• Published on: Dec 12, 2025
  • 4 minute read
  • By: Secondmedic Expert

Genetic Predisposition Testing In India: Understanding Your Health Risks Before They Become Illnesses

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The rise of lifestyle diseases in India has shifted healthcare from reactive treatment to proactive prediction. Genetic predisposition testing is one of the fastest-growing tools in preventive health, providing individuals with deep insights into their inherited risks. By analysing DNA markers, these tests help predict the probability of developing conditions such as diabetes, cardiovascular disease, hypertension, obesity, certain cancers and autoimmune disorders.

According to the ICMR, over 70% of health conditions in India have a genetic component. This makes DNA-based screening an essential foundation for early detection and risk reduction.

SecondMedic integrates genetic testing with expert interpretation and AI-driven preventive guidance, helping individuals understand what their genes say about their future health.

Why Genetic Testing is Becoming Popular in India

1. Rising lifestyle and chronic diseases

India now has:

  • Over 100 million people with diabetes

  • Rapidly increasing heart disease cases

  • High burden of thyroid and metabolic disorders
     

Many of these conditions have inherited risk factors.

2. Growing health awareness

NFHS-5 data shows increased preventive test adoption among urban populations.

3. Increased affordability

Genetic tests, once expensive, are now accessible.

4. Support from global research

WHO and Lancet studies show that genetic insights significantly improve preventive health strategies.

5. Family planning use

Genetic screening helps individuals make informed reproductive decisions.

What Genetic Predisposition Testing Reveals

• Disease susceptibility

Probability of developing conditions like:

  • Type 2 diabetes

  • Heart disease

  • Breast cancer

  • Colon cancer

  • PCOS

  • Hypertension
     

• Metabolic tendencies

How the body handles:

  • fats

  • sugars

  • carbohydrates

  • inflammation
     

• Fitness gene markers

Impact on:

  • endurance

  • strength

  • muscle recovery
     

• Nutritional predispositions

Responses to:

  • vitamins

  • minerals

  • caffeine

  • lactose

  • gluten
     

• Behavioural tendencies

Sleep patterns, stress response and addiction risks.

How the Testing Process Works

Step 1: Sample collection

A saliva or blood sample is collected.

Step 2: DNA extraction and analysis

The lab identifies gene variants associated with disease risk.

Step 3: Risk interpretation

Results indicate whether your risk is:

  • average

  • moderate

  • high
     

Step 4: Expert consultation

SecondMedic’s specialists and genetic counsellors explain what the findings mean.

Step 5: Personalised preventive plan

Includes:

  • diet

  • exercise

  • screening timelines

  • lifestyle adjustments
     

Who Should Consider Genetic Testing?

• Individuals with family history of chronic illness

Especially diabetes, cancer, hypertension and cardiovascular disease.

• Young adults planning long-term wellness

Testing early helps build preventive habits.

• Couples planning pregnancy

Identifies hereditary risks.

• People with unexplained symptoms

Genetics can shed light on hidden conditions.

• High-stress professionals

Certain genetic traits influence stress and sleep.

Benefits of Genetic Predisposition Testing

1. Early disease prediction

Prevention starts before symptoms appear.

2. Personalised wellness roadmap

Guidance is tailored to your DNA.

3. Better screening decisions

Doctors can recommend tests earlier.

4. Improved lifestyle planning

Fitness and nutrition become more effective.

5. Avoiding guesswork in health management

Genetics adds scientific clarity.

The Role of SecondMedic’s AI Health Guide

AI enhances genetic interpretation by:

• Identifying links between lifestyle and genetic markers

• Highlighting overlapping risks

• Personalising diet and exercise recommendations

• Suggesting preventive screenings

• Monitoring long-term health trends

This hybrid model of genetics + AI + expert care builds a powerful preventive framework.

Example of Genetic-Based Preventive Planning

If you have a high genetic risk for diabetes:

  • Reduce refined carbs

  • Increase fibre

  • Begin early A1c screening

  • Focus on aerobic exercise
     

If you have cardiac predisposition:

  • Annual lipid profile

  • Maintain healthy weight

  • Adopt low-salt diet

  • Stress management
     

If you carry cancer risk markers:

  • Regular imaging

  • Avoid tobacco and alcohol

  • Targeted nutrition
     

Conclusion

Genetic predisposition testing empowers individuals in India to understand their inherited risks and take proactive control of their health. With expert interpretation and AI-supported insights, SecondMedic transforms genetic data into actionable preventive strategies that protect long-term wellbeing.

References

• ICMR - Genetic Risk Contribution to Disease in India
• NFHS-5 - Preventive Screening & Family History Trends
• NITI Aayog - Future of Preventive & Predictive Healthcare
• WHO - Genomic Medicine & Risk Assessment Guidelines
• Lancet - Genomic Prediction in Chronic Disease Prevention
• Statista - DNA Testing Market India
• EY-FICCI - Preventive Health Adoption in Urban India

Read FAQs


A. It identifies inherited risks for diseases such as diabetes, heart disease, cancer and autoimmune disorders.

A. People with family history, early symptoms, unexplained conditions or interest in preventive health.

A. Yes. It uses a simple saliva or blood sample with no risk involved.

A. It provides high-precision markers for risk probability but does not guarantee disease outcome.

A. Through genetic counsellors, AI-based preventive insights and personalised lifestyle planning.

Read Blog
Sadness is a normal emotional

Difference Between Sadness and Depression: Understanding Normal Emotions vs Mental Illness

Feeling low or unhappy is a part of being human. However, not all low moods are the same. Many people confuse sadness with depression, which can delay proper support and treatment. Understanding the difference between sadness and depression is crucial for mental health awareness, early intervention and reducing stigma.

