Q. How are histopathology samples obtained?
Doctor Answer is medically reviewed by SecondMedic medical review team.
Histopathology samples are obtained through various procedures, depending on the specific diagnostic requirements. The most common methods include:
1. Biopsy:
- Needle Biopsy: A thin needle is used to extract a small tissue sample from a suspicious area. This is often done with the guidance of imaging techniques such as ultrasound or CT scans.
- Surgical Biopsy: A surgical procedure is performed to remove a larger tissue sample. This is commonly done when a more substantial specimen is needed for diagnosis.
2. Excisional Biopsy:
- The complete removal of a suspicious area or lump for examination.
3. Endoscopic Biopsy:
- Tissue samples are collected using an endoscope, a flexible tube with a light and camera, which is inserted into the body through natural openings or small incisions.
4. Bone Marrow Aspiration and Biopsy:
- Used to obtain samples from the bone marrow, often from the hip bone, to diagnose blood disorders and certain cancers.
5. Cytology:
- Involves the collection of individual cells rather than whole tissue. Common examples include Pap smears for cervical cytology and fine-needle aspirations.
6. Autopsy:
- Post-mortem examination of the entire body or specific organs to determine the cause of death and understand the extent of diseases.
7. Punch Biopsy:
- A circular blade is used to remove a small, cylindrical core of tissue.
8. Skin Biopsy:
- Involves the removal of a small piece of skin for examination, often used in dermatological cases.
The choice of biopsy method depends on factors such as the location of the suspected abnormality, the size of the sample needed, and the nature of the suspected disease. Each method aims to provide a representative sample that can be processed and analyzed under a microscope by a pathologist for accurate diagnosis.
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