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Published on: Apr 13, 2020
3 minute read
By: Dr Rajan Choudhary

Plasma Treatment For COVID-19?

TREATING COVID WITH BLOOD

We have previously covered proposed treatments for COVID-19, in particular hydroxychloroquine, and explained why we shouldn’t look for a magic cure for this disease. Viruses are difficult to treat, and ultimately supportive treatment appears to be best we can achieve. But an editorial published in BioMedicine Central appears to show a novel treatment for the most ill patients, one that may have flown under most people’s radar.

“A novel treatment approach to the novel coronavirus: an argument for the use of therapeutic plasma exchange for fulminant COVID-19”

An interesting title. Lets dissect it.

SUMMARY

- Blood is made up of many different components

- The immune system recognises the virus and produces antibodies against it to neutralise it

- These antibodies float in the blood plasma, a watery solution

- The plasma can be extracted from donated blood, and given to patients suffering from COVID-19

- So far evidence suggests it can help treat the most seriously affected patients.

WHAT IS IN OUR BLOOD

To understand this we must first understand what our blood is made of. Most people know that blood functions to transport oxygen from our lungs. But this is an oversimplification. Blood has many different functions:

- Transport: along with oxygen it transports sugars, fats, protein subunits throughout the body. This is done with the watery PLASMA of the blood.

- Clot: cells and protein structures act to plug any holes that form from cuts and damage. This is done by the PLATELETS in the blood

- Immunity: Immune cells respond to bacteria, viruses, parasites in the blood and body. They target these pathogens, identify and tag them with antibodies, and ultimately destroy them. This is done by the WHITE BLOOD CELLS.

And many more functions that we won’t bore you with.

IMMUNITY

It is this last point that is of interest to us. Our immune system consists of white blood cells that can recognise invading organisms in the blood, around cells and even invaders hiding within our own cells. All cells have protein markers on their surface, no matter if its human cells, bacterial, viral, fungal etc. These markers can be highlighted and targeted by specialised white blood cells, who in turn produce antibodies against these markers. Think of antibodies as handcuffs with flares attached: once attached other white blood cells use this information to find and destroy the invaders.

What is amazing about antibodies is how complex they are. The proteins in our body are incredibly complex. They are long chains that fold into unique shapes depending on hundreds of different types of chemical interactions. These are so complex that supercomputers can take literal years to figure out the shape of a single protein and how it folds depending on the subunits in its chain. This means that our immune system has to recognise these markers and figure out a complementary tag out of hundreds of billions of potential sequences. Antibodies have to be specific to their tag. If an antibody is produced that can target more than one tag, it can cause problems. If it targets a bacterial tag, but accidentally highlights the person’s cells as well, the immune system will start targeting and destroying the person’s organs. These auto-immune disorders can be devastating.

But when they work, antibodies are miraculous. They persist in the blood after an infection, and if a second infection occurs, memory cells in the blood can rapidly produce these antibodies before the infection can even produce symptoms. This is known as immunity, and is why we usually don’t get the same illness twice. Antibody based treatment is see as the future of medical therapy, and is something we will cover in future blogs.

PLASMA EXCHANGE

From population testing we can see that the majority of patients with COVID-19 recover, experiencing either mild symptoms, moderate symptoms requiring some form of treatment and hospitalisation, or no symptoms whatsoever. In these patients their immune system will have successfully recognised the virus and produced antibodies against it to neutralise the virus. It is the patients with severe symptoms, those in which the virus is running rampant in the body, that the production of antibodies happens too late.

Plasma exchange involves obtaining blood from patients who have beaten the virus, spinning the blood to separate out the red cells, white cells, platelets and watery plasma. The plasma contains all the glucose, small proteins and importantly for us, the antibodies. This plasma can be transfused into patients with COVID-19 that cannot cope, in order to help their immune system. These transfused antibodies will neutralise some of the viruses in the patient, reducing the viral load, amount of replication and cell destruction that causes such devastating symptoms in COVID-19.

The published editorial showed that in the most critical pneumonia patients, requiring mechanical ventilators and drugs to support the heart, mortality in plasma exchange patients resulted in a 47.8% mortality instead of 81.3%. Of course it is a single study with a limited number of patients, but the results are encouraging. It is further helped by the fact plasma exchange is a well established therapy, with established protocols known to intensivists and haematologists.

THE FUTURE

We may see the use of Plasma exchange for critically ill patients increase as the pandemic continues. It is not a treatment option available for everyone, as it requires intravenous access and careful monitoring in a controlled setting. But it also needs donation from people who have recovered from COVID and have suitable antibodies. So whilst it might not be a magic pill that everyone expects to cure COVID, it might be the difference between life and death for those that need it most.

Dr Rajan Choudhary, UK, Chief Product Officer, Second Medic Inc

www.secondmedic.com

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Telemedicine Platform Comparison India: Evaluating the Best Digital Healthcare Providers

Telemedicine has transformed the healthcare landscape in India by making medical services more accessible, affordable, and patient-friendly. With growing smartphone usage, improved internet penetration, and digital health adoption under the Ayushman Bharat Digital Mission (ABDM), teleconsultation platforms have become a primary mode of healthcare for millions. But with multiple platforms available, choosing the right one requires a proper telemedicine platform comparison India.

