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Published on: Apr 13, 2020
3 minute read
By: Dr Rajan Choudhary

Plasma Treatment For COVID-19?

TREATING COVID WITH BLOOD

We have previously covered proposed treatments for COVID-19, in particular hydroxychloroquine, and explained why we shouldn’t look for a magic cure for this disease. Viruses are difficult to treat, and ultimately supportive treatment appears to be best we can achieve. But an editorial published in BioMedicine Central appears to show a novel treatment for the most ill patients, one that may have flown under most people’s radar.

“A novel treatment approach to the novel coronavirus: an argument for the use of therapeutic plasma exchange for fulminant COVID-19”

An interesting title. Lets dissect it.

SUMMARY

- Blood is made up of many different components

- The immune system recognises the virus and produces antibodies against it to neutralise it

- These antibodies float in the blood plasma, a watery solution

- The plasma can be extracted from donated blood, and given to patients suffering from COVID-19

- So far evidence suggests it can help treat the most seriously affected patients.

WHAT IS IN OUR BLOOD

To understand this we must first understand what our blood is made of. Most people know that blood functions to transport oxygen from our lungs. But this is an oversimplification. Blood has many different functions:

- Transport: along with oxygen it transports sugars, fats, protein subunits throughout the body. This is done with the watery PLASMA of the blood.

- Clot: cells and protein structures act to plug any holes that form from cuts and damage. This is done by the PLATELETS in the blood

- Immunity: Immune cells respond to bacteria, viruses, parasites in the blood and body. They target these pathogens, identify and tag them with antibodies, and ultimately destroy them. This is done by the WHITE BLOOD CELLS.

And many more functions that we won’t bore you with.

IMMUNITY

It is this last point that is of interest to us. Our immune system consists of white blood cells that can recognise invading organisms in the blood, around cells and even invaders hiding within our own cells. All cells have protein markers on their surface, no matter if its human cells, bacterial, viral, fungal etc. These markers can be highlighted and targeted by specialised white blood cells, who in turn produce antibodies against these markers. Think of antibodies as handcuffs with flares attached: once attached other white blood cells use this information to find and destroy the invaders.

What is amazing about antibodies is how complex they are. The proteins in our body are incredibly complex. They are long chains that fold into unique shapes depending on hundreds of different types of chemical interactions. These are so complex that supercomputers can take literal years to figure out the shape of a single protein and how it folds depending on the subunits in its chain. This means that our immune system has to recognise these markers and figure out a complementary tag out of hundreds of billions of potential sequences. Antibodies have to be specific to their tag. If an antibody is produced that can target more than one tag, it can cause problems. If it targets a bacterial tag, but accidentally highlights the person’s cells as well, the immune system will start targeting and destroying the person’s organs. These auto-immune disorders can be devastating.

But when they work, antibodies are miraculous. They persist in the blood after an infection, and if a second infection occurs, memory cells in the blood can rapidly produce these antibodies before the infection can even produce symptoms. This is known as immunity, and is why we usually don’t get the same illness twice. Antibody based treatment is see as the future of medical therapy, and is something we will cover in future blogs.

PLASMA EXCHANGE

From population testing we can see that the majority of patients with COVID-19 recover, experiencing either mild symptoms, moderate symptoms requiring some form of treatment and hospitalisation, or no symptoms whatsoever. In these patients their immune system will have successfully recognised the virus and produced antibodies against it to neutralise the virus. It is the patients with severe symptoms, those in which the virus is running rampant in the body, that the production of antibodies happens too late.

Plasma exchange involves obtaining blood from patients who have beaten the virus, spinning the blood to separate out the red cells, white cells, platelets and watery plasma. The plasma contains all the glucose, small proteins and importantly for us, the antibodies. This plasma can be transfused into patients with COVID-19 that cannot cope, in order to help their immune system. These transfused antibodies will neutralise some of the viruses in the patient, reducing the viral load, amount of replication and cell destruction that causes such devastating symptoms in COVID-19.

