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Published on: Apr 13, 2020
3 minute read
By: Dr Rajan Choudhary

Plasma Treatment For COVID-19?

TREATING COVID WITH BLOOD

We have previously covered proposed treatments for COVID-19, in particular hydroxychloroquine, and explained why we shouldn’t look for a magic cure for this disease. Viruses are difficult to treat, and ultimately supportive treatment appears to be best we can achieve. But an editorial published in BioMedicine Central appears to show a novel treatment for the most ill patients, one that may have flown under most people’s radar.

“A novel treatment approach to the novel coronavirus: an argument for the use of therapeutic plasma exchange for fulminant COVID-19”

An interesting title. Lets dissect it.

SUMMARY

- Blood is made up of many different components

- The immune system recognises the virus and produces antibodies against it to neutralise it

- These antibodies float in the blood plasma, a watery solution

- The plasma can be extracted from donated blood, and given to patients suffering from COVID-19

- So far evidence suggests it can help treat the most seriously affected patients.

WHAT IS IN OUR BLOOD

To understand this we must first understand what our blood is made of. Most people know that blood functions to transport oxygen from our lungs. But this is an oversimplification. Blood has many different functions:

- Transport: along with oxygen it transports sugars, fats, protein subunits throughout the body. This is done with the watery PLASMA of the blood.

- Clot: cells and protein structures act to plug any holes that form from cuts and damage. This is done by the PLATELETS in the blood

- Immunity: Immune cells respond to bacteria, viruses, parasites in the blood and body. They target these pathogens, identify and tag them with antibodies, and ultimately destroy them. This is done by the WHITE BLOOD CELLS.

And many more functions that we won’t bore you with.

IMMUNITY

It is this last point that is of interest to us. Our immune system consists of white blood cells that can recognise invading organisms in the blood, around cells and even invaders hiding within our own cells. All cells have protein markers on their surface, no matter if its human cells, bacterial, viral, fungal etc. These markers can be highlighted and targeted by specialised white blood cells, who in turn produce antibodies against these markers. Think of antibodies as handcuffs with flares attached: once attached other white blood cells use this information to find and destroy the invaders.

What is amazing about antibodies is how complex they are. The proteins in our body are incredibly complex. They are long chains that fold into unique shapes depending on hundreds of different types of chemical interactions. These are so complex that supercomputers can take literal years to figure out the shape of a single protein and how it folds depending on the subunits in its chain. This means that our immune system has to recognise these markers and figure out a complementary tag out of hundreds of billions of potential sequences. Antibodies have to be specific to their tag. If an antibody is produced that can target more than one tag, it can cause problems. If it targets a bacterial tag, but accidentally highlights the person’s cells as well, the immune system will start targeting and destroying the person’s organs. These auto-immune disorders can be devastating.

But when they work, antibodies are miraculous. They persist in the blood after an infection, and if a second infection occurs, memory cells in the blood can rapidly produce these antibodies before the infection can even produce symptoms. This is known as immunity, and is why we usually don’t get the same illness twice. Antibody based treatment is see as the future of medical therapy, and is something we will cover in future blogs.

PLASMA EXCHANGE

From population testing we can see that the majority of patients with COVID-19 recover, experiencing either mild symptoms, moderate symptoms requiring some form of treatment and hospitalisation, or no symptoms whatsoever. In these patients their immune system will have successfully recognised the virus and produced antibodies against it to neutralise the virus. It is the patients with severe symptoms, those in which the virus is running rampant in the body, that the production of antibodies happens too late.

Plasma exchange involves obtaining blood from patients who have beaten the virus, spinning the blood to separate out the red cells, white cells, platelets and watery plasma. The plasma contains all the glucose, small proteins and importantly for us, the antibodies. This plasma can be transfused into patients with COVID-19 that cannot cope, in order to help their immune system. These transfused antibodies will neutralise some of the viruses in the patient, reducing the viral load, amount of replication and cell destruction that causes such devastating symptoms in COVID-19.

The published editorial showed that in the most critical pneumonia patients, requiring mechanical ventilators and drugs to support the heart, mortality in plasma exchange patients resulted in a 47.8% mortality instead of 81.3%. Of course it is a single study with a limited number of patients, but the results are encouraging. It is further helped by the fact plasma exchange is a well established therapy, with established protocols known to intensivists and haematologists.

THE FUTURE

We may see the use of Plasma exchange for critically ill patients increase as the pandemic continues. It is not a treatment option available for everyone, as it requires intravenous access and careful monitoring in a controlled setting. But it also needs donation from people who have recovered from COVID and have suitable antibodies. So whilst it might not be a magic pill that everyone expects to cure COVID, it might be the difference between life and death for those that need it most.

Dr Rajan Choudhary, UK, Chief Product Officer, Second Medic Inc

www.secondmedic.com

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Nutritional Deficiencies in Indian Kids: Recognizing, Preventing & Overcoming “Hidden Hunger”

Every parent wants their child to grow up healthy — tall, strong, smart, and full of energy. But in India, many kids suffer from what is known as “hidden hunger.” It means that even though they are eating, their diet lacks essential nutrients. These nutritional deficiencies can affect growth, learning, immunity, and long-term health. In this blog, we’ll explore the major nutritional deficiencies in Indian kids, what causes them, how to detect them, and what parents can do. Let’s dive into nutritional deficiencies in Indian kids.

What Are the Most Common Nutritional Deficiencies?

