Tyronib 400mg Tablet is a tyrosine kinase inhibitor used for treating certain cancers It works by blocking specific proteins called tyrosine kinases which are involved in cancer cell growth Taking Imatinib mesylate with or without food is possible but it is recommended to take it at the same time each day for better results Common side effects may include swelling fatigue rash fever hair loss difficulty sleeping joint and muscle pain weight gain night sweats itching gastrointestinal toxicity blood cell abnormalities liver toxicity and renal toxicity Severe or persistent symptoms should be promptly reported to the healthcare provider Tumor lysis syndrome can occur especially in individuals with a high tumor burden so monitoring and preventive measures are necessary If a dose is missed patients should take it as soon as they remember but doubling the dose should be avoided Seeking medical attention is advisable for severe or persistent musculoskeletal pain or cramps