• Published on: May 21, 2025
  • 4 minute read
  • By: Secondmedic Expert

Liver Enzymes Test Explained – What SGPT/SGOT Mean

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The liver is one of the most important organs in your body. It performs hundreds of functions, including filtering toxins, producing bile, and supporting digestion and metabolism. When your liver is under stress or not functioning properly, certain enzymes in your blood can increase. Two of the most common enzymes tested are SGPT (ALT) and SGOT (AST). In this blog, we will break down what these enzymes mean, why your doctor might suggest this test, and what the results indicate.

What is a Liver Enzymes Test?

A liver enzymes test is a type of blood test used to evaluate the health of your liver. It measures specific proteins (called enzymes) that the liver releases into your blood. When liver cells are damaged, these enzymes leak into your bloodstream. The most commonly tested liver enzymes are:

  • SGPT (ALT) – Serum Glutamic Pyruvic Transaminase

  • SGOT (AST) – Serum Glutamic Oxaloacetic Transaminase
     

Why Do Doctors Recommend a Liver Enzymes Test?

Your doctor may ask for a liver enzymes test if you show symptoms of liver problems or are at risk due to lifestyle or existing health conditions. Some common reasons include:

  • Fatigue or weakness

  • Yellowing of skin or eyes (jaundice)

  • Abdominal pain or swelling

  • Dark urine or pale stools

  • Alcohol consumption

  • Hepatitis (A, B, or C)

  • Obesity or fatty liver

  • Long-term medication usage

  • Diabetes or high cholesterol
     

What is SGPT (ALT)?

SGPT, also known as ALT (Alanine Aminotransferase), is an enzyme mainly found in the liver. It plays a role in converting proteins into energy for liver cells. When liver cells are damaged or inflamed, SGPT leaks into the bloodstream.

Normal SGPT Levels:

  • For men: 7 to 56 units per liter of blood

  • For women: 7 to 45 units per liter
     

What Does High SGPT Mean?

High SGPT levels may indicate:

  • Liver inflammation (Hepatitis)

  • Fatty liver disease

  • Alcohol-related liver damage

  • Liver infection or injury

  • Side effects of medications

  • Obesity-related liver stress
     

Sometimes, even intense physical activity or certain supplements can temporarily raise SGPT levels.

What is SGOT (AST)?

SGOT, also known as AST (Aspartate Aminotransferase), is an enzyme found not just in the liver, but also in the heart, kidneys, muscles, and brain. So, while it can point to liver damage, it may also indicate problems in other organs.

Normal SGOT Levels:

  • For men: 8 to 48 units per liter of blood

  • For women: 8 to 43 units per liter
     

What Does High SGOT Mean?

High SGOT levels may be due to:

  • Liver damage or cirrhosis

  • Heart disease or recent heart attack

  • Muscle injuries

  • Pancreatitis

  • Alcohol abuse

  • Use of certain drugs or supplements
     

If both SGPT and SGOT are elevated, it’s more likely to be a liver-related issue.

SGPT vs SGOT – What's the Difference?

Feature

SGPT (ALT)

SGOT (AST)

Location

Mainly in the liver

Liver, heart, kidneys, muscles, brain

Specificity

More liver-specific

Less liver-specific

Indicates

Liver damage

Liver, heart, or muscle damage

Normal Range

7–56 U/L

8–48 U/L

Conclusion: If only SGPT is high, it's more likely to be liver-specific. If both are high, the doctor may run further tests.

Other Liver Tests Often Done Together

To get a full picture of liver health, doctors may also recommend:

  • ALP (Alkaline Phosphatase) – Linked to bile ducts

  • GGT (Gamma-Glutamyl Transferase) – Linked to alcohol use or bile problems

  • Bilirubin – Indicates liver’s ability to process waste

  • Albumin and Total Protein – Reflects liver's protein production

  • PT/INR – Measures blood clotting, another liver function
     

What to Do if SGPT/SGOT Are High?

If your test results show high liver enzymes, don’t panic. A one-time elevation doesn’t always mean serious disease. Here's what you should do:

1. Follow-Up Testing

Your doctor may repeat the test after a few weeks or recommend imaging (ultrasound/CT scan) to check for liver fat, fibrosis, or tumors.

