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Published on: Apr 13, 2020
3 minute read
By: Dr Rajan Choudhary

Plasma Treatment For COVID-19?

TREATING COVID WITH BLOOD

We have previously covered proposed treatments for COVID-19, in particular hydroxychloroquine, and explained why we shouldn’t look for a magic cure for this disease. Viruses are difficult to treat, and ultimately supportive treatment appears to be best we can achieve. But an editorial published in BioMedicine Central appears to show a novel treatment for the most ill patients, one that may have flown under most people’s radar.

“A novel treatment approach to the novel coronavirus: an argument for the use of therapeutic plasma exchange for fulminant COVID-19”

An interesting title. Lets dissect it.

SUMMARY

- Blood is made up of many different components

- The immune system recognises the virus and produces antibodies against it to neutralise it

- These antibodies float in the blood plasma, a watery solution

- The plasma can be extracted from donated blood, and given to patients suffering from COVID-19

- So far evidence suggests it can help treat the most seriously affected patients.

WHAT IS IN OUR BLOOD

To understand this we must first understand what our blood is made of. Most people know that blood functions to transport oxygen from our lungs. But this is an oversimplification. Blood has many different functions:

- Transport: along with oxygen it transports sugars, fats, protein subunits throughout the body. This is done with the watery PLASMA of the blood.

- Clot: cells and protein structures act to plug any holes that form from cuts and damage. This is done by the PLATELETS in the blood

- Immunity: Immune cells respond to bacteria, viruses, parasites in the blood and body. They target these pathogens, identify and tag them with antibodies, and ultimately destroy them. This is done by the WHITE BLOOD CELLS.

And many more functions that we won’t bore you with.

IMMUNITY

It is this last point that is of interest to us. Our immune system consists of white blood cells that can recognise invading organisms in the blood, around cells and even invaders hiding within our own cells. All cells have protein markers on their surface, no matter if its human cells, bacterial, viral, fungal etc. These markers can be highlighted and targeted by specialised white blood cells, who in turn produce antibodies against these markers. Think of antibodies as handcuffs with flares attached: once attached other white blood cells use this information to find and destroy the invaders.

What is amazing about antibodies is how complex they are. The proteins in our body are incredibly complex. They are long chains that fold into unique shapes depending on hundreds of different types of chemical interactions. These are so complex that supercomputers can take literal years to figure out the shape of a single protein and how it folds depending on the subunits in its chain. This means that our immune system has to recognise these markers and figure out a complementary tag out of hundreds of billions of potential sequences. Antibodies have to be specific to their tag. If an antibody is produced that can target more than one tag, it can cause problems. If it targets a bacterial tag, but accidentally highlights the person’s cells as well, the immune system will start targeting and destroying the person’s organs. These auto-immune disorders can be devastating.

But when they work, antibodies are miraculous. They persist in the blood after an infection, and if a second infection occurs, memory cells in the blood can rapidly produce these antibodies before the infection can even produce symptoms. This is known as immunity, and is why we usually don’t get the same illness twice. Antibody based treatment is see as the future of medical therapy, and is something we will cover in future blogs.

PLASMA EXCHANGE

From population testing we can see that the majority of patients with COVID-19 recover, experiencing either mild symptoms, moderate symptoms requiring some form of treatment and hospitalisation, or no symptoms whatsoever. In these patients their immune system will have successfully recognised the virus and produced antibodies against it to neutralise the virus. It is the patients with severe symptoms, those in which the virus is running rampant in the body, that the production of antibodies happens too late.

Plasma exchange involves obtaining blood from patients who have beaten the virus, spinning the blood to separate out the red cells, white cells, platelets and watery plasma. The plasma contains all the glucose, small proteins and importantly for us, the antibodies. This plasma can be transfused into patients with COVID-19 that cannot cope, in order to help their immune system. These transfused antibodies will neutralise some of the viruses in the patient, reducing the viral load, amount of replication and cell destruction that causes such devastating symptoms in COVID-19.

The published editorial showed that in the most critical pneumonia patients, requiring mechanical ventilators and drugs to support the heart, mortality in plasma exchange patients resulted in a 47.8% mortality instead of 81.3%. Of course it is a single study with a limited number of patients, but the results are encouraging. It is further helped by the fact plasma exchange is a well established therapy, with established protocols known to intensivists and haematologists.

THE FUTURE

We may see the use of Plasma exchange for critically ill patients increase as the pandemic continues. It is not a treatment option available for everyone, as it requires intravenous access and careful monitoring in a controlled setting. But it also needs donation from people who have recovered from COVID and have suitable antibodies. So whilst it might not be a magic pill that everyone expects to cure COVID, it might be the difference between life and death for those that need it most.

Dr Rajan Choudhary, UK, Chief Product Officer, Second Medic Inc

www.secondmedic.com

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Digestive System Disorders: Common Causes, Symptoms, and Prevention Tips

The digestive system plays a vital role in overall health by breaking down food, absorbing nutrients and eliminating waste. When this system does not function properly, it can lead to discomfort, poor nutrition and chronic illness. Digestive system disorders are increasingly common due to modern lifestyles, dietary habits and stress. Understanding their causes, symptoms and prevention strategies is essential for maintaining long-term gut health.

