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Published on: Apr 13, 2020
3 minute read
By: Dr Rajan Choudhary

Plasma Treatment For COVID-19?

TREATING COVID WITH BLOOD

We have previously covered proposed treatments for COVID-19, in particular hydroxychloroquine, and explained why we shouldn’t look for a magic cure for this disease. Viruses are difficult to treat, and ultimately supportive treatment appears to be best we can achieve. But an editorial published in BioMedicine Central appears to show a novel treatment for the most ill patients, one that may have flown under most people’s radar.

“A novel treatment approach to the novel coronavirus: an argument for the use of therapeutic plasma exchange for fulminant COVID-19”

An interesting title. Lets dissect it.

SUMMARY

- Blood is made up of many different components

- The immune system recognises the virus and produces antibodies against it to neutralise it

- These antibodies float in the blood plasma, a watery solution

- The plasma can be extracted from donated blood, and given to patients suffering from COVID-19

- So far evidence suggests it can help treat the most seriously affected patients.

WHAT IS IN OUR BLOOD

To understand this we must first understand what our blood is made of. Most people know that blood functions to transport oxygen from our lungs. But this is an oversimplification. Blood has many different functions:

- Transport: along with oxygen it transports sugars, fats, protein subunits throughout the body. This is done with the watery PLASMA of the blood.

- Clot: cells and protein structures act to plug any holes that form from cuts and damage. This is done by the PLATELETS in the blood

- Immunity: Immune cells respond to bacteria, viruses, parasites in the blood and body. They target these pathogens, identify and tag them with antibodies, and ultimately destroy them. This is done by the WHITE BLOOD CELLS.

And many more functions that we won’t bore you with.

IMMUNITY

It is this last point that is of interest to us. Our immune system consists of white blood cells that can recognise invading organisms in the blood, around cells and even invaders hiding within our own cells. All cells have protein markers on their surface, no matter if its human cells, bacterial, viral, fungal etc. These markers can be highlighted and targeted by specialised white blood cells, who in turn produce antibodies against these markers. Think of antibodies as handcuffs with flares attached: once attached other white blood cells use this information to find and destroy the invaders.

What is amazing about antibodies is how complex they are. The proteins in our body are incredibly complex. They are long chains that fold into unique shapes depending on hundreds of different types of chemical interactions. These are so complex that supercomputers can take literal years to figure out the shape of a single protein and how it folds depending on the subunits in its chain. This means that our immune system has to recognise these markers and figure out a complementary tag out of hundreds of billions of potential sequences. Antibodies have to be specific to their tag. If an antibody is produced that can target more than one tag, it can cause problems. If it targets a bacterial tag, but accidentally highlights the person’s cells as well, the immune system will start targeting and destroying the person’s organs. These auto-immune disorders can be devastating.

But when they work, antibodies are miraculous. They persist in the blood after an infection, and if a second infection occurs, memory cells in the blood can rapidly produce these antibodies before the infection can even produce symptoms. This is known as immunity, and is why we usually don’t get the same illness twice. Antibody based treatment is see as the future of medical therapy, and is something we will cover in future blogs.

PLASMA EXCHANGE

From population testing we can see that the majority of patients with COVID-19 recover, experiencing either mild symptoms, moderate symptoms requiring some form of treatment and hospitalisation, or no symptoms whatsoever. In these patients their immune system will have successfully recognised the virus and produced antibodies against it to neutralise the virus. It is the patients with severe symptoms, those in which the virus is running rampant in the body, that the production of antibodies happens too late.

Plasma exchange involves obtaining blood from patients who have beaten the virus, spinning the blood to separate out the red cells, white cells, platelets and watery plasma. The plasma contains all the glucose, small proteins and importantly for us, the antibodies. This plasma can be transfused into patients with COVID-19 that cannot cope, in order to help their immune system. These transfused antibodies will neutralise some of the viruses in the patient, reducing the viral load, amount of replication and cell destruction that causes such devastating symptoms in COVID-19.

The published editorial showed that in the most critical pneumonia patients, requiring mechanical ventilators and drugs to support the heart, mortality in plasma exchange patients resulted in a 47.8% mortality instead of 81.3%. Of course it is a single study with a limited number of patients, but the results are encouraging. It is further helped by the fact plasma exchange is a well established therapy, with established protocols known to intensivists and haematologists.

THE FUTURE

We may see the use of Plasma exchange for critically ill patients increase as the pandemic continues. It is not a treatment option available for everyone, as it requires intravenous access and careful monitoring in a controlled setting. But it also needs donation from people who have recovered from COVID and have suitable antibodies. So whilst it might not be a magic pill that everyone expects to cure COVID, it might be the difference between life and death for those that need it most.