This blog provides a detailed comparison of India’s leading telemedicine providers and evaluates what sets SecondMedic apart in terms of accessibility, specialist availability, user experience, and overall digital healthcare value.

Why Telemedicine Is Growing Rapidly in India

The demand for digital healthcare platforms is driven by:

Busy lifestyles limiting hospital visits
Rising chronic diseases needing follow-ups
Rural populations needing specialist access
Post-pandemic digital health acceptance
Cost efficiency
Faster access to care

According to Statista, the telemedicine market size in India is increasing significantly, driven by digital transformation and patient willingness to adopt virtual care.

Key Parameters for Comparing Telemedicine Platforms

When comparing telemedicine platforms, users should evaluate the following:

1. Doctor Availability

The range of specialists available-cardiology, dermatology, pediatrics, gynecology, orthopedics, etc.-is crucial.

2. Pricing and Consultation Fees

Costs vary significantly between platforms. Affordable, transparent pricing determines long-term usability.

3. User Interface (UI/UX)

The platform must be easy to navigate, especially for elderly patients.

4. Appointment Wait Time

Faster access to doctors enhances the value of telemedicine.

5. E-Prescriptions

Availability of legal, digital prescriptions is essential for seamless continuity of care.

6. Electronic Health Records (EHR)

Platforms offering unified records improve patient experience.

7. Service Range

A good telemedicine platform should provide:

Teleconsultations
Second opinions
Remote monitoring
Home diagnostics
Preventive health packages

SecondMedic is one of the few platforms offering this full ecosystem.

Comparison of Major Telemedicine Platforms in India

1. SecondMedic

Specialties: Full range including cardiology, dermatology, neurology
Strengths:

Instant teleconsultation
Online specialist access
Remote monitoring tools
Second opinion services
Preventive health packages
Strong chronic care management
Patient-first experience
Easy EHR access
Best For: Those wanting comprehensive digital healthcare

2. Practo

Strengths:

Wide doctor network
Pharmacy integration
Lab test bookings
Limitations:
Higher consultation fees
Variable doctor response times

3. Apollo 24/7

Strengths:

Strong specialist network
Integration with Apollo hospitals
Limitations:
High cost
Limited remote monitoring features

4. Tata 1mg

Strengths:

Affordable consultations
Pharmacy + lab tests
Limitations:
Limited specialist variety
Heavy focus on diagnostics and medicines rather than telemedicine

5. MFine

Strengths:

Good specialist availability
Partner-hospital model
Limitations:
Service coverage varies
Less personalized care

This comparison shows that while multiple telemedicine platforms serve specific needs, SecondMedic provides a more integrated healthcare experience connecting consultations, preventive care, and chronic disease management.

What Makes SecondMedic Stand Out

1. Comprehensive Specialty Coverage

From general physicians to cardiologists, dermatologists, neurologists, endocrinologists, and pediatricians, SecondMedic covers major medical specialties.

2. Strong Chronic Disease Management

Continuous monitoring and scheduled check-ins help manage long-term conditions effectively.

3. Online Second Opinions

Patients needing specialist reassessment benefit from high-quality second opinions from top doctors.

4. Remote Monitoring Ecosystem

Compatible with digital ECGs, glucometers, BP monitors, and other wearable tools.

5. Affordable and Transparent Pricing

SecondMedic offers cost-effective consultations without hidden charges.

6. Easy-to-Use Interface

Designed for all age groups with minimal complexity.

7. Integration with Preventive Health Packages

Users can also book diagnostics, screenings, and wellness plans.

Importance of EHR in Telemedicine Platform Comparison India

Electronic Health Records improve:

Safety
Accuracy
Convenience
Treatment continuity

SecondMedic’s EHR system is aligned with ABDM guidelines, making health data secure and portable.

User Experience and Accessibility

A good telemedicine platform must offer:

Multilingual support
Low-bandwidth compatibility
Easy appointment scheduling
Quick report upload

SecondMedic excels in offering a smooth, user-friendly experience.

Future of Telemedicine Platforms in India

The next evolution includes:

AI-assisted triage
Wearable tech integration
Predictive health alerts
Virtual healthcare kiosks
Full ABDM interoperability

SecondMedic is aligning with these innovations to build the next-generation digital healthcare ecosystem.

Conclusion

Telemedicine platform comparison India reveals that while several platforms offer strong digital health services, SecondMedic stands out due to its integrated care model, specialist availability, chronic disease support, remote monitoring tools, and preventive healthcare programs. For patients seeking a complete, reliable, and patient-centric telemedicine experience, SecondMedic remains a top choice.

To explore telemedicine services, visit www.secondmedic.com

References

NITI Aayog - Telemedicine guidelines for India
Statista - Telemedicine adoption and market size
ABDM - Digital health mission framework
WHO - Teleconsultation standards
IMARC - Digital health ecosystem growth
SecondMedic platform insights

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