Based on recent research and national surveys, the following are among the most widespread deficiencies in Indian children:

Iron Deficiency / Anaemia
A large percentage of Indian kids (especially under-5s) have low hemoglobin and low iron stores. Anaemia can cause tiredness, slow cognitive development, and lowered immunity. Lippincott Journals+2PMC+2
Vitamin A Deficiency
Vitamin A is essential for good vision, immunity, and healthy cells. Many children under 5 show sub-clinical deficiency; some show clinical signs like night blindness. Lippincott Journals+1
Iodine Deficiency
Iodine is critical for thyroid hormone production, which affects brain development. Lack of iodine can lead to goitre, delayed mental development, and poor school performance. Lippincott Journals+2thyrocare.com+2
Vitamin D Deficiency
Even though India is sunny, many children have low vitamin D — due to indoor living, limited sun exposure, skin coverage, or dietary gaps. This impacts bone health, growth, and risks rickets. PMC+1
Protein-Energy Malnutrition (PEM)
In poorer or marginalized communities, children may not get enough protein or calories. This leads to underweight, wasting, stunting, and weakened immunity. Lippincott Journals+2HDFC ERGO+2
Other Micronutrients (Vitamin B12, folate, zinc etc.)
Deficiencies in B12 & folate can affect cell division, blood production, nerve function; zinc deficiency weakens immunity & slows growth. PMC+2nanhedil.com+2

Why Do These Deficiencies Happen?

Understanding the causes helps in prevention:

Dietary Factors
Many diets are heavy in cereals or starches but low in diversity. Meals may lack fruits, vegetables, animal-source foods (meat, eggs, fish) or fortified products.
Bioavailability of Nutrients
Even when foods contain nutrients, they may not be absorbed well. For example, plant-based iron is less readily absorbed, phytates in grains and legumes can reduce absorption.
Socioeconomic Constraints
Poverty, food insecurity, access issues, lack of awareness, and sometimes traditional/cultural food beliefs limit access to nutrient-rich foods.
Living Conditions and Health
Frequent infections, parasitic infestations, poor hygiene, etc., can increase nutrient loss or demand. Also sunlight exposure (important for vitamin D) is inadequate in many cases.
Gaps in Implementation of Prevention Programs
Though India has multiple programs (fortification, supplement distribution, ICDS, National Nutrition Mission etc.), challenges remain in reach, compliance, quality, and behavioural change.

Effects of Nutritional Deficiencies

These deficiencies have short-term and long-term effects:

Growth stunting (children don’t reach their full height potential)
Wasting (low weight for height), underweight
Impaired cognitive development & learning difficulties
Weak immune system ? more infections
Delayed motor skills, poor school performance
Bone deformities (rickets, weak bones)
Poor quality of life; in severe cases, increased mortality

How to Detect & Diagnose Early

Taking action early helps avoid permanent harm. Key strategies include:

Regular growth monitoring: Checking weight, height, BMI for age
Look for signs: Pale skin or lips, tiredness, delayed milestones, frequent illness, bone pain or deformities (knees bowing, wrist/ankle enlargement)
Lab tests:
- Haemoglobin & complete blood count
- Serum ferritin for iron stores
- Serum levels for vitamin A (retinol)
- 25-OH vitamin D test
- Serum B12, folate
- Urinary iodine excretion or salt iodine test
- Protein / albumin levels

Using broad vitamin profiles (like those from Thyrocare) can help screen for multiple deficiencies in one go.

Foods, Diet & Prevention: What Parents / Caregivers Can Do

Here are practical steps parents can take:

Diversify diet: Include pulses, legumes, eggs, dairy, meat (if non-vegetarian), fish; plenty of green leafy vegetables & fruits.
Fortified foods: Use iodised salt; choose cereals / milk products fortified with vitamins & iron.
Sunlight exposure: Encourage outdoor activities; even short daily sun exposure (face, arms) helps vitamin D.
Supplementation when needed: Under doctor guidance, provide vitamin A doses, iron/folic acid, vitamin D etc., especially in high-risk children.
Hygiene & health care: Prevent worm infections, diarrhoea etc. which can drain nutrients. Ensure vaccinations.
Education & awareness: Teach families importance of nutrition, balanced meals, what local foods can provide what nutrients.

What Parents Should Ask Healthcare Providers

Ask whether your child needs screening for deficiencies (e.g., iron, vitamin A, D, B12).
If lab tests are suggested, check whether it’s comprehensive or narrow, cost, and follow-up.
Seek help for dietary planning, perhaps from nutritionists or public health bodies.
Learn about local government/NGO programs—free or subsidized supplementation or fortified food programs.

When to Seek Medical Help

If your child has:

Persistent anaemia symptoms (very pale, lethargic)
Growth issues (falling off growth charts)
Bone deformities or pain
Severe or recurrent infections
Unusual signs like night blindness, goitre

Then get a medical evaluation. Early intervention can make a big difference.

Conclusion & Call to Action

Nutritional deficiencies in Indian kids are common—but many are preventable or treatable. By recognizing risks, ensuring good diet, doing appropriate lab tests, and using supplements or fortified foods when needed, children can grow healthier, smarter, and stronger.

If you’re concerned that your child may have one or more of these deficiencies, talk to a trusted pediatrician or nutritionist, and consider getting a comprehensive vitamin & nutrition profile done (for example through Thyrocare or SecondMedic) to know exactly where improvements are needed. Don’t wait—every child deserves a strong foundation.

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