Q. How does immunotherapy work to treat cancer?
Doctor Answer is medically reviewed by SecondMedic medical review team.
Immunotherapy works to treat cancer by harnessing and enhancing the body's own immune system to recognize, target, and destroy cancer cells. The immune system is equipped with various mechanisms to detect and eliminate abnormal cells, including cancer cells. However, cancer cells can often evade detection or suppress the immune response. Immunotherapy interventions are designed to overcome these evasion strategies and bolster the immune system's ability to fight cancer. Here's how immunotherapy works in cancer treatment:
1. Enhancing Immune Recognition: Cancer cells can sometimes avoid detection by the immune system because they may not appear significantly different from normal cells. Immunotherapy, such as checkpoint inhibitors, can block the proteins that inhibit immune responses, allowing the immune system to recognize cancer cells more effectively.
2. Activating T Cells: T cells are a type of immune cell that plays a central role in the immune response. Some immunotherapies, like CAR-T cell therapy, genetically engineer a patient's own T cells to express receptors (CARs) that target specific proteins on cancer cells. These modified T cells can then recognize and destroy cancer cells.
3. Monoclonal Antibodies: Monoclonal antibodies are engineered proteins that can be designed to target specific proteins on the surface of cancer cells. When these antibodies bind to cancer cells, they can mark them for destruction by the immune system or directly interfere with their growth and division.
4. Cancer Vaccines: Cancer vaccines stimulate the immune system to recognize specific proteins or antigens found on cancer cells. These vaccines can help the immune system identify cancer cells more effectively, much like traditional vaccines prepare the immune system to fight infectious diseases.
5. Immune Checkpoint Inhibition: Immune checkpoint inhibitors are drugs that block proteins like PD-1 or CTLA-4, which cancer cells use to dampen the immune response. By blocking these checkpoints, the immune system's activity is restored, allowing it to attack cancer cells.
6. Enhancing Immune Memory: Some immunotherapies aim to create long-lasting immune memory against cancer. This means that even after the initial treatment, the immune system continues to recognize and fight cancer cells if they reappear.
It's important to note that not all cancers respond equally to immunotherapy, and individual responses can vary. Additionally, immunotherapy may be used alone or in combination with other cancer treatments such as chemotherapy, radiation therapy, or targeted therapy, depending on the specific cancer type and stage. Healthcare providers carefully evaluate each patient's condition to determine the most appropriate treatment plan, which may include immunotherapy as part of a comprehensive approach to cancer treatment.