Dr Rajan Choudhary, UK, Chief Product Officer, Second Medic Inc

www.secondmedic.com

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20% Health Time | A Smarter Way to Build Workplace Wellbeing

Modern workplaces are increasingly recognising that employee health is not separate from performance—it is foundational to it. Long work hours, constant digital connectivity and rising stress levels have led to burnout, lifestyle diseases and declining engagement across industries. In this context, the concept of 20% Health Time has emerged as a forward-thinking approach to workplace wellness.

20% Health Time allows employees to dedicate a portion of their paid working hours specifically to activities that support physical, mental and preventive health. Rather than treating wellness as an after-hours responsibility, this model integrates health directly into the work culture.

What Is 20% Health Time?

20% Health Time is a structured workplace initiative where employees are encouraged or allowed to spend approximately one-fifth of their working time on health-related activities.

These activities may include:

physical exercise or movement breaks
mental wellness practices
health education sessions
preventive health screenings
stress management and recovery

The core idea is simple: healthier employees perform better and sustain productivity longer.

Why Traditional Wellness Programs Fall Short

Many organisations offer wellness benefits such as gym memberships or annual checkups. While valuable, these programs often fail because:

employees lack time to use them
wellness is seen as optional
participation remains low
benefits are disconnected from daily work

20% Health Time addresses these gaps by embedding wellness into regular work hours.

Why Health Time Matters in Today’s Workplace

Rising Lifestyle Disease Burden

Public health data shows increasing rates of:

diabetes
hypertension
obesity
mental health disorders

These conditions affect working-age adults and directly impact productivity and healthcare costs.

Burnout and Mental Fatigue

Constant pressure and lack of recovery time lead to:

chronic stress
disengagement
absenteeism
high attrition

Health Time creates space for recovery and resilience.

Sedentary Work Culture

Desk-bound work contributes to:

musculoskeletal problems
cardiovascular risk
low energy levels

Dedicated health time encourages movement and prevention.

How 20% Health Time Benefits Employees

Improved Physical Health

Regular movement and preventive care reduce long-term health risks.

Better Mental Wellbeing

Time for mindfulness, rest and stress management improves emotional balance.

Higher Energy and Focus

Healthy routines improve concentration and reduce fatigue.

Empowerment and Autonomy

Employees feel trusted to manage their wellbeing, increasing engagement.

How Employers Benefit from 20% Health Time

Increased Productivity

Healthy employees work more efficiently and make fewer errors.

Reduced Absenteeism

Preventive care lowers sick days and health-related disruptions.

Lower Healthcare Costs

Early detection and healthier habits reduce long-term medical expenses.

Stronger Employer Brand

Wellbeing-focused policies attract and retain top talent.

Sustainable Performance

Health Time supports long-term performance rather than short-term output.

Activities That Fit into 20% Health Time

Organisations can tailor activities based on workforce needs:

guided fitness or yoga sessions
walking or movement breaks
mental health workshops
preventive health checkups
nutrition education
stress and sleep management programs

Flexibility ensures inclusivity across roles and work models.

Evidence Supporting Health Time Initiatives

Workplace health research consistently shows that:

preventive health improves productivity
employee wellbeing programs reduce burnout
time invested in health yields measurable returns

According to WHO and workplace wellness studies, integrated health initiatives deliver better outcomes than standalone benefits.

Addressing Common Concerns

“Will this reduce working hours?”

No. Health Time improves efficiency, offsetting time spent through better performance.

“Is it suitable for high-pressure roles?”

Yes. High-stress roles benefit the most from structured recovery time.

“How do we measure impact?”

Metrics may include:

reduced absenteeism
improved engagement scores
lower healthcare claims
better retention

Implementing 20% Health Time Effectively

Successful implementation requires:

leadership support
clear guidelines
flexible scheduling
inclusive activity options
regular feedback

Health Time works best when seen as a cultural shift, not a perk.

Long-Term Impact on Organisational Health

Over time, organisations adopting Health Time observe:

healthier workforce
improved morale
reduced burnout
stronger team cohesion
sustainable growth

These benefits compound year after year.

Conclusion

20% Health Time represents a progressive shift in how organisations view employee wellbeing. By dedicating work time to health, companies acknowledge that productivity and wellbeing are deeply connected. Rather than reacting to burnout and illness, Health Time promotes prevention, balance and resilience. In a future where talent, performance and sustainability matter more than ever, integrating health into the workday is not a luxury—it is a strategic necessity.

References

World Health Organization (WHO) – Workplace Health Promotion Guidelines
Indian Council of Medical Research (ICMR) – Lifestyle Disease and Work Health Reports
NITI Aayog – Preventive Healthcare and Workforce Wellbeing Strateg
Lancet – Workplace Wellness and Productivity Studies
Harvard Business Review – Employee Wellbeing and Performance Research
Statista – Corporate Wellness Trends and ROI Data

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