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Published on: Apr 13, 2020
3 minute read
By: Dr Rajan Choudhary

Plasma Treatment For COVID-19?

TREATING COVID WITH BLOOD

We have previously covered proposed treatments for COVID-19, in particular hydroxychloroquine, and explained why we shouldn’t look for a magic cure for this disease. Viruses are difficult to treat, and ultimately supportive treatment appears to be best we can achieve. But an editorial published in BioMedicine Central appears to show a novel treatment for the most ill patients, one that may have flown under most people’s radar.

“A novel treatment approach to the novel coronavirus: an argument for the use of therapeutic plasma exchange for fulminant COVID-19”

An interesting title. Lets dissect it.

SUMMARY

- Blood is made up of many different components

- The immune system recognises the virus and produces antibodies against it to neutralise it

- These antibodies float in the blood plasma, a watery solution

- The plasma can be extracted from donated blood, and given to patients suffering from COVID-19

- So far evidence suggests it can help treat the most seriously affected patients.

WHAT IS IN OUR BLOOD

To understand this we must first understand what our blood is made of. Most people know that blood functions to transport oxygen from our lungs. But this is an oversimplification. Blood has many different functions:

- Transport: along with oxygen it transports sugars, fats, protein subunits throughout the body. This is done with the watery PLASMA of the blood.

- Clot: cells and protein structures act to plug any holes that form from cuts and damage. This is done by the PLATELETS in the blood

- Immunity: Immune cells respond to bacteria, viruses, parasites in the blood and body. They target these pathogens, identify and tag them with antibodies, and ultimately destroy them. This is done by the WHITE BLOOD CELLS.

And many more functions that we won’t bore you with.

IMMUNITY

It is this last point that is of interest to us. Our immune system consists of white blood cells that can recognise invading organisms in the blood, around cells and even invaders hiding within our own cells. All cells have protein markers on their surface, no matter if its human cells, bacterial, viral, fungal etc. These markers can be highlighted and targeted by specialised white blood cells, who in turn produce antibodies against these markers. Think of antibodies as handcuffs with flares attached: once attached other white blood cells use this information to find and destroy the invaders.

What is amazing about antibodies is how complex they are. The proteins in our body are incredibly complex. They are long chains that fold into unique shapes depending on hundreds of different types of chemical interactions. These are so complex that supercomputers can take literal years to figure out the shape of a single protein and how it folds depending on the subunits in its chain. This means that our immune system has to recognise these markers and figure out a complementary tag out of hundreds of billions of potential sequences. Antibodies have to be specific to their tag. If an antibody is produced that can target more than one tag, it can cause problems. If it targets a bacterial tag, but accidentally highlights the person’s cells as well, the immune system will start targeting and destroying the person’s organs. These auto-immune disorders can be devastating.

But when they work, antibodies are miraculous. They persist in the blood after an infection, and if a second infection occurs, memory cells in the blood can rapidly produce these antibodies before the infection can even produce symptoms. This is known as immunity, and is why we usually don’t get the same illness twice. Antibody based treatment is see as the future of medical therapy, and is something we will cover in future blogs.

PLASMA EXCHANGE

From population testing we can see that the majority of patients with COVID-19 recover, experiencing either mild symptoms, moderate symptoms requiring some form of treatment and hospitalisation, or no symptoms whatsoever. In these patients their immune system will have successfully recognised the virus and produced antibodies against it to neutralise the virus. It is the patients with severe symptoms, those in which the virus is running rampant in the body, that the production of antibodies happens too late.

Plasma exchange involves obtaining blood from patients who have beaten the virus, spinning the blood to separate out the red cells, white cells, platelets and watery plasma. The plasma contains all the glucose, small proteins and importantly for us, the antibodies. This plasma can be transfused into patients with COVID-19 that cannot cope, in order to help their immune system. These transfused antibodies will neutralise some of the viruses in the patient, reducing the viral load, amount of replication and cell destruction that causes such devastating symptoms in COVID-19.

The published editorial showed that in the most critical pneumonia patients, requiring mechanical ventilators and drugs to support the heart, mortality in plasma exchange patients resulted in a 47.8% mortality instead of 81.3%. Of course it is a single study with a limited number of patients, but the results are encouraging. It is further helped by the fact plasma exchange is a well established therapy, with established protocols known to intensivists and haematologists.

THE FUTURE

We may see the use of Plasma exchange for critically ill patients increase as the pandemic continues. It is not a treatment option available for everyone, as it requires intravenous access and careful monitoring in a controlled setting. But it also needs donation from people who have recovered from COVID and have suitable antibodies. So whilst it might not be a magic pill that everyone expects to cure COVID, it might be the difference between life and death for those that need it most.

