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Published on: Apr 13, 2020
3 minute read
By: Dr Rajan Choudhary

Plasma Treatment For COVID-19?

TREATING COVID WITH BLOOD

We have previously covered proposed treatments for COVID-19, in particular hydroxychloroquine, and explained why we shouldn’t look for a magic cure for this disease. Viruses are difficult to treat, and ultimately supportive treatment appears to be best we can achieve. But an editorial published in BioMedicine Central appears to show a novel treatment for the most ill patients, one that may have flown under most people’s radar.

“A novel treatment approach to the novel coronavirus: an argument for the use of therapeutic plasma exchange for fulminant COVID-19”

An interesting title. Lets dissect it.

SUMMARY

- Blood is made up of many different components

- The immune system recognises the virus and produces antibodies against it to neutralise it

- These antibodies float in the blood plasma, a watery solution

- The plasma can be extracted from donated blood, and given to patients suffering from COVID-19

- So far evidence suggests it can help treat the most seriously affected patients.

WHAT IS IN OUR BLOOD

To understand this we must first understand what our blood is made of. Most people know that blood functions to transport oxygen from our lungs. But this is an oversimplification. Blood has many different functions:

- Transport: along with oxygen it transports sugars, fats, protein subunits throughout the body. This is done with the watery PLASMA of the blood.

- Clot: cells and protein structures act to plug any holes that form from cuts and damage. This is done by the PLATELETS in the blood

- Immunity: Immune cells respond to bacteria, viruses, parasites in the blood and body. They target these pathogens, identify and tag them with antibodies, and ultimately destroy them. This is done by the WHITE BLOOD CELLS.

And many more functions that we won’t bore you with.

IMMUNITY

It is this last point that is of interest to us. Our immune system consists of white blood cells that can recognise invading organisms in the blood, around cells and even invaders hiding within our own cells. All cells have protein markers on their surface, no matter if its human cells, bacterial, viral, fungal etc. These markers can be highlighted and targeted by specialised white blood cells, who in turn produce antibodies against these markers. Think of antibodies as handcuffs with flares attached: once attached other white blood cells use this information to find and destroy the invaders.

What is amazing about antibodies is how complex they are. The proteins in our body are incredibly complex. They are long chains that fold into unique shapes depending on hundreds of different types of chemical interactions. These are so complex that supercomputers can take literal years to figure out the shape of a single protein and how it folds depending on the subunits in its chain. This means that our immune system has to recognise these markers and figure out a complementary tag out of hundreds of billions of potential sequences. Antibodies have to be specific to their tag. If an antibody is produced that can target more than one tag, it can cause problems. If it targets a bacterial tag, but accidentally highlights the person’s cells as well, the immune system will start targeting and destroying the person’s organs. These auto-immune disorders can be devastating.

But when they work, antibodies are miraculous. They persist in the blood after an infection, and if a second infection occurs, memory cells in the blood can rapidly produce these antibodies before the infection can even produce symptoms. This is known as immunity, and is why we usually don’t get the same illness twice. Antibody based treatment is see as the future of medical therapy, and is something we will cover in future blogs.

PLASMA EXCHANGE

From population testing we can see that the majority of patients with COVID-19 recover, experiencing either mild symptoms, moderate symptoms requiring some form of treatment and hospitalisation, or no symptoms whatsoever. In these patients their immune system will have successfully recognised the virus and produced antibodies against it to neutralise the virus. It is the patients with severe symptoms, those in which the virus is running rampant in the body, that the production of antibodies happens too late.

Plasma exchange involves obtaining blood from patients who have beaten the virus, spinning the blood to separate out the red cells, white cells, platelets and watery plasma. The plasma contains all the glucose, small proteins and importantly for us, the antibodies. This plasma can be transfused into patients with COVID-19 that cannot cope, in order to help their immune system. These transfused antibodies will neutralise some of the viruses in the patient, reducing the viral load, amount of replication and cell destruction that causes such devastating symptoms in COVID-19.

The published editorial showed that in the most critical pneumonia patients, requiring mechanical ventilators and drugs to support the heart, mortality in plasma exchange patients resulted in a 47.8% mortality instead of 81.3%. Of course it is a single study with a limited number of patients, but the results are encouraging. It is further helped by the fact plasma exchange is a well established therapy, with established protocols known to intensivists and haematologists.

THE FUTURE

We may see the use of Plasma exchange for critically ill patients increase as the pandemic continues. It is not a treatment option available for everyone, as it requires intravenous access and careful monitoring in a controlled setting. But it also needs donation from people who have recovered from COVID and have suitable antibodies. So whilst it might not be a magic pill that everyone expects to cure COVID, it might be the difference between life and death for those that need it most.

Dr Rajan Choudhary, UK, Chief Product Officer, Second Medic Inc

www.secondmedic.com

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Employee Wall of Fame: Celebrating Uniqueness to Build a Positive Workplace Culture

In today’s evolving workplaces, employee engagement is no longer driven solely by compensation or job titles. People seek recognition, inclusion and a sense of belonging. One of the most effective yet simple ways to achieve this is through an Employee Wall of Fame. By celebrating individuality and contribution, organisations can create a culture where employees feel seen, valued and motivated.