The published editorial showed that in the most critical pneumonia patients, requiring mechanical ventilators and drugs to support the heart, mortality in plasma exchange patients resulted in a 47.8% mortality instead of 81.3%. Of course it is a single study with a limited number of patients, but the results are encouraging. It is further helped by the fact plasma exchange is a well established therapy, with established protocols known to intensivists and haematologists.

THE FUTURE

We may see the use of Plasma exchange for critically ill patients increase as the pandemic continues. It is not a treatment option available for everyone, as it requires intravenous access and careful monitoring in a controlled setting. But it also needs donation from people who have recovered from COVID and have suitable antibodies. So whilst it might not be a magic pill that everyone expects to cure COVID, it might be the difference between life and death for those that need it most.

Dr Rajan Choudhary, UK, Chief Product Officer, Second Medic Inc

www.secondmedic.com

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Digital Healthcare Automation India: Enabling Smart Workflows, Faster Care, and a Modern Clinical Ecosystem

Digital healthcare automation is redefining how India delivers medical services, manages clinical operations, and coordinates patient journeys. As hospitals, clinics, and digital health platforms move toward technology-driven processes, automation has become essential for ensuring efficiency, reducing manual work, minimizing delays, and improving care accuracy. In a healthcare system where patient volumes are high and specialist availability is uneven, automation empowers organizations to deliver faster, smarter, and more consistent care.

India’s healthcare automation growth aligns with national initiatives like ABDM (Ayushman Bharat Digital Mission), growing telemedicine adoption, rising digital literacy, and the increased use of AI-based medical tools. SecondMedic integrates automation into every stage of digital care-appointments, reporting, monitoring, follow-ups, and preventive health-allowing users and clinicians to experience a seamless, intelligent healthcare ecosystem.

Digital healthcare automation India is not simply about digitizing manual tasks; it is about augmenting healthcare with intelligent workflows that respond to real-time needs. By reducing repetitive workloads, automation allows clinicians to focus on what matters most: patient care.

Why Automation Matters in Indian Healthcare

India faces significant challenges: overloaded outpatient departments, resource shortages, manual data entry errors, delayed reports, and administrative inefficiencies. Automation addresses these issues by introducing structured, rule-based processes supported by AI and digital tools.

Key systemic challenges automation helps solve:

High patient-to-doctor ratios
Slow movement of information across departments
Inconsistent follow-up and monitoring
Manual errors in documentation and reporting
Unpredictable appointment flow
Inadequate time for patient–doctor interaction

Digital automation supports a more organized, reliable, and high-performance healthcare environment.

What Is Digital Healthcare Automation?

Digital healthcare automation refers to the use of AI, software systems, connected devices, and workflow engines to automate medical and administrative procedures. These tools reduce manual intervention wherever possible and ensure accuracy, repeatability, and continuity.

Core areas of automation include:

Appointment management and scheduling
Electronic medical record updates
Auto-generation of diagnostic summaries
Automated clinical reminders
Medication and health-plan notifications
Remote monitoring and alert systems
Digital report formatting
Workflow optimization for hospital operations

SecondMedic incorporates automation across its telemedicine, diagnostics, monitoring, and preventive-care systems.

Automated Appointment Scheduling and Coordination

Appointment automation is one of the most practical innovations in India’s digital health landscape. Without automation, patients often encounter long queues, missed follow-ups, and scheduling conflicts.

Automated scheduling helps by:

Matching patients to the right doctor
Reducing wait times
Preventing double bookings
Prioritizing urgent cases
Coordinating virtual and in-person consults
Helping doctors manage daily workloads efficiently

SecondMedic’s automated scheduling engine analyzes doctor availability, user urgency, and specialty requirements to optimize appointment flow.

Automation in Diagnostics and Reporting

Medical diagnostics often involve multiple steps that traditionally require human intervention-uploading reports, comparing past results, formatting summaries, highlighting abnormalities, and generating clear interpretations.