Public health research shows that a large proportion of adults experience digestive symptoms at some point in their lives, yet many delay seeking care until problems become severe.

What Are Digestive System Disorders?

Digestive system disorders are conditions that affect:

the oesophagus
stomach
intestines
liver
pancreas
gallbladder

They may be temporary or chronic and range from mild functional issues to serious inflammatory or structural diseases.

Common Digestive System Disorders

Acid Reflux and GERD

Gastroesophageal reflux disease (GERD) occurs when stomach acid flows back into the oesophagus.

Symptoms include:

heartburn
chest discomfort
sour taste in mouth
difficulty swallowing

Long-term reflux can damage the oesophagus if untreated.

Irritable Bowel Syndrome (IBS)

IBS is a functional bowel disorder.

Symptoms include:

abdominal pain
bloating
diarrhoea or constipation
alternating bowel habits

Stress and diet often trigger symptoms.

Constipation

Constipation involves infrequent or difficult bowel movements.

Causes include:

low fibre intake
dehydration
sedentary lifestyle

Chronic constipation affects comfort and gut function.

Diarrhoea

Diarrhoea results from rapid bowel movements.

Common causes include:

infections
food intolerance
medication side effects

Persistent diarrhoea may lead to dehydration and nutrient loss.

Peptic Ulcer Disease

Ulcers are sores in the stomach or intestinal lining.

Symptoms include:

burning stomach pain
nausea
bloating

They are often linked to infections or long-term medication use.

Inflammatory Bowel Disease (IBD)

IBD includes conditions like Crohn’s disease and ulcerative colitis.

Symptoms include:

chronic diarrhoea
abdominal pain
weight loss
fatigue

IBD requires long-term medical management.

Common Symptoms of Digestive Disorders

Digestive system disorders often present with:

abdominal pain or cramps
bloating and gas
nausea or vomiting
constipation or diarrhoea
heartburn
unexplained weight changes

Symptoms may fluctuate and worsen with stress or poor diet.

Causes of Digestive System Disorders

Poor Dietary Habits

Diets high in:

processed foods
refined sugars
unhealthy fats

strain the digestive system and alter gut microbiota.

Stress and Mental Health

Chronic stress affects gut-brain communication, worsening digestive symptoms.

Infections

Bacterial, viral or parasitic infections disrupt gut function.

Food Intolerances

Lactose, gluten or other intolerances cause digestive distress.

Sedentary Lifestyle

Lack of physical activity slows digestion and bowel movement.

Medication Use

Certain medications irritate the stomach lining or alter gut flora.

Who Is at Higher Risk?

People at increased risk include:

individuals with poor diet
those under chronic stress
older adults
people with family history of gut disease
individuals with sedentary lifestyles

Early lifestyle correction reduces risk significantly.

Diagnosis of Digestive Disorders

Evaluation may include:

medical history
physical examination
blood tests
stool tests
imaging or endoscopy

Diagnosis depends on symptom severity and duration.

Treatment Approaches

Medical Management

Treatment varies by condition and may include:

acid suppressants
anti-inflammatory medications
probiotics
antibiotics when needed

Dietary Modifications

increase fibre intake
limit trigger foods
eat regular meals
avoid excessive alcohol

Diet plays a central role in gut health.

Lifestyle Changes

manage stress
exercise regularly
stay hydrated
maintain sleep routine

Healthy habits support digestive function.

Prevention Tips for Digestive Health

Eat a Balanced Diet

Include fruits, vegetables, whole grains and lean proteins.

Stay Hydrated

Water supports digestion and prevents constipation.

Manage Stress

Mindfulness and relaxation techniques improve gut-brain balance.

Be Physically Active

Movement stimulates bowel activity and gut motility.

Avoid Smoking and Excess Alcohol

These irritate the digestive tract and worsen symptoms.

Seek Early Medical Advice

Early care prevents complications and chronic disease.

Long-Term Impact of Ignoring Digestive Problems

Untreated digestive disorders may lead to:

nutrient deficiencies
chronic inflammation
poor quality of life
increased disease complications

Early intervention is more effective and less invasive.

When to Consult a Doctor

Medical advice is recommended if:

symptoms persist beyond weeks
pain is severe
blood appears in stool
unexplained weight loss occurs

Prompt evaluation ensures safe management.

Conclusion

Digestive system disorders are common but often underestimated health issues. Symptoms such as bloating, pain, constipation and heartburn may seem minor initially but can signal deeper problems if ignored. Understanding causes, recognising early symptoms and adopting preventive habits help protect digestive health. With timely care, balanced nutrition and healthy lifestyle choices, most digestive disorders can be effectively managed, allowing the digestive system to function smoothly and support overall wellbeing.

References

Indian Council of Medical Research (ICMR) – Digestive Health and Nutrition Reports
World Health Organization (WHO) – Digestive Disorders and Gut Health Guideline
National Institute of Nutrition (NIN) – Dietary Fibre and Gut Health Researc
Lancet – Gastrointestinal Disease and Prevention Studies
Indian Journal of Gastroenterology – Digestive Disorder Research
Statista – Digestive Health Trends and Lifestyle Factors

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