Home      What is the main cause of Alzheimer's
Alzheimer's  medical second opinion

What is the main cause of Alzheimer's

There are many potential causes, but Alzheimer's is primarily caused by an accumulation of beta-amyloid plaques.

What is the main cause of Alzheimer's & Can You Prevent Alzheimer’s Disease?

There are many potential causes, but Alzheimer's is primarily caused by an accumulation of beta-amyloid plaques. This is a complicated question without a simple answer, but the most widely accepted theory is that it's an autoimmune disease.

The immune system recognizes brain cells as foreign invaders and kills them by accident, causing inflammation which disrupts brain function. Immunosuppressive medications can slow or even reverse some of the effects of Alzheimer's, but there are no known treatments to stop the damage to cells. Luckily, psychotherapy has shown good results in boosting mental health in patients who are also dealing with Alzheimer's because it helps them resist the ravages of forgetting by reminding themselves about old memories that would have otherwise slipped away.

We are only beginning to understand the causes of Alzheimer's, but some good guesses are plaques containing amyloid-beta deposits on nerve cells. Alzheimer's Disease is an uncertain diagnosis because there are many conditions that can cause symptoms related to dementia or loss of cognitive functioning due to cell death in various parts of the brain. Along with these conditions, not everyone with Alzheimer's Disease exhibits all one symptom according to what is found by their tests. For example, people might have memory problems while still being able to function well enough at work or home without too much emotional inconvenience.


It's not clear what the cause of Alzheimer's disease is. However, there are hypotheses as to what might be the main causes. The leading hypothesis for Alzheimer's disease causation is that it is caused by two types of protein that allow harmful cellular structures called beta-amyloids to form and accumulate: amyloid precursor protein (APP) and presenilin 1 (PS1). Some evidence suggests that APP and PS1 may interact with each other in a way that leads to increased production of beta-amyloids, forming aggregates or tangles which can damage memory and thinking functions.

Alzheimer's used to be thought to be a single disease. Today it is believed that Alzheimer's is actually a group of related conditions with different causes. Alzheimer's is a neurodegenerative disease that destroys the brain cells and their abilities to function properly. Nobody knows what causes it, but there are a few leading theories.

One theory is that a protein called amyloid-beta starts to accumulate in the brain and other parts of the body after we reach middle age. Normally this protein sticks together with other proteins to form webs since it helps protect cell membranes from damage. But for some people who exhibit symptoms during midlife, this may cause changes in one nerve cell which makes memories and sends messages within minutes instead of seconds.

The main cause of Alzheimer's and other forms of dementia is abnormalities in brain structure due to defects in the elimination process. When there are not enough functioning cells or when they can't remember to get rid of worn-out cells, it creates chaos throughout the entire body which manifests itself through inflammation. Brain tangles are just another name for advanced-stage degeneration within the brain. And once this protein is released without being caught by phagocytic cells, inflammation appears because this protein actually attracts immune cells that produce more cytokines.

Alzheimer's Disease is a neurological disease that can affect memory, behavior, and mental capacity. While many factors of the aging process play a role in the development of Alzheimer's, scientists do not yet know how these factors interact and cause symptoms to appear. A link between levels of physical activity and cognitive function has been observed during the course of age-related neurodegenerative diseases. Typical recommendations for brain health include eating healthy food, staying social with family/friends, getting adequate sleep, and following a healthy diet plan as an example with omega 3 fatty acids as key nutrients with protecting the body from inflammation.

The evidence points to a type of protein called amyloid-beta that builds up in the brain and blocks cell receptors with its fibers. Clumps of this type of protein can cause plaque deposits, which is what eventually causes Alzheimer's disease. This plaque contains several forms of beta-amyloid proteins and other substances such as phosphorylated tau proteins, metals, bone fragments, and fat cells. This makes it difficult for nutrients to reach the tissue next to these clumps causing healthy brain cells nearby to die off gradually or break down more quickly than they would otherwise due to their exposure to toxic substances.

Alzheimer’s disease prevention starts with the elimination of toxins in food, air, and water which can harm brain cells. As with any other chronic medical condition, Alzheimer’s disease is a lifestyle-driven disorder that might be prevented by avoiding one or more risk factors found in our daily habits.

