gliclazide, pioglitazone hydrochloride, and metformin hydrochloride are combination medicines that work by different mechanisms to control blood sugar better when single or dual therapy is not beneficial. gliclazide is a sulfonylurea that works by increasing the secretion of insulin released by the pancreas to lower blood glucose levels. pioglitazone is a thiazolidinedione that increases insulin sensitivity. metformin is a biguanide that reduces glucose production in the liver, delays glucose absorption from the intestines, and further increases the body's sensitivity to insulin. continue the medication even if you feel better and your blood sugar levels are under control.
suppose you quit the drug without consulting your doctor, your blood sugar levels could rise, and it may lead to the risk of kidney damage, blindness, nerve problems, and loss of limbs. you should be aware of the treatment, including a healthy diet, regular exercise, and weight reduction as advised by your doctor. your lifestyle modifications play a significant role in controlling diabetes.
the most common side effect of this medication is low blood glucose levels (hypoglycemia). to prevent this, always carry a candy or fruit juice that acts as a fast-acting glucose source. avoid alcohol consumption as it increases your risk of low blood sugar levels.
other side effects include nausea, taste changes, diarrhoea, stomach pain, headache, oedema (swelling), blurred vision, bone fracture, and upper respiratory tract infections. some people would gain weight by taking this medication. do not take medicine if you have type 1 diabetes mellitus, diabetic ketoacidosis (high levels of acid in your blood), or severe kidney or liver disease.
before taking this medicine, inform your doctor if you have ever had heart disease. it may not be suitable. inform your doctor if you are pregnant or intend to be pregnant or breastfeeding a baby. monitor your blood sugar levels regularly. your doctor may also advise blood tests to monitor your blood cell counts and liver function.
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