Q. What is meant by neo-adjuvant therapy?
Doctor Answer is medically reviewed by SecondMedic medical review team.
Neo-adjuvant therapy, sometimes referred to as preoperative or neoadjuvant therapy, is a type of treatment given to patients prior to surgery in order to reduce tumor size and improve the chances of success during the surgical procedure. Typically, this type of therapy is used for malignant tumors (cancerous growths) that are not easily removed without first shrinking the tumor mass. Generally, neo-adjuvant therapies are administered according to an individualized plan tailored towards each patient's specific diagnosis and medical history.
The primary goal of neo-adjuvant therapies is twofold: 1) achieve favorable response rates on imaging studies; and 2) decrease local recurrence rates (e.g., cancer returning after removal). To accomplish this goal, many different types of treatments may be employed together or consecutively in order to best affect positive outcomes for patients before entering into surgery. Commonly utilized techniques may include: radiation therapy; systemic chemotherapy; hormone therapy; immunotherapy; targeted therapy (i.e., small molecule inhibitors); biologic agents such as monoclonal antibodies; and aggressive combination chemotherapy regimens with other drugs or drug cocktails.
It should be noted that while neo-adjuvant therapies can provide remarkable benefits when applied appropriately — such as increased survival rates due to shrinking tumors – there also exist certain drawbacks associated with their use including potentially serious side effects including intestinal perforation, tissue necrosis/ulceration among others—much more so than with adjuvant (after surgery) approaches alone—as well as greater costs incurred prior to any surgeries being performed due to additional treatments required beforehand by medical professionals before entering into the operating room itself when compared one–to–one against comparable results achieved without their implementation—making it all–the–more critical for physicians/patients alike take full stock regarding these potential risks & rewards when deciding whether or not utilizing them will prove beneficial in any particular case presentation going forward from there onwards onwards from then onwards too...but alas! Isn't that what medicine should always do? ;)
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