Q. What are the main causes of atrial septal defect (ASD)?
Doctor Answer is medically reviewed by SecondMedic medical review team.
Atrial septal defect (ASD) is a congenital heart defect that occurs when an opening in the wall between the two upper chambers of the heart does not close completely. It is one of the most common types of birth defects, affecting approximately 40,000 babies each year in the United States alone.
The exact cause of ASD is unknown, though research suggests that it may be caused by a combination of genetic and environmental factors. A family history of congenital heart defects appears to increase risk for ASD, as do certain medical conditions such as Down syndrome or other chromosomal anomalies, maternal diabetes mellitus type 1 and/or 2 during pregnancy, exposure to certain medications or chemicals during pregnancy (such as retinoic acid), or intrauterine infections like rubella or cytomegalovirus.
A recent study also suggests that high levels of folic acid intake before and during early pregnancy may reduce the risk for ASD in children born to women with folate-sensitive genotypes. As such, many doctors recommend taking prenatal vitamins containing folic acid starting at least three months prior to conception.
In conclusion, while there may not be one single known cause behind all cases of atrial septal defect (ASD), there are several risk factors associated with this condition which parents should pay attention to in order to reduce their child’s chances for developing it – including family history; prenatal diagnosis; exposure to diseases like rubella virus infection; chemical toxins such as retinoic acid; and changeable lifestyle elements such maternal nutrition patterns before and during early stages on pregnancy - which could have an impactful role on reducing risks.