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Published on: Apr 13, 2020
3 minute read
By: Dr Rajan Choudhary

Plasma Treatment For COVID-19?

TREATING COVID WITH BLOOD

We have previously covered proposed treatments for COVID-19, in particular hydroxychloroquine, and explained why we shouldn’t look for a magic cure for this disease. Viruses are difficult to treat, and ultimately supportive treatment appears to be best we can achieve. But an editorial published in BioMedicine Central appears to show a novel treatment for the most ill patients, one that may have flown under most people’s radar.

“A novel treatment approach to the novel coronavirus: an argument for the use of therapeutic plasma exchange for fulminant COVID-19”

An interesting title. Lets dissect it.

SUMMARY

- Blood is made up of many different components

- The immune system recognises the virus and produces antibodies against it to neutralise it

- These antibodies float in the blood plasma, a watery solution

- The plasma can be extracted from donated blood, and given to patients suffering from COVID-19

- So far evidence suggests it can help treat the most seriously affected patients.

WHAT IS IN OUR BLOOD

To understand this we must first understand what our blood is made of. Most people know that blood functions to transport oxygen from our lungs. But this is an oversimplification. Blood has many different functions:

- Transport: along with oxygen it transports sugars, fats, protein subunits throughout the body. This is done with the watery PLASMA of the blood.

- Clot: cells and protein structures act to plug any holes that form from cuts and damage. This is done by the PLATELETS in the blood

- Immunity: Immune cells respond to bacteria, viruses, parasites in the blood and body. They target these pathogens, identify and tag them with antibodies, and ultimately destroy them. This is done by the WHITE BLOOD CELLS.

And many more functions that we won’t bore you with.

IMMUNITY

It is this last point that is of interest to us. Our immune system consists of white blood cells that can recognise invading organisms in the blood, around cells and even invaders hiding within our own cells. All cells have protein markers on their surface, no matter if its human cells, bacterial, viral, fungal etc. These markers can be highlighted and targeted by specialised white blood cells, who in turn produce antibodies against these markers. Think of antibodies as handcuffs with flares attached: once attached other white blood cells use this information to find and destroy the invaders.

What is amazing about antibodies is how complex they are. The proteins in our body are incredibly complex. They are long chains that fold into unique shapes depending on hundreds of different types of chemical interactions. These are so complex that supercomputers can take literal years to figure out the shape of a single protein and how it folds depending on the subunits in its chain. This means that our immune system has to recognise these markers and figure out a complementary tag out of hundreds of billions of potential sequences. Antibodies have to be specific to their tag. If an antibody is produced that can target more than one tag, it can cause problems. If it targets a bacterial tag, but accidentally highlights the person’s cells as well, the immune system will start targeting and destroying the person’s organs. These auto-immune disorders can be devastating.

But when they work, antibodies are miraculous. They persist in the blood after an infection, and if a second infection occurs, memory cells in the blood can rapidly produce these antibodies before the infection can even produce symptoms. This is known as immunity, and is why we usually don’t get the same illness twice. Antibody based treatment is see as the future of medical therapy, and is something we will cover in future blogs.

PLASMA EXCHANGE

From population testing we can see that the majority of patients with COVID-19 recover, experiencing either mild symptoms, moderate symptoms requiring some form of treatment and hospitalisation, or no symptoms whatsoever. In these patients their immune system will have successfully recognised the virus and produced antibodies against it to neutralise the virus. It is the patients with severe symptoms, those in which the virus is running rampant in the body, that the production of antibodies happens too late.

Plasma exchange involves obtaining blood from patients who have beaten the virus, spinning the blood to separate out the red cells, white cells, platelets and watery plasma. The plasma contains all the glucose, small proteins and importantly for us, the antibodies. This plasma can be transfused into patients with COVID-19 that cannot cope, in order to help their immune system. These transfused antibodies will neutralise some of the viruses in the patient, reducing the viral load, amount of replication and cell destruction that causes such devastating symptoms in COVID-19.

The published editorial showed that in the most critical pneumonia patients, requiring mechanical ventilators and drugs to support the heart, mortality in plasma exchange patients resulted in a 47.8% mortality instead of 81.3%. Of course it is a single study with a limited number of patients, but the results are encouraging. It is further helped by the fact plasma exchange is a well established therapy, with established protocols known to intensivists and haematologists.

THE FUTURE

We may see the use of Plasma exchange for critically ill patients increase as the pandemic continues. It is not a treatment option available for everyone, as it requires intravenous access and careful monitoring in a controlled setting. But it also needs donation from people who have recovered from COVID and have suitable antibodies. So whilst it might not be a magic pill that everyone expects to cure COVID, it might be the difference between life and death for those that need it most.

