Sigdoth 50mg Tablet is a tricyclic antidepressant used to treat depression It works by increasing the levels of noradrenaline and serotonin in the brain It inhibits the reuptake of these neurotransmitters amplifying their effects in the brain Sigdoth also interacts with specific receptors such as 2adrenoceptors and serotonin receptors which contribute to its antidepressant effects It can cause sedation and dry mouth by affecting histamine and muscarinic acetylcholine receptors It is important to follow your doctors instructions when taking Sigdoth and it can be taken with or without food Some common side effects include dry mouth difficulty urinating constipation dizziness sedation and loss of accommodation Sigdoth can affect the hearts conduction system and increase intraocular pressure so individuals with heart problems or glaucoma should inform their healthcare provider If a dose is missed it should be taken as soon as remembered but double doses should be avoided