Recognition is not a luxury. It is a fundamental driver of organisational wellbeing and performance.

Why Recognition Matters in the Workplace

Recognition fulfills a basic human need: appreciation.

When employees feel recognised:

morale improves
motivation increases
loyalty strengthens
burnout reduces

According to global workplace studies, lack of recognition is one of the top reasons for employee disengagement.

What Is an Employee Wall of Fame?

An Employee Wall of Fame is a physical or digital space dedicated to highlighting employees for their achievements, values, creativity or unique strengths.

It may showcase:

professional accomplishments
teamwork contributions
innovation and problem-solving
leadership qualities
personal milestones

The focus is not competition, but appreciation.

Celebrating Uniqueness, Not Just Performance

Traditional recognition often focuses only on targets or numbers.

A Wall of Fame expands recognition to include:

collaboration
consistency
empathy
creativity
positive attitude

This approach ensures diverse strengths are valued.

Psychological Impact of Workplace Recognition

Recognition positively affects mental health.

Benefits include:

improved self-esteem
reduced stress
increased sense of purpose
stronger emotional connection to work

WHO recognises psychosocial wellbeing as a key component of healthy workplaces.

Inclusion and Belonging Through Recognition

Celebrating uniqueness supports inclusion.

It helps:

recognise diverse backgrounds
reduce bias
promote equal visibility

When employees see people like themselves being appreciated, trust and belonging grow.

Employee Wall of Fame as a Culture-Building Tool

Culture is shaped by what organisations choose to celebrate.

A visible Wall of Fame:

reinforces company values
sets behavioural standards
inspires others

It becomes a living reflection of organisational culture.

Types of Recognition on a Wall of Fame

Achievement-Based Recognition

For milestones, project success or innovation.

Value-Based Recognition

For demonstrating company values such as integrity or teamwork.

Peer Recognition

Employees nominate colleagues, increasing engagement.

Personal Growth Recognition

Celebrating learning, upskilling or personal achievements.

How an Employee Wall of Fame Improves Engagement

Engaged employees:

perform better
collaborate more
stay longer

EY-FICCI workplace studies show recognition-driven programs significantly improve engagement scores.

Impact on Productivity and Performance

Recognition creates positive reinforcement.

Employees who feel valued:

take ownership of work
show initiative
maintain consistency

Appreciation fuels sustained performance.

Supporting Mental Wellbeing at Work

Recognition reduces workplace stress by:

validating effort
reducing feelings of invisibility
encouraging positive feedback loops

Mental wellbeing improves when employees feel respected and acknowledged.

How to Design an Effective Employee Wall of Fame

Key principles include:

inclusivity
transparency
fairness
consistency

Clear criteria prevent bias and ensure credibility.

Physical vs Digital Wall of Fame

Physical Wall

Creates visual impact in office spaces.

Digital Wall

Ideal for remote or hybrid teams.

Both formats can coexist for maximum reach.

Frequency of Updates Matters

Stale recognition loses impact.

Best practices include:

monthly highlights
quarterly rotations
special occasion features

Fresh content sustains enthusiasm.

Role of Leadership in Recognition

Leadership participation strengthens impact.

When leaders:

nominate employees
share appreciation publicly

recognition becomes part of organisational identity.

Employee Participation and Ownership

Encouraging peer nominations:

increases engagement
reduces hierarchy
builds mutual respect

Recognition becomes a shared responsibility.

Measuring the Impact of Recognition Initiatives

Impact can be assessed through:

engagement surveys
retention metrics
feedback forms
participation rates

Data-driven insights help refine programs.

Long-Term Benefits of Celebrating Uniqueness

Over time, organisations experience:

stronger culture
higher retention
improved employer branding
healthier workplace relationships

Recognition is a long-term investment, not a one-time activity.

Common Mistakes to Avoid

Avoid:

recognising only top performers
favouritism
lack of transparency
irregular updates

Consistency and fairness are essential.

Employee Wall of Fame as Part of Holistic Wellness

Recognition complements:

mental health initiatives
team-building programs
wellness activities

A supportive culture enhances overall wellbeing.

Conclusion

An Employee Wall of Fame is more than a display—it is a statement of values. By celebrating uniqueness and recognising diverse contributions, organisations create workplaces where people feel valued, motivated and connected. In an era where employee wellbeing and engagement define success, recognition-driven initiatives like a Wall of Fame play a vital role in building resilient, inclusive and high-performing teams. Celebrating people is not just good culture—it is good leadership.

References

World Health Organization (WHO) – Workplace Mental Health and Wellbeing
EY-FICCI – Employee Engagement and Workplace Culture Reports
NITI Aayog – Future of Work and Organisational Wellbeing Studies
Lancet – Psychosocial Work Environment Research
Statista – Global Employee Engagement and Recognition Trends

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