Book Progesterone Test in Madurai

The Progesterone test is a blood test that measures the level of progesterone, a steroid hormone produced primarily by the corpus luteum in the ovary following ovulation, by the placenta during pregnancy, and in smaller amounts by the adrenal glands in both men and women. Progesterone plays an indispensable role in preparing and maintaining the uterine lining for embryo implantation, suppressing uterine contractions to sustain early pregnancy, modulating the immune response to prevent foetal rejection, and regulating the menstrual cycle in coordination with oestrogen. In men, progesterone is produced in small quantities by the adrenal glands and testes and serves as a precursor for testosterone and other steroid hormones. Progesterone levels vary dramatically across the menstrual cycle, remaining low during the follicular phase before ovulation, rising sharply after ovulation during the luteal phase as the corpus luteum becomes the primary progesterone source, and falling again at the end of the cycle if fertilisation does not occur, triggering menstruation. If conception occurs, progesterone continues to rise as the corpus luteum is maintained by human chorionic gonadotropin from the implanting embryo, and placental progesterone production takes over from approximately the eighth to tenth week of pregnancy, sustaining progressively rising levels throughout gestation. In India, reproductive health conditions including polycystic ovary syndrome affecting an estimated one in five women, recurrent pregnancy loss, and infertility are among the most prevalent causes of healthcare consultation in women of reproductive age, making progesterone measurement a routinely essential investigation in gynaecological and reproductive endocrinological practice. The test is performed on a small blood sample drawn from a vein and completed in under five minutes.

Doctors prescribe a Progesterone test in the following situations: Confirming ovulation in women being investigated for infertility or menstrual irregularities where a mid-luteal phase progesterone level, typically measured on day 21 of a 28-day cycle, above 3 ng/mL confirms that ovulation has occurred and that the corpus luteum is producing adequate progesterone to support potential implantation. Evaluating luteal phase deficiency in women with recurrent implantation failure and early pregnancy loss where inadequate mid-luteal progesterone production impairs endometrial receptivity and embryo implantation, and where progesterone supplementation is a well-established treatment to support early pregnancy in affected individuals. Monitoring early pregnancy viability in women with threatened miscarriage, vaginal bleeding, and lower abdominal pain where serial progesterone measurements provide prognostic information about pregnancy outcome, with levels above 25 ng/mL generally associated with a viable intrauterine pregnancy and levels below 5 ng/mL suggesting a failing or ectopic pregnancy. Investigating ectopic pregnancy in women with a positive pregnancy test and no intrauterine gestational sac on ultrasound where a low or declining progesterone level supports the diagnosis of an ectopic or non-viable pregnancy and assists clinical decision-making regarding surgical or medical management. Assessing progesterone supplementation adequacy in women undergoing assisted reproductive technology including IVF and frozen embryo transfer cycles where exogenous progesterone is administered to support the luteal phase and endometrial preparation, and where serum progesterone monitoring ensures therapeutic levels are being achieved and maintained. Evaluating adrenal and ovarian disorders including congenital adrenal hyperplasia and certain ovarian tumours where elevated progesterone levels may indicate specific enzymatic defects in steroid synthesis or autonomous progesterone secretion by a neoplastic process requiring further specialist investigation.

The Progesterone test measures the concentration of progesterone in the blood serum, expressed in nanograms per millilitre (ng/mL) or nanomoles per litre (nmol/L). Reference ranges vary significantly depending on the phase of the menstrual cycle and pregnancy status, making timing of the test critically important for result interpretation. Normal ranges are less than 1 ng/mL in the follicular phase, 2 to 25 ng/mL in the mid-luteal phase, less than 1 ng/mL in postmenopausal women, and progressively rising from 11 to 44 ng/mL in the first trimester to 65 to 290 ng/mL in the third trimester of pregnancy. Normal for Cycle Phase A result within the expected range for the specific cycle phase at the time of testing indicates appropriate progesterone production. A mid-luteal progesterone above 3 ng/mL confirms ovulation, while levels above 10 ng/mL suggest adequate corpus luteum function and a favourable endometrial environment for implantation and early pregnancy maintenance. Low Progesterone A low progesterone result relative to the expected cycle phase indicates absent or inadequate ovulation, luteal phase insufficiency, or in early pregnancy, a failing or ectopic pregnancy. In women undergoing fertility treatment, low progesterone during the luteal phase or early pregnancy despite supplementation may indicate the need for dose adjustment or alternative progesterone delivery methods under specialist guidance. Elevated Progesterone An elevated progesterone result outside of the expected luteal or pregnancy range may indicate a luteinised unruptured follicle, ovarian cysts with progesterone secretion, congenital adrenal hyperplasia with 21-hydroxylase or 11-beta hydroxylase deficiency, or rarely a progesterone-secreting adrenal or ovarian tumour requiring further specialist evaluation and imaging.

The timing of the Progesterone test relative to the menstrual cycle is the single most important preparation consideration, as progesterone levels vary enormously across cycle phases and a result cannot be accurately interpreted without knowing the day of the cycle on which the sample was collected. For confirming ovulation, the test should be performed on day 21 of a 28-day cycle, or seven days before the expected next period in cycles of different lengths, to capture the mid-luteal progesterone peak. No fasting is required for the Progesterone test, as food and fluid intake do not affect progesterone concentrations in the blood. The test can be performed at any time of day without specific dietary restrictions, though morning collection is generally preferred when the test is ordered alongside other hormonal investigations including LH, FSH, oestradiol, and prolactin. Inform your doctor about all medications and hormonal preparations currently being taken, particularly progesterone suppositories, vaginal gels, intramuscular progesterone injections, oral micronised progesterone, oral contraceptives, and fertility medications including clomiphene and gonadotropins, as exogenous progesterone directly elevates serum levels and must be factored into clinical interpretation. Staying well hydrated before the blood draw facilitates easier venous access and a smooth collection experience.

If you are booking through the SecondMedic platform the Progesterone test price in Madurai can cost you around Rs. 638. You may also consider booking a comprehensive female hormonal panel that includes Progesterone alongside LH, FSH, oestradiol, prolactin, and AMH for a complete assessment of ovarian function and reproductive hormonal health at a bundled price on SecondMedic.

SecondMedic offers convenient home sample collection for the Progesterone test in Madurai, making it easy to get tested without visiting a diagnostic centre. Home collection is available free of charge for orders above Rs. 300. A trained phlebotomist will visit your preferred address between 7 AM and 10 PM, seven days a week, including Sundays and public holidays. Your blood sample is processed at NABL-accredited partner laboratories, and your report is delivered within 24 hours directly to your WhatsApp and email.