifestyle modification
prevention of organ damage

Routine screening is crucial, even in the absence of symptoms.

When Should Men Get Tested?

Men should consider testing if they:

are over 30 years old
have a family history of diabetes
are overweight
have a sedentary lifestyle
experience any warning signs

Annual screening is recommended for at-risk individuals.

Managing Diabetes After Diagnosis

Effective management includes:

healthy diet
regular physical activity
weight control
stress management
medical treatment as advised

Early management improves quality of life.

Role of Preventive Healthcare

Preventive healthcare focuses on:

early screening
lifestyle intervention
regular follow-up

According to NITI Aayog, preventive strategies are essential to control India’s diabetes burden.

Mental Health and Diabetes in Men

Diabetes can affect mental wellbeing, leading to:

stress
anxiety
depression

Addressing emotional health improves diabetes outcomes.

Breaking the Stigma Around Men’s Health

Men often avoid seeking help due to stigma.

Promoting awareness helps:

normalise health conversations
encourage timely medical care
reduce preventable complications

Conclusion

Diabetes symptoms in men often develop gradually and may go unnoticed for years. Frequent urination, fatigue, unexplained weight changes and sexual health issues should never be ignored. Early diagnosis and timely management significantly reduce the risk of serious complications and improve long-term health outcomes. Awareness, routine screening and proactive healthcare are essential steps for men to protect their health and wellbeing in an era of rising lifestyle diseases.

References

Indian Council of Medical Research (ICMR) – Diabetes Epidemiology and Risk Studies
World Health Organization (WHO) – Diabetes Prevention and Management Guidelines
National Family Health Survey (NFHS-5) – Diabetes Prevalence in Men
Lancet Diabetes & Endocrinology – Male-Specific Diabetes Outcomes
NITI Aayog – Non-Communicable Disease Prevention Reports
Statista – Global Diabetes Trends and Gender Differences

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