Dr Rajan Choudhary, UK, Chief Product Officer, Second Medic Inc

www.secondmedic.com

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Monthly Health Survey via SecondMedic App: A Smarter Approach to Preventive Healthcare

Healthcare is gradually shifting from reactive treatment to proactive prevention. Traditional health models rely heavily on annual checkups or medical visits only after symptoms become severe. However, many chronic and lifestyle-related conditions develop silently over time. The Monthly Health Survey via the SecondMedic App addresses this gap by enabling continuous health monitoring and early risk identification.

According to the Indian Council of Medical Research (ICMR) and NITI Aayog, early detection and preventive care are critical to reducing the growing burden of non-communicable diseases in India. Digital health tools play a key role in achieving this shift.

What Is the Monthly Health Survey?

The Monthly Health Survey is a structured digital questionnaire delivered through the SecondMedic App. It captures key health indicators such as:

recurring symptoms
lifestyle habits
stress and sleep patterns
nutrition and activity levels
chronic condition markers

By repeating the survey monthly, subtle health trends become visible.

Why Monthly Health Tracking Matters

Annual Checkups Miss Gradual Changes

Many health issues develop slowly. Annual tests may appear normal while symptoms quietly progress between visits.

Monthly surveys:

detect early warning signs
capture symptom patterns
identify lifestyle-related risks

Health Is Dynamic, Not Static

Stress, sleep, diet and activity fluctuate monthly. Regular tracking reflects real-life health variation more accurately than isolated tests.

How the Monthly Health Survey Works

Each month, users answer a guided set of questions related to:

physical symptoms
mental wellbeing
lifestyle behaviours
known medical conditions

The app analyses responses to highlight:

risk trends
symptom persistence
areas needing attention

This structured approach simplifies health awareness.

Key Health Areas Covered

Symptom Monitoring

Persistent fatigue, headaches, breathlessness or digestive issues are tracked across months to identify patterns.

Lifestyle Risk Factors

The survey captures:

sedentary behaviour
sleep quality
stress levels
dietary habits

These factors strongly influence long-term health outcomes.

Chronic Disease Indicators

For individuals with diabetes, hypertension or thyroid conditions, monthly monitoring supports better disease control and early escalation.

Role in Preventive Healthcare

Preventive healthcare focuses on stopping disease before complications arise.

Monthly health surveys support prevention by:

identifying risks early
prompting timely consultations
supporting lifestyle modification
reducing emergency care needs

WHO and NITI Aayog both highlight digital monitoring as a cornerstone of preventive health systems.

Benefits for Individuals

Early Awareness

Users become aware of health changes before symptoms become severe.

Empowered Decision-Making

Access to regular health insights encourages proactive lifestyle choices.

Reduced Anxiety

Structured tracking reduces uncertainty and fear about unexplained symptoms.

Better Doctor Consultations

Survey data provides doctors with a clearer health history, improving consultation quality.

Benefits for Chronic Care Management

For chronic conditions, consistency is key.

Monthly surveys help:

track symptom control
identify early deterioration
support medication adherence
reduce complications

This continuous loop improves long-term outcomes.

Data-Driven Personalised Care

The survey supports personalised care by:

tailoring recommendations
prioritising high-risk users
guiding preventive interventions

This approach moves healthcare from generic advice to individualised guidance.

Privacy and Responsible Use

Health data is sensitive.

The survey framework is designed to:

collect only relevant information
support medical decision-making
maintain confidentiality

Responsible data use builds trust and long-term engagement.

Why Digital Surveys Are Effective in India

India’s healthcare challenges include:

large population
limited access to preventive care
high lifestyle disease burden

Digital surveys overcome barriers by:

being accessible anywhere
requiring minimal time
enabling large-scale preventive monitoring

This scalability makes them highly impactful.

Integration with Broader Health Ecosystems

Monthly health surveys work best when integrated with:

medical consultations
diagnostic services
preventive checkups
digital health records

Integration ensures continuity of care.

Long-Term Impact on Healthcare Outcomes

Over time, regular health tracking leads to:

earlier diagnoses
reduced hospitalisations
better chronic disease control
lower healthcare costs
improved quality of life

Lancet studies show that continuous monitoring significantly improves preventive outcomes.

Who Should Use a Monthly Health Survey?

adults over 30
individuals with chronic conditions
people with high-stress lifestyles
those focusing on preventive health
corporate wellness participants

Proactive monitoring benefits all age groups.

Conclusion

The Monthly Health Survey via the SecondMedic App represents a modern, preventive approach to healthcare. By capturing health trends regularly rather than annually, it empowers individuals to act early, supports doctors with better insights and reduces the burden of advanced disease. In an era where prevention is the most effective medicine, monthly health surveys transform awareness into action and data into healthier lives.

References

Indian Council of Medical Research (ICMR) – Preventive Healthcare and Early Detection Report
NITI Aayog – Digital Health and Preventive Care Strateg
World Health Organization (WHO) – Digital Health Monitoring Guideline
Lancet – Preventive Healthcare and Continuous Monitoring Studies
National Health Authority – Digital Health Mission Indi
Statista – Digital Health App Adoption Trends India

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