Dr Rajan Choudhary, UK, Chief Product Officer, Second Medic Inc

www.secondmedic.com

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Insomnia in Teens and How to Manage It

Sleep is essential for growing teens, yet many struggle to get enough of it. From school stress to social media scrolling, teenagers today face multiple challenges that affect their sleep. One of the most common sleep disorders among adolescents is insomnia—the inability to fall asleep, stay asleep, or wake up feeling rested.

In this blog, we’ll break down the causes, effects, and simple strategies to handle insomnia in teens and how to manage it naturally.

What is Insomnia?

Insomnia is a sleep disorder that makes it hard to fall asleep, stay asleep, or get quality rest. Teens with insomnia often feel tired during the day, even if they’ve spent enough time in bed.

There are two main types:

Short-term insomnia: Lasts for a few days or weeks, often triggered by stress or changes in routine.
Chronic insomnia: Occurs at least three times a week for over three months.

Why Is Insomnia Common in Teens?

Teenagers go through many physical, emotional, and social changes. All these factors can disturb their sleep:

1. Hormonal Shifts

During puberty, the sleep hormone melatonin is released later at night. This shifts the body clock, making teens naturally want to sleep and wake up later.

2. Screen Time

Excessive use of phones, tablets, or laptops before bedtime exposes the brain to blue light, which delays melatonin release and interferes with sleep.

3. Academic Stress

Homework, exams, and performance pressure can cause anxiety and overthinking at night, preventing restful sleep.

4. Caffeine Intake

Energy drinks, tea, coffee, and cola consumed in the evening can make it difficult to fall asleep due to their stimulating effects.

5. Mental Health Issues

Anxiety, depression, and emotional distress are often linked with poor sleep in teens.

Signs of Insomnia in Teenagers

Difficulty falling asleep at night
Waking up multiple times during the night
Feeling tired or sleepy during the day
Irritability or mood swings
Trouble focusing in school
Frequent headaches or stomach issues
Increased use of stimulants (coffee, energy drinks)

How Insomnia Affects Teens

Sleep deprivation can harm a teen's physical and mental health. Here are a few ways it affects their well-being:

Poor concentration in school
Weakened immunity
Increased risk of depression and anxiety
Weight gain due to hormonal imbalance
Risky behaviors due to impaired judgment

Teens who consistently sleep less than 7–8 hours are more likely to face emotional and academic challenges.

Natural Ways to Manage Insomnia in Teens

Thankfully, insomnia doesn’t always need medication. Many teens can improve their sleep with simple lifestyle changes.

1. Set a Regular Sleep Schedule

Encourage going to bed and waking up at the same time every day—even on weekends. This helps reset the body’s internal clock.

2. Limit Screen Time Before Bed

Avoid phones, TVs, and tablets at least 1 hour before bedtime. Use “night mode” or blue light filters if screen use is necessary.

3. Practice Relaxation Techniques

Deep breathing, meditation, gentle yoga, or reading a book before bed can calm the mind and prepare the body for sleep.

4. Watch Food and Drink

Avoid heavy meals, sugar, or caffeine in the evening. A light snack like warm milk, bananas, or almonds can promote better sleep.

5. Get Daily Exercise

Physical activity during the day can improve sleep quality—but avoid intense workouts right before bedtime.

6. Create a Sleep-Friendly Environment

Keep the bedroom cool, dark, and quiet. Use blackout curtains, soft bedding, and remove distractions like phones or bright lights.

When to See a Doctor

If your teen’s insomnia lasts longer than 3 weeks or affects their daily life, school, or mood, it’s important to consult a doctor or sleep specialist. Underlying conditions like anxiety, ADHD, or depression might need professional care.

Lab Tests That May Help

If your teen complains of constant fatigue or disrupted sleep, you might consider lab tests to rule out medical reasons such as:

Thyroid Function Test (for hormonal imbalance)
Vitamin D & B12 Tests (deficiency can affect sleep)
Stress Hormone Panel (Cortisol)
Iron Levels (especially in girls)

These tests are available through diagnostic providers like Thyrocare on platforms like SecondMedic.

Helping Teens Build Healthy Sleep Habits

As a parent, here’s how you can support better sleep:

Encourage open conversations about school pressure or emotional issues.
Set boundaries for screen use, especially at night.
Make the home environment calm and supportive before bedtime.
Lead by example—follow healthy sleep habits yourself.

Quick Tips for Teens

Sleep 8–10 hours every night
Don’t study in bed
Use a sleep diary or app to track sleep patterns
Avoid naps longer than 30 minutes in the day
Try journaling to clear the mind before sleep

Conclusion

Teenage insomnia is more common than many people realize. Fortunately, with the right support, structure, and healthy routines, it can be managed without medication.

If your teen shows signs of poor sleep, don’t ignore it. Better sleep leads to better mood, focus, and health.

So, if you’re wondering how to support better sleep for your child, remember to understand insomnia in teens and how to manage it the natural way—with empathy, good habits, and expert care when needed.

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