Many steps can be taken to avoid developing Alzheimer's disease (likely age-related dementia caused by accumulations of amyloid plaques and tau tangles in the brain). Here are some simple healthy lifestyle changes you should incorporate into daily life:

1) Increase your dietary intake of antioxidants such as those found in blueberries and other dark-colored fruits

2) Increase your intake of omega-3 fatty acids found in fish and nuts which help combat inflammation

3) Exercise on a regular basis which increases blood flow for supplying nutrients to brain cells

4) Stop smoking or drinking alcohol excessively as these


Alzheimer's is a progressive, age-related brain disease that slowly destroys memory and thinking skills. Sadly, there are no medicines to prevent or cure Alzheimer's. Treatment focuses on managing the symptoms of the disease

There are several things you can do to help reduce your risk of getting Alzheimer’s Disease--see below for more information. Some things will also help in slowing down its progression once it does show up in your life--again, see below for important suggestions...

- Drink plenty of water (minimum 8 glasses daily)

- Fish oil offers omega 3 fatty acids (good fats)- Garlic (protects against cognitive decline because it contains vitamin B12)

- Eat nuts regularly, if not allergic

What we know is that the more glucose there is in the brain of an Alzheimer's patient, the worse their condition gets. This makes sense because Alzheimer’s Disease has been linked to chronic inflammation and over-activation of immune cells within the brain – conditions which are exacerbated by sugar consumption. If you or someone you know has diabetes it would really be a good idea not only to lower your blood sugar levels through diet, medication, and lifestyle changes; lowering those levels might be one way of mitigating against developing Alzheimer’s Disease.

Unfortunately, although early detection is important in Alzheimer's Disease, there are no preventative treatments available. However, one out of three Americans over the age of 65 has dementia. By eating a diet rich in dark leafy greens and getting enough exercise, you can reduce your risk of developing this disease. This is because these foods are high in folate which helps to prevent damage due to oxidative stress. And extra cardio by walking 30-60 minutes five days a week will help to cleanse the brain of toxins that could build-up due to certain neurotransmitters that may be less active than normal such as acetylcholine and glutamate that work together with magnesium and vitamin B6.

There is significant evidence to suggest the use of all the following. Studies show that achieving and maintaining a healthy weight, exercising on a regular basis, not smoking, eating a heart-healthy diet, lowering stress levels, and getting plenty of sleep can dramatically reduce your risk for Alzheimer’s.

However recent studies have shown that Alzheimer’s Disease may be due to an infection from amoeba toxins found in water as one's immune system weakens as they age. In these cases, antibiotics could provide some prevention against this disease. In rare cases where surgery has gone wrong or left some part open to germs, those areas often degenerate with damage from bacteria or fungi.

It is not yet known whether preventive measures can be taken to prevent Alzheimer's Disease. However, identifying high-risk individuals early on might allow for the halting of cognitive decline before symptoms become severe enough for an Alzheimer’s diagnosis. Evaluation by a medical professional should occur well in advance of any changes in cognition so that treatment options can be explored if need be before symptoms develop. And many times it takes no more than changing one's diet and cutting back on caffeine to allay the symptoms of forgetfulness or short-term memory loss which are often precursors to Alzheimer’s Disease. Cognitive stimulation through reading, puzzles, games, and active engagement may also prove helpful.

In the decades ahead, the development of new diagnostic tests and treatments with properties that can combat or cure Alzheimer’s as well as continuing efforts to decrease the negative effects on cognitive function from conditions such as stroke is presumed to result in a huge increase in life expectancy with diminished levels of dementia. For those who have made it this far with good health and no history of significant mental decline, continued research is being done with laboratory mice which suggests a powerful effect may be possible by targeting a specific gene family, called MST1/4/5-like genes.

People with Alzheimer’s who exercise moderately may have a reduced risk for developing the condition. In other words, it can help. In order for exercise to matter, one should be consistently exercising over time and also eating plenty of vegetables and fruit. This way, aging biomarkers in the brain can be affected so that they adopt a more youthful profile—like lowering inflammation and reducing cell death rates—which may lead to better cognitive performance later in life.



Get Quick Consultation & Support
Chat with Whatsapp