In India, mental health conditions are often misunderstood, with emotional distress frequently dismissed as temporary sadness.

 

What Is Sadness?

Sadness is a normal human emotion.

It usually occurs due to:

  • loss or disappointment

  • relationship issues

  • failure or stress

  • temporary life challenges

Sadness serves a psychological purpose, allowing individuals to process emotions and adapt.

 

Key Characteristics of Sadness

Sadness is:

  • situational

  • temporary

  • emotionally painful but manageable

  • responsive to support and positive events

A person experiencing sadness can still function, enjoy moments and feel hopeful.

 

What Is Depression?

Depression is a medical condition classified as a mood disorder.

It affects:

  • emotions

  • thinking patterns

  • behaviour

  • physical health

According to WHO, depression is one of the leading causes of disability worldwide.

 

Core Symptoms of Depression

Depression involves a combination of symptoms such as:

  • persistent low mood

  • loss of interest or pleasure

  • fatigue

  • sleep disturbances

  • appetite changes

  • feelings of worthlessness

  • difficulty concentrating

These symptoms last at least two weeks or longer.

 

Duration: A Key Difference

One major difference lies in duration.

Sadness:

  • lasts hours or days

  • improves with time

Depression:

  • lasts weeks or months

  • persists despite positive events

Duration helps distinguish emotional response from illness.

 

Impact on Daily Functioning

Sadness:

  • allows continuation of work and relationships

  • may reduce motivation temporarily

Depression:

  • interferes with work, studies and relationships

  • reduces self-care and productivity

Functional impairment is a defining feature of depression.

 

Emotional Experience: Sadness vs Depression

Sadness:

  • allows emotional range

  • moments of joy still occur

Depression:

  • creates emotional numbness

  • joy and interest disappear

People with depression often describe feeling empty rather than sad.

 

Physical Symptoms in Depression

Depression is not only emotional.

Physical symptoms include:

  • chronic fatigue

  • body aches

  • headaches

  • digestive issues

ICMR mental health studies highlight the physical burden of depression.

 

Thought Patterns and Self-Perception

Sadness:

  • thoughts remain realistic

  • self-worth is preserved

Depression:

  • negative self-talk dominates

  • feelings of guilt and worthlessness increase

These cognitive changes deepen emotional suffering.

 

Risk Factors for Depression

Factors increasing depression risk include:

  • chronic stress

  • trauma

  • family history

  • medical illnesses

  • hormonal changes

NFHS-5 data indicates rising mental health concerns among young adults.

 

Can Sadness Turn Into Depression?

Yes, prolonged or unresolved sadness can progress into depression.

This is more likely when:

  • stressors are ongoing

  • support systems are weak

  • coping mechanisms are limited

Early emotional support can prevent progression.

 

When to Seek Professional Help

Seek help if:

  • low mood lasts more than two weeks

  • daily functioning is affected

  • sleep and appetite are disturbed

  • thoughts of self-harm occur

Early care leads to better outcomes.

 

Treatment Differences

Sadness:

  • improves with rest, support and time

Depression:

  • requires psychotherapy

  • may need medication

  • benefits from structured care

WHO emphasises early treatment to reduce disability.

 

Role of Social Support

Support systems help both conditions but are essential for recovery.

Depression recovery improves with:

  • understanding family

  • supportive workplaces

  • accessible mental healthcare

Stigma reduction is key.

 

Mental Health Awareness in India

Mental health remains underdiagnosed in India.

NITI Aayog reports:

  • limited access to mental health services

  • low awareness

  • high stigma

Education helps bridge this gap.

 

Importance of Early Recognition

Recognising depression early:

  • prevents worsening

  • reduces suicide risk

  • improves quality of life

Delay increases suffering and complications.

 

Supporting Someone With Depression

Helpful actions include:

  • listening without judgement

  • encouraging professional help

  • avoiding minimising feelings

Compassion is more effective than advice.

 

Conclusion

Understanding the difference between sadness and depression is essential for emotional wellbeing and mental health care. Sadness is a natural, temporary response to life events, while depression is a serious medical condition that affects thoughts, emotions and daily functioning. Recognising the signs early and seeking appropriate help can prevent long-term suffering and promote recovery. Mental health deserves the same attention and care as physical health.

 

References

  • World Health Organization (WHO) – Depression and Mental Health Disorders

  • Indian Council of Medical Research (ICMR) – Mental Health Research and Burden

  • National Family Health Survey (NFHS-5) – Mental Health Indicators

  • Lancet – Depression, Disability and Public Health

  • NITI Aayog – National Mental Health Policy and Awareness Reports

  • Statista – Global and Indian Mental Health Trends

See all

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