Automation enhances diagnostic workflows by:

Auto-organizing digital medical reports
Highlighting abnormal ranges
Identifying missing test values
Summarizing patient history for doctors
Formatting structured reports instantly
Automating comparisons with past results

For AI-based imaging and lab analytics, automation helps radiologists and clinicians detect patterns faster and reduce minor reporting inconsistencies.

Remote Monitoring and Automated Alerts

Remote patient monitoring has grown rapidly in India, especially for chronic diseases. Wearable devices and home-health tools generate continuous data streams. Automation helps turn these raw inputs into actionable insights.

Monitoring automation includes:

Auto-detection of abnormal vitals
Alerts for risky trends
Medication reminders
Follow-up triggers
Predictive alerts using AI
Aggregated health reports for doctors

For chronic care, this ensures timely intervention and reduces emergency visits.

Enhancing Hospital and Clinic Workflows

Healthcare automation in clinical facilities improves operational efficiency and reduces administrative bottlenecks. Hospitals benefit significantly from automated workflows that ensure consistency and speed.

Applications include:

Patient flow management
Automated admission and discharge processes
Digital billing and inventory management
Lab and pharmacy integration
Nursing task automation
Centralized communication dashboards

These improvements reduce patient wait times and improve overall care delivery.

Improving Patient Engagement Through Automation

Automation supports patients by making healthcare more accessible and predictable. Many individuals struggle to remember follow-ups or understand complex medical guidance. Automated systems simplify this journey.

Key patient-facing automation benefits include:

Reminders for medications and appointments
Preventive health notifications
Personalized care tips
AI-driven chat support for common queries
Post-consultation guidance delivery
Automated sharing of doctor notes and reports

SecondMedic uses automation to ensure patients remain engaged throughout their health journey.

Automation and AI: A Powerful Combination

AI enhances healthcare automation by making it adaptive and context-aware. Instead of following fixed rules, AI learns from patterns, outcomes, and user behavior to optimize workflows.

AI strengthens automation through:

Predictive recommendations
Dynamic scheduling adjustments
Automated report summaries
Early detection of errors
Smart escalation of high-risk cases

This combination powers advanced clinical systems that support both providers and patients.

Challenges in Implementing Healthcare Automation in India

Automation requires planning, infrastructure, and careful integration. Key challenges include:

Fragmented patient data across facilities
Infrastructure limitations in rural areas
Varying digital readiness across hospitals
Need for staff training
Ensuring compliance with DPDP and ABDM standards

Despite these challenges, adoption is increasing as digital health becomes mainstream.

The Future of Digital Healthcare Automation in India

India is poised for significant automation growth, driven by advancements in AI, 5G connectivity, cloud platforms, and interoperable health records. Over the next decade, digital healthcare automation will include:

AI-powered hospital command centers
Fully automated radiology and pathology workflows
Robotic process automation (RPA) in administrative processes
Automated care coordination for chronic diseases
Voice-based digital assistants for patient queries
Smart triage algorithms integrated across telemedicine networks
Predictive automation for emergency care

SecondMedic is building a modern digital ecosystem that integrates AI, automation, and predictive healthcare tools, creating a seamless and intelligent healthcare experience for users.

Conclusion

Digital healthcare automation India is unlocking a new era of efficiency, precision, and patient-centered care. By automating clinical workflows, diagnostic tasks, and patient engagement processes, healthcare organizations can deliver faster, more reliable services. Automation supports doctors with real-time insights, reduces administrative burdens, and ensures that patients receive timely interventions.

SecondMedic continues to lead this transformation by integrating automation into virtual care, diagnostics, monitoring, and preventive health solutions, shaping the future of digital healthcare in India.

To access advanced automated digital healthcare tools, visit www.secondmedic.com

References

NITI Aayog – Digital Health India
ABDM – National Digital Health Mission
IMARC – Healthcare Automation Market India
WHO – Digital Health Workflow Automation
FICCI – Hospital Automation India

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