2. Lifestyle Changes

  • Avoid alcohol completely

  • Maintain a healthy diet (low-fat, high-fiber)

  • Exercise regularly

  • Control blood sugar and cholesterol

  • Stay hydrated
     

3. Review Medications

Some over-the-counter drugs like paracetamol, or supplements like bodybuilding products, can raise liver enzymes.

4. Monitor Regularly

If you have a chronic condition like diabetes, high cholesterol, or obesity, make liver function tests part of your routine health checks.

When to See a Doctor Immediately

  • Yellow eyes or skin (jaundice)

  • Severe abdominal pain

  • Swelling in legs or abdomen

  • Confusion or mood changes

  • Dark-colored urine or light-colored stools
     

These signs may indicate serious liver issues and need immediate attention.

Final Thoughts

The liver is a silent warrior – it works 24/7 and rarely complains until it's seriously damaged. That’s why regular check-ups, especially liver enzyme tests, are essential for early detection and prevention.

Understanding your SGPT and SGOT levels can give you valuable insights into your liver’s health. Whether you’re dealing with symptoms, managing a chronic condition, or just doing a preventive health check, this simple blood test can help you stay one step ahead.

Call to Action

Worried about your liver health? Book a full liver function test online today and get your results from the comfort of your home. Know your SGPT and SGOT levels now – because your health can’t wait.

Liver Enzymes Test Explained – What SGPT/SGOT Mean – Book Now on SecondMedic.com!

Read FAQs


A. It helps diagnose liver diseases, monitor liver health, and assess the impact of medications, alcohol, or infections on the liver.

A. SGPT (ALT): 7–56 U/L SGOT (AST): 8–48 U/L Ranges may vary slightly based on labs.

A. Elevated levels may indicate liver inflammation, fatty liver, hepatitis, alcohol-related damage, or side effects from medications.

A. Fasting is not always required, but it's best to follow your doctor’s or lab’s instructions.

A. A Liver Function Test (LFT), which includes SGPT, SGOT, Bilirubin, ALP, GGT, Albumin, and Total Protein, is recommended.

Read Blog
Liver Cirrhosis vs Fatty Liver

Liver Cirrhosis vs Fatty Liver: What’s the Difference?

Our liver plays a vital role in keeping our body healthy. It filters toxins from the blood, helps digest food, stores energy, and supports immunity. But like any organ, it can get damaged. Two common liver conditions people often confuse are fatty liver and liver cirrhosis. While both affect the liver, they are very different in terms of causes, symptoms, and outcomes.

In this blog, we’ll help you understand the key differences between liver cirrhosis and fatty liver, how they develop, their symptoms, treatments, and how to prevent them.

 

What Is Fatty Liver?

Fatty liver, also called hepatic steatosis, is a condition where fat builds up in the liver. It’s normal for the liver to have some fat, but if more than 5-10% of the liver's weight is fat, it's considered a fatty liver.

There are two main types:

  • Non-Alcoholic Fatty Liver Disease (NAFLD) – Most common, seen in people who don’t drink much alcohol.
     

  • Alcoholic Fatty Liver Disease (AFLD) – Caused by heavy alcohol use.
     

Fatty liver is often a silent condition. Many people don’t know they have it because it usually doesn’t cause symptoms in early stages.

 

Causes of Fatty Liver

  • Obesity
     

  • High cholesterol or triglycerides
     

  • Type 2 diabetes
     

  • High blood pressure
     

  • Rapid weight loss
     

  • Poor diet (high in sugar and fat)
     

  • Excessive alcohol intake (in AFLD)
     

 

What Is Liver Cirrhosis?

Liver cirrhosis is a late-stage liver disease where healthy liver tissue is replaced by scar tissue (fibrosis). This scarring blocks blood flow and affects the liver’s ability to work properly.

Unlike fatty liver, cirrhosis is permanent and serious. It develops slowly over years, often due to long-term liver damage from alcohol, hepatitis, or untreated fatty liver.

