Zimalgin 15 mg/500 mg Tablet is a combination of two medicines used in the treatment of headache. It helps relieve headache by blocking the release of certain chemical messengers that causes headache. Your doctor will advise how much Zimalgin 15 mg/500 mg Tablet you need to take. It can be taken with or without food. You should take the medicine regularly while you do need it and try not to miss doses as it will become less effective. It should be used with caution in people who have any problems with their heart, kidneys, or liver.