Ask a doctor - How do hormones contribute to mood swings?

Q. How do hormones contribute to mood swings?

Doctor Answer is medically reviewed by SecondMedic medical review team.

Answered by Secondmedic Expert

Hormones play a significant role in regulating mood, and fluctuations in hormone levels can contribute to mood swings. The primary hormones involved in mood regulation are estrogen, progesterone, testosterone, and cortisol. Here's how they contribute to mood swings:

1. Estrogen and Progesterone (Women):
- Menstrual Cycle: Hormonal changes during the menstrual cycle, particularly the premenstrual phase, can lead to mood swings. Fluctuations in estrogen and progesterone levels influence neurotransmitters like serotonin, affecting mood.

- Pregnancy: Hormonal changes during pregnancy, especially elevated levels of estrogen and progesterone, can impact mood. Some women experience mood swings during different trimesters.

- Menopause: The transition to menopause involves a decline in estrogen levels, which can lead to mood swings, irritability, and increased susceptibility to stress.

2. Testosterone (Men and Women):
- Menopause (Women): While estrogen and progesterone changes are more prominent, a decline in testosterone during menopause can also contribute to mood swings.

- Andropause (Men): Similar to menopause in women, aging men may experience a gradual decline in testosterone, which can influence mood.

3. Cortisol (Stress Hormone):
- Stress Response: Cortisol, often referred to as the "stress hormone," is released in response to stress. Chronic stress can lead to persistently elevated cortisol levels, contributing to mood swings, anxiety, and irritability.

4. Thyroid Hormones:
- Hyperthyroidism and Hypothyroidism: Imbalances in thyroid hormones (thyroxine and triiodothyronine) can impact mood. Hyperthyroidism (excessive thyroid hormone) can lead to anxiety and irritability, while hypothyroidism (insufficient thyroid hormone) may cause depression and fatigue.

5. Adrenal Hormones:
- Adrenal Insufficiency: Issues with adrenal gland function, such as adrenal insufficiency or Addison's disease, can disrupt hormone balance and influence mood.

It's important to note that individual responses to hormonal changes vary, and not everyone will experience mood swings to the same extent. Additionally, other factors, such as genetics, lifestyle, and environmental influences, can interact with hormonal changes to contribute to mood fluctuations. If hormonal-related mood swings are severe or persistent, seeking guidance from a healthcare professional is recommended.