 

Causes of Liver Cirrhosis

  • Chronic alcohol use
     

  • Hepatitis B and C infections
     

  • Non-alcoholic steatohepatitis (NASH – advanced form of fatty liver)
     

  • Autoimmune diseases
     

  • Genetic disorders (like Wilson’s disease)
     

  • Long-term use of certain medications
     

 

Key Differences Between Fatty Liver and Cirrhosis

Aspect

Fatty Liver

Liver Cirrhosis

Nature

Fat accumulation in liver cells

Scarring and permanent damage to liver tissue

Reversibility

Reversible with lifestyle changes

Irreversible, but progression can be slowed

Symptoms

Usually no symptoms early on

Fatigue, jaundice, swelling, confusion

Causes

Obesity, diabetes, alcohol, diet

Long-term liver damage, hepatitis, alcohol

Severity

Mild to moderate

Severe and life-threatening if not managed

Treatment

Lifestyle and diet changes

Medication, regular monitoring, sometimes transplant

 

Symptoms to Watch Out For

Fatty Liver Symptoms (if any):

  • Fatigue
     

  • Mild discomfort or pain in upper right abdomen
     

  • Elevated liver enzymes in blood tests
     

Liver Cirrhosis Symptoms:

  • Yellowing of skin and eyes (jaundice)
     

  • Swelling in legs or abdomen (edema or ascites)
     

  • Easy bruising or bleeding
     

  • Confusion or memory loss (hepatic encephalopathy)
     

  • Itchy skin
     

  • Spider-like blood vessels on skin
     

 

Diagnosis: How Doctors Tell the Difference

Doctors use a combination of the following to diagnose liver issues:

  • Blood tests – Check liver enzymes, liver function.
     

  • Imaging (ultrasound, CT, MRI) – Shows fat or scarring in the liver.
     

  • Fibroscan or Liver Biopsy – Measures liver stiffness or checks for scarring directly.
     

Fatty liver shows fat deposits, while cirrhosis shows scar tissue and shrinkage of the liver.

 

Treatment Options

For Fatty Liver:

  • Weight loss – Losing 7-10% of body weight can reverse the condition.
     

  • Healthy diet – Focus on fruits, veggies, whole grains, lean protein.
     

  • Exercise – At least 30 minutes daily.
     

  • Avoid alcohol – Especially if it’s alcohol-related fatty liver.
     

  • Control diabetes/cholesterol – With diet or medication.
     

For Liver Cirrhosis:

  • Treat the underlying cause – Like hepatitis or alcohol use.
     

  • Avoid alcohol completely
     

  • Healthy diet with low salt – Prevent fluid buildup.
     

  • Medications – To manage symptoms and complications.
     

  • Regular screening – For liver cancer or internal bleeding.
     

  • Liver transplant – In advanced or end-stage cases.
     

 

Can Fatty Liver Turn into Cirrhosis?

Yes, if fatty liver is not treated, especially in non-alcoholic steatohepatitis (NASH), it can cause inflammation, fibrosis, and eventually cirrhosis over time. But the good news is – fatty liver is reversible, especially if caught early and proper steps are taken.

 

How to Keep Your Liver Healthy

  • Maintain a healthy weight
     

  • Eat a balanced diet – Avoid sugary, fried, or processed food
     

  • Exercise regularly
     

  • Avoid alcohol or drink in moderation
     

  • Don’t share needles or personal items that may carry blood
     

  • Get vaccinated for hepatitis A and B
     

  • Take medicines only as prescribed
     

 

When Should You See a Doctor?

If you feel constantly tired, have unexplained weight loss, jaundice, swelling in your abdomen or legs, or abnormal liver test results – don’t ignore it. Early diagnosis can make a big difference.

 

Conclusion

Fatty liver and liver cirrhosis are both serious liver conditions, but they are very different. Fatty liver is often the first stage of liver damage, and is reversible with lifestyle changes. Cirrhosis, on the other hand, is irreversible, and needs medical attention and sometimes life-long treatment.

Understanding the difference between the two helps you take better care of your liver and make informed health decisions. If you or someone you know is at risk, it’s never too early to make a change.

Want to know more about how to keep your liver healthy? Talk to your doctor today and understand the risks. Liver cirrhosis vs fatty liver: What’s the difference? Find out now and protect your health before it’s too late.

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