Book IgG Test: Purpose, Normal Range and Price

The IgG test is a blood test that measures the level of Immunoglobulin G, the most abundant antibody class in the human bloodstream, accounting for approximately 75 to 80% of all circulating antibodies. IgG is produced by plasma cells as part of the adaptive immune response and plays the central role in long-term immunity against bacterial and viral infections, providing protection through neutralisation of pathogens, activation of complement, and facilitation of phagocytosis. IgG is the only antibody class that crosses the placenta, providing passive immunity to the newborn during the first months of life before the infant's own immune system matures. IgG measurement is clinically important across a broad range of conditions. Deficiency of IgG, either isolated or as part of a wider immunodeficiency syndrome, results in recurrent bacterial infections, chronic sinopulmonary disease, and failure to respond normally to vaccines. Excess IgG in the form of a monoclonal IgG spike is the hallmark of IgG multiple myeloma, the most common type of multiple myeloma in India and globally. Polyclonal IgG elevation reflects chronic immune activation seen in autoimmune diseases, chronic infections, and liver disease. In India, where both primary immunodeficiency disorders and plasma cell malignancies are increasingly diagnosed, IgG measurement is an essential component of immune function evaluation, myeloma workup, and chronic disease assessment. The test involves a simple blood draw completed in under five minutes.

Doctors prescribe an IgG test in the following situations: Diagnosing primary immunodeficiency disorders including common variable immunodeficiency and selective IgG subclass deficiency in patients with recurrent bacterial infections, chronic sinusitis, recurrent pneumonia, and failure to mount adequate responses to vaccines. Evaluating IgG multiple myeloma in patients with bone pain, anaemia, hypercalcaemia, and renal impairment where a markedly elevated monoclonal IgG identified on serum protein electrophoresis is characterised by IgG quantification and immunofixation as part of the complete myeloma diagnostic workup. Monitoring IgG replacement therapy with intravenous or subcutaneous immunoglobulin in patients with confirmed immunodeficiency where serial IgG measurements confirm that trough levels are maintained above the protective threshold between infusions. Investigating autoimmune conditions including systemic lupus erythematosus, rheumatoid arthritis, and autoimmune hepatitis where polyclonal IgG elevation reflects sustained immune activation and contributes to the overall autoimmune serological assessment. Evaluating chronic liver disease and autoimmune hepatitis where significantly elevated polyclonal IgG, particularly IgG above twice the upper limit of normal, is a characteristic feature of autoimmune hepatitis that supports the diagnosis alongside liver histology and specific autoantibodies. Assessing immune reconstitution in patients recovering from bone marrow transplantation, chemotherapy, or immunosuppressive therapy where rising IgG levels confirm restoration of humoral immune function. Investigating recurrent infections in children where low IgG alongside low IgA and IgM may indicate a primary immunodeficiency requiring specialist immunological evaluation and long-term immunoglobulin replacement.

The IgG test measures the total concentration of Immunoglobulin G in the blood, reported in milligrams per decilitre (mg/dL) or grams per litre (g/L). Normal IgG Range in India The standard reference ranges used across most Indian diagnostic laboratories are as follows. For adults, a normal IgG level is between 700 and 1600 mg/dL. IgG levels are lower in infants and young children due to physiological immunological immaturity and rise progressively to adult levels by late childhood. Reference ranges may vary slightly between laboratories. Interpreting IgG Results An IgG level below 700 mg/dL in adults indicates hypogammaglobulinaemia. Levels below 400 mg/dL represent significant IgG deficiency associated with substantially increased susceptibility to bacterial infections and typically require immunoglobulin replacement therapy under immunologist supervision. An IgG level between 1600 and 3000 mg/dL represents moderate elevation and is most commonly seen in chronic infections such as tuberculosis and HIV, autoimmune diseases, and chronic liver disease where polyclonal immune activation drives sustained antibody production. An IgG level above 3000 mg/dL is markedly elevated and raises concern for a monoclonal IgG plasma cell disorder including IgG myeloma or MGUS, or for severe autoimmune hepatitis, and warrants serum protein electrophoresis and immunofixation to characterise the nature of the elevation.

No fasting is strictly required for the IgG test alone. However if IgG is part of a broader immunological or metabolic panel that includes fasting parameters, fast as advised by your doctor. Our team confirms preparation requirements at the time of booking. Inform the phlebotomist about all medications you are currently taking, particularly immunosuppressants, corticosteroids, rituximab, chemotherapy agents, and intravenous immunoglobulin infusions, as these directly affect IgG levels and must be disclosed for accurate interpretation. Inform your doctor about any recent IVIG infusion as intravenously administered immunoglobulin transiently raises serum IgG levels significantly and will not reflect endogenous production. Trough level testing should be performed immediately before the next scheduled infusion for the most meaningful monitoring result. Inform your doctor about any recent or active infections as acute infections can transiently affect immunoglobulin levels and may complicate result interpretation. Stay normally hydrated before sample collection.

If you are booking through the SecondMedic platform the IgG test price starts at approximately Rs. 830. The exact price will be confirmed at the time of booking through SecondMedic. If your doctor has prescribed multiple tests alongside IgG, SecondMedic health packages include IgG as part of a broader immunology, myeloma workup, or autoimmune panel at a significantly lower combined price.

SecondMedic provides home sample collection for IgG test across all major areas. You do not need to visit a lab or collection centre. A certified and trained phlebotomist comes to your home or workplace at your chosen time, collects the sample using sterile single-use equipment, and ensures it is transported to the NABL-accredited lab within the required time window for accurate processing. Please note that SecondMedic provides free home sample collection on all tests priced above Rs. 300. Our team will check your pincode and confirm if your address falls under our free sample collection eligibility criteria, which depends upon the lab location and phlebotomist availability. Home collection is available between 7 AM and 10 PM, seven days a week, including Sundays and public holidays. For patients on IVIG therapy, the collection will be scheduled immediately before the next infusion for the most accurate trough level measurement. Enter your pincode on the booking page or call our helpline to confirm availability at your address.