Q.

There are some major differences between benign and malignant tumours, so why does a tumour become benign or malignant? Why does it not form the same type of tumour every time?

Asked by KAVITA MISHRA ·

Medically reviewed by SecondMedic medical review team

Doctor avatar

Answered by SecondMedic Expert

Oncologist · Cancer / Oncology / Cancer Surgery

The difference between benign and malignant tumors occurs when the cells in the tumor become cancerous. A malignant tumor, or cancer, can spread to other parts of the body, while a benign tumor stays put, growing but not spreading to other parts of the body.

Many factors influence why a tumour becomes benign or malignant. The most important factor is genetic mutations; mutations within certain genes increase a cell’s potential for becoming cancerous. Mutations happen when an error occurs during DNA replication, allowing changes that can cause cells to divide uncontrollably and create tumors with abnormal characteristics.

Environmental carcinogens such as air pollution, high levels of sun exposure, industrial chemicals and smoking may also contribute to causing genetic mutations which can turn normal cells into cancerous ones over time.

Infection by viruses like HPV (human papilloma virus) has been linked with some forms of infection-induced cancers too. Viruses have oncogenes – mutated genes which reproduce rapidly enough in human cells so that they override normal cellular controls mechanisms normally used for gene expression regulation as well as growth control – increasing chances for creating conditions favorable for tumour formation and development.

Other factors such as age and diet also play key roles in influencing potential risks for developing malignant tumours due to effects on hormones and immune system functioning under different circumstances over time; these effects further amplify any genetic predispositions from environmental causes creating conditions favorable for transformation from benign status into increasingly aggressive characteristics so characteristic of many advanced cancers types today .

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